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Matti Narkia

Targeting lipoxygenases with care. - ScienceDirect - Chemistry & Biology 2006 Nov - 0 views

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    Targeting lipoxygenases with care.
    de Souza PM, Newson J, Gilroy DW.
    Chem Biol. 2006 Nov;13(11):1121-2.
    PMID: 17113992
    doi:10.1016/j.chembiol.2006.11.002  
Matti Narkia

Effects of Dietary Flaxseed on Intestinal Tumorigenesis in ApcMin Mouse - Nutrition and... - 0 views

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    Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse.
    Bommareddy A, Zhang X, Schrader D, Kaushik RS, Zeman D, Matthees DP, Dwivedi C.
    Nutr Cancer. 2009;61(2):276-83.
    PMID: 19235044
    DOI: 10.1080/01635580802419764
Matti Narkia

Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in d... - 0 views

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    Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: athymic mouse xenograft model simulating radical prostatectomy.
    Kelavkar UP, Hutzley J, Dhir R, Kim P, Allen KG, McHugh K.
    Neoplasia. 2006 Feb;8(2):112-24.
    PMID: 16611404
Matti Narkia

Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory... - 0 views

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    Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators.
    Serhan CN.
    J Periodontol. 2008 Aug;79(8 Suppl):1520-6. Review.
    PMID: 18673006
    doi:10.1902/jop.2008.080231
Matti Narkia

Prostacyclin - Wikipedia, the free encyclopedia - 0 views

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    Prostacyclin (or PGI2) is a member of the family of lipid molecules known as eicosanoids.\nAs a drug, it is also known as "epoprostenol".[1] The terms are sometimes used interchangeably

    Prostacyclin (PGI2) chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation). It is also an effective vasodilator. Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage.


Matti Narkia

Thromboxane B2 - Wikipedia, the free encyclopedia - 0 views

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    Thromboxane B2 is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine.
    It itself is not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is. Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets).
Matti Narkia

Thromboxane A2 - Wikipedia, the free encyclopedia - 0 views

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    Thromboxane A2 (TXA2) is a thromboxane. It is generated from prostaglandin H2 by thromboxane-A synthase. It is also a major component of blood clots. Aspirin irreversibly inhibits platelet cyclooxygenase 1 preventing the formation of prostaglandin H2, and therefore thromboxane A2.
    TXA2 is very unstable in aqueous solution, since it is hydrolyzed within about 30 seconds to the biologically inactive thromboxane B2. Due to its very short half life, TXA2 primarily functions as an autocrine or paracrine mediator in the nearby tissues surrounding its site of production.
Matti Narkia

Thromboxane - Wikipedia, the free encyclopedia - 0 views

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    Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2.
    Thromboxane is named for its role in clot formation (thrombosis).
Matti Narkia

The role of eicosanoids in the brain. [Asia Pac J Clin Nutr. 2008] - PubMed Result - 0 views

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    The role of eicosanoids in the brain.
    Tassoni D, Kaur G, Weisinger RS, Sinclair AJ.
    Asia Pac J Clin Nutr. 2008;17 Suppl 1:220-8. Review.
    PMID: 18296342

    Liberation of these PUFA from the phosphoglycerides occurs via the action of specific phospholipases (PLA2).
Matti Narkia

Eicosanoid - Wikipedia, the free encyclopedia - 0 views

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    In biochemistry, eicosanoids are signaling molecules derived from omega-3 (ω-3) or omega-6 (ω-6) fats. They exert complex control over many bodily systems, especially in inflammation, immunity and as messengers in the central nervous system. The network
Matti Narkia

Cyclooxygenase - Wikipedia, the free encyclopedia - 0 views

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    Cyclooxygenase (COX) is an enzyme (EC 1.14.99.1) that is responsible for formation of important biological mediators called prostanoids (including prostaglandins, prostacyclin and thromboxane). Pharmacological inhibition of COX can provide relief from the
Matti Narkia

Overexpression of 5-Lipoxygenase and Cyclooxygenase 2 in Hamster and Human Oral Cancer ... - 0 views

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    Li N, Sood S, Wang S, Fang M, Wang P, Sun Z, Yang CS, Chen X.
    Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib.
    Clin Cancer Res. 2005 Mar 1;11(5):2089-96.
    PMID
Matti Narkia

Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz... - 0 views

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    Sun Z, Sood S, Li N, Ramji D, Yang P, Newman RA, Yang CS, Chen X.
    Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinoge
Matti Narkia

Prostaglandins regulate acid-induced cell-mediated bone resorption -- Krieger et al. 27... - 0 views

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    Krieger NS, Parker WR, Alexander KM, Bushinsky DA.
    Prostaglandins regulate acid-induced cell-mediated bone resorption.
    Am J Physiol Renal Physiol. 2000 Dec;279(6):F1077-82. Erratum in: Am J Physiol Renal Physiol 2001 Sep;281(3):section F following tabl
Matti Narkia

Metabolic, but not respiratory, acidosis increases bone PGE2 levels and calcium release... - 0 views

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    Bushinsky DA, Parker WR, Alexander KM, Krieger NS. Metabolic, but not respiratory, acidosis increases bone PGE(2) levels and calcium release.
    Am J Physiol Renal Physiol. 2001 Dec;281(6):F1058-66.
    PMID: 11704556 [PubMed - indexed for MEDLINE]
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