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Nathan Goodyear

Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Am... - 0 views

circ.ahajournals.org/...731

CRP cardiovascular risk women

shared by Nathan Goodyear on 04 Feb 11 - No Cached
  • CRP is a strong independent risk factor for cardiovascular disease that adds to the predictive value of risk models based on usual factors alone.
  • Nathan Goodyear on 04 Feb 11
     
    CRP is marker for cardiovascular risk in women
Nathan Goodyear

Subclinical thyroid dysfunctions are independent risk factors for mortality in a 7.5-ye... - 0 views

www.eje-online.org/...569

subclinical thyroid dysfunctions

shared by Nathan Goodyear on 24 Mar 11 - No Cached
  • subclinical hyperthyroidism is an independent risk factor for all-cause and cardiovascular mortality, while subclinical hypothyroidism is associated with all-cause mortality
  • Nathan Goodyear on 24 Mar 11
     
    sub-clinical hypothyroidism and sub-clinical hyperthyroidism associated with increased mortality
Nathan Goodyear

Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity... - 0 views

diabetes.diabetesjournals.org/...344.short

sirt1 Resveratrol Diabetes NF-KappaB inflammation

shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function
  • central role of NF-κB in cytokine-mediated pancreatic β-cell damage
  • SIRT1 as a possible target to attenuate cytokine-induced β-cell damage.
  • Nathan Goodyear on 18 Mar 11
     
    SIRT1 as possible target to reduce pancreatic inflammation and thus prevent/reduce diabetes;  Oh by the way Resveratrol acts at SIRT1
Nathan Goodyear

Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian f... - 0 views

www.mendeley.com/...n-metabolic-factors-women-pcos

myo-inositol weight loss leptin insulin overweight

shared by Nathan Goodyear on 01 Jun 11 - No Cached
  • significant weight loss (and leptin reduction) (P < 0.01) was recorded in the myo-inositol group, whereas the placebo group actually increased weight
  • hese data support a beneficial effect of myo-inositol in women with oligomenorrhea and polycystic ovaries in improving ovarian function.
  • Nathan Goodyear on 01 Jun 11
     
    myo-inositol improves weight loss and leptin resistance through insulin secondary messenger
Nathan Goodyear

Testosterone Making an Entry Into the Cardiometabolic World -- Basaria and Dobs 116 (23... - 0 views

circ.ahajournals.org/...2658

low testosterone T cardiovascular disease risk

shared by Nathan Goodyear on 02 Jun 11 - No Cached
  • Nathan Goodyear on 02 Jun 11
     
    low Testosterone increase cardiovascular risk factors
Nathan Goodyear

Prevalence of cardiovascular disease risk factors ... [JAMA. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19470988

cardiovascular prevalence disease NFL players

shared by Nathan Goodyear on 14 May 11 - No Cached
  • NFL players had a lower prevalence of impaired fasting glucose, less reported smoking, a similar prevalence of dyslipidemia, and a higher prevalence of hypertension. Increased size measured by BMI was associated with increased CVD risk factors in this combined population.
  • Nathan Goodyear on 14 May 11
     
    higher disease risk in NFL players
Nathan Goodyear

Melatonin might help control weight gain and prevent heart disease associated with obesity - 0 views

www.sciencedaily.com/...110428092501.htm

melatonin obesity weight loss cardiovascular disease

shared by Nathan Goodyear on 05 May 11 - No Cached
  • Nathan Goodyear on 05 May 11
     
    Melatonin helps weight loss and improves cardiovascular disease risk factors
Nathan Goodyear

Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the ... - 0 views

diabetes.diabetesjournals.org/...2357.full

CRP fibrinogen obesity inflammation metabolic syndrome

shared by Nathan Goodyear on 14 Aug 11 - No Cached
  • Nathan Goodyear on 14 Aug 11
     
    obesity increases inflammation and Metabolic syndrome factors
Nathan Goodyear

Chemical toxins: a hypothesis to explain the globa... [J Altern Complement Med. 2002] -... - 0 views

www.ncbi.nlm.nih.gov/...12006126

chemical toxins obesity overweight

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Because the obesity epidemic occurred relatively quickly, it has been suggested that environmental causes instead of genetic factors maybe largely responsible
  • exponential production and usage of synthetic organic and inorganic chemicals. Many of these chemicals are better known for causing weight loss at high levels of exposure but much lower concentrations of these same chemicals have powerful weight-promoting actions.
  • his paper presents a hypothesis that the current level of human exposure to these chemicals may have damaged many of the body's natural weight-control mechanisms. Furthermore, it is posited here that these effects, together with a wide range of additional, possibly synergistic, factors may play a significant role in the worldwide obesity epidemic.
  • Nathan Goodyear on 06 Apr 11
     
