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Nathan Goodyear

Salivary testosterone, cortisol, and progesterone:... [Physiol Behav. 2010] - PubMed re... - 0 views

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    Salivary testosterone, cortisol, and progesterone: two-week stability, interhormone correlations, and effects of time of day, menstrual cycle, and oral contraceptive use on steroid hormone levels.
Nathan Goodyear

Acute Suppression of Circulating Testosterone Levels by Cortisol in Men: The Journal of... - 0 views

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    Cortisol inhibits Testosterone production in men.
Nathan Goodyear

Effect of meal fat content on salivary testosterone and cortisol levels in healthy fema... - 0 views

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    higher fat diet found to increase cortisol and Testosterone levels post meal in health women.  The effect was first seen early after lunch (30 minutes).
Nathan Goodyear

Effects of heavy-resistance training on hormonal response patterns in younger vs. older... - 0 views

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    resistance training associated with an increase in Total Testosterone and free Testosterone in young men with exercise and rest.  In contrast, with older men, the increase was seen with TT only.  An increase in IGF-1 was seen and a decrease in resting cortisol was seen.
Nathan Goodyear

Testosterone and cortisol in relationship to dietary nutrients and resistance exercise - 0 views

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    resistance training increases testosterone post exercise.  Dietary protein increased basal testosterone production.
Nathan Goodyear

Leptin and Androgens in Male Obesity: Evidence for Leptin Contribution to Reduced Andro... - 0 views

  • in male obesity basal and LH-stimulated androgen levels are reduced and inversely correlated with circulating leptin
  • functional leptin receptors are present in rodent Leydig cells
  • it is conceivable that in males high leptin concentrations may have a direct inhibitory effect(s) on Leydig cell function.
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  • insulin is an important inhibitor of the synthesis of SHBG
  • no correlation between leptin and SHBG levels
  • SHBG reduction in obesity is a minor determinant of lowered androgen levels
  • SHBG can explain only up to 3% of the correlation
  • testicular T de novo production is impaired in obese men and that leptin seems to be the best hormonal predictor of this blunted response to LH stimulation
  • The low basal 17-OH-P levels found in massively obese men are consistent with a global impairment of Leydig cell steroidogenic function in this group of subjects.
  • These findings indicate that obese men have a FM-related defect in the enzymatic conversion of 17-OH-P to T, which is revealed by hCG stimulation.
  • Other studies have investigated the adrenal function in male obesity and have shown that basal cortisol and 17-OH-progesterone levels tend to decrease with the increase in the degree of obesity
  • High E2 can inhibit the expression and activity of the 17,20-lyase and may be responsible for this steroidogenic lesion
  • However, stimulated E2 levels were not higher in the obese than in controls, excluding the fact that the lower androgen response was due to an increased aromatization of T to E2 and that estrogens have a major role in the observed defect of 17,20-lyase activity in obese men.
  • the percentage increase in the 17-OH-progesterone to T molar ratio paralleled the increase in leptin levels of obese men
  • Multiple regression analysis indicated that the best hormonal predictor of the obesity-related reduction in T and FT basal levels and androgen changes after hCG stimulation was serum leptin concentration
  • insulin has no negative influences on androgen production in obese men
  • insulin is known to have stimulatory actions on T production that have been demonstrated in obese and normal weight men (57) and in Leydig cells in culture
  • the negative correlation between insulin and basal T can be partly explained by the inhibitory action of insulin on SHBG production
  • hypogonadal men have higher circulating leptin levels compared with hypogonadal patients under effective androgen substitution therapy
  • The impaired androgen response to LH stimulus was due to a defect in the enzymatic conversion of 17-OH-progesterone to T, which was disclosed by a leptin-related increase in 17-OH-progesterone to T ratio
  • Estrogens, which are inhibitory modulators of LH pulsatility and bioactivity
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    Leptin appears to be a good marker of low Testosterone.  This study proposes that the mechanism of action is potentially 2 fold: first, a decrease in LH release by leptin (kisspeptin?) and 2nd, a directed decrease in Testosterone production by the leydig cells in the testes.
Nathan Goodyear

Using testosterone and cortisol as bioma... [J Strength Cond Res. 2014] - PubMed - NCBI - 0 views

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    Study followed Total Testosterone:Cortisol ratios to monitor catabolic/anabolic states in basketball players.  The authors followed serum levels and monitored them 24-36 hours post game.  Those playing > 25 min/game had the lowest TT:C and highest cortisol indicating a catabolic state and making recovery critical.
Nathan Goodyear

Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsa... - 0 views

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    INteresting.  Estradiol enhances cortisol negative feedback on ACTH production in both men and women.
Nathan Goodyear

Overtraining Syndrome - 0 views

  • Alterations in the HPA and hypothalamic-pituitary-gonadal axes with a resultant decrease in testosterone:cortisol ratios have been implicated in OTS. Proinflammatory cytokines are potent activators of the HPA system, which cause release of corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol. These cytokines suppress testosterone through central inhibition
  • Some have suggested that a decreased testosterone:cortisol ratio can be diagnostic of NFO and/or OTS. However, the ratio represents the physiologic strain of training rather than the athlete’s maladaption to that stress
  • Cortisol (catabolic and anti-inflammatory) is converted to inactive cortisone by 11β-HSD2
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  • A prospective study found a clinically significant increase in overnight urinary cortisol:cortisone ratio during a high training load period in triathletes, who subsequently underperformed and reported fatigue
  • It is proposed that cytokines may inhibit 11β-HSD2 activity and result in relative increases in cortisol and, hence, catabolism
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    Overtraining syndrome described.
Nathan Goodyear

Regulation of production and secretion of sex hormone-binding globulin in HepG2 cell cu... - 0 views

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    SHBG and hormones.  Insulin, IGF-1, and EGF decrease SHBG levels.  Contrast that with estradiol, testosterone, T3, and cortisol that increase SHBG
Nathan Goodyear

Psychoendocrine and physical performan... [Aggress Behav. 2008 Nov-Dec] - PubMed - NCBI - 0 views

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    Rugby training resulted in a decrease in T:C salivary ratio through a decline in resting testosterone level.  In contrast, competition events increased the T:C ratio primarily through an increase in Cortisol production.
Nathan Goodyear

An update: salivary hormones and physical exercise - Gatti - 2010 - Scandinavian Journa... - 0 views

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    salivary cortisol, testosterone, DHEA testing is a "real alternative" to serum testing in the scrutiny of athletes.
Nathan Goodyear

The acute hormonal response to free weig... [J Strength Cond Res. 2013] - PubMed - NCBI - 0 views

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    This study found that free weights induced a greater increase in Testosterone, GH, and cortisol, than machine.  This study only looked at serum levels.
Nathan Goodyear

Plasma and salivary steroid hormone resp... [J Strength Cond Res. 2011] - PubMed - NCBI - 0 views

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    plasma and salivary cortisol and Testosterone correlate in study of study assessing overreaching.
Nathan Goodyear

Effects of Acute Exposure to M... [Res Sports Med. 2014 July-September] - PubMed - NCBI - 0 views

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    Article looked at the anabolic effect of low-intensity resistance exercise.  This study found a decrease in cortisol post-exercise, but no increase in anabolic effects: GH and total Testosterone.  The exercise was in untrained men, which could explain some of the decrease in the anabolic effect with the men in this study.
Nathan Goodyear

Endocrine biomarkers and symptom clusters during t... [Menopause. 2014] - PubMed - NCBI - 0 views

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    Study finds that low estrogen, assuming estradiol, higher FSH, low epinephrine, higher norepinephrine are associated with severe hot flashes.  Of interesting note, Cortisol and Testosterone were not associated with symptom severity.
Nathan Goodyear

IEEE Xplore - Astronaut physical load research and applications - 0 views

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    saliva testing of testosterone and cortisol in astronauts; Research conducted by NASA
Nathan Goodyear

Age-related hormonal adaptations, muscle circumference and strength development with 8w... - 0 views

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    Moderate resistance training program over 8 weeks associated with increased Testosterone production in young and middle age lean men.  Growth hormone was also increased in both groups.  ACTH and cortisol decreased in this lean men.  
Nathan Goodyear

Recovery after an Ironman triathlon: sustained inflammatory respons... - PubMed - NCBI - 0 views

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    Recovery period of Ironman triathlon associated with significantly increased inflammatory response.  The vast majority is resolved by day 5 in this study, though low-grade inflammation persisted beyond day 5.  Cortisol was significantly elevated and Testosterone was significantly decreased in the early recovery period.  Muscle damage and significant inflammation is a prominent finding in the recovery phase of a triathlon.
Nathan Goodyear

Oral contraceptive use and saliva diurnal pattern of metabolic ster... - PubMed - NCBI - 0 views

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    Oral contraceptives shown to reduce Testosterone and DHEA in women, but no effect on cortisol was seen.
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