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Berberine--a novel approach to cholesterol lowering. Doggrell SA. Expert Opin Investig Drugs. 2005 May;14(5):683-5. PMID: 15926873

Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y. J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15-21. PMID: 19352059 It has been reported that treatment with a pharmacological dose (45 mg/d) of menaquinone-4 (MK-4) prevents bone loss in postmenopausal women. However, it is not known whether supplementation with low dose MK-4 has beneficial effects on bone metabolism in healthy women. The aim of this study is to examine the effects of the supplementation of 1.5 mg/d MK-4 for 4 wk on bone and lipid metabolism in healthy postmenopausal Japanese women. The study was performed as a randomized double blind placebo-controlled trial. The participants aged 53-65 y were randomly assigned to 2 groups and supplemented with 1.5 mg/d of MK-4 or a placebo for 4 wk (n=20 for each group). The most marked effects of MK-4 intake were observed on serum osteocalcin (OC) concentrations. Serum undercarboxylated OC (ucOC) concentration decreased, and the gamma-carboxylated OC (GlaOC) and GlaOC/GlaOC+ucOC ratio that indicates the degree of OC gamma-carboxylation increased significantly at 2 and 4 wk compared with that at baseline in the MK-4 group. The serum ucOC and GlaOC concentrations in the MK-4 group were significantly different from those in the placebo group at 2 wk. These results suggest that supplementation with 1.5 mg/d MK-4 accelerated the degree of OC gamma-carboxylation. The concentrations of serum lipids and other indices were not different between the groups at either intervention period. Thus, the additional intake of MK-4 might be beneficial in the maintenance of bone health in postmenopausal Japanese women.

A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers. Stolzenberg-Solomon RZ, Vieth R, Azad A, Pietinen P, Taylor PR, Virtamo J, Albanes D. Cancer Res. 2006 Oct 15;66(20):10213-9. PMID: 17047087 Higher vitamin D concentrations were associated with a 3-fold increased risk for pancreatic cancer (highest versus lowest quintile, >65.5 versus <32.0 nmol/L: OR, 2.92; 95% CI, 1.56-5.48, Ptrend = 0.001) that remained after excluding cases diagnosed early during follow-up. Contrary to expectations, subjects with higher prediagnostic vitamin D status had an increased pancreatic cancer risk compared with those with lower status. Our findings need to be replicated in other populations and caution is warranted in their interpretation and implication. Our results are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer. In conclusion, contrary to expectation, subjects with higher 25(OH)D concentrations were at greater risk for pancreatic cancer compared with those with lower concentrations in our prospective study with long-term follow-up. Caution is warranted in the interpretation and implication of our findings, however, as vitamin D inadequacy is an important public health problem and adequate status is desirable to prevent bone and other diseases (5). Our results, however, are intriguing and may provide clues that further the understanding of the etiology of this highly fatal cancer.

Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A. Am J Clin Nutr. 2007 Nov;86(5):1420-5. PMID: 17991655

"18 645 patients with a total cholesterol of 6·5 mmol/L or greater were recruited from local physicians throughout Japan between 1996 and 1999. Patients were randomly assigned to receive either 1800 mg of EPA daily with statin (EPA group; n=9326) or statin only (controls; n=9319) with a 5-year follow-up. The primary endpoint was any major coronary event, including sudden cardiac death, fatal and non-fatal myocardial infarction, and other non-fatal events including unstable angina pectoris, angioplasty, stenting, or coronary artery bypass grafting. Analysis was by intention-to-treat. Findings At mean follow-up of 4·6 years, we detected the primary endpoint in 262 (2·8%) patients in the EPA group and 324 (3·5%) in controls-a 19% relative reduction in major coronary events (p=0·011). Post-treatment LDL cholesterol concentrations decreased 25%, from 4·7 mmol/L in both groups. Serum LDL cholesterol was not a significant factor in a reduction of risk for major coronary events. Unstable angina and non-fatal coronary events were also significantly reduced in the EPA group. Sudden cardiac death and coronary death did not differ between groups. In patients with a history of coronary artery disease who were given EPA treatment, major coronary events were reduced by 19% (secondary prevention subgroup: 158 [8·7%] in the EPA group vs 197 [10·7%] in the control group; p=0·048). In patients with no history of coronary artery disease, EPA treatment reduced major coronary events by 18%, but this finding was not significant (104 [1·4%] in the EPA group vs 127 [1·7%] in the control group; p=0·132)."