    Toxins as chemical cause of obesity problem?
Nathan Goodyear

Understanding and determining the etiology of auti... [Cell Mol Neurobiol. 2010] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...19774457

autism ASD detoxification

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • Worldwide, the rate of autism has been steadily rising.
  • Genetic polymorphisms of cytochrome P450 enzymes have also been linked to autism, specifically CYP27B1 that is essential for proper vitamin D metabolism
  • There are several environmental factors in concert with genetic susceptibilities that are contributing to this rise. Impaired methylation and mutations of mecp2 have been associated with autistic spectrum disorders, and related Rett syndrome.
  • ...1 more annotation...
  • Other factors that have been considered include: maternally derived antibodies, maternal infection, heavy metal exposure, folic acid supplementation, epigenetics, measles, mumps, rubella vaccination, and even electromagnetic radiation.
  • Nathan Goodyear on 05 Jul 11
     
    Autism has many potential causes.  At the heart is poor detoxification
Nathan Goodyear

How environmental and genetic factors combine to c... [Neurotoxicology. 2008] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...18031821

autism spectrum disorders ASD

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • Genetic polymorphisms adversely affecting sulfur metabolism, methylation, detoxification, dopamine signaling and the formation of neuronal networks occur more frequently in autistic subjects.
  • a "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.
  • Nathan Goodyear on 05 Jul 11
     
    proposed hypothesis of autism
Nathan Goodyear

Reduced testosterone levels indicate need to trea... [Nurs Stand. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24823562

prostate cancer Testosterone men male hormone hormones

shared by Nathan Goodyear on 20 May 14 - No Cached
  • Nathan Goodyear on 20 May 14
     
    I can only find the abstract of this article.  This article fits with the growing body of evidence that low Testosterone is a poor prognostic factor for men with prostate cancer.  This very short abstract points to using low levels of "free Testosterone" as a biomarker to treat low-risk prostate cancer.
Nathan Goodyear

Semen quality, infertility and mortality in the USA - 0 views

humrep.oxfordjournals.org/...humrep.deu106

infertility semen sperm mortality men male men's health health wellness

shared by Nathan Goodyear on 20 May 14 - No Cached
  • Nathan Goodyear on 20 May 14
     
    Men with infertility associated with 2.3 fold higher risk of death. The factors evaluated were semen volume, sperm concentration, sperm motility, total sperm count, total motile sperm count.  Those that have 2 or more positive parameters were associated with increased death compared to those with normal semen analysis.
Nathan Goodyear

Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human ... - 0 views

www.jbc.org/...21136.full

DIM I3C PSA AR androgen receptor prostate cancer men male hormone hormones androgen

shared by Nathan Goodyear on 05 Nov 14 - No Cached
  • Inhibition of Endogenous PSA Expression by DIM
  • DIM strongly inhibited DHT induction of androgen-responsive genes by more than 50%
  • antiandrogenic activity of DIM
  • ...8 more annotations...
  • DIM suppresses DHT-induced cell growth and PSA expression and exhibits no AR agonist activity
  • DIM has a strong affinity for both the mutant AR inLNCaP cells and for recombinant wild-type human AR
  • nuclear translocation and foci formation of DHT-bound AR are inhibited by DIM
  • Our investigation, leads to the conclusion that DIM is a strong, pure androgen antagonist.
  • The down-regulation of PSA by DIM
  • PSA has been reported to promote the proliferation, migration, and metastasis of prostate cancer cells through several mechanisms, including cleavage of insulin-like growth factor-binding protein-3 and degradation of extracellular matrix proteins fibronectin and laminin
  • PSA expression is regulated by the AR and is thought to function as a growth factor in LNCaP cells
  • down-regulation of PSA expression may be important in the antiproliferative effects of DIM in LNCaP cells
  • Nathan Goodyear on 05 Nov 14
     
    DIM, from cruciferous veggies often used to aid estrogen metabolism, is found to decrease PSA transcription and function as an androgen receptor antagonist in prostate cancer cell lines.
Shelia Morales

