n-3 deficient diet and fructose interventions disrupted insulin receptor signalling in hippocampus as evidenced by a decrease
in phosphorylation of the insulin receptor and its downstream effector Akt
rats fed high fructose diet and omega-3 diet found to have memory decline. The purpose of this study was to look at the effects of Metabolic syndrome on the brain.
Omega-3, DHA and EPA, exert anti-inflammatory effects through GPR120 receptor. This improved insulin sensitivity and had diabetes effects in-vivo model. The effect was through the reduction of macrophage-induced inflammatory cytokines.
diets with high high-fructose corn syrup and low omega-3 shown to slow cognitive processing in rat model. This is basically, metabolic syndrome of the brain, as it is the result of hyperinsulinemia.
The purpose of this post is not that prednisone should be used to improve the fatty acid profile in those with Lupus. That is ridiculous. But, that fatty acid abnormalities are consistently found in Lupus and particularly omega-3 fatty acids should be evaluated.
diet and exercise increases BDNF. Diets rich in omega 3, curcumin, and polyphenols increase BDNF and thus increase neuroplasticity and associated cognition. In contrast, sugar and saturated fats in crease oxidative stress and worsened spatial learning. This study is a review.
Omega-3 intake reduced inflammation and pain in Juvenile idiopathic arthritis. Associated inflammatory markers were decreased in study. Anti-inflammatory drug usage was decreased as well.
Animal model shows that n-3 intake reduced axonal injury after injury insult. This implies a use in n-3 intake even after an insult has occured. This implies a role for n-3 in neuroplasticity.