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Nathan Goodyear

Obesity, Abdominal Obesity, Physical Activity, and Caloric Intake in US Adults: 1988 to... - 0 views

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    Observational study finds BMI increase of 0.375 in both men and women per year.  The waist circumference also increased by 0.37% per year in women compared to 0.27% in men.  There was a significant reduction in physical activity over the same time period.  In women, the reporting of physical inactivity increased to 52% FROM 19% compared to 44% FROM 11% in men.  The authors found no association with change in calories.  However, an assessment in quality of calories would have likely shown a glaring difference.  Clear causation can not be concluded due to the fact that the study was observational.
Nathan Goodyear

PLOS ONE: Low Mercury Concentration Produces Vasoconstriction, Decreases Nitric Oxide B... - 0 views

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    Animal model found that low Hg decreased NO availability.  The result is vasoconstriction induced by ROS and hypertension. The hypertension is the result of an activation of the renin angiotensin system.  The importance here is that low Hg levels induced this change.
wheelchairindia9

Reclining Commode Wheelchair - 0 views

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    wheelchair category (standard, transport, power, etc.) could be classified as a reclining wheelchairs, since the product class is built around one key feature: the capability to adjust the backrest and/or footrest into a reclined position. This feature is especially important to users who find it difficult or impossible to sit in a fully upright position, and users who sleep in their chairs frequently. For those that are looking for a more portable chair, however, products from this category may not be a great fit. When compared with a similar, non-reclining chair, a reclining wheelchair tends to weigh more and - unlike other manual models - manual wheelchairs that recline typically aren't foldable. Some people use special wheelchairs to distribute pressure and thus reduce the risk of skin sores. These chairs also increase comfort and sitting tolerance. One type of chair, called "tilt in space," changes a person's orientation while maintaining fixed hip, knee, and ankle angles. The whole seat, in effect, tilts. The other chair option is called a recline system, which basically changes the seat-to-back angle, flattening out the back of the chair and in some cases raising the legs to form a flat surface. Different Types Of Reclining Wheelchairs: Reclining Wheelchair 902 GC Reclining Wheelchair 609 GC Karma Aurora 4 Reclining Wheelchair Karma Reclining Wheelchair KM 5000 Karma VIP 515 Wheelchair Reclining Wheelchair 902 GC: Reclining Wheelchair 902 GC is one of the basic models of a Reclining Wheelchair which helps transfer to bed to wheelchair easily and comes with head and neck support and Calf support for added comfort. Reclining Wheelchair 902 GC Features: The chair boast of movable armrest and elevating footrest. A well padded thigh support helps the user thigh's during reclining. The front and the rear wheels are designed and placed in such a way so as to support the users weight during reclining. The Pneumatic rear wheels help the movement
wheelchairindia9

Karma KP-80 - 0 views

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    Powerchair, is more compact and has a better turning radius, making it is easier to navigate narrow doorways and tight turns. Another advantage of the powerchair wheelchair is that its armchair joystick does not require an upright posture like an electric scooter's handlebars. Most powerchair wheelchairs can also be taken apart and stowed, while scooters usually can't. Powerchair wheelchairs are also usually less. Power Wheelchairs/Electric Wheelchairs is specially designed for Disabled and Handicapped People. They are recognized as the prominent manufacturer and supplier of a wide array of Power Wheelchairs. Variety of Power Wheelchairs for handicapped and disability product like: Variety of Power Wheelchairs: Karma KP 10-2 Power Wheelchair Karma KP 10-3 Power Wheelchair Karma KP 80 Power Wheelchair GM Lite Power Wheelchair Bronco Wheelchair Angel Wheelchair Bronco Wheelchair: Bronco Reclining Power Wheelchair Description: Comfort mobility is a professional Bronco Wheelchair and power scooter manufacturer established in 1978 in Taiwan. It operates with the policy of combining high quality with innovation. With dedication to research and development, Bronco wheelchair are exported around the world and earned solid reputation for its superior quality, comfort and convenience. Bronco wheelchair - comfortable, durable, designed for easy and healthy movement with full precautions. Bronco Reclining Power Wheelchair Specifications: Anchorage points Adjustable footplates LED front lights Detachable backrest Flip-back armrests Adjustable headrest Mechanic repairs Optional handbrake Power Wheelchair Features: Battery Power Wheelchair. Seat, base & battery quickly detach for easy storage and transportation Come with captain seat. With seat platform, the captain seat can be moved forward or backward using tools which is included. Adjustable armrest width and height. Footrests can be moved forward or backward for optimum placeme
Nathan Goodyear

