Metabolic influences on neuroendocrine regulation of reproduction - 0 views
www.ncbi.nlm.nih.gov/...PMC3898855
metabolism metabolic regulation reproduction Leptin Ghrelin Insulin Kisspeptin GNRH
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Energy storage occurs mainly at the level of white adipose tissue, where adipocytes secrete the anorexigenic adipokine leptin
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humans and laboratory animals with leptin or insulin deficiency or resistance and/or increased ghrelin levels exhibit delayed or absent puberty and frequently display hypogonadotropic hypogonadism, which prevents fertility
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Ghrelin suppresses pulsatile gonadotropin-releasing hormone (GnRH) release [14,15], thus serving as a signal to suppress reproduction in times of famine
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Neuropeptides derived from POMC/CART neurons exert a potent anorectic action, thus decreasing food intake and body weight
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GnRH neurons have been shown to express insulin receptor mRNA and protein [27] and are activated by insulin
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Kisspeptins (encoded by KISS1) have been identified in the last decade as the most potent secretagogues of GnRH release.