Group items tagged

CSF norepinephrine levels found to be elevated in those with PTSD.  This is one of the few, if not only study, that has looked at epinephrine concentrations in PTSD.  Plasma norepinephrine levels were found to not be associated with PTSD.

lower methylation status increases risk of PTSD.  Those with PTSD should be evaluated for methylation status.

sleep disruption is a major symptom in those with PTSD.  There is no greater stress than combat.  The majority of research on PTSD is done on combat veterans

Low T found in young combat veteran with PTSD and SI.  This is no surpass as there is significant HPA dysfunction in these men/women.  The overwhelming cortisol response and resultant PTSD will shut down endogenous Testosterone production.  I have seen this in several combat veterans.

delayed PTSD

Not so interested in the discussion on pharmacotherapy, but the discussing on the neuroendocrinology of PTSD.

low cortisol pattern with elevated DHEA found in women with PTSD.  Additionally, elevated levels of TNF-alpha and IL-6 were found. Hormone evaluation was tested through saliva.

Gut microbiome diversity is different in stressed mice and calm mice in animal study.  Authors propose intricate connection between gut:brain and possible evaluation and therapy in PTSD.

Link between TBI and PTSD.

Individuals with type II DM, found to have blunted morning cortisol and decreased hippocampal volume.  The hippocampus is the focus of memory.  This is similar to what is found in PTSD.

PTSD in military deployed in combat is very high.  Estimated from between 20.3% to 42.4% of returning soldiers.  

stress results in shrinkage of the hippocampus of the brain.  This would result in deficiency in serotonin and thus contribute to many of the symptoms found in those with PTSD.

Neuroendocrinology of PTSD.

low cortisol and elevated LPS, IL-6, and TNF-alpha found in people with PTSD.

elevated cortisol levels found in moderate/severe PTSD in police officers.  Again, saliva testing was used for cortisol evaluation.

PTSD is not just a short term issue.  The HPA dysfunction can persist long-term causing symptoms that extend far beyond the time of injury/healing.  What is interesting, is that the cortisol was evaluated with cortisol.  The new gold standard.

Low cortisol found in those with PTSD.  This study suggest the high ACTH/cortisol ratio is not due to enhanced peripheral sensitization to glucocorticoids.

chronic elevated norepinephrine and sympathetic activation foun din those individuals suffering from PTSD.

elevated pm saliva cortisol and increased IL-6 is predictive of PTSD in children and adolescents.  

appears that PTSD results in divergent catecholamine and cortisol levels as patients age.  The catecholamines (norepinephrine) will elevate and the cortisol will progressive decrease.  Additionally, this is revealed in salivary cortisol testing