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Nathan Goodyear

Uric acid in chronic heart failure: a marker of chronic inflammation - 0 views

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    uric acid is inflammatory marker associated with chronic heart failure
Nathan Goodyear

Case Report: Testicular failure possibly associated with chronic us... - PubMed - NCBI - 0 views

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    Case report links possible methylphenidate, Ritalin, use to Testicular failure. 
star yu

Kidney Failure with 15% Kidney Function are there Any Other Treatment besides Dialysis - 0 views

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    It is known that dialysis is the most common ways to treat kidney failure, but what if the patient don't want to take it or can not take it ? Are there any other treatment besides dialysis for kidney failure with 15% kidney function ?
Nathan Goodyear

Heart failure improvement from a supplement containing copper | European Heart Journal - 0 views

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    heart failure improved with copper supplementation.
Nathan Goodyear

Renal Failure Associated with Cancer and Its Treatment: An Update - 0 views

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    great review of renal failure in cancer patients.
Nathan Goodyear

High Progesterone Receptor Expression in Prostate Cancer Is Associated with Clinical Fa... - 0 views

  • Currently, there is a general agreement of PGR presence in the stromal cells of PCa
  • expressed in both stromal and tumor cells of the PCa tissue
  • In univariate analysis, a high density level of PGR in both TE and TS was associated with CF
  • ...17 more annotations...
  • High density level of PGR in the TE was an independent prognostic factor for CF.
  • Our large-sized study demonstrates a wide distribution of PGR in stromal and epithelial cells of both benign and malignant prostate tissue
  • there seems to be a general agreement of PGR presence in the stromal cells of PCa
  • In line with our findings, several have also reported a high PGR expression in TE of PCa [9,10,23,25]. In contrast, others have demonstrated a total lack of PGR expression in TE
  • the actions of progesterone are tissue specific
  • In our work univariate analysis demonstrated a high PGR expression in TS to be associated with clinical failure in PCa patients. So far we have not yet demonstrated the mechanism underlying this association
  • Several non-genomic proliferative actions of progesterone have been proposed in tumor cells of other organs, including breast [35–37], astrocytoma [38] and osteosarcoma [39] cell lines. However, such results are contradicted by suggestions of anti-proliferative actions of progesterone in endometrial cancer
  • Yu et al. found PGR to be negatively regulating stromal cell proliferation in vitro
  • high PGR density level in TE was associated with CF in patients with Gleason score ≥ 7
  • Bonkhoff et al. have suggested progressive emergence of PGR during PCa progression and metastasis
  • Latil and co-workers found a decreased PGR expression in clinically localized tumors and increased PGR expression in hormone-refractory tumors, when compared with normal prostate tissue
  • Our findings provide further support to these findings, indicating that PGR plays a role in the pathogenesis of PCa
  • Ki67 and PGR in TE were correlated with CF (S3 Text), indicating an association between PGR and proliferative activity
  • The mechanism behind the PGR up-regulation in PCa has not yet been elucidated
  • The PGR is, like the glucocorticoid receptor, similar to androgen receptor with 88% sequence homology in the ligand-binding domain
  • progesterone induced expression of androgen receptor-regulated genes could be a potential mechanism contributing to the development of castrate resistant PCa
  • A possibility of different roles by the two PGR isoforms in normal prostate tissue and PCa, as is suggested for the estrogen receptors [13], must also be taken into account
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    STudy finds that increased Progesterone receptor expression on epithelial and stromal cells is associated with increased clinical failure of therapy.  Several proposed mechanisms: 88% homologous with androgen receptor suggesting cross-stimulation and via progesterone induced increased androgen receptor gene stimulation i.e. epigenetics.
Nathan Goodyear

Cross-sectional relationship of a Mediterranean type diet to diastolic heart function i... - 0 views

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    Cardiac systolic/diastolic function improved with Mediterranean diet in individuals with chronic heart failure.
Nathan Goodyear

Effect of the Mediterranean diet on heart failure biomarkers: a randomized sample from ... - 0 views

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    Mediterranean diet reduces heart failure risk as determined by modified biomarkers: decreased ox LDL, natriuretic peptide...
Nathan Goodyear

Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis - 0 views

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    Meta-analysis shows that coQ10 "may" improve heart function in those with CHF.
Nathan Goodyear

Vitamin B6 supplementation can improve peripheral polyneuropathy in patients ... - 0 views

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    vitamin B6 was shown to improve peripheral neuropathy in renal failure patients.  
Nathan Goodyear

Effect of Hysterectomy With Ovarian Preservation on Ovarian... : Obstetrics & Gynecology - 0 views

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    premature ovarian failure shown to be more common post hysterectomy
Nathan Goodyear

Association of Preoperative Testosterone Levels with Biochemical Failure in Men Undergo... - 0 views

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    Low Testosterone as defined via serum levels found to correlate with poor outcome in prostate cancer: positive margins, seminal vesicle invasion, and biochemical failure (ADR).
Nathan Goodyear

Effects of physiologic testosterone therapy on qua... [Menopause. 2014] - PubMed - NCBI - 1 views

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    12 months of Testosterone in women with premature ovarian failure found no benefit in quality of life measures.  Testosterone is being marketed and touted as a means to help women through menopause.  This study, though no side effects found, no benefit found.
Nathan Goodyear

Low circulating androgens and mortality risk in heart ... [Heart. 2010] - PubMed - NCBI - 0 views

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    low androgens, DHEA and free Testosterone, associated with increased poor prognosis in men with heart failure
Nathan Goodyear

Association of Preoperative Testosterone Levels with Biochemical Failure in Men Undergo... - 0 views

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    Study finds that low Testosterone preoperative is associated with increased positive surgical margins and worse staging post radical prostatectomy.  Also association with a non-statistical increase in biochemical failure.
Nathan Goodyear

Association of serum androgen concentrations with... [Aging Male. 2014] - PubMed - NCBI - 0 views

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    Men with heart failure have lower Total Testosterone, free Testosterone, DHEAS levels and increased SHBG when compared to those without.
Nathan Goodyear

Wasting syndrome with deep bradycardia as ... [BMC Endocr Disord. 2014] - PubMed - NCBI - 0 views

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    long standing low T linked to bradycardia and heart failure in case series.  Exact relationship of cause/effect unknown, though low T has been shown to be associated with wide spectrum of increased risk of CVD.
Nathan Goodyear

Human papilloma virus vaccine and primar... [Am J Reprod Immunol. 2013] - PubMed - NCBI - 0 views

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    3 cases of primary ovarian failure following HPV vaccination.
Nathan Goodyear

Reverse T3 as a parameter of myocardial function impairment in heart failure. - 0 views

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    reverse T3 and the free T3:rT3 can be used to assess prognosis of those with CHF.
Nathan Goodyear

Testosterone and pro-inflammatory cytokines in men with chronic heart failure - 0 views

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    Low bioavailable Testosterone associated with increased IL-1beta and TNF-alpha in men with CHF.
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