Welcome to the English language website for the "Optimal Diet" movement. The Optimal Diet is a dietary model of human nutrition devised and implemented by Dr. Jan Kwasniewski. The Optimal Diet is a movement, which originated in recent years in Poland, and has rapidly spread to a number of countries worldwide, is to improve the well-being, health and biological value of people as individuals, and to correct nutritional mistakes of human kind as a whole, through promotion and implementation of the "optimal" model of human nutrition. Optimal Diet is based on the delivery of the most important nutritional elements, e.g., the most valuable proteins and fats, whilst leaving the body in charge of the distribution of these elements to the most critical areas. The ideal proportion between the main food components of protein, fat and carbohydrates should be in the range of : m m m m 1 : 2.5 - 3.5 : 0.5 In order to work out the correct daily food intake using this proportion, one has to know how many grams of protein needs to be ingested in a day to satisfy body's requirements.

Litchi is a fruit with amazing health benefits belongs to Sapindaceae family. It is grown in the tropical and subtropical regions of the world and found abundantly in the summer season. It was first originated in the Chinese regions of Guangdong and Fujian and has been started cultivating in the various countries of the world (India, Vietnam, Sri Lanka, Thailand, Taiwan, Japan, Bangladesh, Nepal, Australia, Pakistan, Malaysia, Vietnam, Mexico, Southern Africa and etc). It is very delicate and attractive smelling fruit which is usually eaten fresh. It is found in many types such as emperor lychee or biggest lychee, ohia lychee or litchi with little seed, Brewster lychee and etc. Benefits of Litchi (Lychee) Fruit Juice It is loaded with numerous healthy nutrients including vitamins, minerals, antioxidants, fatty acids and so many. It protects from various diseases, infections and skin problems by enhancing the immunity power. It contains polyphenols which helps in fighting with weight problems, liver damage and type-2 diabetes. Some of its amazing health benefits are mentioned below: Benefits of Litchi for Heart Benefits of Litchi for Cancer Benefits of Litchi for Digestive System Benefits of Litchi for Bones, Teeth and Joints Benefits of Litchi for Hair Benefits of Litchi for Weight Loss Benefits of Litchi for Aging Benefits of Litchi for Women during Pregnancy Benefits of Litchi for Kids Benefits of Litchi for Men Benefits of Litchi Seeds Benefits of Litchi Juice of Skin Nutrition Facts of Litchi Dash per 100 ml Energy: 60 Kcal Fat: 0 gm Carbohydrate: 14.8 gm Protein: 0 gm Sugar: 12.5 g Vitamins Thiamine: 0.011 mg Riboflavin: 0.065 mg Niacin: 0.603 mg Choline: 7.1 mg Pyridoxine: 0.100 mg Folates: 14 µg Vitamin C: 71.5 mg Vitamin E: 0.07 mg Vitamin K: 0.4 µg Minerals Calcium: 5 mg Copper: 0.148 mg Iron: 0.31 mg Magnesium: 10 mg Manganese: 0.055 mg Phosphorus: 31 mg Selenium: 0.6 µg Zinc: 0.07 mg

Litchi is sweet and a very fragrant fruit, which is usually available in the summer. This fruit originated in China but today is found in most of the South East Asian countries. It is the member of soapberry family, Sapindaceae. There are three sub-species of Litchi. It has rough skin outside while contains juicy and creamy white flesh inside. Litchi has a wonderful taste and in modern times it has found its niche in desserts, juices and ice creams.

