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Nathan Goodyear

Regulation of mitochondrial biogenesis by thyroid hormone - 0 views

ep.physoc.org/...121.full.pdf+html

T3 mitochondria thyroid hormone receptors TRH thyroid hormone response elements TRE hormone thyroid

shared by Nathan Goodyear on 29 Jun 13 - No Cached
  • Nathan Goodyear on 29 Jun 13
     
    Study describes the T3 effect on mitochondrial biogenesis.  T3 interacts with receptors involved with mitochondrial biogenesis in 3 ways: thyroid hormone receptors (TR), thyroid hormone receptor elements (TRE), and a combination of the two.
Nathan Goodyear

Rebuilding the post-infarcted myocardium by a... [Heart Fail Rev. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18773293

thyroid MI myocardial infarction heart attack hormone hormones post-MI heart cardiac remodeling

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    Wow, thyroid hormones play a significant role in cardiac remodeling post MI.  Thyroid hormones, "promotes tissue growth and differentiation and favorably remodels cardiac cell while increases cellular survival..."  How many people post-MI are having their thyroid evaluated, let alone correctly evaluated?
Nathan Goodyear

Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidi... - 0 views

press.endocrine.org/...jc.2012-4107

hypothyroid hypothyroidism thyroid T4 T3 hormones metabolism

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Our study has shown DTE therapy caused modest weight loss, and nearly half (48.6%) of the study patients expressed preference for DTE over l-T4
  • our study showed significantly higher TSH in the DTE-treated group, which suggests that the improvement observed in the DTE-treated group is not mediated through the changes in TSH levels
  • Nathan Goodyear on 24 Sep 14
     
    Study finds desiccated thyroid (armour thyroid) was associated with great weight loss, mood improvement than T4 alone.  Desiccated thyroid was preferred by patients in the study.  Conversion rate was 100 mcg T4 to 88 mg desiccated thyroid.
Nathan Goodyear

Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns: Molecular Endocr... - 0 views

press.endocrine.org/...me.2010-0095

thyroid hormone receptors hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • the majority of TRs is located in the nucleus
  • Nathan Goodyear on 24 Sep 14
     
    thyroid hormone transportation.  The majority of the thyroid hormone receptors are in the nucleus of the cell.
Nathan Goodyear

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC2647704

thyroid hormone T3 T4 rT3 deiodinase selenium hormones

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Nathan Goodyear on 10 Nov 14
     
    Anything and everything one would want to know regarding thyroid hormone signaling.  Doctors, especially endocrinologists, need to read this.  T4 is not or is ever inside target cells.  The enzymes, deiodinase types 1, 2, and 3, are what control the thyroid hormone at the cellular levels.  Deiodinase-2 is what generates T3 in the cytosol of the cell.  In contrast, deiodinase-3 is what generates rT3 which is inactive.  High Fat diet increases deiodinase-3.
Nathan Goodyear

Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist - 0 views

jcem.endojournals.org/...5185.abstract

BPA Bisphenol A T3 thyroid hormone thyroid hormone environmental toxins

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Bisphenol A (BPA) shown to interfere with the T3 and thyroid hormone receptor interaction.  This study even showed that BPA inhibited thyroid receptor transcription.
Nathan Goodyear

An Adult Female With Resistance to Thyroid Hormone Mediated by Defective Thyr... - 0 views

jcem.endojournals.org/...4254.abstract

thyroid hormone receptor resistance

shared by Nathan Goodyear on 14 Nov 13 - No Cached
  • Nathan Goodyear on 14 Nov 13
     
    case study of 6 year old with thyroid hormone resistance as a mechanism of disrupted thyroid metabolism
Nathan Goodyear

Thyroid hormone and "cardiac metamorphosis": poten... [Pharmacol Ther. 2008] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...18455802

thyroid hormone heart cardiac

shared by Nathan Goodyear on 02 Feb 11 - No Cached
  • Nathan Goodyear on 02 Feb 11
     
    thyroid hormone plays important role in heart failure and heart repair; thyroid balance critical
Nathan Goodyear

JCI - Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mu... - 0 views

www.jci.org/115225

thyroid hormone resistance thyroid hormone resistance syndrome

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Thyroid hormone resistance is not a new term.  This study goes back to 1991.
Nathan Goodyear

