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Matti Narkia

Hyperlipid: Vitamin D and UV fluctuations (2) - 0 views

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    "I discussed in my last post how Dr Vieth has a model of tissue 1,25(OH)2D synthesis and degradation in which the level of active substance is pretty well independent of blood vitamin D level, provided the level is either rising or stable. I think it is also worth pointing out that he is talking, hypothetically, about tissue 1,25(OH)2D, not plasma level... As we know, almost nothing is known about tissue 1,25(OH)2D control.

    By Vieth's hypothesis tissue 1,25(OH)2D is OK so long as there is at least SOME vitamin D present in plasma and the level dose not vary too much. Obviously there is a level below which you can have as much of the enzyme for converting vitamin D to the active form as you like, if there is no vitamin D in your blood you can't make any 1,25(OH)2D in your tissues, or in your kidneys for export to your blood to control calcium levels. At the lower extremes we have rickets and osteomalacia. These are clear cut, unarguable markers of vitamin D deficiency, in the absence of confounding factors (there are a few)."
Matti Narkia

Seasonality of UV-radiation and vitamin D status at 69 degrees north. - Photochem Photo... - 1 views

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    Seasonality of UV-radiation and vitamin D status at 69 degrees north.
    Brustad M, Edvardsen K, Wilsgaard T, Engelsen O, Aksnes L, Lund E.
    Photochem Photobiol Sci. 2007 Aug;6(8):903-8. Epub 2007 Jun 27.
    PMID: 17668121

    The generally high dietary intakes of vitamin D, especially in winter, mask largely the effect of seasonal variation in UV-exposure, causing an atypical seasonal variation in vitamin D status. The UV-hour variable significantly predicted 25(OH)D levels in blood when adjusted for intakes and artificial UV-radiation exposure and sun holidays abroad.
Matti Narkia

Melatonin.com - Experts compared, sleep tips, jet lag, seasonal affective disorder. - 0 views

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    We compare the experts' advice and save you the time.

    Current Evidence for the Benefits of Melatonin,
    Dosage, Cautions and Interactions, Buyers Guide,
    Sleep Tips, Jet Lag Remedies, Seasonal Affective Disorder,
    Current News and Books.
Matti Narkia

Vitamin D deficiency is the cause of common obesity - 0 views

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    Vitamin D deficiency is the cause of common obesity.
    Foss YJ.
    Med Hypotheses. 2009 Mar;72(3):314-21. Epub 2008 Dec 2.
    PMID: 19054627
    doi:10.1016/j.mehy.2008.10.005

    Common obesity and the metabolic syndrome may therefore result from an anomalous adaptive winter response. The stimulus for the winter response is proposed to be a fall in vitamin D. The synthesis of vitamin D is dependent upon the absorption of radiation in the ultraviolet-B range of sunlight. At ground level at mid-latitudes, UV-B radiation falls in the autumn and becomes negligible in winter. It has previously been proposed that vitamin D evolved in primitive organisms as a UV-B sensitive photoreceptor with the function of signaling changes in sunlight intensity. It is here proposed that a fall in vitamin D in the form of circulating calcidiol is the stimulus for the winter response, which consists of an accumulation of fat mass (obesity) and the induction of a winter metabolism (the metabolic syndrome). Vitamin D deficiency can account for the secular trends in the prevalence of obesity and for individual differences in its onset and severity. It may be possible to reverse the increasing prevalence of obesity by improving vitamin D status.
Matti Narkia

Vitamin D and influenza - Wikipedia, the free encyclopedia - 0 views

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    "Numerous studies link Vitamin D and influenza, as well as Vitamin D and respiratory infections more generally. This vitamin up-regulates genetic expression of various endogenous antimicrobial peptides (AMP), which exhibit broad-spectrum microbicidal activity against bacteria, fungi, and viruses. Reports discussed below indicate that susceptibility to influenza is reduced with higher levels of sun exposure or vitamin D supplementation. Seasonal variation of vitamin D levels in humans can help explain the seasonality of flu epidemics."
Matti Narkia

Vitamin D and mood disorders among women: an integrative review. - [J Midwifery Womens ... - 0 views

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    Vitamin D and mood disorders among women: an integrative review.
    Murphy PK, Wagner CL.
    J Midwifery Womens Health. 2008 Sep-Oct;53(5):440-6. Review.
    PMID: 18761297

    Four of six studies reviewed imparted significant results, with all four showing an association between low 25(OH)D levels and higher incidences of four mood disorders: premenstrual syndrome, seasonal affective disorder, non-specified mood disorder, and major depressive disorder. This review indicates a possible biochemical mechanism occurring between vitamin D and mood disorders affecting women, warranting further studies of these variables using rigorous methodologies.
Matti Narkia

Vitamin D Deficiency and Seasonal Variation in an Adult South Florida Population -- Lev... - 0 views