Litchi is a small fruit packed with loads of healthy nutrients. Litchi is considered an exotic fruit and has a very short shelf life. This is why it is available for a very limited time even during its season. In ancient China, Litchi was the favored fruit in the imperial corridors finding its greatest fans amongst the Kings and queens; who would get these beautiful fruit transported to capital at a great cost to the Kingdom.

Nutritional Value of Litchi
Litchi has a high level of vitamin C in it and meets about 86% of the body's daily requirement of this vitamin. It is a little high on sugar and has reasonable amount of dietary fiber. It is a rich source of Polyphenols that make it a strong and highly recommended anti-oxidant. The composition of minerals make it a great fuel for the electrolyte balance in our body.

PET Bottles: Litchi Dash 200 ml
Nutrition Facts of Litchi Dash per 100 ml
Energy: 60 Kcal
Fat: 0 gm
Carbohydrate: 14.8 gm
Protein: 0 gm
Sugar: 12.5 g
Dietary fiber: 1.3 gms
Vitamin B1: 0.011 mg
Vitamin B2: 0.065 mg
Vitamin B3: 0.603 mg
Vitamin B6: 0.10 mg
Vitamin C: 71.5 mg
Calcium: 5 mg
Magnesium: 10 mg
Manganese: 0.055 mg
Phosphorus: 31 mg
Potassium: 171 mg

Health Benefits
It contains a healthy blend of nutrients that promote health. So, know the amazing health benefits of Litchi that can make a lot of difference t

Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia -- Krauss et al. 83 (5): 1025 -- American Journal of Clinical Nutrition Changes in peak LDL diameter (Table 2) and mass concentrations of LDL subfractions (Table 3) induced by each of the diets were reflected by changes in the proportions of subjects exhibiting LDL subclass pattern B (Figure 2). There were linear reductions in the prevalence of pattern B as a function of reduced carbohydrate intake after both the stable-weight and weight-loss periods. However, the slopes of these relations differed (P = 0.04) such that the magnitude of the reduction in expression of pattern B induced by weight loss increased in association with the percentage of carbohydrate intake. Conclusions: Moderate carbohydrate restriction and weight loss provide equivalent but nonadditive approaches to improving atherogenic dyslipidemia. Moreover, beneficial lipid changes resulting from a reduced carbohydrate intake were not significant after weight loss. Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia. Krauss RM, Blanche PJ, Rawlings RS, Fernstrom HS, Williams PT. Am J Clin Nutr. 2006 May;83(5):1025-31; quiz 1205. Erratum in: Am J Clin Nutr. 2006 Sep;84(3):668. PMID: 16685042

Sun Z, Sood S, Li N, Ramji D, Yang P, Newman RA, Yang CS, Chen X. Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinoge

Conclusion The data point to a critical role for the VDR and 1,25(OH)2D3 in control of innate immunity and the response of the colon to chemical injury. Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury. Froicu M, Cantorna MT. BMC Immunol. 2007 Mar 30;8:5. PMID: 17397543 doi:10.1186/1471-2172-8-5

If you're searching for some healthy breakfast ideas, this article reveals 5 easy to follow healthy breakfast tips that can help you lose weight.

