Group items tagged

the standard technique of "free testosterone" calculation today is via equilibrium dialysis.  This article describes the problem with current evaluation techniques of current free testosterone evaluation: "this method, although sensitive and reproducible, is cumbersome and not easily adaptable to automated methods".  Most values of "free testosterone" today are either calculated or estimated as this article points out.  Why not just measure with saliva?!

Though this article looked at diet and exercise on PCOS, this article gives a great review of the pathophysiology of PCOS. This study did show that diet and exercise were effective in lowering androgens and improving insulin resistance.

another awesome article dealing with hormone metabolites. Physicians that don't understand metabolites and receptors may be doing more harm than good.   One of the mainstays of the treatment of metastatic prostate disease is androgen deprivation therapy.  This article requires a reassessment of this due to the DHT metabolite 3-beta androstanediol.  This metabolite is produced from DHT production via the enzyme 3beta HSD.  This metabolite binds to ER beta, an estrogen receptor, and inhibits proliferation, migration, promotes adhesion (limits spreading), and stimulates apoptosis.  This is contrast to 3-alpha androstanediol.  Androgen deprivation therapy will decrease 3-beta androstanediol.  This is the likely reason for the increased aggressive prostate cancer found in those men using 5 alpha reductase inhibitors.

another review of the science on curcumin in treatment of disease.  Pay careful attention to the pharmacokinetics portion of this article.  Notice this is an "alternative Medicine" article, yet it is all science.  The use of the word alternative is simply fear mongering.

full pdf article of previously posted article on SAMe and how it increases CBS activity to increase GSH and thus reduce liver oxidative stress and fat accumulation. SAMe also decreases IL-10 and TNF-alpha.

European journal of endocrinology article compared serum to salivary cortisol and found them to be equal, but due to ease of collection, salivary cortisol to be preferable.  This article was using cortisol to assess HPA axis dysfunction.

2008 article from diabetes.  This article supports metabolic endotoxemia arising out of the gut.  High fat diet intake results in disrupted gut flora, resulting in increrased LPS release, resulting in inflammation, leads to leaky gut, systemic endotoxemia, inflammation, and thus metabolic dysfunction: see obesity, DM..

discussion of the declining levels of androgens in the aging male.  But the focus of this entire article is wrong.  They are focusing on the blood levels of these androgens.  The biological effects of hormones occur in tissue not blood.  Though this article provides a good discussion of how transport of androgens are effected, it falls far short of providing any useful clinical application, because it fails to discuss peripheral levels of androgens.  

More recent articles have been published, but this review article reviews the link between low T and cardiovascular disease in men.

Good article.  This article (case series) found that 40% of the men included had no increase in PSA with Testosterone.  One point on the Testosterone dosage is that they used androgen, which is an overdose of Testosterone.  That gives 60% that the PSA did increase.  These men had higher PSA to begin with which leads to the suggestion that the prostate cells were abnormal.  Those men that had a prostatectomy were more likely to have little if any increase in PSA.  This study did use a the 5 alpha reductase inhibitor dutasteride.

Get article on estrogen metabolism/metabolites and their effects on the risk of breast cancer in post menopause women.  This article brings to light new information: 2:16alpha estrone ratio is not a great predicted of risk, 2-OH and 4-OH metabolites can form quinone intermediates...

I can only find the abstract of this article.  This article fits with the growing body of evidence that low Testosterone is a poor prognostic factor for men with prostate cancer.  This very short abstract points to using low levels of "free Testosterone" as a biomarker to treat low-risk prostate cancer.

Must read and a great read at that, of the GI's contribution to health or disease.  The article reviews the current understanding of the GALT layer and it's contribution to health or metabolic endotoxemia and how this then leads to disease. The article reviews the effects of disrupted GI bacteria in the gut as well as in other organ systems.

This article finds that Testosterone transdermal therapy addition to Diet and exercise improved glycemic control and reversed Metabolic Syndrome in men with low T and type II Diabetes.  This article really highlights the proper approach to therapy: combined nutrition, exercise, and Testosterone therapy, when indicated, for men with Metabolic Syndrome and/or Diabetes.  A reduction in IR, adiponectin and hsCRP was observed.

Full article of previously posted abstract.  Cancers are unique.  Not all cancers are alike.  Whether they are tissue specific or not, cancers are unique.  This article describes the uniqueness of DHEA and Testosterone cancer, with particular attention to colon.

Article highlights the problems with the definition of low T.  This article finds consistent decline in Total Testosterone and FAI with increasing age groups, with a significant portion of men > 60 meeting the required levels for "low T".  This study found a decrease in total T and FAI at a consistent rate independent of variables, such as BMI.    This study did find a decrease in SHBG and total T with obesity; in contrast to other studies.

Breast cancer is a metabolic disease.  Now, where have I heard that cancer is a metabolic disease?

Ivermectin shows promise and usefullness in several cancer types.  This is a review article.

very nice of how glucocorticoids and progesterone interact with the immune system.   This review article discusses the current understanding of  how hormones can contribute to autoimmune disease states through inflammation.

HIV/AIDS patients are plagues with muscle loss through varying mechanism. This article discusses the various contributors to the muscle mass found in these men. However, this can be applicable to other men with chronic muscle loss, low T, HGH deficiency...