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finchloe121

How To Diagnose And Defeat Insomnia In An Easy Manner! - 0 views

www.pharmahealthonline.com/...eat-insomnia-in-an-easy-manner

Health Pharmacy Medicine

shared by finchloe121 on 24 Sep 22 - No Cached
  • finchloe121 on 24 Sep 22
     
    Insomnia is a condition that prevents a person from getting peaceful and sound sleep for hours. It is a symptom that occurs due to various symptoms and causes. This sleep disorder affects people in different ways. If you suffer from insomnia, you may not be able to fall asleep or stay asleep. Cognitive behavioral therapy or CBT is a type of psychotherapy used to treat insomnia, anxiety disorders, depression, eating disorders, marital disorders, and quality of life. Cognitive-behavioral therapy focuses on changing individuals' negative thoughts because thoughts can primarily contribute to the construction of anxiety, depression, and emotional difficulties. Many people typically need at least 3-4 hours of sleep a night, but the average sleep time is 6-9 hours. This means that sleep duration and sleep cycles vary from person to person. The most important thing is to get enough sleep, no matter how long it takes. The best remedy to treat the symptoms of this disorder is to use OTC Zolpidem 5mg Tablets Online.
Nathan Goodyear

Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty ac... - 0 views

www.dietaryfiberfood.com/...atty-acid-mental-disorders.php

Omega-3 mood disorders depression bi-polar

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • The most convincing evidence for beneficial effects of omega-3 PUFA is to be found in mood disorders. A meta-analysis of trials involving patients with major depressive disorder and bipolar disorder provided evidence that omega-3 PUFA supplementation reduces symptoms of depression. Furthermore, meta-regression analysis suggests that supplementation with eicosapentaenoic acid may be more beneficial in mood disorders than with docosahexaenoic acid,
  • Nathan Goodyear on 15 Feb 11
     
    Omega-3 beneficial in depression and bi-polar clients
Nathan Goodyear

Kynurenine Pathway Metabolites in Humans: Disease and Healthy States - 0 views

www.la-press.com/and-healthy-stat-article-a1204

kynurenine pathway neurodegenerative disorders excitotoxicity ALS Parkinson's disease Alzheimer's mood disorder depression anxiety quinolinate picolinate disordered tryptophan metabolism

shared by Nathan Goodyear on 27 Oct 11 - No Cached
  • Nathan Goodyear on 27 Oct 11
     
    review of studies looking at kyneurenine pathway and it's contribution to neurodegenerative disorders and mood disorders
Nathan Goodyear

http://ac.els-cdn.com/S0303720713002426/1-s2.0-S0303720713002426-main.pdf?_tid=360bb0b2... - 0 views

ac.els-cdn.com/...2.0-S0303720713002426-main.pdf

endocrine disorders mitochondria disease biochemistry diabetes aging hypoparathyroidism hypothyroidism hypogonadism hormones

shared by Nathan Goodyear on 30 Apr 14 - No Cached
  • Nathan Goodyear on 30 Apr 14
     
    Very well done article that discusses the relationship between mitochondria and endocrine disorders.  Mitochondrial disorders cannot just include inherited mitochondriopathies, but acquired mitochondriopathies as well.
Nathan Goodyear

Effect of inositol on bulimia nervosa and binge ea... [Int J Eat Disord. 2001] - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...11262515

inositol eating disorders binge

shared by Nathan Goodyear on 01 Jun 11 - No Cached
  • Inositol is as therapeutic in patients with bulimia nervosa and binge eating as it is in patients with depression and panic and obsessive-compulsive disorders
  • Nathan Goodyear on 01 Jun 11
     
    inositol effective in eating disorders, including binge eating
Nathan Goodyear

Inositol treatment of obsessive-compulsive disorde... [Am J Psychiatry. 1996] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...8780431

inositol depression panic obsessive-compulsive disorders

shared by Nathan Goodyear on 01 Jun 11 - No Cached
  • he authors conclude that inositol is effective in depression, panic, and obsessive-compulsive disorder
  • Nathan Goodyear on 01 Jun 11
     
    inositol effective in depression, panic, and obsessive-compulsive disorders
Nathan Goodyear

Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disor... - 0 views

ajp.psychiatryonline.org/...1084

inositol panic disorders anxiety

shared by Nathan Goodyear on 01 Jun 11 - No Cached
  • The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder.
  • Nathan Goodyear on 01 Jun 11
     
    inositol proven effective in panic disorders
Nathan Goodyear

Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ... - 0 views

pediatrics.aappublications.org/...S1.full

ASDs autism gastrointestinal disorder ASD

shared by Nathan Goodyear on 28 Jun 11 - No Cached
  • The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders
  • Nathan Goodyear on 28 Jun 11
     
    ASD behavior problems may have underlying gastrointestinal disorders as the cause
Nathan Goodyear

Mood Disorders and Obesity: Understanding Inflammation as a Pathophysiological Nexus | ... - 0 views

www.academia.edu/..._as_a_Pathophysiological_Nexus

obesity overweight mood disorders depression anxiety weight loss' leptin adiponectin inflammation cytokines

shared by Nathan Goodyear on 22 Jan 13 - No Cached
  • Nathan Goodyear on 22 Jan 13
     
    good review of the interaction between the immune system and the neuroendocrine system in obesity and mood disorders.  
Nathan Goodyear

Salivary testosterone: Associations with depression, anxiety disorders, and antidepress... - 0 views

www.jpsychores.com/...abstract

saliva salivary low testosterone depression anxiety mood disorders

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    large study revealed that low salivary testosterone is associated with increased depression, anxiety, and other mood disorders.
Nathan Goodyear

PsychiatryOnline | The Journal of Neuropsychiatry and Clinical Neurosciences | Can Trau... - 0 views

neuro.psychiatryonline.org/article.aspx

TBI traumatic brain injury psychiatric disorders depression anxiety schizophrenia insomnia

shared by Nathan Goodyear on 16 Feb 12 - No Cached
  • Nathan Goodyear on 16 Feb 12
     
    research, though limited, supports the hypothesis that TBI contributes to psychiatric disorders.
Nathan Goodyear

Nutritional therapies for mental disorders - 0 views

www.ncbi.nlm.nih.gov/...PMC2248201

vitamins nutritional therapy vitamin mood disorders depression anxiety bipolar shizophrenia OCD

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    Nutritional therapies for mood disorders.
Nathan Goodyear

Inflammatory cause of metabolic syndrome via brain stress and NF-κB - 0 views

www.ncbi.nlm.nih.gov/...PMC3314172

metabolic syndrome TLR cytokines hypothalamus brain neurology metabolic syndrome NF-kappaB DIO diet induced obesity over nutrition nutrition inflammation

