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Nathan Goodyear

Divergence of gut permeability and mucosal immune gene expression in two glut... - 0 views

fulltextreports.com/...disease-and-gluten-sensitivity

Gluten sensitivity

shared by Nathan Goodyear on 03 May 11 - No Cached
  • GS as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function.
  • Nathan Goodyear on 03 May 11
     
    Gluten sensitivity a result of the innate immunity
Nathan Goodyear

The intestinal epithelial barrier: how to dist... [Semin Immunol. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17324587

TLR toll-like receptors NODs GI gut immunity inflammation microbiota bacteria dysbiosis

shared by Nathan Goodyear on 08 Mar 12 - No Cached
  • Nathan Goodyear on 08 Mar 12
     
    TLRs and NODs play important role in GI mucosal immunity.
Nathan Goodyear

Chemotherapy-driven dysbiosis in the intestinal microbiome. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26147207

gut gut flora gut microbiome gut microbiota chemotherapy cancer prostate men hormone hormones Testosterone

shared by Nathan Goodyear on 07 Jul 15 - No Cached
  • Nathan Goodyear on 07 Jul 15
     
    Gut microbiome effected by chemotherapy and the result is GI mucositis.  A decrease in Firmicutes and Actinobacteria was found.
Nathan Goodyear

Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epi... - 0 views

aem.asm.org/...3655.full

gut gut bacteria gut flora gut health gut microbiome gut microbiota akkermansia muciniphila

shared by Nathan Goodyear on 11 Jul 17 - No Cached
  • Nathan Goodyear on 11 Jul 17
     
    Akkermansia muciniphila found to increase the integrity of the gut mucosal lining.  Important in gut healing and likely a good biomarker of good/bad gut health and integrity.
Nathan Goodyear

Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) - a novel theory for t... - 0 views

www.ncbi.nlm.nih.gov/...PMC4918028

GELDING theory GELDING LPS gut gut health inflammation low T low Testosterone Testosterone hypogonadism obesity

shared by Nathan Goodyear on 30 Jun 16 - No Cached
  • GELDING theory (Gut Endotoxin Leading to a Decline IN Gonadal function)
  • trans-mucosal passage of bacterial lipopolysaccharide (LPS) from the gut lumen into the circulation is a key inflammatory trigger underlying male hypogonadism
  • Obesity and a high fat/high calorie diet are both reported to result in changes to gut bacteria and intestinal wall permeability, leading to the passage of bacterial endotoxin (lipopolysaccharide- LPS) from within the gut lumen into the circulation (metabolic endotoxaemia), where it initiates systemic inflammation.
  • ...1 more annotation...
  • Endotoxin is known to reduce testosterone production by the testis, both by direct inhibition of Leydig cell steroidogenic pathways and indirectly by reducing pituitary LH drive, thereby also leading to a decline in sperm production.
  • Nathan Goodyear on 30 Jun 16
     
    Ever heard of the GELDING theory?  This involves the link between LPS endotoxin from the gut and low Testosterone in obese men.
Nathan Goodyear

Intestinal Lymphocyte Populations in Children with Regressive Autism: Evidence for Exte... - 0 views

mercola.fileburst.com/....lymphocytes%20in%20autism.pdf

ASD autism IBD inflammation gut intestine

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    inflammatory changes in the intestines of children with regression autism found that is different from others with inflammatory bowel diseases.
Nathan Goodyear

Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in ... - 0 views

mercola.fileburst.com/...Ileal%20cytokines.pdf

ASD autism inflammation

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    immune dysfunction found in children with autism. This again, suggests a gut-brain link in autism.
Nathan Goodyear

Histamine and mucosal mast cells in interstitial cystitis. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2750582

IC interstitial cystitis histamine mast cells bladder

shared by Nathan Goodyear on 12 May 15 - No Cached
  • Nathan Goodyear on 12 May 15
     
    Interstitial cystitis is a histamine/mast cell mediated event.
Nathan Goodyear

The pleiotropic role of vitamin A in regulating mucosal immunity. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26141028

vitamin A gut immune system immunity

shared by Nathan Goodyear on 07 Jul 15 - No Cached
  • Nathan Goodyear on 07 Jul 15
     
    only abstract available--vitamin A plays role in immune tolerance/intolerance via gut mucosa.
Nathan Goodyear

Mucosal Immunology - Molecular signatures of a disturbed nasal barrier function in the ... - 0 views

www.nature.com/...mi20119a.html

S aureus Staphylococcus aureus autoimmune disease disease autoimmune Wegener's granulomatosis WG Wegener's vasculitis

shared by Nathan Goodyear on 15 Sep 15 - No Cached
  • Nathan Goodyear on 15 Sep 15
     
    nasal mucos colonization of S aureus found to be associated with Wegener's vasculitis as well as relapse.
Nathan Goodyear