PLOS ONE: Probiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular ... - 0 views

  • Studies in both humans and rodents, however, suggest that low testosterone is due to age-related lesions in testes rather than irregular luteinizing hormone metabolism
  • Various dietary factors and diet-induced obesity have been shown to increase the risk for late onset male hypogonadism and low testosterone production in both humans and mice
  • Testosterone deficiency and metabolic diseases such as obesity appear to inter-digitate in complex cause-and-effect relationships
  • ...28 more annotations...
  • dietary supplementation of aged mice with the probiotic bacterium Lactobacillus reuteri makes them appear to be younger than their matched untreated sibling mice
  • These results indicate that gut microbiota induce modulation of local gastrointestinal immunity resulting in systemic effects on the immune system which activate metabolic pathways that restore tissue homeostasis and overall health
  • all these studies we consistently observed that young and aged mice consuming purified L. reuteri organisms had particularly large testes and a dominant male behavior.
  • The testes of probiotic-fed aged mice were rescued from both seminiferous tubule atrophy and interstitial Leydig cell area reduction typical of the normal aging process. Preservation of testicular architecture despite advanced age or high-fat diet coincided with remarkably high levels of circulating testosterone. The beneficial effects of probiotic consumption were recapitulated by the depletion of the pro-inflammatory cytokine Il-17.
  • feeding of L. reuteri consistently increased the gonadal weights, consumption of a non-pathogenic strain of Escherichia coli (E. coli) K12 organisms did not affect testicular weight
  • mice with dietary L. reuteri supplements were rescued from diet-induced obesity and had normal body weight and lean physique
  • Despite the comparable numbers of ST profiles, we determined that testes from L. reuteri-treated mice had increased ST cross-sectioned profiles
  • the probiotic organism induced prominent Leydig cell accumulations in the interstitial tissue between the ST's
  • The probiotic-associated increase of interstitial Leydig cell areas was sustained with advancing age at 7 (CD vs CD+LR, P = 0.0025; CD+E.coli vs CD+LR, P = 0.0251) and 12 months
  • mice eating L. reuteri had profoundly increased levels of circulating testosterone regardless of the type of diet they consumed
  • blocking pro-inflammatory Il-17 signaling entirely recapitulates the beneficial effects of probiotics
  • previous studies we found that dietary probiotics counteract obesity [19] and age-related integumentary pathology [18] at least in part by down-regulating systemic pro-inflammatory IL-17A-dependent signaling
  • Testes histomorphometry and serum androgen concentration data were both suggestive of a probiotic-associated up-regulation of spermatogenesis in mice
  • Lactobacillus reuteri we discovered that aging male animals had larger testes compared to their age-matched controls
  • xamined testes of probiotic microbe-fed mice and found that they had less testicular atrophy coinciding with higher levels of circulating testosterone compared to their age-matched controls
  • Similar testicular health benefits were produced using systemic depletion of the pro-inflammatory cytokine Il-17 alone, implicating a chronic inflammatory pathway in hypogonadism
  • One specific aspect of this paradigm is reciprocal activities of pro-inflammatory Th-17 and anti-inflammatory Treg cells
  • Feeding of L. reuteri organisms was previously shown to up-regulate IL-10 levels and reduce levels of IL-17 [19] serving to lower systemic inflammation
  • insufficient levels of IL-10 may increase the risk for autoimmunity, obesity, and other inflammatory disease syndromes
  • Westernized diets are also low in vitamin D, a nutrient that when present normally works together with IL-10 to protect against inflammatory disorders
  • Physiological feedback loops apparently exist between microbes, host hormones, and immunity
  • The hormone testosterone has been shown to act directly through androgen receptors on CD4+ cells to increase IL-10 expression
  • studies in both humans and rodents suggest that hypogonadism is due to age-related lesions in testes rather than irregular LH metabolism
  • We postulate that probiotic gut microbes function symbiotically with their mammalian hosts to impart immune homeostasis to maintain systemic and testicular health [34]–[35] despite suboptimal dietary conditions.
  • Dietary factors and diet-induced obesity were previously shown to increase risk for age-associated male hypogonadism, reduced spermatogenesis, and low testosterone production in both humans and mice [2]–[4], [8]–[11], [14]–[17], phenotypic features that in this study were inhibited by oral probiotic therapy absent milk sugars, extra protein, or vitamin D supplied in yogurt.
  • Similar beneficial effects of probiotic microbes on testosterone levels and sperm indices were reported in male mice that had been simultaneously supplemented with selenium
  • L. reuteri-associated prevention of age- and diet-related testicular atrophy correlates with increased numbers and size of Leydig cells
  • the initial changes of testicular atrophy begin to occur in mice from the age of 6 moths onwards [7] and indicates that the trophic effect of L. reuteri on Leydig cells is a key event which precedes and prevents age-related changes in the testes of mice. This effect is reminiscent of earlier studies describing Leydig cell hyperplasia and/or hypertrophy in the mouse and the rat testis that were achievable by the administration of gonadotropins, including human chorionic gonadotropin, FSH and LH
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    Fascinating study on how the addition of Lactobacillus reuteri increased Testicular size, prevented testicular atrophy, increased serum Testosterone production and protected against diet-induced/obesity-induced hypogonadism.  This was a mouse model
wheelchairindia9

