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Nathan Goodyear

Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsa... - 0 views

ajpregu.physiology.org/...R627

Testosterone Estradiol hormone hormones cortisol ACTH stress

shared by Nathan Goodyear on 04 Apr 15 - No Cached
  • Nathan Goodyear on 04 Apr 15
     
    INteresting.  Estradiol enhances cortisol negative feedback on ACTH production in both men and women.
Nathan Goodyear

Levels of estradiol and testosterone are altered in Chinese men with sexual dysfunction... - 0 views

onlinelibrary.wiley.com/...abstract

male hormones' hormones estradiol Testosterone sexual dysfunction ED erectile dysfunction

shared by Nathan Goodyear on 12 Oct 16 - No Cached
  • Nathan Goodyear on 12 Oct 16
     
    Men with sexual dysfunction found to have higher E:T ratio and higher Estradiol overall.  This was a retrospective study.
Nathan Goodyear

Circulating estradiol, but not testosterone, is a significant predictor of high-grade p... - 0 views

onlinelibrary.wiley.com/...full

Estradiol Testosterone prostate cancer men male hormone hormones prostate cancer

shared by Nathan Goodyear on 21 Aug 13 - No Cached
  • Nathan Goodyear on 21 Aug 13
     
    Estradiol found to be significantly associated with high grad prostate cancer, not Total Testosterone.
Nathan Goodyear

Estradiol Activates the Prostate Androgen Receptor and Prostate-specific Antigen Secret... - 0 views

www.jbc.org/...6838.full

Estradiol aromatase aromatase activity PSA prostate disease male men hormone hormones

shared by Nathan Goodyear on 22 Aug 13 - No Cached
  • Nathan Goodyear on 22 Aug 13
     
    Estradiol increases PSA secretion.
Nathan Goodyear

In Men, Peripheral Estradiol Levels Directly Reflect the Action of Estrogens at the Hyp... - 0 views

jcem.endojournals.org/...3324.long

low T low Testosterone low Testosterone aromatase Estradiol

shared by Nathan Goodyear on 27 Sep 13 - No Cached
  • Nathan Goodyear on 27 Sep 13
     
    peripheral aromatase activity and Testosterone to Estradiol production have central HPA axis suppression resulting in decreased LH and FSH and low Testosterone.
Nathan Goodyear

Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostat... - 0 views

www.ncbi.nlm.nih.gov/...15215045

estrogen estradiol prostate inflammation cytokines male men hormones

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    Estradiol induces prostatitis in male rat model.
Nathan Goodyear

Circulating Estrone Levels Are Associated Prospectively With Diabetes Risk in Men of th... - 0 views

care.diabetesjournals.org/...2591.full

low T Testosterone Estrone Estradiol type II diabetes Framingham heart study men male hormone hormones diabetes estrogen heart

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    A cross-sectional study of 1,458 men over a 13 years found an increase risk of diabetes incidence with elevated Estradiol and Estrone levels.  The greatest association was found with Estrone.  This should come as no surprise to anybody as type II diabetes is clearly associated with increasing weight and this is the source of 80% of estrogen production in men.
Nathan Goodyear

Androgen Deprivation Therapy and the Re-em... [Oncol Hematol Rev. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24932461

androgen deprivation therapy ADT estrogen Testosterone men male hormone hormones Prostate cancer CVD cardiovascular disease

shared by Nathan Goodyear on 08 Jul 14 - No Cached
  • Nathan Goodyear on 08 Jul 14
     
    Sometimes I think medicine has lost its mind.  Or at least, it is not thinking things through.  To give IV estrogen to decrease Testosteorne in men with prostate cancer is devoid of the pathophysiology of prostate cancer and cardiovascular disease in men.  Elevated Estradiol in men increases CRP, IL-1beta, and TNF-alpha to name a few cytokines.  The proported purpose of the IV estrogen is to prevent the cardiovascular complications associated with ADT.  Yet, elevated aromatase activity and low T in men are both shown to be associated with increased CVD in men.
Nathan Goodyear

Sex hormones and cognitive decline ... [Psychoneuroendocrinology. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18845400

men estrogen estradiol estrone dementia cognitive decline low T low testosterone hormones hormone