Anatomical basis of tolerance and immunity to intestinal antigens : Abstract : Nature R... - 0 views

www.nature.com/...nri1057.html

Mucosal associated lymphoid tissue MALT intestinal immune system gut

shared by Nathan Goodyear on 07 Sep 11 - No Cached
  • Nathan Goodyear on 07 Sep 11
     
    review of the physiology of the intestinal immune system
Nathan Goodyear

PLOS ONE: Microbial Dysbiosis in Colorectal Cancer (CRC) Patients - 0 views

journals.plos.org/...article

dybsiosis cancer colon cancer Bacteroidetes Prevotella IL-17

shared by Nathan Goodyear on 26 Feb 15 - No Cached
  • differences in the colon microbiota in individuals with colon cancer versus those with a normal colonoscopy
  • qPCR revealed significant elevation of the Bacteroides/Prevotella population in cancer patients that appeared to be linked with elevated IL17 producing cells in the mucosa of individuals with cancer.
  • Bacteroides genus populations and more specifically those of Bacteroides fragilis, have recently been shown to produce a metalloprotease in colon cancer patients, but not in controls [12] suggesting this species sub population might favor carcinogenesis
  • ...3 more annotations...
  • It is noteworthy that among the many mechanisms that may mediate associations between microbiota and human health [21]–[22], pro-inflammatory and immune cell activation in colon mucosa are of great importance in relation to malignancy
  • B. fragilis has been shown to induce mucosal regulatory T-cell responses in the intestine involving TH17 cell recruitment in experimental models
  • the elevations of Bacteroides in the stool and/or IL17 immunoreactive cells in the normal mucosa appear to be promising sensitive markers
  • Nathan Goodyear on 26 Feb 15
     
    A relationship between dysbiosis and colon cancer appears to be present.  Particularly an increase in Bacteroidetes and Prevotella species were found in those with colon cancer versus those without.  An inflammatory up regulation of IL-17 appears to be involved.  Whether this is a cause or effect is yet to be determined, but the presence of elevated Bacteroidetes species with increased IL17 could be used as sensitive biomarkers.
Nathan Goodyear

CLINICAL CHARACTERISTICS AND ENDOSCOPIC FINDINGS ASSOCIATED WITH BLASTOCYSTIS HOMINIS I... - 1 views

www.ajtmh.org/...213.long

blastocystis hominis blastocystis hepatitis

shared by Nathan Goodyear on 06 Apr 15 - No Cached
  • patients with alcoholic cirrhosis and chronic hepatitis experienced more severe symptoms when infected with B. hominis
  • individuals with chronic HBV infection were at increased risk of acquiring B. hominis
  • Among the 34 individuals with chronic HBV infection in this study, individuals who harbored B. hominis were more likely to have an abnormal liver function test result than those who did no
  • ...1 more annotation...
  • intense inflammatory cell infiltration, edematous lamina propria, and mucosal sloughing. However, the pathogenicity of B. hominis in human intestine has only been elucidated from case reports and a case series study
  • Nathan Goodyear on 06 Apr 15
     
    Blastocystis hominis.
Nathan Goodyear

Mucosal Immunology - Commensal Gram-positive bacteria initiates colitis by inducing mon... - 0 views

www.nature.com/...mi201453a.html

commensal bacteria gut gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 12 Jan 16 - No Cached
  • Nathan Goodyear on 12 Jan 16
     
    good discussion of commensal bacteria interaction with immune system.
Nathan Goodyear

Histamine and histamine intolerance - 0 views

ajcn.nutrition.org/...1185.long

histamine histamine intolerance DAO diamine oxidase HNMT methylation

shared by Nathan Goodyear on 24 Mar 15 - No Cached
  • Histamine intolerance can develop through both increased availability of histamine and impaired histamine degradation
  • increased availability may be an endogenous histamine overproduction caused by allergies, mastocytosis, bacterias, gastrointestinal bleeding, or increased exogenous ingestion of histidine or histamine by food or alcohol
  • Other biogenic amines, such as putrescine, may also be involved in displacing histamine from its mucosal mucine linkage, which results in an increase of free absorbable histamine in circulation
  • ...2 more annotations...
  • the main cause of histamine intolerance is an impaired enzymatic histamine degradation caused by genetic or acquired impairment of the enzymatic function of DAO or HNMT
  • The main enzyme for metabolism of ingested histamine is diamine oxidase (DAO)
  • Nathan Goodyear on 24 Mar 15
     
    good discussion of histamine and histamine intolerance.  All centers around diamine oxidase function (DAO).
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