good article on the biochemistry of COX2 in inflammation. Particularily with AGE and it the receptors RAGE. COX2 has been shown to decrease insulin secretion through inhibition of islet cell production, but in the presence of disease level inflammation, COX2 can be a part of a very dangerous autocrine/paracrine loop.
Inhibition of NO production will result in increased COX and thus vasoconstriction in rate model. Hg has been shown to both inhibit NO synthase and increase COX.
Cox-2 found to increase prolactin expression to increase metastatic spread of cancer cells. Cox-2 may work here more in the autocrine/paracrine prolactin signaling. This is an animal study.
Cox II inhibition helps to slow surgical induced metastatic and local recurrence of cancer. Surgery does cause metastasis and local recurrence and cox II inhibition stops spread.
Animal study from '09 found that COX2 inhibitor blunted LPS decrease in testes weight, decrease in testicular interstitial fluid, and serum Testosterone. The point here is that LPS, in this animal model, decreased gonadal weight and Testosterone production and the anti inflammatory, COX2, blunted that effect.
Rat model induced inflammatory reaction in brain via LPS injection. The result was impaired memory. RG3 from panax ginseng was shown to reduce inflammation, TNF-alpha, IL-1beta, cox-2, thus improving memory and cognitive function.
COX-2 is overexpressed in a variety of human cancers i.e. colorectal, prostate, lung adenocarcinoma. This study hightlights the increased tumor metastatic potential via upregulation of VEGF-C via EP1 and HER-2 dependent pathways. This upregulation was correlated with survival and mets.
O2-O3 triggers tumoricidal immune response after application of a repetitive highly oxidative stimulus by insufflation of a medical O3/O2 gas mixture into the peritoneal cavity in animal model. O3/O2-PP treatment, indicates an enhanced activation of the innate and adaptive arms of the immune system, implicating a role of activated TILs In the anti cancer effects of the O3. Interestingly, COX2 expression was decreased.