Acute myocardial infarction and thyroid function: New pathophysiological and therapeuti... - 0 views

informahealthcare.com/...07853890.2011.573501

thyroid hormone hormones T3 heart attack heart health myocardial infarction MI

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Thyroid hormone plays significant role in cardiac remodeling after acute myocardial infarction.  Thyroid hormone, particularly T3 as the vast majority of T3 is produced in heart tissue via D1 enzymatic activity, improves cardiac contractility, reduces systemic vascular resistance, reduces cardiac work load, decreases blood pressure, improves cardiac metabolism, and thus improves outcomes post MI.
Nathan Goodyear

The association between papillary thyroid carcinoma and histologically proven Hashimoto... - 0 views

www.eje-online.org/...343.abstract

Hashimoto's thyroiditis hypothyroidism Hashimoto hypothyroid papillary thyroid cancer papillary cancer hormone hormones

shared by Nathan Goodyear on 05 Mar 13 - No Cached
  • Nathan Goodyear on 05 Mar 13
     
    patients with Hashimoto's thyroiditis are at increased risk for papillary thyroid cancer.
Nathan Goodyear

Thyroidectomy for Hashimoto's thyroiditis: complicat... [Thyroid. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18631001

Hashimoto's thyroiditis autoimmune disease inflammation thyroid cancer hormone hormones

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Thyroid cancer increased in those with Hashimoto's thyroiditis.  
Nathan Goodyear

INCREASED INCIDENCE OF WELL-DIFFERENTIATED THYROID CANCER ASSOCIATED WITH HASHIMOTO'S T... - 0 views

www.ncbi.nlm.nih.gov/...PMC2430882

Hashimoto's thyroiditis thyroid cancer hormone hormones autoimmune disease inflammation

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Strong link between Hashimoto's thyroiditis and thyroid cancer.  Risk increased 3 fold.
Nathan Goodyear

Resistance to thyroid hormone due to defective thyroid receptor alpha - 0 views

www.ncbi.nlm.nih.gov/...PMC4559105

thyroid hormone resistance thyroid hormones

shared by Nathan Goodyear on 27 Apr 16 - No Cached
  • Nathan Goodyear on 27 Apr 16
     
    Thyroid hormone resistance.
Nathan Goodyear

EHP - Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for t... - 0 views

ehp.niehs.nih.gov/1206198

polychlorinated biphenyls PCBs thyroid xenoestrogens hormone hormones

shared by Nathan Goodyear on 19 Jun 13 - No Cached
  • Nathan Goodyear on 19 Jun 13
     
    Polychlorinated biphenyl (PCBs) shown to disrupt thyroid hormone function through disruption of the transthyretin binding sites.  Not only is it a xenoestrogen, but it disrupts thyroid function too.
Nathan Goodyear

Thyroid hormone receptors and resistance to thyroid hormone disorders - 0 views

www.ncbi.nlm.nih.gov/...PMC4578869

receptors" "thyroid hormone thyroid receptors

shared by Nathan Goodyear on 07 Nov 18 - No Cached
  • Nathan Goodyear on 07 Nov 18
     
    Great review on thyroid hormone receptors alpha and beta, which are nuclear receptors.
Nathan Goodyear

Sex Hormone-Binding Globulin in the Diagnosis of Peripheral Tissue Resistance to Thyroi... - 0 views

jcem.endojournals.org/...740.abstract

hypothyroid thyroid thyroid disease T3 T4 SHBG hormone resistance hormones

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    T3, and T4 for that matter, increases SHBG.  This would be a novel method to determine thyroid hormone receptor insensitivity or resistance.
Nathan Goodyear

Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC3159779

thyroid hormone hormones reverse T3 free T3 rT3 T4 metabolism

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Here is a great review of thyroid hormone metabolism published in the very relevant journal Endocrinology.  The review describes the peripheral metabolism of the pro hormone T4 and the peripheral metabolism to free T3 and/or reverse T3 and the associated metabolic implications.  Why don't more endocrinologists read?This is an animal study.
Nathan Goodyear

Assessment of thyroid function during ... [Clin Endocrinol (Oxf). 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19094075

Hashimoto's thyroiditis hypothyroid hypothyroidism autoimmune disease thyroid hormone hormones inflammation

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Hashimoto's Thyroiditis can show variability in thyroid function.
Nathan Goodyear

Cardiac Involvement in Thyroid Hormone Resistance - 0 views

jcem.endojournals.org/...204.abstract

thyroid hormone resistance thyroid hormone resistance cardiac heart

shared by Nathan Goodyear on 02 Apr 13 - No Cached
  • Nathan Goodyear on 02 Apr 13
     
    Thyroid hormone resistance has cardiac effects.
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