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • Nathan Goodyear on 30 Apr 13
     
    increased estradiol and estrone levels in men associated with cognitive decline.  This was distinct from age, CVD, and APOE genotype.  This points to a clear association between increased aromatase activity and inflammation that contributes to cognitive decline in men.
Nathan Goodyear

Relation between markers of inflammation and e... [Med Sci Monit. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21119577

estradiol aromatase testosterone inflammation CRP fibrinogen men male markers

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • Nathan Goodyear on 24 Apr 12
     
    Estradiol found to be associated with elevated CRP and fibrinogen with men.  This association was not found between Testosterone and the same inflammatory markers.  This points to the conversion of Testosterone to estrogen as a contributor to inflammation and CVD in men.
Nathan Goodyear

Association between endogenous sex steroid hormone... [Andrology. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24124163

men aromatase estradiol estrogen inflammation CRP

shared by Nathan Goodyear on 21 Oct 13 - No Cached
  • Nathan Goodyear on 21 Oct 13
     
    Total and free Estradiol associated with increased CRP in men.  This study found that it also correlated with WBC count as well.   Not new, but builds on the accumulative literature that high aromatase activity and estrogen production in men produces inflammation.
Nathan Goodyear

Serum oestradiol and ischaemic heart disease--relati... [Q J Med. 1985] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2867579

estradiol men MI CVD male hormone hormones heart

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    Significantly higher estradiol levels found in men with a history of MI.  These men would likely have an increase in adverse effects associated with Testosterone therapy.
Nathan Goodyear

The relationship between sex hormones and lipi... [Int J Cardiol. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15860391

aromatase estradiol men male hormone hormones lipids cholesterol Testosterone

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    High aromatase activity and estradiol production in men was found to be associated with elevated total cholesterol, LDL, TC:HDL, and triglycerides.  No association was found with Testosterone or SHBG.  The 111 men in this study had "stable CAD"
Nathan Goodyear

Review of health risks of low testosterone and testosterone administration - 0 views

www.ncbi.nlm.nih.gov/...PMC4391003

low Testosterone low T Testosterone men male hormone hormones health

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • Hypogonadism may be defined either as serum concentration of T (either total T, bioavailable T or free T) or as low T plus symptoms of hypogonadism
  • The Baltimore Longitudinal Study on Aging reported the incidence of total serum T < 325 ng/dL to be 20% for men in their 60s, 30% for men in their 70s and 50% for men over 80
  • The Massachusetts Aging Male Study reported that 12.3% of men aged 40 to 70 had a total serum T of < 200 ng/dL with 3 or more symptoms of hypogonadism
  • ...19 more annotations...
  • The Boston Area Community Health Study reported that 5.6% of men aged 30 to 70 were hypogonadal, as defined by total serum T < 300 ng/dL; or, free serum T < 5 ng/dL plus 3 or more symptoms of hypogonadism
  • In a health screening project among 819 men in Taiwan, the prevalence of hypogonadism (total serum T < 300 ng/dL) ranged from 16.5% for men in their 40s, 23.0% for men in their 50s, 28.9% for men in their 60s, and 37.2% for men older than 70 years of age
  • The prevalence of hypogonadism among men in Taiwan is higher than the prevalence reported in the Massachusetts Male Aging Study
  • CAG repeat sequence, within the androgen receptor (AR). Rajender et al[12] reviewed over 30 studies on the AR trinucleotide repeat and infertility
  • suggestion that CAG repeat length may determine androgen responsiveness, this issue is not clearly settled
  • reported prevalence of low T in older men range from 5.6% to 50%
  • Those in the hypogonadal group (n = 4269) had direct health care costs, that exceeded the eugonadal group (n = 4269) by an average of $7100 over the course of the observation window
  • higher economic burden and presence of co-morbidities for hypogonadism
  • minor to moderate improvements in lean mass and muscle strength
  • increased bone mineral density
  • modest enhancement in sexual function
  • reduced adiposity
  • lessening of depressive symptoms
  • Meta-analyses of clinical TRT trials as of 2010 have identified three major adverse events resulting from TRT: (1) polycythemia; (2) an increase in prostate-related events; and (3) and a slight reduction in serum high-density lipoprotein (HDL) cholesterol
  • polycythemia (> 3.5-fold increase in risk
  • TRT produced a 40% prostate enlargement in older hypogonadal male Veterans over 12 mo
  • no published analysis has reported measurable increases in prostate cancer risk or Gleason score in men undergoing TRT, or in hypogonadal men with a history of prostate cancer undergoing TRT
  • the prostate which highly expresses the type II 5α-reductase enzyme. Inhibition of this enzyme via finasteride (a type II 5α-reductase inhibitor) or dutasteride (a dual type I and II 5α-reductase inhibitor) reduces circulating DHT 50%-75% and > 90%, respectively[47], and reduces prostate mass[48] and prostate cancer risk
  • Normally estradiol partially regulates testosterone levels, at the hypothalamus, blunting LH and FSH release from the pituitary. As a selective estrogen receptor modulator, CC interrupts this pathway, and consequently there is a greater stimulation for the production of testosterone in Leydig cells
    • Nathan Goodyear
      Nathan Goodyear on 28 Apr 15
       
