Group items tagged

another awesome article dealing with hormone metabolites. Physicians that don't understand metabolites and receptors may be doing more harm than good.   One of the mainstays of the treatment of metastatic prostate disease is androgen deprivation therapy.  This article requires a reassessment of this due to the DHT metabolite 3-beta androstanediol.  This metabolite is produced from DHT production via the enzyme 3beta HSD.  This metabolite binds to ER beta, an estrogen receptor, and inhibits proliferation, migration, promotes adhesion (limits spreading), and stimulates apoptosis.  This is contrast to 3-alpha androstanediol.  Androgen deprivation therapy will decrease 3-beta androstanediol.  This is the likely reason for the increased aggressive prostate cancer found in those men using 5 alpha reductase inhibitors.

Article highlights the problems with the definition of low T.  This article finds consistent decline in Total Testosterone and FAI with increasing age groups, with a significant portion of men > 60 meeting the required levels for "low T".  This study found a decrease in total T and FAI at a consistent rate independent of variables, such as BMI.    This study did find a decrease in SHBG and total T with obesity; in contrast to other studies.

Good discussion of the different effects of ER-alpha and ER-beta in breast cancer.  ER-beta inhibits growth in contrast to ER-alpha.

Review of data analyzing salivary cortisol finds saliva is a great medium, with sensitivity and specificity exceeding 90%, for evaluating the stress response.  So, where is the Louisiana State Board of Medicine, BCBS, and other insurance companies on this.  They are in favor of inferior testing and treatments ie.  hysterectomies for pelvic pain (50% success rate).   The great item here is this is not one study but an analysis of multiple studies. This is contrast to "opinions" that often govern the above mentioned organizations/businesses.

ER beta appears to be expressed through the menstruation cycle with predominance follicular and early secretory phases. Contrast with ER alpha predominance in late follicular and early secretory phases.

SHBG and hormones.  Insulin, IGF-1, and EGF decrease SHBG levels.  Contrast that with estradiol, testosterone, T3, and cortisol that increase SHBG

Testosterone by mouth decreases SHBG.  This is in contrast to IM, transdermal routes.

Testosterone levels fluctuate seasonally, with the peak production in the fall of the year.  Contrast that with LH, with it's peak in the spring of the year.  This study found that men with Klinefelter's syndrome had only seasonal fluctuations of testosterone, suggesting a testicular independent role.  This is a small study.  

No surprise, testosterone in men and women have different effects.  I just wrote a post on this.  Testosterone is positively associated with increased risk of diabetes in women, but inversely with men.  That is increased T in women equals increased Diabetes in women; contrast with increased T associated with decreased Diabetes in men.   But the interesting point is SHBG.  This study found a strong inverse association between SHBG with diabetes in women when compared to men.  Meaning: low SHBG is associated with an increased risk of type II Diabetes.  This is at the same time that testosterone is associated with an increased risk.

This is a dissertation, but they found ER alpha expression in all meningioma samplings. This is in contrast to previous studies. As further research has come with meningiomas, more ER presence is found, likely due to improved testing techniques. What is interesting here is that Low/no PR status was associated with Increased ER alpha status. This has been shown to be a more pro-inflammatory/pro-growth picture in disease states, such as breast and prostate CA.

Rugby training resulted in a decrease in T:C salivary ratio through a decline in resting testosterone level.  In contrast, competition events increased the T:C ratio primarily through an increase in Cortisol production.

new study finds increase AE and ER with supplements at 22,000 annually; in contrast, 700,000 ER visits due to prescription drugs annually according to CDC--with 120,000 hospitalized.

ER-beta receptors have "distinct antiproliferative and anti-inflammatory biological effects".  This is in contrast to ER-alpha.

This study looked at estrogen receptors and breast cancer.  But, they found anti estrogen therapy might actually increase NF-KappB activity i.e.inflammation.  In contrast, ER inhibited NF-kappaB and resultant inflammation.

Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging.  In contrast, telomerase activity is found to be involved in carcinogenesis.  Increased carcinogenic potential of telomerase activity has not borne out in studies.  In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.

small study, but complex carbs found to increase Testosterone more than high protein diet.  That goes against most marketing.  In contrast, cortisol was the opposite.

great review article on the relationship between gut dysbiosis and type I diabetes--particularly the bacteroidetes and Veillonella species; in contrast, Prevotella and Akkermansia special protects and maintains a healthy gut epithelium.

study of adjuvant chemotherapy in Asian women found no weight gain post treatment; this is in contrast to American and European women in other studies.

Asthma associated with low selenium, low zinc, high copper, low glutathione peroxidase, glutathione reductase, and catalase activity; in contrast, increased hs-CRP, and TBARS was  noted.  Interesting that FEV1 and FVC positively correlated with Se levels.

only abstract available here, but estradiol increases inflammatory pathways in SLE; in contrast, progesterone decreases these pathways.