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    Vitamin d deficiency and seasonal variation in an adult South Florida population.
    Levis S, Gomez A, Jimenez C, Veras L, Ma F, Lai S, Hollis B, Roos BA.
    J Clin Endocrinol Metab. 2005 Mar;90(3):1557-62. Epub 2005 Jan 5.
    PMID: 15634725

    The prevalence of hypovitaminosis D is considerable even in southern latitudes and should be taken into account in the evaluation of postmenopausal and male osteoporosis.
Matti Narkia

Can vitamin D supplementation prevent winter-time blues? A randomised trial among older... - 0 views

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    Can vitamin D supplementation prevent winter-time blues? A randomised trial among older women.
    Dumville JC, Miles JN, Porthouse J, Cockayne S, Saxon L, King C.
    J Nutr Health Aging. 2006 Mar-Apr;10(2):151-3.
    PMID: 16554952

    CONCLUSIONS: Supplementing elderly women with 800 IU of vitamin D daily did not lead to an improvement in mental health scores.
Matti Narkia

Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorde... - 0 views

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    Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder.
    Gloth FM 3rd, Alam W, Hollis B.
    J Nutr Health Aging. 1999;3(1):5-7.
    PMID: 10888476

    All subjects receiving vitamin D improved in all outcome measures. The phototherapy group showed no significant change in depression scale measures. Vitamin D status improved in both groups (74% vitamin D group, p < 0.005 and 36% phototherapy group, p < 0.01). Improvement in 25-OH D was significantly associated with improvement in depression scale scores (r2=0.26; p=0.05). Vitamin D may be an important treatment for SAD. Further studies will be necessary to confirm these findings..
Matti Narkia

An evaluation of the relative contributions of exposure to sunlight and of diet to the ... - 0 views

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    An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston.
    Webb AR, Pilbeam C, Hanafin N, Holick MF.
    Am J Clin Nutr. 1990 Jun;51(6):1075-81.
    PMID: 2349922
Matti Narkia

Rise in prostate-specific antigen in men with untreated low-grade prostate cancer is sl... - 0 views

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    Rise in prostate-specific antigen in men with untreated low-grade prostate cancer is slower during spring-summer.
    Vieth R, Choo R, Deboer L, Danjoux C, Morton GC, Klotz L.
    Am J Ther. 2006 Sep-Oct;13(5):394-9.
    PMID: 16988533
    doi: 10.1097/01.mjt.0000174346.36307.02
Matti Narkia

A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in... - 0 views

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    A seasonal variation of calcitropic hormones, bone turnover and bone mineral density in early and mid-puberty girls - a cross-sectional study.
    Viljakainen HT, Palssa A, Kärkkäinen M, Jakobsen J, Cashman KD, Mølgaard C, Lamberg-Allardt C.
    Br J Nutr. 2006 Jul;96(1):124-30.
    PMID: 16870000

    Seasonal variation in S-25-OHD and bone remodelling markers accompanied by negative correlation between S-25-OHD and S-iPTH was seen in this cross-sectional study of adolescent girls. In addition, the seasonal rhythm contributed 7.0-7.6 % difference in the BMD of lumbar vertebrae and left femur in early puberty girls. This variation should be avoided since it could hamper peak bone mass attainment.
Matti Narkia

The Dependency of Vitamin D Status on Body Mass Index, Gender, Age and Season - Antican... - 0 views

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    The dependency of vitamin D status on body mass index, gender, age and season.
    Lagunova Z, Porojnicu AC, Lindberg F, Hexeberg S, Moan J.
    Anticancer Res. 2009 Sep;29(9):3713-20.
    PMID: 19667169

    CONCLUSION: The 25(OH)D3 level, as well as its seasonal variation and the prevalence of vitamin D deficiency, are all dependent on BMI, and age separately. The results of the study suggest that 1 in 3 women and 1 in 2 men with BMI > or = 40 are vitamin D deficient.
Matti Narkia

Vitamin D3 and Solar Power for Optimal Health: Vitamin D and depression: how SAD! - 0 views

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    Seasonal affective disorder (SAD) is a type of winter-time depression experienced by people those who live in northern latitudes such as those of New York, Seattle, all of Canada, and Northern Europe. I believe it is primarily a disorder of sunlight/vitamin D deficiency.
    Vitamin D, when administered in late winter, produces a positive effect on mood in only five days.[1] One theory for this is that vitamin D stimulates the brain to produce more serotonin. In a wintertime experiment, serum vitamin D levels doubled in six months through supplementation and dramatically increased scores on a wellbeing assessment.[2] Two groups were given either 1,000 IU or 4,000 IU of vitamin D daily. And although both groups improved, the higher dose produced better results.
Matti Narkia

How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptati... - 0 views

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    How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
    Vieth R.
    Anticancer Res. 2009 Sep;29(9):3675-84.
    PMID: 19667164
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