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Testosterone therapy in post menopausal women appears to have adverse cardiovascular effects in women.  The negative effects were an increase in Pulsatility index and adverse change in lipid profiles.  This seemed to counter the positive effects by estrogen.  Others have proposed that combination E2 and T therapy hide the negative effects of testosterone on CV health in women.

This study looked at post menopause women and found that those with PCOS had an increase in CAD and worse cardiovascular event survival.  PCOS is a metabolic syndrome, in part, driven by elevated androgens in women.

colon cancer risk reduced in post-menopausal women taking or recently taking estrogen.

low vitamin D associated with an increased odds ratio of elevated blood pressure and elevated triglycerides in post-menopausal women with metabolic syndrome.

Correlation between increasing male hormones (androgens) and poor glucose control and metabolic syndrome in post menopause women.

Study finds that HRT is associated with a 35% reduction in relative risk of colorectal cancer in postmenopausal women.  Even use within the previous 5 years was associated with reduced risk.  This benefit is lost at 5 years..

This article focus' more on the risks of colorectal cancer in men.  It does perform a mini-review on risks for women.  It appears progesterone is important in prevention of colorectal cancer in women.  Post-menopause, women with HRT have a reduced risk. In contrast, men with androgen deprivation therapy, there is an increase risk of colorectal cancer.

Review of the data points to poor quality of evidence dealing with DHEA in post-menopausal women with normal adrenal function.  Yet if DHEA is low, which is >95% produced by adrenals in women, then how can the adrenal function be "normal".   The meta-analysis found no improvement in libido and/or sexual function, and no improvement in lipids, glucose, weight... was noted.  Essentially not positive or negative effects were noted.  Abstract only available here, so dosage is a question.

Get article on estrogen metabolism/metabolites and their effects on the risk of breast cancer in post menopause women.  This article brings to light new information: 2:16alpha estrone ratio is not a great predicted of risk, 2-OH and 4-OH metabolites can form quinone intermediates...

Post-menopause women with increased gut microbiome diversity found to be associated with increased urinary excretion of estrogen metabolites compared to parent estrogens.  This relationship has been shown to be associated with a reduced breast cancer risk.

women with post menopause breast cancer have altered gut flora compared to women without.

One of the main instances for which women need Testosterone, is post-hysterectomy.  This study confirms that.  This study found benefit in those with and without the removal of the ovaries.

study finds increases risk of breast cancer in postmenopausal women on HRT with increased 2OH-estrone metabolism.  Confusing?

Study looked at hormone levels via serum analysis at the time of sudden cardiac arrest in both men and women.  Low Testosterone and elevated Estrogen levels in  men were associated with increased odds (OR) versus women only had increased odds with elevated Estrogen.   ManBoob nation, my first book, discusses the mechanism behind this for men.  The finding in women really calls into question the Estrogen only model currently employed by physicians for post menopausal women.

Cochrane review for Testosterone therapy for women points to lacking data.  The lengths of study reached a maximum of 2 years with the average at 6 months.  Improvement in sexual function was found in post-menopausal women, but safety and long-term data is lacking.

Time that physicians start following the science.  Study using data from the Multi-ethnic Study of Atherosclerosis was used to assess hormones and fatty liver in men and women.  Increasing bioavailable Testosterone levels in women was found to be associated with increasing fatty liver in post-menopausal women.  The opposite was found to be true in men.  Higher Estradiol levels were found to be associated with increased fatty liver in both sexes.  However, the statistical significance was higher with men.  Higher SHBG was associated with lower fatty liver incidence in men.  

Study finds increased risk of diabetes in post menopause women on statin therapy.  The authors here propose it as a class effect but also is associated with increased dosing.

Very interesting. Obesity increases NF-kappaB inflammation signaling and increased aromatase expression and activity. The result is increased estrogen production and increase in post menopausal ER+ cancer. Directly counters the narrative that obesity is in anyways healthy.

Studies like this surprise me. This study lauds the benefit of metformin as a breast cancer protective in postmenopuasal womb.  Their focus is on the bandaid--the prescription drug.  They completely ignore the cause--glucose.  The Warburg effect in cancer is well known.  Limit simple sugar intake and support oxidative phosphorylation will do the same.  That is treating the cause.

increased 2 and 4-OH metabolites compared to parent compounds associated with decreased breast cancer in postmenopausal women.