shared by Nathan Goodyear on 09 Jul 13 - No Cached
  • Mechanistic studies further showed that such metabolic inflammation is related to the induction of various intracellular stresses such as mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and autophagy defect under prolonged nutritional excess
  • intracellular stress-inflammation process for metabolic syndrome has been established in the central nervous system (CNS) and particularly in the hypothalamus
  • the CNS and the comprised hypothalamus are known to govern various metabolic activities of the body including appetite control, energy expenditure, carbohydrate and lipid metabolism, and blood pressure homeostasis
  • ...56 more annotations...
  • Reactive oxygen species (ROS) refer to a class of radical or non-radical oxygen-containing molecules that have high oxidative reactivity with lipids, proteins, and nucleic acids
  • a large measure of intracellular ROS comes from the leakage of mitochondrial electron transport chain (ETC)
  • Another major source of intracellular ROS is the intentional generation of superoxides by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase
  • there are other ROS-producing enzymes such as cyclooxygenases, lipoxygenases, xanthine oxidase, and cytochrome p450 enzymes, which are involved with specific metabolic processes
  • To counteract the toxic effects of molecular oxidation by ROS, cells are equipped with a battery of antioxidant enzymes such as superoxide dismutases, catalase, peroxiredoxins, sulfiredoxin, and aldehyde dehydrogenases
  • intracellular oxidative stress has been indicated to contribute to metabolic syndrome and related diseases, including T2D [72; 73], CVDs [74-76], neurodegenerative diseases [69; 77-80], and cancers
  • intracellular oxidative stress is highly associated with the development of neurodegenerative diseases [69] and brain aging
  • dietary obesity was found to induce NADPH oxidase-associated oxidative stress in rat brain
  • mitochondrial dysfunction in hypothalamic proopiomelanocortin (POMC) neurons causes central glucose sensing impairment
  • Endoplasmic reticulum (ER) is the cellular organelle responsible for protein synthesis, maturation, and trafficking to secretory pathways
  • unfolded protein response (UPR) machinery
  • ER stress has been associated to obesity, insulin resistance, T2D, CVDs, cancers, and neurodegenerative diseases
  • brain ER stress underlies neurodegenerative diseases
  • under environmental stress such as nutrient deprivation or hypoxia, autophagy is strongly induced to breakdown macromolecules into reusable amino acids and fatty acids for survival
  • intact autophagy function is required for the hypothalamus to properly control metabolic and energy homeostasis, while hypothalamic autophagy defect leads to the development of metabolic syndrome such as obesity and insulin resistance
  • prolonged oxidative stress or ER stress has been shown to impair autophagy function in disease milieu of cancer or aging
  • TLRs are an important class of membrane-bound pattern recognition receptors in classical innate immune defense
  • Most hypothalamic cell types including neurons and glia cells express TLRs
  • overnutrition constitutes an environmental stimulus that can activate TLR pathways to mediate the development of metabolic syndrome related disorders such as obesity, insulin resistance, T2D, and atherosclerotic CVDs
  • Isoforms TLR1, 2, 4, and 6 may be particularly pertinent to pathogenic signaling induced by lipid overnutrition
  • hypothalamic TLR4 and downstream inflammatory signaling are activated in response to central lipid excess via direct intra-brain lipid administration or HFD-feeding
  • overnutrition-induced metabolic derangements such as central leptin resistance, systemic insulin resistance, and weight gain
  • these evidences based on brain TLR signaling further support the notion that CNS is the primary site for overnutrition to cause the development of metabolic syndrome.
  • circulating cytokines can limitedly travel to the hypothalamus through the leaky blood-brain barrier around the mediobasal hypothalamus to activate hypothalamic cytokine receptors
  • significant evidences have been recently documented demonstrating the role of cytokine receptor pathways in the development of metabolic syndrome components
  • entral administration of TNF-α at low doses faithfully replicated the effects of central metabolic inflammation in enhancing eating, decreasing energy expenditure [158;159], and causing obesity-related hypertension
  • Resistin, an adipocyte-derived proinflammatory cytokine, has been found to promote hepatic insulin resistance through its central actions
  • both TLR pathways and cytokine receptor pathways are involved in central inflammatory mechanism of metabolic syndrome and related diseases.
  • In quiescent state, NF-κB resides in the cytoplasm in an inactive form due to inhibitory binding by IκBα protein
