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Nathan Goodyear

Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisp... - 0 views

endo.endojournals.org/...s56.long

bisphenol A xenoestrogen xenoestrogens estrogen hormone hormones male estrogen receptor estrogen receptors estrogen receptor alpha estrogen receptor beta

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    bisphenol A increases estrogen signaling.
Nathan Goodyear

Mechanism of Action of Bisphenol A and other Biochemical/Molecular interactions - 0 views

www.who.int/...ological_activities_of_bpa.pdf

Bisphenol-A xenoestrogen xenoestrogens hormone hormones estrogen receptor estrogen receptor receptors

shared by Nathan Goodyear on 08 Jan 13 - No Cached
  • Nathan Goodyear on 08 Jan 13
     
    Thorough discussion of the scientific knowledge on bisphenol A and its hormonal and receptor effects.
Nathan Goodyear

PLOS ONE: Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and ... - 0 views

www.plosone.org/...journal.pone.0051579

Bisphenol-A leydig cells hormone hormones testosterone xenoestrogen

shared by Nathan Goodyear on 07 May 13 - No Cached
  • Nathan Goodyear on 07 May 13
     
    Bisphenol A decreases testicular testosterone production at the sight of the leydig cells.
Nathan Goodyear

Antiandrogenic effects of bisphenol A and nonylp... [Toxicol Sci. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12805653

Bisphenol-A androgen receptor antagonist androgen receptor androgen receptor hormone hormones xenoestrogens xenoestrogen

shared by Nathan Goodyear on 07 May 13 - No Cached
  • Nathan Goodyear on 07 May 13
     
    Bisphenol A acts as androgen receptor antagonist.
Nathan Goodyear

Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist - 0 views

jcem.endojournals.org/...5185.abstract

BPA Bisphenol A T3 thyroid hormone thyroid hormone environmental toxins

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Bisphenol A (BPA) shown to interfere with the T3 and thyroid hormone receptor interaction.  This study even showed that BPA inhibited thyroid receptor transcription.
Nathan Goodyear

Bisphenol A and Metabolic Syndrome: Results from NHANES - 0 views

www.hindawi.com/...598180

metabolic syndrome MetS bisphenol A BPA EDC endocrine disruptors

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Bisphenol A clearly associated with increased risk of MetS.
Nathan Goodyear

Environmental Health Perspectives: Relationship between Urinary Phthalate and Bisphenol... - 0 views

ehp03.niehs.nih.gov/...fetchArticle.action

Phthalate Bisphenol A thyroid hormone hypothyroidism

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    Phthalate and Bisphenol A interferes with thyroid levels
Nathan Goodyear

Sex differences in the adult HPA axis and affectiv... [Brain Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24857958

bisphenol A Bisphenol-A BPA xenoestrogen HPA hypothalamic-pituitary-adrenal EDR endocrine disrupter brain hormone hormones

shared by Nathan Goodyear on 27 May 14 - No Cached
  • Nathan Goodyear on 27 May 14
     
    Animal study finds that Bisphenol A exposure in utero has profound different effects in male offspring versus female offspring.  In the male offspring there appears to be an up regulation of the HPA axis.  The opposite appears true in the female off spring.  Additionally, the receptors are effected differently as well.
Nathan Goodyear

Sex-specific effects of long-term exposure to bi... [Chemosphere. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25112706

bisphenol A BPA xenoestrogens ER beta ER-beta hormone hormones anxiety depression

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    really interesting abstract.  Bisphenol A (BPA)  is a xenoestrogen.  This animal study finds that BPA down regulated ER-beta in the brains of male rats.  It also blocked the production of GABA(A)alpha 2 receptor.  These long term effects were evident in anxiety and depression in adult mice. Pregnancy exposure would set up an ER-alpha dominance in the male brain increasing risk of continuous ER alpha stim.
Nathan Goodyear

Disruption of adult expression of s... [Proc Natl Acad Sci U S A. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21709224

Bisphenol A hormone disruptors envornmental toxins

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    Female deer mice want nothing to do with Bisphenol A toxic male deer mice
Nathan Goodyear

Bisphenol A Promotes Human Prostate Stem-Proge... [Endocrinology. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24424067

BPA bisphenol A Bisphenol-A prostate cancer xenoestrogen xenoestrogens

shared by Nathan Goodyear on 17 Jan 14 - No Cached
  • Nathan Goodyear on 17 Jan 14
     
    Another strike against BPA.  This time, BPA exposure during development increased hormone-dependent cancer risk in the prostate through its interaction with prostate stem-progenitor cells.  Again, we are being altered prior to birth.
Nathan Goodyear

Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response i... - 0 views

joe.endocrinology-journals.org/...207.abstract

bisphenol A Bisphenol-A BPA xenoestrogens stress hormone hormones

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Nathan Goodyear on 04 Feb 14
     
    intra uterine exposure to BPA disrupts stress response in rat model.
Nathan Goodyear