Karma Power Wheelchair KP-10.3 - 0 views

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    Electric wheelchairs, also called power chairs, are often a more suitable option for those who are physically unable to self propel a manual wheelchair.Power Wheelchairs/Electric Wheelchairs is specially designed for Disabled and Handicapped People. This are recognized as the prominent manufacturer and supplier of a wide array of Power Wheelchairs. Variety of Power Wheelchairs for handicapped and disability product like- Variety of Power Wheelchairs: Karma KP 10-2 Power Wheelchair Karma KP 10-3 Power Wheelchair Karma KP 80 Power Wheelchair GM Lite Power Wheelchair Bronco Wheelchair Angel Wheelchair Karma KP 10.2 Power Wheelchair: Features: Seat, base & battery quickly detach for easy storageand transportation. Come with captain seat. With seat platform, the captain seat can be moved forward or backward using tools which is included. Adjustable armrest width and height. Footrests can be moved forward or backward for optimum placement. Quick release battery pack for easy storage and battery pack change. Karma KP 10-2 Power Wheelchair is a lightweight, compact, manoeuvrable power chair which now incorporates Karma's patented 'S-Ergo' seating system. It is compact enough for indoor use but powerful enough for outdoors. The concept behind the design of the power chair was to make it as light as possible and convenient to transport. The Karma KP 10-2 Power Wheelchair can be taken apart quickly and easily into four manageable components. The heaviest part weighs just 24kg. The quick release battery box has a convenient charging point built into it, which allows the batteries to be charged away from the power chair. Karma KP 10.3 Power Wheelchair: Ergonomic seat system provides comfortable seating. Tool-free disassembled into 3 parts for traveling and transportation. Quick-release battery pack. Washable upholstery. Height adjustable and flip back armrest. 2-level adjustable back angle. Features: Frame: Breaks down into 4
wheelchairindia9

