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Nathan Goodyear

In older men an optimal plasma testo... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

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    Study finds that "midrange" Testosterone and DHT associated with a reduced ischemic heart disease and death rate.  No association was found with Estradiol.  One flaw of this study is in their use of serum.
Nathan Goodyear

Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of stat... - 0 views

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    Lp(a) found to highly correlate with obstructive coronary disease.
Nathan Goodyear

Blood Pressure and Left Ventricular Hypertrophy During American-Style Football Particip... - 0 views

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    football lineman found to have increased heart dysfunction (increased left ventricular hypertrophy and increased left ventricular mass) and hypertension, compared to all other positions, throughout one season.
Nathan Goodyear

Long-Term Immunomodulatory Effects of a Mediterranean Diet in Adults at High ... - 0 views

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    Mediterranean diet found to reduce hsCRP, IL-6, TNF-alpha, and MCP in high-risk adults out to 5 years!  This study compared the Mediterranean diet to a low fat diet.
Nathan Goodyear

Effects of lowering elevated LDL cholesterol on the car... [JAMA. 1995] - PubMed - NCBI - 0 views

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    Lp(a) is a distinct lipoprotein from from LDL.  An Lp(a) is a distinct cardiovascular  biomarker risk.
Nathan Goodyear

Lipoprotein(a) Mass: A Massively Misunderstood Metric - Journal of Clinical Lipidology - 0 views

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    Lp(a), especially the particle #, is highly associated with increased cardiovascular risk.
Nathan Goodyear

Extreme high high-density lipoprotein cholesterol is paradoxically associated with high... - 0 views

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    High HDL found to actually increase cardiovascular risk in men and women. Peak benefit is found at 58 mg/dl and 77 mg/dl for men and women respectively. Higher levels of HDL >90 increased risk and all-cause mortality in men and women.
Nathan Goodyear

What does my patient's coronary artery calcium score mean? Combining information from t... - 0 views

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    good review of the coronary calcium score and associated risk estimates.
Nathan Goodyear

A rare case of amiodarone-induced hypothyroidis... [Int J Angiol. 2011] - PubMed - NCBI - 0 views

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    Very interesting case study of amiodarone induced hypothyroidism that resulted in pericardial effusion and cardiac tamponade.
Nathan Goodyear

Elderly men over 65 years of age with late-onset hypogonadism benefit as much from test... - 0 views

  • The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins.
  • obesity, but also impaired general health, are the more common causes of low testosterone in aging men
  • Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality,
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  • advanced age, obesity, a diagnosis of metabolic syndrome, and poor general health status were predictors of LOH
  • Diabetes mellitus was correlated with hypogonadism in most studies
  • coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with the incidence of low testosterone
  • LOH can be defined by the presence of at least three sexual symptoms associated with a total testosterone level of less than 11 nmol/L (3.2 ng/mL) and a free testosterone level of less than 220 pmol/L (64 pg/mL)
    • Nathan Goodyear
       
      the European Male Aging study defined low T as total < 320 ng/dl and free < 64 pg/ml.  
  • Mean weight decreased
  • Waist circumference decreased
  • Total cholesterol decreased
  • Low-density lipoprotein decreased
  • Triglycerides decreased
  • High-density lipoprotein (HDL) increased
  • ratio of total cholesterol to HDL improved
  • Prostate volume increased
  • PSA increased
  • The benefits for men older than 65 years of age were compared with those of younger men, and the improvements in body weight, metabolic factors, psychological functioning, and sexual functioning were of the same magnitude in both age groups
  • weight loss was progressive over the 6-year period, effects of testosterone on lipids and on psychological and sexual functioning reached a plateau after approximately 3 years and these effects were sustained
  • Effects of testosterone on hematopoiesis, on the prostate, and on bladder function were not more severe in older men than in younger men
  • observe a mild increase in prostate volume and serum PSA over time, which is a normal finding in aging men. Maybe somewhat surprising, postvoiding residue and the IPSS did not deteriorate with aging but showed a degree of improvement
  • the severity of the metabolic syndrome is associated with the severity of lower urinary tract symptoms
  • The symptoms of the metabolic syndrome improve upon testosterone treatment and testosterone may thus have a favorable effect on lower urinary tract symptoms
  • it seems reasonable to conclude that the risks of testosterone administration to elderly men are not disproportionately higher in elderly men than in younger men.
  • Despite evidence to the contrary, physicians still harbor a wrongful association between testosterone and the development of prostate pathology (prostate cancer and benign prostate hyperplasia)
  • Not surprisingly, the incidence of prostate cancer was higher in older men; however, it was lower than expected in both groups
  • These observations suggest that the incidence of prostate cancer in patients receiving testosterone therapy, both in the younger and in the older group, was not greater than in the general population not receiving testosterone treatment
  • The historical fear that raising testosterone levels will result in more prostate cancer has been dispelled, particularly by the work of Abraham Morgentaler
  • Higher serum testosterone levels fail to show an increased risk of prostate cancer, and supraphysiological testosterone does not increase prostate volume or PSA in healthy men
  • This apparent paradox is explained by the "saturation model,"
  • Recent studies indicate no increased risk of prostate cancer among men with serum testosterone in the therapeutic range
  • In the present observational study, no cases of major adverse cardiovascular events occurred.
  • the benefits of testosterone therapy are fully achieved only by long-term treatment
  • To achieve maximal benefits, good patient adherence is a prerequisite
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    Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.
Nathan Goodyear

Abstract 3608: Lipoprotein (a) Cholesterol, But Not Lp(a) Mass, Is An Independent Predi... - 0 views