Association of Serum Bisphenol-A... [Arch Environ Contam Toxicol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25213476

BPA bisphenol A Bisphenol-A SHBG androstenedione men male hormone hormones

shared by Nathan Goodyear on 15 Sep 14 - No Cached
  • Nathan Goodyear on 15 Sep 14
     
    Increasing BPA levels associated with declining androstenedione levels,but positively associated with SHBG levels in exposed men.
Nathan Goodyear

PRECLINICAL STUDY: Changes in central dopaminergic systems and morphine reward by prena... - 0 views

onlinelibrary.wiley.com/...full

bisphenol-A bisphenol A BPA dopamine mesolimbic lactation organogenesis prenatal exposure

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    great study that shows how BPA exposure has its largest impact on the mesolimbic/dopamine system during organogenesis and lactation periods.
Nathan Goodyear

Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Ass... - 0 views

www.ncbi.nlm.nih.gov/...PMC2290985

BPA plastics endocrine disruptor immune T reg cells

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • BPA promotes the development of TH2 cells in adulthood and both TH1 and TH2 cells in prenatal stages by reducing the number of regulatory T cells.
  • Bisphenol A (BPA), an estrogenic endocrine-disrupting chemical (EDC
  • BPA is one of the most widespread EDCs.
  • ...12 more annotations...
  • BPA antagonizes the actions of thyroid hormone
  • Prenatal exposure to BPA has been shown to alter a variety of reproductive endocrine parameters, such as testosterone and luteinizing hormone levels
  • arly onset of sexual maturation of female mice
  • imbalanced T-helper (TH)1/TH2 immune responses have been demonstrated on exposure to BPA
  • indicating that BPA exerted its effects by reducing the number of Treg cells.
  • Exposure to BPA by subcutaneous injection in adulthood significantly promoted antigen-stimulated production of IL-4, IL-10, and IL-13 in TH2-skewed
  • BPA can leak from the placenta and accumulate in the fetus
  • We showed that prenatal exposure to BPA increased the production of a TH1 cytokine, IFN-γ, and a TH2 cytokine, IL-4, after the offspring developed, suggesting that prenatal exposure to BPA can induce persistent immunologic effects lasting into adulthood.
  • These results are consistent with a previous report that fetal exposure to BPA augmented TH1 and TH2 immune responses
  • our results clearly demonstrate that the production of TH2 cytokines is promoted by BPA in adult mice and in offspring during developmental exposure.
  • The decrease of Treg cells would predispose to immune dysfunction in aged individuals, explaining their higher risk of immune-mediated diseases, cancer, and infections.
  • BPA might cause these diseases. Thus, avoiding exposure to or promoting the excretion of BPA and other EDCs would help in preventing diseases and adverse health effects.
  • Nathan Goodyear on 01 Jul 11
     
    BPA as endocrine disruptor and as immune disruptor
Nathan Goodyear

Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphe... - 0 views

press.endocrine.org/...en.2015-1937

BPA toxins environmental toxins xenoextrogens bisphenol A hormones

shared by Nathan Goodyear on 18 May 16 - No Cached
  • Nathan Goodyear on 18 May 16
     
    low dose of BPA in rat model finds delayed sexual maturation.
Nathan Goodyear

BPA, BPA glucuronide, and BPA sulfate in... [Environ Sci Technol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23941471

BPA Bisphenol A Bisphenol-A endocrine disruptor EDC

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Startling finding: 100% of all pregnancies in this study were found to have detectable BPA levels.  BPA is a known endocrine disruptor.
Nathan Goodyear

Dynamic Changes in Dopaminergic Neurotransmission Induced by a Low Concentration of Bis... - 0 views

onlinelibrary.wiley.com/...full

BPA Bisphenol-A dopamine mesolimbic system psychological dependence

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    BPA and changes in the mesolimbic/dopamine system
Nathan Goodyear

Large Effects from Small Exposures. III. Endocrine Mechanisms Mediating Effects of Bisp... - 0 views

endo.endojournals.org/...s56.full

BPA bisphenol A pregnant children hormone receptors environment environmental toxins

shared by Nathan Goodyear on 15 Dec 12 - No Cached
  • Nathan Goodyear on 15 Dec 12
     
    Very low levels of BPA shown to be present in pregnant and unborn children.  These levels exceed the levels at which documented receptor change occurs as the result of BPA.
Nathan Goodyear

Serum bisphenol-A concentration and sex hormone levels in men - 0 views

www.fertstert.org/...abstract

BPA hormone hormones xenoestrogen Bisphenol-A low testosterone low T testosterone male man SHBG

shared by Nathan Goodyear on 09 May 13 - No Cached
  • Nathan Goodyear on 09 May 13
     
    Study finds that men exposed to BPA have lower androstenedione and free testosterone compared to those not exposed.  Also of note, SHBG is increased, which is what one would expect with xenoestrogen exposure.
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