Choosing Correct Power wheel chair - 0 views

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    Power wheel chair is one type of wheel chairs which is also referred and known as Electric Power Wheel Chair or (EPW). An Power wheel chair is used to move such wheel chairs instead of pushing by some attendant or by hand rims. It also has navigational controls so that it can be moved to any desired direction. Power wheel chairs are suitable for those, who are weaker to move the manual wheel chair using the hand rims and also provides its users a level of comfort. The user can control its speed and direction by a joystick sort of control while sitting on the chair. There are many different types of Power wheel chair and finding the appropriate one will depend on each individual's medical condition. Wheelchairs can be manual or electrically powered. Manual wheelchairs can come in either a folding or rigid design. Rigid type wheelchairs tend to be lighter and more easily maneuvered and should be used by more active wheelchair users. Folding wheelchairs would be an excellent choice for individuals needing to use the wheelchair for travel on a frequent basis. Many people have disabilities that make it difficult to propel themselves in a manual wheelchair and in this situation an electrically powered wheelchair may prove more useful. Power chairs are little bit more complex and the user can control it with minimum effort. This kind of chair will give extraordinary maneuverability, stability and power and it is perfect for people who want more from their wheelchairs. Better Life Mobility Center offers various models, so sure that won't have problem to choose one that will suit completely. All the power chairs that offer are the result of the extensive research and designed with the user's needs in mind. Karma latest power standing wheelchair is now available in India. Power Wheelchairs For Sale - Increase freedom Stand up again improve independence and be find of body. Karma KP 10.2 Power Wheelchair: Features: Seat, base & battery quickly detach f
wheelchairindia9

Choosing Correct Power wheel chair - 0 views

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    Power wheel chair is one type of wheel chairs which is also referred and known as Electric Power Wheel Chair or (EPW). An Power wheel chair is used to move such wheel chairs instead of pushing by some attendant or by hand rims. It also has navigational controls so that it can be moved to any desired direction. Power wheel chairs are suitable for those, who are weaker to move the manual wheel chair using the hand rims and also provides its users a level of comfort. The user can control its speed and direction by a joystick sort of control while sitting on the chair. There are many different types of Power wheel chair and finding the appropriate one will depend on each individual's medical condition. Wheelchairs can be manual or electrically powered. Manual wheelchairs can come in either a folding or rigid design. Rigid type wheelchairs tend to be lighter and more easily maneuvered and should be used by more active wheelchair users. Folding wheelchairs would be an excellent choice for individuals needing to use the wheelchair for travel on a frequent basis. Many people have disabilities that make it difficult to propel themselves in a manual wheelchair and in this situation an electrically powered wheelchair may prove more useful. Power chairs are little bit more complex and the user can control it with minimum effort. This kind of chair will give extraordinary maneuverability, stability and power and it is perfect for people who want more from their wheelchairs. Better Life Mobility Center offers various models, so sure that won't have problem to choose one that will suit completely. All the power chairs that offer are the result of the extensive research and designed with the user's needs in mind. Karma latest power standing wheelchair is now available in India. Power Wheelchairs For Sale - Increase freedom Stand up again improve independence and be find of body. Karma KP 10.2 Power Wheelchair: Features: Seat, base & battery quickly detach f
Nathan Goodyear

Combined Diet and Physical Activity Promotion Programs to Prevent Type 2 Diabetes Among... - 0 views

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    Meta analysis does find that diet and exercise (lifestyle changes) do reduce risk of diabetes.
wheelchairindia9

Choosing Correct Power wheel chair - 0 views

  •  
    Power wheel chair is one type of wheel chairs which is also referred and known as Electric Power Wheel Chair or (EPW). An Power wheel chair is used to move such wheel chairs instead of pushing by some attendant or by hand rims. It also has navigational controls so that it can be moved to any desired direction. Power wheel chairs are suitable for those, who are weaker to move the manual wheel chair using the hand rims and also provides its users a level of comfort. The user can control its speed and direction by a joystick sort of control while sitting on the chair. There are many different types of Power wheel chair and finding the appropriate one will depend on each individual's medical condition. Wheelchairs can be manual or electrically powered. Manual wheelchairs can come in either a folding or rigid design. Rigid type wheelchairs tend to be lighter and more easily maneuvered and should be used by more active wheelchair users. Folding wheelchairs would be an excellent choice for individuals needing to use the wheelchair for travel on a frequent basis. Many people have disabilities that make it difficult to propel themselves in a manual wheelchair and in this situation an electrically powered wheelchair may prove more useful. Power chairs are little bit more complex and the user can control it with minimum effort. This kind of chair will give extraordinary maneuverability, stability and power and it is perfect for people who want more from their wheelchairs. Better Life Mobility Center offers various models, so sure that won't have problem to choose one that will suit completely. All the power chairs that offer are the result of the extensive research and designed with the user's needs in mind. Karma latest power standing wheelchair is now available in India. Power Wheelchairs For Sale - Increase freedom Stand up again improve independence and be find of body. Karma KP 10.2 Power Wheelchair: Features: Seat, base & battery quickly detach f
wheelchairindia9