  • IKKβ activation via receptor-mediated pathway, leading to IκBα phosphorylation and degradation and subsequent release of NF-κB activity
  • Research in the past decade has found that activation of IKKβ/NF-κB proinflammatory pathway in metabolic tissues is a prominent feature of various metabolic disorders related to overnutrition
  • it happens in metabolic tissues, it is mainly associated with overnutrition-induced metabolic derangements, and most importantly, it is relatively low-grade and chronic
  • this paradigm of IKKβ/NF-κB-mediated metabolic inflammation has been identified in the CNS – particularly the comprised hypothalamus, which primarily accounts for to the development of overnutrition-induced metabolic syndrome and related disorders such as obesity, insulin resistance, T2D, and obesity-related hypertension
  • evidences have pointed to intracellular oxidative stress and mitochondrial dysfunction as upstream events that mediate hypothalamic NF-κB activation in a receptor-independent manner under overnutrition
  • In the context of metabolic syndrome, oxidative stress-related NF-κB activation in metabolic tissues or vascular systems has been implicated in a broad range of metabolic syndrome-related diseases, such as diabetes, atherosclerosis, cardiac infarct, stroke, cancer, and aging
  • intracellular oxidative stress seems to be a likely pathogenic link that bridges overnutrition with NF-κB activation leading to central metabolic dysregulation
  • overnutrition is an environmental inducer for intracellular oxidative stress regardless of tissues involved
  • excessive nutrients, when transported into cells, directly increase mitochondrial oxidative workload, which causes increased production of ROS by mitochondrial ETC
  • oxidative stress has been shown to activate NF-κB pathway in neurons or glial cells in several types of metabolic syndrome-related neural diseases, such as stroke [185], neurodegenerative diseases [186-188], and brain aging
  • central nutrient excess (e.g., glucose or lipids) has been shown to activate NF-κB in the hypothalamus [34-37] to account for overnutrition-induced central metabolic dysregulations
  • overnutrition can present the cell with a metabolic overload that exceeds the physiological adaptive range of UPR, resulting in the development of ER stress and systemic metabolic disorders
  • chronic ER stress in peripheral metabolic tissues such as adipocytes, liver, muscle, and pancreatic cells is a salient feature of overnutrition-related diseases
  • recent literature supports a model that brain ER stress and NF-κB activation reciprocally promote each other in the development of central metabolic dysregulations
  • when intracellular stresses remain unresolved, prolonged autophagy upregulation progresses into autophagy defect
  • autophagy defect can induce NF-κB-mediated inflammation in association with the development of cancer or inflammatory diseases (e.g., Crohn's disease)
  • The connection between autophagy defect and proinflammatory activation of NF-κB pathway can also be inferred in metabolic syndrome, since both autophagy defect [126-133;200] and NF-κB activation [20-33] are implicated in the development of overnutrition-related metabolic diseases
  • Both TLR pathway and cytokine receptor pathways are closely related to IKKβ/NF-κB signaling in the central pathogenesis of metabolic syndrome
  • Overnutrition, especially in the form of HFD feeding, was shown to activate TLR4 signaling and downstream IKKβ/NF-κB pathway
  • TLR4 activation leads to MyD88-dependent NF-κB activation in early phase and MyD88-indepdnent MAPK/JNK pathway in late phase
  • these studies point to NF-κB as an immediate signaling effector for TLR4 activation in central inflammatory response
  • TLR4 activation has been shown to induce intracellular ER stress to indirectly cause metabolic inflammation in the hypothalamus
  • central TLR4-NF-κB pathway may represent one of the early receptor-mediated events in overnutrition-induced central inflammation.
  • cytokines and their receptors are both upstream activating components and downstream transcriptional targets of NF-κB activation
  • central administration of TNF-α at low dose can mimic the effect of obesity-related inflammatory milieu to activate IKKβ/NF-κB proinflammatory pathways, furthering the development of overeating, energy expenditure decrease, and weight gain
  • the physiological effects of IKKβ/NF-κB activation seem to be cell type-dependent, i.e., IKKβ/NF-κB activation in hypothalamic agouti-related protein (AGRP) neurons primarily leads to the development of energy imbalance and obesity [34]; while in hypothalamic POMC neurons, it primarily results in the development of hypertension and glucose intolerance
  • the hypothalamus, is the central regulator of energy and body weight balance [
  • Nathan Goodyear on 09 Jul 13
     
