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"THURSDAY, Dec. 17 (HealthDay News) -- In a surprise finding, Canadian researchers report that the immediate effect of the fish oil fatty acids that are good for the heart is a short-term increase in blood fats and the molecules that help them form clots.

"We were surprised to find that the acute response has some potentially negative effects in comparison to what you might expect from chronic, long-term intake," said Lindsay E. Robinson, an associate professor of nutrition at the University of Guelph, and leader of the group reporting the finding in the January issue of the Journal of Nutrition.

However, the study results shouldn't affect the current recommendation for eating more oily fish to get the omega-3 polyunsaturated acids that reduce the risk of blood clots that can cause heart attacks and stroke, Robinson said.

"The recommendation to increase intake is very well-studied, and this doesn't change it," she said.

And the effects were seen in a selected group of middle-aged men with metabolic syndrome, a combination of high blood pressure, obesity and elevated blood fat levels, Robinson noted.

In the study, eight men had controlled intake of three regimens: high doses of omega-3 fatty acids, low doses of them and just plain water. Robinson and her colleagues measured several blood components involved in clotting, including fats and clotting factors such as plasminogen-activator inhibitor-1 (PAI-1) for the following eight hours.

PAI-1 inhibits the destruction of blood clots, so high levels of it in the blood increase the risk of artery-blocking clots.

The researchers found that both omega-3 fatty acid regimens increased blood fat and clotting factor activity. But the increase in clotting factor was greater for the higher doses of omega-3 fatty acids than for the lower intakes.

Robinson said her group hopes to do further studies of the immediate effects of omega-3 fatty acid intake. "We need to look at the mechanisms, why blood lipid levels go up," she

Effects of chili consumption on postprandial glucose, insulin, and energy metabolism.
Ahuja KD, Robertson IK, Geraghty DP, Ball MJ.
Am J Clin Nutr. 2006 Jul;84(1):63-9.
PMID: 16825682

An isoenergetic very low carbohydrate diet improves serum HDL cholesterol and triacylglycerol concentrations, the total cholesterol to HDL cholesterol ratio and postprandial pipemic responses compared with a low fat diet in normal weight, normolipidemic women.
Volek JS, Sharman MJ, Gómez AL, Scheett TP, Kraemer WJ.
J Nutr. 2003 Sep;133(9):2756-61.
PMID: 12949361

The results suggest that a short-term ketogenic diet does not have a deleterious effect on CVD risk profile and may improve the lipid disorders characteristic of atherogenic dyslipidemia.

A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men.
Sharman MJ, Kraemer WJ, Love DM, Avery NG, Gómez AL, Scheett TP, Volek JS.
J Nutr. 2002 Jul;132(7):1879-85.
PMID: 12097663

The postprandial effect of components of the Mediterranean diet on endothelial function.
Vogel RA, Corretti MC, Plotnick GD.
J Am Coll Cardiol. 2000 Nov 1;36(5):1455-60.
PMID: 11079642

Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and ghrelin concentrations in healthy subjects.
Hlebowicz J, Hlebowicz A, Lindstedt S, Björgell O, Höglund P, Holst JJ, Darwiche G, Almér LO.
Am J Clin Nutr. 2009 Jan 21. [Epub ahead of print]
PMID: 19158209
doi:10.3945/ajcn.2008.26807

Jenkins DJ, Kendall CW, Josse AR, Salvatore S, Brighenti F, Augustin LS, Ellis PR, Vidgen E, Rao AV. Almonds Decrease Postprandial Glycemia, Insulinemia, and Oxidative Damage in Healthy Individuals.J Nutr. 2006 Dec;136(12):2987-2992.PMID: 17116708 [