Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views
nnr.sagepub.com/...75.long
curcumin DHA TBI traumatic brain injury brain injury neuroinflammation BDNF brain derived neurotrophic factor brain
shared by Nathan Goodyear on 31 Aug 15
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concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
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DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
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curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
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Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
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Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
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curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
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previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
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the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
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curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.