Skinmedica Fairview heights | Edwardsville | Swansea | Shiloh - 0 views

www.kristenjacobs.com/...skinmedica

Skincare Shiloh Skincare Swansea Skincare Belleville Skincare Fairview heights Skincare Maryville Skinmedica Fairview heights Anti-aging Shiloh Anti-aging Fairview heights Coolsculpt Fairview heights

shared by Shelia Morales on 07 Jan 15 - No Cached
  • Shelia Morales on 07 Jan 15
     
    SkinMedica skincare products are formulated with scientifically proven recovery compounds including essential ingredients ranging from vitamins C & E to retinol to TNS (Tissue Nutrient Solution), a patented blend of growth factors, soluble collagen, antioxidants and matrix proteins.
Nathan Goodyear

Hypothalamic-Pituitary-Testicular Axis Disruptions in Older Men Are Differentially Link... - 0 views

press.endocrine.org/...jc.2007-1972

low T low Testosterone low T Testosterone aging LH hormone hormones men male SHBG

shared by Nathan Goodyear on 03 Sep 14 - No Cached
  • 0.4–2% annual decline
  • the age trend in free T was more substantial (−1.3% per annum)
  • The core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total T and progressively blunted free T associated with higher LH.
  • ...16 more annotations...
  • Obesity was associated with progressively lower total and free T independent of the simultaneous decrease in SHBG.
  • our data highlight the fact that LH was unchanged or even lower in older men in the face of lower T in obesity, suggesting that there may be a failure at the hypothalamic-pituitary level.
  • a change in BMI from nonobese to obese may be equivalent to a 15 yr fall in T.
  • This pattern supports the hypothesis that different underlying mechanisms influence the functions of the HPT axis: age predominantly affects testicular function, whereas obesity impairs hypothalamic/pituitary function.
  • the effects of aging on testicular function can be moderated by increased LH compensation for many decades
  • obesity impairs hypothalamic/pituitary function independent of age, arguably an adaptive response for which there should be no compensatory mechanism.
  • the concurrent but opposite (and separate) effects of obesity and age on SHBG
  • SHBG was negatively associated with increasing strata of obesity
  • Obesity is associated with insulin resistance (28), and the increased circulating insulin inhibits hepatic SHBG synthesis
  • the SHBG increase with age may be related to relative IGF-I deficiency (27), although this has not been directly proven.
  • Obesity is associated with peripheral and central insulin resistance (30) and proinflammatory cytokine production (TNFα and IL-6) from adipocytes (31) and central nervous system endocannibinoid release (32), all of which are potential candidates for abrogating hypothalamic endocrine and downstream reproductive axis functions.
    • Nathan Goodyear
      Nathan Goodyear on 03 Sep 14
       
      The HPA axis effect may be the result of inflammation.
  • The relationship between obesity and T can be bidirectional: low T may be the cause rather than consequence of obesity
  • chronic alcohol abuse is known to suppress LH (40), our data showed no significant association among the three hormones or SHBG and alcohol intake.
  • increase in total T in smokers occurs through a primary increase in SHBG with a compensatory rise in LH
  • the effects of obesity (BMI or waist circumference) was by far the most important determinant of variance in total T, whereas age per se was important for SHBG, LH, and free T with comorbidity and smoking being comparatively minor contributors
  • It is noteworthy that these predisposing lifestyle and health factors are modifiable. This implies that the apparent age-related decline in T may constitute a barometer of health and thus be potentially preventable and/or reversible.
  • Nathan Goodyear on 03 Sep 14
     
    Age induced decline in Testosterone is more associated with a decline in leydig cell function and thus elevated LH will be associated.  In contrast, obesity is more of a HPA axis disruption and thus LH may be normal to low.  The pulse amplitude is decrease.  No change in pulse frequency is noted.   With obesity, a decline in TT and fT was independent of SHBG. Aging is associated with a greater decrease in fT versus TT.
Nathan Goodyear

International Journal of Impotence Research - Obesity, low testosterone levels and erec... - 0 views

www.nature.com/...ijir200842a.html

low T low Testosterone men male hormone hormones ED erectile dysfunction Testosterone diabetes metabolic syndrome obesity