Folding Power Wheelchair - 0 views

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    GM LITE POWER WHEELCHAIR GM Lite Brushless Power Wheelchair with Batteries is a revolutionary light weight power wheelchair using brushless motor. It is the most economic power wheelchair without sacrificing safety & durability. The wheelchair promotes pressure redistribution, reduces downward sliding and helps maintain good posture. Specifications: 10 times longer life Lightest - 23 kg 5 year long life, safe LiFePO4 battery (10ah) High efficiency brushless hub motor 5 seconds folding and unfolding Easy to carry Load : 120 kg Speed : 8km/hr Range: 15 km Slope : 12% 24V180W brushless 8-inch gear hub motor
Nathan Goodyear

The Effects of Pre-Exercise Ginger Supplementation on Muscle Damage and Delayed Onset M... - 0 views

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    Could Ginger be aid in recovery?  Results are mixed.  Study finds 4 g of ginger improves strength in muscle recovery, yet no change in muscle biomarkers.
Nathan Goodyear

PLOS ONE: Testosterone Induces Molecular Changes in Dopamine Signaling Pathway Molecule... - 0 views

  • The majority of the gene expression changes reported here are only induced by DHT and testosterone, and not by estradiol, indicating that in adolescent males androgen receptor, not ERα, activation is critical for these responses
  • It is less clear whether ERβ is involved or not as DHT, via conversion to 3β-diol has a high affinity for ERβ
  • the testosterone-induced, AR-driven modulation of molecular indices of dopamine responsivity of the nigrostriatal pathway may involve regulation of dopamine feedback inhibition in the somatodendritic field and post-synaptic dopamine action in the terminal field.
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    Testosterone increases dopamine signaling.  This study was done on male rats.  No effect was seen with Estradiol.
Nathan Goodyear

Thyroid Hormone Replacement Therapy in Primary Hypothyroidism: A Randomized Trial Compa... - 0 views

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    study shows end points, designed in study, showed no change with combined thyroid therapy; but patients preferred combined therapy.
Nathan Goodyear

Stress Sensitivity in Metastatic Breast Cancer: Analysis of Hypothalamic-Pituitary-Adre... - 0 views

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    salivary cortisol and DHEA used to evaluate hypothalamic-pituitary changes in cancer survivors to predict survival
Nathan Goodyear

Lack of normal increase in saliva estriol/progeste... [Am J Obstet Gynecol. 1992] - Pub... - 0 views

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    salivary estriol/progesterone in late pregnancy correlates with other studies showing changes in hormone levels at initiation of labor
Nathan Goodyear

Reciprocal Changes in Serum Concentrations of 3,3',5'-Triiodothyronine (Reverse T3) and... - 0 views

  • The mechanism or the biological significance of such a diversion of T4, from the normally occurring conversion to highly potent T3, to the generation of poorly calorigenic rT3 in systemic illness
  • such a change in the metabolism of T4 can be reversible.
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    effects of systemic illness on thyroid function: elevated Reverse T3 and low free T3
Nathan Goodyear

Arch Dermatol -- Abstract: The Response of Skin Disease to Stress: Changes in the Sever... - 0 views

  • suggesting that emotional stress from external sources may have a significant influence on acne
  • changes in acne severity correlate highly with increasing stress
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    Stress increase severity of acne
Nathan Goodyear

Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions : ... - 0 views

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    Omega-3 deficient diets alter brain neurochemistry resulting in mood changes
Nathan Goodyear

Telomere shortening and ageing of the immune system | Mendeley - 0 views

  • The immune system is highly sensitive to shortening of telomeres
  • they can up-regulate telomerase, the telomere extending enzyme
  • In ageing immune system adaptive immunity deteriorates because of a progressive decline of naive T and B cells and decrease of absolute numbers of T and B lymphocytes
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    the immune system is very sensitive to shortening of telomere length. This change in the immune system can be a pivotal role in disease development
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