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Nathan Goodyear

Multicenter Phase II Study of Sequential Brentuximab Vedotin and Doxorubicin, Vinblasti... - 0 views

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    monoclonal Ab used in sequence with AVD found to have event-free survival, progression-free survival, and overal survival rates of 80%, 84%, and 93% respectively in older adults with Hodgkin's lymphoma.
Nathan Goodyear

Safety of Combined Treatment With Monoclonal Antibodies and Viscum album L Preparations - 0 views

  • Among the most encouraging mAb is trastuzumab, which targets the human epidermal growth factor receptor 2 and is indicated in the treatment of breast cancer
  • bevacizumab, which inhibits vascular endothelial growth factor and is indicated in the treatment of a range of diseases, including colorectal, lung, and ovarian cancer3; and cetuximab, which blocks the epidermal growth factor receptor and is indicated in the treatment of colorectal and lung cancer
  • Viscum album L (VA or European mistletoe) preparations are widely used as additive cancer therapy in Europe, especially in German-speaking countries, and have been associated with a reduction in chemotherapy-related adverse drug reactions and increased HRQL
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  • leading to enhancement of interleukin-12 secretion and natural killer cell function
  • Helixor VA preparations
  • A multivariable GEE model indicated that the odds for patients experiencing an AE following mAb therapy were nearly 5 times higher compared with that for mAb plus VA
  • VA preparations (Iscador Ltd) did not inhibit chemotherapy-induced cytostasis or cytotoxicity and showed an additive inhibitory effect at higher concentrations of VA.
  • previous in vitro investigations have shown that VA preparations have either no or minor effects on a range of CYPs, suggesting that VA-drug interactions based on drug metabolism are unlikely
  • mAb do not undergo hepatic metabolism but undergo proteolytic catabolism throughout the body
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    VAE therapy found to reduce adverse events in those receiving monoclonal Ab therapy.
Nathan Goodyear

Evidence for Aerosol Transfer of SARS-CoV-2-Specific Humoral Immunity | ImmunoHorizons ... - 0 views

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    Passive immune transfer of Abs
Nathan Goodyear

An obesity-associated gut microbiome with increased capacity for energy harvest : Abstr... - 0 views

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    gut bacteria balance associated with obesity.  The balance of ones gut bacteria plays a significant role in whether a high fat,western diet leads to obesity or not.
Nathan Goodyear

Total testosterone levels, metabolic parameters, cardiac remodeling and exercise capaci... - 0 views

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    Low Total testosterone associated with poor exercise capacity, increased obesity, poor glucose control including diabetes, increased cardiac hypertrophy in those with CAD.  Simply put, low T in men is associated with metabolic dysregulation.
Nathan Goodyear

Suppression of Rat Thyrotroph and Thyroid Cell Function by Tumor Necrosis Factor-&#x3b1... - 0 views

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    TNF-alpha inhibits TSH secretion in response to TRH stimulus.
Nathan Goodyear

Dietary and lifestyle factors in functional dyspepsia : Abstract : Nature Reviews Gastr... - 0 views

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    Ingestion may actually be a result of what we eat. But, of course that makes sense.  Nice to see traditional medicine coming on board with this.
Nathan Goodyear

Taylor & Francis Online :: Dietary Patterns as Predictors of Prostate Cancer in Jamaica... - 0 views

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    No surprise here, highest refined sugar intake associated with increased risk of Prostate Cancer.
Nathan Goodyear

OASIS - 0 views

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    Just the abstract, but author finds that cancer cells can survive solely on glutamine through substrate level phosphorylation.
Nathan Goodyear

Testosterone and insulin resistance in the metabolic syndrome and T2DM in men : Abstrac... - 0 views

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    low Testosterone in men negatively impacts insulin sensitivity, glucose metabolism and oxidative phosphorylation resulting in physical manifest ions found in metabolic syndrome.
Nathan Goodyear

Diagnostic significance of free salivary testosterone measurement using a direct lumine... - 0 views

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    salivary testosterone found to correlate will with blood free testosterone in men.
Nathan Goodyear

Salivary cortisol and testosterone responses to resistance and plyometric exercise in 1... - 0 views

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    Study of 12-14 y/o boys found increased Testosterone after resistance training and plyometric exercise.  Cortisol did increase after plyometric, but not resistance exercise.
Nathan Goodyear

Subcutaneous Testosterone: An Effective Delivery Mechanism for Masculinizing Young Tran... - 0 views

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    This post is only on the concept of subcutaneous Testosterone as an effective alternative to IM.
Nathan Goodyear

Effects of Korean Red Ginseng Extract on Behavior in Children with Symptoms of Inattent... - 0 views

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    Panax ginseng, or korean ginseng, maybe helpful in the treatment for attention and hyperactivity.
Nathan Goodyear

The Association Between Sleep Duration, Insulin Sensitivity, and β-Cell Funct... - 0 views

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    sleep duration linearly associated with insulin sensitivity.
Nathan Goodyear

Diet and Sex Hormone-Binding Globulin: The Journal of Clinical Endocrinology & Metaboli... - 0 views

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    diets lower in protein, result in decreases SHBG and thus decreased bioavailable Testosterone.
Nathan Goodyear

Low-Fat High-Fiber Diet Decreased Serum and Urine Androgens in Men: The Journal of Clin... - 0 views

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    lower fat, higher fiber diets result in 12% reduction in circulating male hormones
Nathan Goodyear

11-Ketotestosterone Is a Major Androgen Produced in Human Gonads: The Journal of Clinic... - 0 views

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    Only abstract available here; 11-ketotestosterone found not to be susceptible to aromatase activity as is testosterone.  This was a breast cell culture study.  It was found to actually inhibit cell proliferation in opposition to aromatized testosterone.
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