Group items tagged Community - Dr. Goodyear

Spine And Neuro Surgery Hospital India: Why These Epilepsy Surgeons Are Highly Recommen... - 0 views

spineandneurosurgeryhospitalindia.blogspot.com/...ghly-recommended-in-india.html

epilepsy treatment 12 best epilepsy doctors in India Best surgeons for epilepsy in India

shared by spineneuro on 24 Jun 24 - No Cached

spineneuro on 24 Jun 24

The best epilepsy surgeons in India will provide detailed information about the benefits, potential side effects, and proper administration of the prescribed medication. Adhering to the prescribed treatment plan is crucial, and it's important to communicate any concerns or side effects to your healthcare provider promptly.

<div class="cArrow"> </div><div class="cContentInner">The best epilepsy surgeons in India will provide detailed information about the benefits, potential side effects, and proper administration of the prescribed medication. Adhering to the prescribed treatment plan is crucial, and it's important to communicate any concerns or side effects to your healthcare provider promptly.</div>

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Association between circulating specific leukocyte types and blood pressure: the Athero... - 0 views

www.ashjournal.com/...abstract

hypertension blood pressure blood pressure inflammation

shared by Nathan Goodyear on 25 Sep 12 - No Cached

Nathan Goodyear on 25 Sep 12

Blood pressure is a s symptom of inflammation. In this study it was found that elevated neutrophils and decreased lymphocytes was associated with hypertension in the African American population

<div class="cArrow"> </div><div class="cContentInner">Blood pressure is a s symptom of inflammation. In this study it was found that elevated neutrophils and decreased lymphocytes was associated with hypertension in the African American population</div>

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China to lift ban on disposable foamed plastic tableware - 0 views

George Thomas on 23 Mar 13

Plastics News Portal, Plastics Jobs, Plastics Directory And Trade Website for World and India - Plasticsinfomart.com

<div class="cArrow"> </div><div class="cContentInner">Plastics News Portal, Plastics Jobs, Plastics Directory And Trade Website for World and India - Plasticsinfomart.com</div>

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TPE kills pathogens without toxins - 0 views

George Thomas on 01 Apr 13

Plastics News Portal, Plastics Jobs, Plastics Directory And Trade Website for World and India - Plasticsinfomart.com

<div class="cArrow"> </div><div class="cContentInner">Plastics News Portal, Plastics Jobs, Plastics Directory And Trade Website for World and India - Plasticsinfomart.com</div>

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New extrusion coating line from Davis-Standard targets flexible packaging market - 0 views

George Thomas on 01 Apr 13

Plastics News Portal, Plastics Jobs, Plastics Directory And Trade Website for World and India - Plasticsinfomart.com

<div class="cArrow"> </div><div class="cContentInner">Plastics News Portal, Plastics Jobs, Plastics Directory And Trade Website for World and India - Plasticsinfomart.com</div>

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Akkermansia muciniphila mediates negative effects of IFNγ on glucose metaboli... - 0 views

www.nature.com/...ncomms13329

gut gut bacteria gut flora gut microbiome gut microbiota metabolism immunometabolism akkermansia muciniphila glucose inflammation IFN-gamma

shared by Nathan Goodyear on 17 Nov 16 - No Cached

Nathan Goodyear on 17 Nov 16

fascinating read on gut inflammation and glucose metabolism. The gut bacteria implicated her is Akkermansia muciniphila.

<div class="cArrow"> </div><div class="cContentInner">fascinating read on gut inflammation and glucose metabolism. The gut bacteria implicated her is Akkermansia muciniphila.</div>

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High School Football and Risk of Neurodegeneration: A Community-Based Study - Mayo Clin... - 0 views

www.mayoclinicproceedings.org/...fulltext

TBI football traumatic brain injury brain brain injury brain health neurodegenerative disease

shared by Nathan Goodyear on 16 Dec 16 - No Cached

Nathan Goodyear on 16 Dec 16

Study finds increased TBI in high school football players, but not an increase in neurodegenerative disease.

