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TK-1 is a proliferation biomarker of DNA repair. TK-1 is a nuclear biomarker of cancer prognosis, survival, recurrence and predicts risk of progression of pre-malignant disease.

Thymidine kinase is a good marker for DNA synthesis and proliferative activity in cancer. Healthy controls had low TK-1 levels. In contrast, advancing stage of disease was associated with increasing TK-1 levels. TK-1 also was useful in following treatment efficacy. Inflammatory GI disease was found have TK-1 levels comparable to "healthy" controls. This is important to be able to differentiate between inflammation and a useful cancer biomarker

Upregulation of TK-1 found to be an early event in breast tumor development. This has implications in precancerous tissue and elevations correlate to stage of cancer. TK-1 has also been found to correlate with Cancer recurrence.

TK-1 to screen for cancer, as well as to follow therapy and recurrence.

Thymidine kinase 1 useful as a prognostic biomarker and to monitor therapy efficacy. TK-1 levels were very low in those without cancer. Higher TK-1 levels pretreatment were associated with poor prognosis and poor survival. TK-1 "increases with progress of the disease, decreases during successful therapy, and finally increases during relapse.

another thumbs up for TK-1.  This finds serum and tumor TK-1 differentiate from normal, healthy tissue.

TK-1 useful in evaluation of disease stage and therapy efficacy. TK-1 was used in conduction with LDH, CEA, NSE, and TPA.

salivary TK-1 increased in response to stimulated increased DNA synthesis in mouse model.

Curcumin shown to be a natural TK inhibitor