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Studies have shown that ED may be an early biomarker of general endothelial dysfunction, atherosclerosis and CVD
  • testosterone treatment of hypogonadal young and older men improves sexual function, increases lean mass and decreases fat mass
  • In men with low serum testosterone (for example, <8 or 230 nmol l−1) with obesity, metabolic syndrome and diabetes mellitus, treatment with testosterone is warranted
  • ...12 more annotations...
  • In obese middle-aged men, testosterone treatment reduced visceral adipocity, insulin resistance, serum cholesterol and glucose levels
  • testosterone replacement has a favorable impact on body mass, insulin secretion and sensitivity, lipid profile and blood pressure in hypogonadal men with the metabolic syndrome as well as type 2 diabetes mellitus
  • Testosterone significantly inhibits lipoprotein lipase activity, which reduces triglycerides uptake into adipocytes in the abdominal adipose tissue
  • testosterone treatment decreased endogenous inflammatory cytokines (tumor necrosis factor-α and IL-1β) and lipids (total cholesterol) and increased IL-10 in hypogonadal men
  • Testosterone treatment reduced leptin and adiponectin levels in hypogonadal type 2 diabetic men after 3 months of testosterone replacement
  • available data clearly show a relationship between obesity, low testosterone levels and ED
  • Obesity adversely affects endothelial function and lowers serum testosterone levels through the development of insulin resistance and metabolic syndrome
  • Metabolic disturbances as well as production of cytokines and adipokines by inflamed fat cells may be causal factors in the development of ED
  • The onset of ED and the associated risk of CVD may be delayed through lifestyle modifications that affect obesity, such as diet and exercise
  • Very low testosterone levels contribute to the development of ED in obesity, metabolic syndrome and type 2 diabetes mellitus
  • Obesity is associated with low total testosterone levels that can be explained at least partially by lower sex hormone-binding globulin (SHBG) in obese men
  • epidemiological studies have shown a negative correlation between BMI and total testosterone and to a lesser extent with free and bioavailable (biologically active) testosterone levels
  • Nathan Goodyear on 27 Jan 15
     
    Obesity is associated with low Testosterone and ED in men.
Nathan Goodyear

Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adole... - 0 views

eje-online.org/...1093.long

PCOS polycystic ovarian syndrome CRP inflammation insulin insulin resistance women female hormone hormones androgens Testosterone hyperandrogenism

shared by Nathan Goodyear on 10 Mar 15 - No Cached
  • subjects with hyperandrogenemic phenotypes displayed the greatest degree of hyperinsulinemia, β-cell function, and chronic inflammation
  • The rise in serum androgens is accompanied by excess insulin secretion, suggesting that insulin directly stimulates ovarian androgen production
  • The degree of hyperinsulinemia does not seem to be directly correlated with the development of HS
  • ...7 more annotations...
  • higher androgen and insulin levels stimulate hair growth
  • genetic and epigenetic changes may be involved in the pathogenesis of PCOS
  • HA has been identified as an important risk factor for MS and dyslipidemias in premenopausal women and adolescents
  • In our study, HA was found to be an independent risk factor for MS as previously reported by Coviello et al.
  • obesity and HA, and not insulin resistance, are the major determinants of chronic inflammation and risk of atherosclerosis in adolescents with PCOS
  • use of an inflammation marker may help identify high-risk females with PCOS
  • hyperandrogenemic PCOS phenotypes have greatest degree of hyperinsulinemia, insulin resistance, and inflammation
  • Nathan Goodyear on 10 Mar 15
     
    Elevated androgens are associated increasing insulin, insulin resistance, and inflammation (as measured by CRP).
star yu

Cómo Mejorar El Pronóstico de La Nefropatía Por IgA - 0 views

www.enfermedad-renal.com/...2068.html

nefropatía por IgA tratamiento

shared by star yu on 08 Mar 15 - No Cached
  • star yu on 08 Mar 15
     
    Nefropatía por IgA se refiere a un trastorno autoinmune y se caracteriza principalmente por complejos inmunes depositados en la zona mesangial.Para los pacientes la nefropatía IgA, su pronóstico varía de casos a casos.El desarrollo de la nefropatía por IgA es influenciada por muchos factores.Y antes de la presentación de los métodos para mejorar el pronóstico de la nefropatía por IgA, debemos tener una comprensión básica acerca de sus factores de riesgo.
Nathan Goodyear

Association of serum lead and mercury level with cardiometabolic ri... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25017868

ALT liver enzymes cholesterol blood pressure triglycerides metabolic syndrome lead Pb mercury Hg

shared by Nathan Goodyear on 09 Mar 15 - No Cached
  • Nathan Goodyear on 09 Mar 15
     
    study finds Pb and Hg associated with increased cardiometabolic risk factors.  Elevated liver enzymes found to be positively associated with serum Pb levels.  Metabolic Syndrome was found to be associated with higher Pb and Hg levels.
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