<div class="cArrow"> </div><div class="cContentInner">Study finds increased TBI in high school football players, but not an increase in neurodegenerative disease.</div>

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Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Re... - 0 views

www.sciencedirect.com/...S1931312816305170

gut gut bacteria gut flora gut health gut microbiome gut microbiota diet nutrition

shared by Nathan Goodyear on 02 Jan 17 - No Cached

Long-term DPs play a large role in determining the selective environment that the gut microbiota faces, ultimately influencing the composition and diversity of taxa maintained within the gut microbial community
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Americans consuming unrestricted diets maintained less diverse fecal microbiota than those of individuals adhering to a plant-rich diet with restricted caloric intake
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Experiments in mice have shown that multigenerational exposure to a Western diet poor in “microbiota-accessible carbohydrates” can lead to extirpation of specific bacterial lineages
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Nathan Goodyear on 02 Jan 17

Diet is the key to gut microbe diversity. Gut microbes are key to maintaining optimal cellular metabolism. Nutrition can be a prescription for improving and reprogramming gut bacteria.

<div class="cArrow"> </div><div class="cContentInner">Diet is the key to gut microbe diversity. Gut microbes are key to maintaining optimal cellular metabolism. Nutrition can be a prescription for improving and reprogramming gut bacteria.</div>

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communica... - 0 views

www.cell.com/...S0092-8674(13)01521-3

NAD mitochondria disease aging sirloins SIRT SIRT1 HIF-1alpha

shared by Nathan Goodyear on 07 Jun 16 - No Cached

Nathan Goodyear on 07 Jun 16

NAD found to slow mitochondrial decline associated with aging. SIRT1 is involved; interesting of note is the inverse association with HIF-1alpha

<div class="cArrow"> </div><div class="cContentInner">NAD found to slow mitochondrial decline associated with aging. SIRT1 is involved; interesting of note is the inverse association with HIF-1alpha</div>

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ADDM Network 2012 - 0 views

www.cdc.gov/...ADDM-2012-Community-Report.pdf

ASD autism spectrum disorder ADDM

shared by Nathan Goodyear on 17 Apr 12 - No Cached

Nathan Goodyear on 17 Apr 12

Government review of trends of states reporting on Autism incidence/prevalence. The question, is why are not all of the state following this? Especially Louisiana and Mississippi.

<div class="cArrow"> </div><div class="cContentInner">Government review of trends of states reporting on Autism incidence/prevalence. The question, is why are not all of the state following this? Especially Louisiana and Mississippi.</div>

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Stanford scientists discover multitude of drug side effects, interactions using new com... - 0 views

med.stanford.edu/...offsides.html

stanford side effects medicine prescription drugs

shared by Nathan Goodyear on 05 Apr 12 - No Cached

Nathan Goodyear on 05 Apr 12

A proper title would have been, "are the drugs your are taking killing you?"

<div class="cArrow"> </div><div class="cContentInner">A proper title would have been, "are the drugs your are taking killing you?"</div>

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A prospective study of diurnal cortisol and cognitive function in community-dwelling el... - 0 views

www.ncbi.nlm.nih.gov/...PMC2894868

cognitive decline cognition saliva salivary cortisol urinary elderly stress hormone hormones

shared by Nathan Goodyear on 20 Feb 12 - No Cached

Nathan Goodyear on 20 Feb 12

High salivary cortisol and decrease metabolism of cortisol (urinary) is associated with increased cognitive decline in the elderly.

<div class="cArrow"> </div><div class="cContentInner">High salivary cortisol and decrease metabolism of cortisol (urinary) is associated with increased cognitive decline in the elderly.</div>

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JCI - Inflammatory links between obesity and metabolic disease - 0 views

