Study finds that men exposed to BPA have lower androstenedione and free testosterone compared to those not exposed. Also of note, SHBG is increased, which is what one would expect with xenoestrogen exposure.
Birth control pills were found to reduce IGF-1 levels in the short term and long term. Those that had used birth control pills had lower IGF-1 levels compared to those that had never used birth control pills. This fits with the current knowledge that oral estrogen reduces HGH and IGF-1. Those were in post-menopausal women, but this is in pre-menopaus women. This has implications on health, weight, disease...
2012 study that shows a slight uptick in sperm count/concentration in Danish men. However, as the conclusion states, on 25% have optimal sperm quality. When you look at the numbers deeper, the current general population sperm count/concentration was lower than that of men of infertile couples from 1940-1943 cohort. Additionally, when the general population sperm count/concentration was lower than that of compared recent fertile men.
salivary testosterone and DHEA using LC-MS/MS accuracy exceeds 98.5%. Compare that with historical 50% resolution of pain with a hysterectomy. There is no perfect test, but if accuracy exceeds 98%, you have reliable test.
study finds that HRT given as women transition through menopause has benefiical effect in people with Alzheimer's. However, when given years later, after menopause, no benefit is found. In fact, rates increased. Several flaws with this study. First, they used synthetic hormones, particularily progestins. Second, there seems to be no thought that the interpretation of the signal has changed. For example, we know that when men have low T, their estrogen receptor status changes from ER beta to ER alpha, which is more proinflammatory. Third, use bioidentical hormones and compare these to synthetic hormones.
death rate in medicare population higher that previously reported post-bariatric surgery. Those 65 and higher had higher mortality rates compared to younger individuals.
somewhat flawed study in that they looked at serum sex hormones to evaluate men with gynecomastia compared to controls. A better eval would have been of saliva or blood spot. Free levels will show more subtle changes physiologically than will serum as to the sex hormones. The study did find decreased sexual function in the men with gynecomastia--indicating hormone issues not picked up by the serum.
TA-65 administration during 4 months significantly improved the capacity to uptake glucose after a glucose pulse
liver protective action of TA-65
A disadvantage of mTERT potentiation could be associated to its capacity to favor proliferation of cancerous cells in murine models
TA-65 treated mice presented a similar incidence of malignant cancers at time of death, with a tendency to show decreased sarcomas and slightly increased lymphomas
We demonstrate here that TA-65 leads to a significant rescue of short telomeres through telomerase activation
TA-65 treatment increases proliferation and mobilization potential of mouse keratinocytes in vitro, a situation mimicking telomerase overexpression
TAT2, a similar molecule, have beneficial effects in the activation of CD8+ T lymphocytes from HIV-infected patients where they observe an increase of the proliferative potential and enhancement of cytokine/chemokine production
TA-65 resulted in a similar rescue of short telomeres in leukocytes post-treatment as observed with humans, most likely through an activation of telomerase
we observe that TA-65 lead to 10 fold increase of telomerase RNA levels in the liver of treated mice comparing to the non-treated same-age cohorts
TA-65 regulates telomerase at the transcription level, probably through the regulation of the MAPK pathway
TA-65 dependent telomerase activation results in a better organ fitness as demonstrated by the improved scores at the glucose tolerance test and insulin levels at fasting
TA-65 supplemented mice also present modest enhancement of the subcutaneous and epidermal thickness, as well as higher bone density, representative of an overall fitness status improvemen
TA-65 treated mice present higher levels of RBC and hemoglobin comparing to the control cohorts
improved health-span of TA-65 treated mice is not accompanied by increased cancer incidence, which may be related to the fact that TERT levels are very modestly increased in all tissues tested except for the liver
systemic telomerase overexpression from the germline leads to protection from aging associated pathologies
similar situation could be mimicked expressing telomerase late in life in a telomerase deficient background
we observed a higher proliferation rate and a partial protection from cell death in some tissues of TA65 treated mice
ketones promote cerebral metabolic recovery after TBI. Younger brains switch to ketone metabolism more readily compared to older brains. Only abstract available here.
At the age of 60, testosterone levels are typically only 40-50% of youthful levels and may be lower
Eurycoma contains a group of small peptides referred to as “eurypeptides” that are known to have effects in improving energy status and sex drive in studies of rodents
The effects of tongkat ali in restoring normal testosterone levels appears to be less due to actually “stimulating” testosterone synthesis, but rather by increasing the release rate of “free” testosterone from its binding hormone, sex-hormone-binding-globulin (SHBG)
The current study found that daily supplementation with tongkat ali root extract (200 mg/day) improves stress hormone profile (lower cortisol; higher testosterone) and certain mood state parameters (lower tension, anger, and confusion)
tongkat ali supplementation (100 mg/day) improved lean body mass, 1-RM strength, and arm circumference to a significantly greater degree compared to a placebo group.
In a recent 12-week trial [46] of Eurycoma longifolia supplementation (300 mg/day), men (30–55 years of age) showed significant improved compared to placebo in the Physical Functioning domain of the SF-36 quality of life survey
sexual libido was increased by 11%
In men with low testosterone levels (average age 51 years), one month of daily supplementation with tongkat ali extract (200 mg/day) resulted in a significant improvement in serum testosterone levels and quality-of-life parameters
rise in cortisol and drop in testosterone is an early signal of “overtraining”
Tongkat Ali, commonly known as long jack, is found to reduce stress and increase Testosterone. Stress is one of the common causes of low T in men. It appears that long Jack functions as an adaptogen.
study finds that hand-grip strength was a strong predictor of all cause and cardiovascular mortality; this was more correlated with mortality compared to systolic blood pressure.
One advantage of FMI, as compared to the BMI concept, is that it amplifies the relative effect of aging on body fat
We believe that the definition of obesity based on relative body fat (ie percentage) remains of great value for the definition of obesity. However, in a situation in which a patient is losing weight without substantially changing his/her relative body fat (as is the case with crash diets), the calculation of FMI will quantitatively reveal the amount of body fat store lost.
high sensitivity of FMI (respectively FFMI) to a slight change of body fat stores
Sarcopenic obesity has been defined as a low FFM associated with a high body fat
relative FFM lower than 73% (ie a relative body fat greater than 27%) in men and a FFM lower than 62% (ie a body fat greater than 38%) in women.
FMIs greater than 8.2 kg/m2 in men and 11.8 kg/m2 in women would define the 'overfat' status (rather than the overweight range) in terms of fat mass
In young women, FMI averaged 5.5 kg/m2 (range 5th-95th percentile: 3.5-8.7 kg/m2) ie 38% higher than in males