Written by, Samuel K. Burlum, Investigative Reporter and author of The Green Lane, a syndicated column Published on 4/30/16, a SamBurlum.com Exclusive Source: As we take a look at the poor water quality issues that have hit major metro centers such as Flint, Michigan and Newark, New Jersey, we examine the source of these issues and what some are doing to rush in protecting the most important natural resource vital to the existence of the human race. As our world's population grows and our available sources of clean drinkable freshwater dwindle, the race to find ways to preserve and protect our current water supplies have rapidly increased; while other alternatives on how to clean up used and polluted water supplies are explored. Schools of thought and tech companies are eager to find ways to filter recycled water for reuse; fresh water supplies continue to be maxed out. According to the U.S. Geological Survey; only 2.5% of the Earth's water supply is fresh water. The main sources of available drinkable freshwater supply mainly come from glaciers and ice caps; ground ice and permafrost, and lakes and ground water. It is so surprising that with this natural resource being so scarce, we as a society don't do more to preserve and protect it. And so as a society, we continue to sabotage ourselves by contributing to actions and behaviors that increase pollution of our rivers and lakes. Only about half of the world's population has access to clean drinking water, leaving the other 3 billion people to fight for a source of quality water. In addition to that, according to United Nations Educational, Scientific and Cultural Organization (UNESCO); 783 Million people have no access to any clean water sources. They must rely on "dirty" water or no water at all. This seems like a problem that would only plague impoverished countries, countries without infrastructure and societies without developed economies; however that stereo-typical outlook has been crushed by

Written by, Samuel K. Burlum, Investigative Reporter and author of The Green Lane, a syndicated column Published on 4/30/16, a SamBurlum.com Exclusive Source: As we take a look at the poor water quality issues that have hit major metro centers such as Flint, Michigan and Newark, New Jersey, we examine the source of these issues and what some are doing to rush in protecting the most important natural resource vital to the existence of the human race. As our world's population grows and our available sources of clean drinkable freshwater dwindle, the race to find ways to preserve and protect our current water supplies have rapidly increased; while other alternatives on how to clean up used and polluted water supplies are explored. Schools of thought and tech companies are eager to find ways to filter recycled water for reuse; fresh water supplies continue to be maxed out. According to the U.S. Geological Survey; only 2.5% of the Earth's water supply is fresh water. The main sources of available drinkable freshwater supply mainly come from glaciers and ice caps; ground ice and permafrost, and lakes and ground water. It is so surprising that with this natural resource being so scarce, we as a society don't do more to preserve and protect it. And so as a society, we continue to sabotage ourselves by contributing to actions and behaviors that increase pollution of our rivers and lakes. Only about half of the world's population has access to clean drinking water, leaving the other 3 billion people to fight for a source of quality water. In addition to that, according to United Nations Educational, Scientific and Cultural Organization (UNESCO); 783 Million people have no access to any clean water sources. They must rely on "dirty" water or no water at all. This seems like a problem that would only plague impoverished countries, countries without infrastructure and societies without developed economies; however that stereo-typical outlook has been crushed by th

Association between vitamin D and age-related macular degeneration in the Third National Health and Nutrition Examination Survey, 1988 through 1994. Parekh N, Chappell RJ, Millen AE, Albert DM, Mares JA. Arch Ophthalmol. 2007 May;125(5):661-9. PMID: 17502506

M. F. McCarty and K. I. Block Toward a core nutraceutical program for cancer management. Integr Cancer Ther, June 1, 2006; 5(2): 150 - 171.

Frick KK, LaPlante K, Bushinsky DA. RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro. Am J Physiol Renal Physiol. 2005 Nov;289(5):F1005-11. Epub 2005 Jun 21. PMID: 15972386 [PubMed - indexed for MEDLINE

Controlling inflammation: a fat chance? Flower RJ, Perretti M. J Exp Med. 2005 Mar 7;201(5):671-4. Review. PMID: 15753201 doi:10.1084/jem.20050222

Calcium, protein, and fruit and vegetables as dietary determinants of bone health. New SA, Millward DJ. Am J Clin Nutr. 2003 May;77(5):1340-1; author reply 1341. PMID: 12716695

High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks. Kamangar F, Schantz MM, Abnet CC, Fagundes RB, Dawsey SM. Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1262-8. PMID: 18483349 doi: 10.1158/1055-9965.EPI-08-0025

Conclusion: The associations suggest that replacing SFAs with PUFAs rather than MUFAs or carbohydrates prevents CHD over a wide range of intakes. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A. Am J Clin Nutr. 2009 May;89(5):1425-32. Epub 2009 Feb 11. PMID: 19211817 doi:10.3945/ajcn.2008.27124