www.jci.org/57132

obesity overweight weight-loss inflammation metabolic disease

shared by Nathan Goodyear on 04 Jan 12 - No Cached

metainflammation
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The chronic nature of obesity produces a tonic low-grade activation of the innate immune system that affects steady-state measures of metabolic homeostasis over time
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It is clear that inflammation participates in the link between obesity and disease
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...25 more annotations...
Multiple inflammatory inputs contribute to metabolic dysfunction, including increases in circulating cytokines (10), decreases in protective factors (e.g., adiponectin; ref. 11), and communication between inflammatory and metabolic cells
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adipose tissue macrophage (ATM)
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Physiologic enhancement of the M2 pathways (e.g., eosinophil recruitment in parasitic infection) also appears to be capable of reducing metainflammation and improving insulin sensitivity (27).
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increasing adiposity results in a shift in the inflammatory profile of ATMs as a whole from an M2 state to one in which classical M1 proinflammatory signals predominate (21–23).
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The M2 activation state is intrinsically linked to the activity of PPARδ and PPARγ
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well-known regulators of lipid metabolism and mitochondrial activity
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Independent of obesity, hypothalamic inflammation can impair insulin release from β cells, impair peripheral insulin action, and potentiate hypertension (63–65).
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inflammation in pancreatic islets can reduce insulin secretion and trigger β cell apoptosis leading to decreased islet mass, critical events in the progression to diabetes (33, 34)
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Since an estimated excess of 20–30 million macrophages accumulate with each kilogram of excess fat in humans, one could argue that increased adipose tissue mass is de facto a state of increased inflammatory mass
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JNK, TLR4, ER stress)
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NAFLD is associated with an increase in M1/Th1 cytokines and quantitative increases in immune cells
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Upon stimulation by LPS and IFN-γ, macrophages assume a classical proinflammatory activation state (M1) that generates bactericidal or Th1 responses typically associated with obesity
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DIO, metabolites such as diacylglycerols and ceramides accumulate in the hypothalamus and induce leptin and insulin resistance in the CNS (58, 59)
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saturated FAs, which activate neuronal JNK and NF-κB signaling pathways with direct effects on leptin and insulin signaling (60)
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Lipid infusion and a high-fat diet (HFD) activate hypothalamic inflammatory signaling pathways, resulting in increased food intake and nutrient storage (57)
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Maternal obesity is associated with endotoxemia and ATM accumulation that may affect the developing fetus (73)
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Placental inflammation is a characteristic of maternal obesity
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a risk factor for obesity in offspring, and involves inflammatory macrophage infiltration that can alter the maternal-fetal circulation (74
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Of these PRRs, TLR4 has received the most attention, as this receptor can be activated by free FAs to generate proinflammatory signals and activate NF-κB
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Nod-like receptor (NLR) family of PRRs
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ceramides and sphingolipids
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The adipokine adiponectin has long been recognized to have positive benefits on multiple cell types to promote insulin sensitivity and deactivate proinflammatory pathways.
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adiponectin stimulates ceramidase activity and modulates the balance between ceramides and sphingosine-1-phosphate
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Inhibition of ceramide production blocks the ability of saturated FAs to induce insulin resistance (101)
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NF-κB, obesity also activates JNK in insulin-responsive tissues
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Nathan Goodyear on 04 Jan 12

must read to see our current knowledge on the link between inflammation and obesity.

<div class="cArrow"> </div><div class="cContentInner">must read to see our current knowledge on the link between inflammation and obesity.</div>

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Macrophage-secreted factors induce adipocyte inflammation and insulin resistance 10.101... - 0 views

www.sciencedirect.com/...S0006291X06000714

inflammation insulin resistance ATM macrophages obesity overweight weight-loss

shared by Nathan Goodyear on 10 Jan 12 - No Cached

Nathan Goodyear on 10 Jan 12

macrophage infiltration of your excess fat results in inflammation and thus insulin resistance. These are also called ATMs or Adipose Tissue Macrophages.

<div class="cArrow"> </div><div class="cContentInner">macrophage infiltration of your excess fat results in inflammation and thus insulin resistance. These are also called ATMs or Adipose Tissue Macrophages.</div>

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Glucose tolerance status and risk of dementia in the community - 0 views

neurology.org/...1126.abstract

dementia Alzheimer's Alzheimer's disease OGTT post prandial glucose tolerance test glucose tolerance

shared by Nathan Goodyear on 11 Jun 12 - No Cached

Nathan Goodyear on 11 Jun 12

elevated 2 hour post prandial OGTT associated with all-cause dementia, including Alzheimer's disease. Interestingly, the association was not found with fasting glucose levels.

