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Nathan Goodyear

Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) - a novel theory for t... - 0 views

www.ncbi.nlm.nih.gov/...PMC4918028

GELDING theory GELDING LPS gut gut health inflammation low T low Testosterone Testosterone hypogonadism obesity

shared by Nathan Goodyear on 30 Jun 16 - No Cached
  • GELDING theory (Gut Endotoxin Leading to a Decline IN Gonadal function)
  • trans-mucosal passage of bacterial lipopolysaccharide (LPS) from the gut lumen into the circulation is a key inflammatory trigger underlying male hypogonadism
  • Obesity and a high fat/high calorie diet are both reported to result in changes to gut bacteria and intestinal wall permeability, leading to the passage of bacterial endotoxin (lipopolysaccharide- LPS) from within the gut lumen into the circulation (metabolic endotoxaemia), where it initiates systemic inflammation.
  • ...1 more annotation...
  • Endotoxin is known to reduce testosterone production by the testis, both by direct inhibition of Leydig cell steroidogenic pathways and indirectly by reducing pituitary LH drive, thereby also leading to a decline in sperm production.
  • Nathan Goodyear on 30 Jun 16
     
    Ever heard of the GELDING theory?  This involves the link between LPS endotoxin from the gut and low Testosterone in obese men.
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