      this would only apply if E1 and/or E2 levels were elevated, which the authors make no mention of.
  • Nathan Goodyear on 28 Apr 15
     
    to be read
Nathan Goodyear

Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study - 0 views

eje-online.org/...687.long

low T low T testosterone CVD cardiovascular mortality men Estradiol E2

shared by Nathan Goodyear on 10 Nov 12 - No Cached
  • Nathan Goodyear on 10 Nov 12
     
    meta-analysis finds that low T associated with increased cardiovascular mortality in men.  Additionally, higher Estradiol is associated with increased CVD and CV mortality
Nathan Goodyear

Serum sex hormone and plasma homocysteine levels in middle-aged and elderly men - 0 views

www.eje-online.org/...887.full

Testosterone estradiol DHEAS DHEA homocysteine men hormones

shared by Nathan Goodyear on 25 Jul 16 - No Cached
  • Nathan Goodyear on 25 Jul 16
     
    no correlation between Testosterone, estradiol, and DHEAS levels and homocysteine in men >40.
Nathan Goodyear

Roles of the gonadal steroid hormones in psychiatric depression in men and women - Rese... - 0 views

www.researchgate.net/...ic_depression_in_men_and_women

depression estradiol estrogen men Testosterone women hormones hormone

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Fascinating difference in the sexes.  High estradiol is found to be associated with depression in men and high Testosterone is found to be associated with depression in women.  The exact mechanism or strength of association is unstated.
Nathan Goodyear

Oestradiol levels in diabetic men with and without a... [Q J Med. 1987] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3671665

aromatase Estradiol E2 Testosterone men male Diabetes hormone hormones MI myocardial infarction

shared by Nathan Goodyear on 04 Mar 14 - No Cached
  • Nathan Goodyear on 04 Mar 14
     
    High Estradiol is reproducible finding in men with Diabetes.  Link to MI not able to be determined.
Nathan Goodyear

Association of endogenous sex hormone with C-reactive protein levels in middle-aged and... - 0 views

www.ncbi.nlm.nih.gov/...17302874

inflammation men hormones CRP hsCRP estradiol estrogen Testosterone total Testosterone bioavailable Testosterone

shared by Nathan Goodyear on 14 Sep 15 - No Cached
  • Nathan Goodyear on 14 Sep 15
     
    total and bioavailable Estradiol associated with increased hsCRP in men age 40-80.  Bioavailable is calculated with serum calculated free Testosterone and albumin bound Testosterone.
Nathan Goodyear

ScienceDirect - The Journal of Urology : AROMATASE INHIBITORS FOR MALE INFERTILITY - 0 views

www.sciencedirect.com/...S0022534701690992

AROMATASE INHIBITORS MALE INFERTILITY Testosterone Estradiol hormone hormonal imbalance

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    aromatase inhibition in men to increase Testosterone:Estradiol ratio.  Men with infertility have a low Testosterone:Estradiol ratio.  Aromatase inhibitors inhibit Testosterone to Estradiol conversion
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