    Great article chronicles the biochemistry of "over nutrition" and inflammation through NF-kappaB activation and its impact on the brain.
Dr. Jennifer Martinick

Dr Jennifer Martinick - Warning about Hair Disorders - 0 views

speakerdeck.com/...k-warning-about-hair-disorders

Dr Jennifer Martinick

shared by Dr. Jennifer Martinick on 20 Nov 13 - No Cached
  • Dr. Jennifer Martinick on 20 Nov 13
     
    Dr Jennifer Martinick shares this informative slide show to spread awareness about Hair Disorders.
Nathan Goodyear

Tryptophan-Kynurenine Metabolism as a Common Mediator of Genetic and Environmental Impa... - 0 views

www.ncbi.nlm.nih.gov/...PMC3021918

disordered tryptophan metabolism depression kynurenine pathway Tryptophan

shared by Nathan Goodyear on 26 Sep 13 - No Cached
  • Nathan Goodyear on 26 Sep 13
     
    Disordered tryptophan metabolism in depression
wheelchairindia9

Chair For Cerebral Palsy Child - 0 views

www.wheelchairindia.com/...Cerebral-Palsy-Wheelchair

cerebellum and the cortex common causes of brain damage cause like chicken pox or measles neurological problems are properly managed

shared by wheelchairindia9 on 12 May 15 - No Cached
  • wheelchairindia9 on 12 May 15
     
    Cerebral palsy (CP) is a group of conditions caused by medical abnormalities in the development of a fetus or the early life of a child. These lead to damage or delayed development in the brain. The disorder is permanent and, though it does not worsen with age, the level of functionality of a person with cerebral palsy varies widely: in some cases, effects may be very minor, while in others, movement is impaired to the extent that a wheelchair is required. Common complications associated with CP vary by the type of CP disorder but can include vision problems, seizures, learning disabilities, and issues speaking, writing, and performing other tasks. Cerebral palsy causes problems with muscle tone, movement, balance and/or coordination. Symptoms and effects range from mild to severe. In some infants, problems are evident soon after birth. In others, diagnosis comes in later infancy or toddlerhood. Cerebral Palsy Wheelchair Description: The model designed for cerebral palsy child only. Ultra light weight aluminium alloy frame. Seat Width 38 cms (15"). Net Weight: 18.5 kgs. Epoxy powder coated frame. Detachable arm rest & foot rest provided. Elevated and swinging foot rest. Elevated foot rest provided to elevate leg angle. Height adjustable and detachable head rest. Hydraulic reclining high back for a comfortable posture. Hydraulic adjustable seat angle. Detachable back and seat pad. Extra cushion upholstery provided to under arm, head & calg Foldable. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cloth look like water proof upholstery. Anti wheels for better safety and stability. Extra cushion upholstery provided to under arm, head & leg Folding action. Lever and paddle brakes provided. Safety belt provided. Maintenance free rear solid wheels. Cerebral Palsy Wheelchair Recline system: Recline system provides kids with the most comfortable resting environment. It also allows stretching abdomin
Nathan Goodyear

Mitochondrial disorders - 0 views

brain.oxfordjournals.org/...2153.abstract

mitochondrial disorders

shared by Nathan Goodyear on 03 Mar 11 - No Cached
  • Nathan Goodyear on 03 Mar 11
     
    highly technical discussion on mitochondrial disorders
Nathan Goodyear

SpringerLink - Journal of Autism and Developmental Disorders, Volume 36, Number 3 - 0 views

www.springerlink.com/...8575wx07436024k5

gluten-free casein-free autism spectrum disorder ASD children pediatrics

shared by Nathan Goodyear on 06 Sep 11 - No Cached
  • Nathan Goodyear on 06 Sep 11
     
    Gluten-free and Casein-free diet in children with autism spectrum disorder shown to have improvement in some children
Nathan Goodyear

EDTA Chelation Therapy: Efficacy in Brain Disorders - 0 views

drcranton.com/...study4.htm

EDTA therapy brain disorders chelation

shared by Nathan Goodyear on 07 Jul 11 - No Cached
  • Nathan Goodyear on 07 Jul 11
     
    EDTA chelation benefits cerebral blood flow.  Has important implications in many brain disorders
fnfdoc

Acne Problems Diagnose And Treatment | Your Health Our Priority - 0 views

www.fnfdoc.com/...ne-problems-diagnose-treatment

Acne Symptoms Treatment Causes Of

shared by fnfdoc on 30 Apr 18 - No Cached
  • fnfdoc on 30 Apr 18
     
    Acne commonly named vulgaris, a disorder of hair follicles of the face, back and chest or neck.acne also characterized by blackheads or whiteheads on oily skin (Pimples). Dermatologists find different treatments for improvement of this disorder by regulating oil-producing glands.
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