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Matti Narkia

Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuk... - 0 views

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    Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies.
    Prior IA, Davidson F, Salmond CE, Czochanska Z.
    Am J Clin Nutr. 1981 Aug;34(8):1552-61.
    PMID: 7270479

    Two populations of Polynesians living on atolls near the equator provide an opportunity to investigate the relative effects of saturated fat and dietary cholesterol in determining serum cholesterol levels. The habitual diets of the toll dwellers from both Pukapuka and Tokelau are high in saturated fat but low in dietary cholesterol and sucrose. Coconut is the chief source of energy for both groups. Tokelauans obtain a much higher percentage of energy from coconut than the Pukapukans, 63% compared with 34%, so their intake of saturated fat is higher. The serum cholesterol levels are 35 to 40 mg higher in Tokelauans than in Pukapukans. These major differences in serum cholesterol levels are considered to be due to the higher saturated fat intake of the Tokelauans. Analysis of a variety of food samples, and human fat biopsies show a high lauric (12:0) and myristic (14:0) content. Vascular disease is uncommon in both populations and there is no evidence of the high saturated fat intake having a harmful effect in these populations.
Matti Narkia

Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an ess... - 0 views

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    Holick, M. F., MacLaughlin, J. A. & Doppelt, S. H. (1981)
    Factors that influence the cutaneous photosynthesis of previtamin D3. Science 211:590-593

    When human skin was exposed to simulated solar ultraviolet radiation, epidermal 7-dehydrocholesterol was converted to previtamin D3. During prolonged exposure to simulated solar ultraviolet radiation, the synthesis of previtamin D3 reached a plateau at about 10 to 15 percent of the original 7-dehydrocholesterol content, and previtamin D3 was photoisomerized to two biologically inert isomers, lumisterol3 and tachysterol3. Increases either in skin melanin concentration or in latitude necessitated increases in the exposure time to simulated solar ultraviolet radiation required to maximize the formation, but not the total content, of previtamin D3. In order of importance, the significant determinants limiting the cutaneous production of previtamin D3 are (i) photochemical regulation, (ii) pigmentation, and (iii) latitude.
Matti Narkia

Active specific immunotherapy with supportive measures in the treatment of advanced pal... - 0 views

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    Active specific immunotherapy with supportive measures in the treatment of advanced palliatively nephrectomised renal adenocarcinoma. A controlled clinical study.
    Tykkä H.
    Scand J Urol Nephrol Suppl. 1981;63:1-107.
    PMID: 6184775
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