<div class="cArrow"> </div><div class="cContentInner">elevated 2 hour post prandial OGTT associated with all-cause dementia, including Alzheimer's disease. Interestingly, the association was not found with fasting glucose levels.</div>

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Sex Hormones and Age: A Cross-sectional Study of Testosterone and Estradiol and Their B... - 0 views

aje.oxfordjournals.org/...750.short

hormone hormones men male Estradiol Estrogen testosterone

shared by Nathan Goodyear on 03 Feb 14 - No Cached

Nathan Goodyear on 03 Feb 14

Older men have Estradiol levels that are 3 x that of a post-menopausal women. The bioavailable levels of Testosterone and Estradiol showed the greatest precipitous decline.

<div class="cArrow"> </div><div class="cContentInner">Older men have Estradiol levels that are 3 x that of a post-menopausal women. The bioavailable levels of Testosterone and Estradiol showed the greatest precipitous decline.</div>

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Plasma membrane receptors for the... [Biochem Biophys Res Commun. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10860824

hormone receptors hormones progesterone metabolite metabolites 3-alpha pregnene 5-alpha pregnene 5-alpha pregnenes

shared by Nathan Goodyear on 28 Jan 14 - No Cached

Nathan Goodyear on 28 Jan 14

The receptors for 5 alpha progesterone and 3 alpha hydroxyprogesterone are distinct from other hormone receptors. These receptors are plasma membrane bound. Through these receptors, these progesterone metabolites initiate autocrine and paracrine activity. E2 increased 5 alpha progesterone receptors. This is very important in ER-/PR- breast cancer, but does still have significance in ER+/PR+ cancer as well.

<div class="cArrow"> </div><div class="cContentInner">The receptors for 5 alpha progesterone and 3 alpha hydroxyprogesterone are distinct from other hormone receptors. These receptors are plasma membrane bound. Through these receptors, these progesterone metabolites initiate autocrine and paracrine activity. E2 increased 5 alpha progesterone receptors. This is very important in ER-/PR- breast cancer, but does still have significance in ER+/PR+ cancer as well.</div>

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Longitudinal Changes in Testosterone Over Five Years in Community-Dwelling Men - 0 views

jcem.endojournals.org/...3289.abstract

testosterone obesity overweight smoking men male hormone hormones

shared by Nathan Goodyear on 21 Aug 13 - No Cached

Nathan Goodyear on 21 Aug 13

Large group of men followed for 5 years. Declining Testosterone found to be associated with obesity and smoking.

<div class="cArrow"> </div><div class="cContentInner">Large group of men followed for 5 years. Declining Testosterone found to be associated with obesity and smoking.</div>

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Mumps Outbreak in Orthodox Jewish Communities in the United States - NEJM - 0 views

www.nejm.org/...NEJMoa1202865

mumps vaccine vaccination MMR

shared by Nathan Goodyear on 12 Nov 13 - No Cached

Nathan Goodyear on 12 Nov 13

2009 study finds that in 3502 cases of mumps, 97% of the adolescents had received the mumps vaccine (89% 2 doses and an additional 9% 1 dose).

<div class="cArrow"> </div><div class="cContentInner">2009 study finds that in 3502 cases of mumps, 97% of the adolescents had received the mumps vaccine (89% 2 doses and an additional 9% 1 dose).</div>

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Fructosamine and glycated albumin for risk stratification and prediction of incident di... - 0 views

www.thelancet.com/...abstract

fructosamine glycated albumin diabetes biomarkers

shared by Nathan Goodyear on 03 Apr 14 - No Cached

Nathan Goodyear on 03 Apr 14

Fructosamine and glycated albumin shown to correlate with diabetes and associated microvascular complications. These biomarkers would compare to HgbA1C diagnostically, but their interval of glycemic evaluation would be less i.e.2-4 weeks versus 3 months with HgbA1c.

<div class="cArrow"> </div><div class="cContentInner">Fructosamine and glycated albumin shown to correlate with diabetes and associated microvascular complications. These biomarkers would compare to HgbA1C diagnostically, but their interval of glycemic evaluation would be less i.e.2-4 weeks versus 3 months with HgbA1c.</div>

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