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    Lipoprotein (a) cholesterol is a better predictor of CAD and CVD events than Lipoprotein (a) mass.
Nathan Goodyear

Selenium and L-carnitine reduce oxidative stress in the heart of rat induced by 2.45-GH... - 0 views

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    animal study finds high dose Carnitine plus selenium protects against oxidative stress of the heart.
Nathan Goodyear

Thyroid Hormone Treatment to Mend a Broken Heart -- Klein and Danzi 93 (4): 1172 -- Jou... - 0 views

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    Incredible read on how T3 improves heart remodeling, healing,and function; sadly, most physicians are unaware
Nathan Goodyear

Effects of Thyroid Hormone on the Cardiovascular System -- Fazio et al. 59 (1): 31 -- R... - 0 views

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    Great article on how the thyroid helps to regulate the heart
Nathan Goodyear

Interpretation of the Coronary Artery Calcium Score in Combination with Conventional Ca... - 0 views

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    A more recent article on the interpretation of the coronary calcium score.  Score alone must be taken in context with the individual.
Nathan Goodyear

Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme ... - 0 views

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    CoQ10 supplementation of 150 mg in individuals with CAD found to have increased catalase activity, increased SOD activity, an increased MDA levels.  This reduced oxidative stress, TC, and LDL levels.
Nathan Goodyear

Low-T3 Syndrome - 0 views

  • More than 80% of the biologically active hormone triiodothyronine (T3) derives from peripheral conversion of prohormone thyroxine (T4) secreted by the thyroid gland
  • Low thyroid hormone concentrations, in particular low serum T3 concentrations, are a common finding in patients with nonthyroidal illnesses, including cardiac disorders
  • a direct relationship between low circulating levels of T3 and adverse prognosis of cardiac patients
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  • The present study clearly shows the existence of a strong association between the reduction of biologically active T3 and mortality in a large population of cardiac hospitalized patients
  • highly significant increase in the incidence of cardiac and cumulative deaths in patients with low T3 compared with patients with normal T3 levels
  • the relevance of the low T3 state as a strong, independent predictor of mortality in cardiac patients
  • low T3 concentrations are a strong independent predictive marker of poor prognosis in cardiac patients
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    low T3 associated with poor prognosis in cardiac patients.   Poor prognosis = death.  T3 is important in cardiac remodeling, which is inherently important with cardiac disease.
Nathan Goodyear

Nutrients | Free Full-Text | Vitamin C Status Correlates with Markers of Metabolic and ... - 0 views

  • vitamin C deficiency is the fourth most prevalent nutrient deficiency reported in the United States
  • Hypovitaminosis C (defined as a plasma concentration ≤23 µmol/L)
  • The CHALICE (Canterbury Health, Ageing and Lifecourse) study is a unique New Zealand study comprising a comprehensive database of determinants of health
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  • The CHALICE cohort of 404 individuals aged 50 years had an average vitamin C intake of ~110 mg/day, which should provide adequate plasma concentrations [14]. Despite this, a significant proportion of the participants had inadequate plasma vitamin C status
  • inadequate plasma vitamin C concentrations (i.e., &lt;50 µmol/L)
  • adequate plasma levels (i.e., &gt;50 µmol/L)
  • Higher plasma vitamin C status was associated with lower weight, BMI and waist circumference
  • plasma vitamin C was negatively associated with blood triglycerides, HbA1c and insulin, and positively associated with HDL levels.
  • No correlation was found between plasma vitamin C and the two indicators of heart health; blood pressure and cardiovascular risk score.
  • 2.4% of 50-year-olds were deficient in vitamin C (i.e., &lt;11 µmol/L)
  • hypovitaminosis C (i.e., &lt;23 µmol/L)
  • A high proportion (63%) of our participants had inadequate plasma vitamin C concentrations (i.e., &lt;50 µmol/L)
  • The association of low vitamin C with obesity in this study replicates results in the literature [35,40,41,42,43,44], and it is apparent that individuals with higher weight require higher intakes of vitamin C to reach adequate vitamin C status
  • higher plasma vitamin C status is associated with lower circulating levels of blood triglycerides, insulin and HbA1c
  • A role for vitamin C in the prevention or management of diabetes and/or metabolic syndrome has been suggested
  • In this study, we also demonstrate lower levels of mild cognitive impairment in those with high vitamin C status
  • The odds of mild cognitive impairment were twice as high for those below 23 μmol/L plasma vitamin C concentration.
  • Vitamin C is present at very high concentrations in the brain
  • animal models have shown that the brain is the last organ to be depleted of the vitamin during prolonged deficiency
  • A recent animal study has shown that moderate vitamin C deficiency may play a role in accelerating amyloid plaque accumulation in Alzheimer’s disease
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    New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue.  Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.
Nathan Goodyear

Effects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Dis... - 0 views

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    Intracoronary Testosterone infusion of Testosterone found to increase arterial dilation and improve blood flow.
Nathan Goodyear

Risk of Myocardial Infarction in Older Men Receiving Testosterone Therapy - 0 views

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    This study appears to fly in the face of the recent studies on the dangers of Testosterone therapy in those with comorbidities.  This study was a retrospective cohort.  The study found that men in the highest risk for MI, had a reduced MI risk with Testosterone therapy.  Men in the lower risk quartiles had no such benefit.  Of note, the frequency of injections suggests inadequate dosing i.e. 4.4 in first year and 8.2 in follow up.  Most injection regimens will require at least monthly injections, though Testosterone pellets were used.  Of special note, no mention of level testing of Testosterone prior to study and/or during study and follow up.
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