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curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders

Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction

Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI

curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus

previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF

Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.

curcumin may promote the conversion of n-3 DPA to DHA

the combination of both nutrients has been reported to produce anti-inflammatory action

the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane

curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.

changes in expression of HIF1-α

alteration of pH regulators V-ATPase and MCT1, and other cell survival regulators such as PUMA, GLUT1, Bcl2 and p53

DCA as a cancer stabilizing agent

A protocol of natural medications was developed to address the dose-limiting neurologic toxicity, in collaboration with a naturopathic physician (Andrews). The oral DCA regimen that was developed included three natural medications acetyl L-carnitine[29-31], R-alpha lipoic acid[32-34] and benfotiamine[35-37], for the primary purpose of neuropathy prevention

measurable benefits from DCA therapy in 60%-70% of cases