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What is C-reactive protein (CRP)? It is a blood-borne protein that originates in the liver and serves as an index of the body's inflammatory state. It is triggered by yet another inflammatory signal molecule, interleukin-6. What triggers this cascade of inflammatory markers? Any inflammatory stimulus, such as being overweight, lack of exercise, vitamin D deficiency, viral illness no matter how trivial, any inflammatory disease like arthritis, small LDL, high triglycerides, poor diet rich in processed foods, resistance to insulin, any injury, incipient diabetes, hidden cancer, lack of education (no kidding), etc.

Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men. Ratliff JC, Mutungi G, Puglisi MJ, Volek JS, Fernandez ML. Nutr Metab (Lond). 2008 Feb 20;5:6. PMID: 18289377 Carbohydrate restricted diets (CRD) consistently lower glucose and insulin levels and improve atherogenic dyslipidemia [decreasing triglycerides and increasing HDL cholesterol (HDL-C)]. We have previously shown that male subjects following a CRD experienced significant increases in HDL-C only if they were consuming a higher intake of cholesterol provided by eggs compared to those individuals who were taking lower concentrations of dietary cholesterol. Here, as a follow up of our previous study, we examined the effects of eggs (a source of both dietary cholesterol and lutein) on adiponectin, a marker of insulin sensitivity, and on inflammatory markers in the context of a CRD. Conclusion A CRD with daily intake of eggs decreased plasma CRP and increased plasma adiponectin compared to a CRD without eggs. These findings indicate that eggs make a significant contribution to the anti-inflammatory effects of CRD, possibly due to the presence of cholesterol, which increases HDL-C and to the antioxidant lutein which modulates certain inflammatory responses.

Anti Inflammatory Diet: Know Everything About Inflammation & Ways To Control It [Cheryl Barnhart] on Amazon.com. *FREE* shipping on qualifying offers. Anti-Inflammatory Diet - Know Everything About Inflammation & Ways To Control It According to years of research

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"Anti-inflammatory Diet Components of an Anti-inflammatory Diet (focus on meats, fish, eggs and leafy vegetables)"

A nutrition blog by Dr. Ayers Inflammation is the foundation for cancer and degenerative/autoimmune diseases. Small changes in diet and exercise, e.g. omega-3 oils, vitamin D, low starch, plant antioxidants, and maintaining muscle mass, can dramatically alter predisposition to disease and aging, and minimize the negative impact of genetic risks. Based on my experience in biological research, I am trying to explain how the anti-inflammatory diet and lifestyle combat disease. Anti-Inflammatory Diet All health care starts with diet. Here are my recommendations for a basic Anti-Inflammatory Diet and Lifestyle. There are over 140 articles on diet, inflammation and disease here, and more articles by Dr. Ayers on Suite101 .

A plethora of research documents the role of chronic inflammatory mediators such as 5-lipooxygenase (5-LOX) and tumor necrosis factor-alpha (TNF-α) in the manifestation and progression of prostate and other cancers.7-19,30,31,33,49,52-54,87,88 The typical American diet is high in omega-6 fatty acids, saturated fats, and arachidonic acid. Over-consumption of these foods, and under-consumption of omega-3 fatty acids, contribute significantly to systemic chronic inflammatory states. Boswellia extracts have been thoroughly studied as natural remedies for inflammatory disorders. A patented extract from boswellia called 5-LOXIN® has potent ability to inhibit the enzyme 5-LOX, preventing the formation of protein-degrading enzymes, and protecting against inflammation-induced events that can promote tumor angiogenesis.

Is the MP Treatment for Sarcoidosis Helpful for Other Chronic Diseases? MP's Vitamin D Theories Are Not Supported by Lab Studies. Updated July 2, 2008 "The MP treatment plan was originally designed to treat an inflammatory condition known as sarcoidosis. The treatment consists of using the drug Benicar, combined with the avoidance of all sources of vitamin D, and eventually adding various antibiotics, especially minocycline. After being used by sarcoidosis patients for some years, it was then theorized and claimed that the treatment could treat other inflammatory conditions. Eventually it was also claimed that it could treat fibromyalgia and CFS, conditions which are not recognized by the medical literature as being inflammatory in nature. "

A look at 10 of the best natural anti-inflammatory foods that you should add to your diet if you suffer from chronic inflammation and pain.

New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases. Yacoubian S, Serhan CN. Nat Clin Pract Rheumatol. 2007 Oct;3(10):570-9; quiz 1 p following 589. Review. PMID: 17906612

Modulation of inflammatory cytokines by omega-3 fatty acids. Kang JX, Weylandt KH. Subcell Biochem. 2008;49:133-43. Review. PMID: 18751910

March 7, 2005 Boston, MA - The anti-inflammatory effect of fish oils appears to be due to a powerful anti-inflammatory compound called resolvin (resolution-phase interaction product) E1, which is produced from eicosapentaenoic acid (EPA), Dr Makoto Arita (Brigham and Women's Hospital and Harvard Medical School, Boston, MA) and colleagues report in the March 7, 2005 issue of the Journal of Experimental Medicine [1]. Arita writes, "At nanomolar levels, resolvin E1 dramatically reduced dermal inflammation, peritonitis, dendritic cell migration, and interleukin (IL)-12 production.

"Apigenin is one of the flavonoids - more precisely one of the citrus bioflavonoids. Apigenin, just like most flavonoids, has antioxidant, anti-inflammatory, and anti-tumor properties. Perhaps apigenin can even block the formation of uric acid leading to beneficial effects in gout. Apigenin is found in high amounts in several herbs including parsley, thyme, and peppermint. It is is also found in a number of other herbs, including chamomile herb, Horsetail herb, lemon balm herb, perilla herb, vervain herb, and yarrow. Benefits of apigenin As with many flavonoids, apigenin has potential to reduce the risk of cancer since it has anti-tumor activity. Apigenin also could potentially be useful in allergy conditions since it can have anti-inflammatory properties.

Rosehip is widely believed to possess anti-inflammatory and antioxidant properties which may help to assist in the defence of damage-causing inflammatory chemical molecules attacking the joints.

Ginger--an herbal medicinal product with broad anti-inflammatory actions. Grzanna R, Lindmark L, Frondoza CG. J Med Food. 2005 Summer;8(2):125-32. Review. PMID: 16117603 doi:10.1089/jmf.2005.8.125

Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density. Abreu MT, Kantorovich V, Vasiliauskas EA, Gruntmanis U, Matuk R, Daigle K, Chen S, Zehnder D, Lin YC, Yang H, Hewison M, Adams JS. Gut. 2004 Aug;53(8):1129-36. PMID: 15247180 doi: 10.1136/gut.2003.036657. Conclusions: These data demonstrate that elevated 1,25(OH)2D is more common in CD than previously appreciated and is independently associated with low bone mineral density. The source of the active vitamin D may be the inflamed intestine. Treatment of the underlying inflammation may improve metabolic bone disease in this subgroup of patients.

Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Bazan NG. Curr Opin Clin Nutr Metab Care. 2007 Mar;10(2):136-41. Review. PMID: 17285000

Lipoxins and resolvins in inflammatory bowel disease. Weylandt KH, Kang JX, Wiedenmann B, Baumgart DC. Inflamm Bowel Dis. 2007 Jun;13(6):797-9. Review. PMID: 17262807

nightsurfer's Anti-inflammatory Lipid Mediators Diigo list

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Serhan CN, Chiang N, Van Dyke TE. Nat Rev Immunol. 2008 May;8(5):349-61. Review. PMID: 18437155 doi:10.1038/nri2294