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Nathan Goodyear

Magnesium metabolism in health and disease. [Dis Mon. 1988] - PubMed result - 0 views

  • Less than 1% of the total body magnesium is present in blood
  • A large segment of the U.S. population may have an inadequate intake of magnesium and may have a chronic latent magnesium deficiency that has been linked to atherosclerosis, myocardial infarction, hypertension, cancer, kidney stones, premenstrual syndrome, and psychiatric disorders.
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    Magnesium in health and disease
Nathan Goodyear

The relationship between testosterone and molecula... [J Endocrinol Invest. 2005] - Pub... - 0 views

  • close relationship exists between the development of a pro-inflammatory state and the decline in T levels
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    inflammation and low testosterone
Nathan Goodyear

Perioperative Nutrition and Postoperative Complications in P... : Spine - 0 views

  • Patients with suboptimal nutritional parameters should be supplemented and replenished before elective surgery.
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    Nutrition status should be evaluated before surgery to help improve outcomes
Nathan Goodyear

Improved wound healing response in surgical patients receiving intravenous nutrition - ... - 0 views

  • These results show that the wound healing response in surgical patients requiring intravenous nutrition is improved by this treatment
  • improved wound healing response is more marked when intravenous nutrition is given before, rather than after the surgical procedure.
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    IV nutrition improves healing after surgery
Nathan Goodyear

ingentaconnect Immunonutrition in Surgical Patients - 0 views

  • Surgery induces an inflammatory response
  • A range of nutrients, including several amino acids, antioxidant vitamins and minerals, ω-3 fatty acids, and nucleotides, are able to modulate inflammation and the associated oxidative stress, and maintain or improve immune function
  • parenteral glutamine is recommended in patients receiving parenteral nutrition
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  • Antioxidants, particularly selenium, should be considered for critically ill patients
  • enteral formulas enriched with fish oils are recommended for patients with acute respiratory distress syndrome.
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    nutrition to improve inflammation in surgical patiens
Nathan Goodyear

A Guide to Perioperative Nutrition - 0 views

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    nutritional therapy before and after surgery improve surgical outcomes
Nathan Goodyear

Gastric Bypass Surgery for Morbid Obesity Leads to an Increase in Bone Turnover and a D... - 0 views

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    Gastric Bypass leads to bone loss; through malabsorption
Nathan Goodyear

Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity... - 0 views

  • SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function
  • central role of NF-κB in cytokine-mediated pancreatic β-cell damage
  • SIRT1 as a possible target to attenuate cytokine-induced β-cell damage.
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    SIRT1 as possible target to reduce pancreatic inflammation and thus prevent/reduce diabetes;  Oh by the way Resveratrol acts at SIRT1
Nathan Goodyear

Mechanism of Human SIRT1 Activation by Resveratrol - 0 views

  • The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell cycle regulation, and life span extension
  • resveratrol was shown to increase life span in three model organisms through a Sir2-dependent pathway.
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    Resveratrol potentially increases life span through SIRT1 activation
Nathan Goodyear

Modulation of NF-[kappa]B-dependent transcription and cell survival by the SIRT1 deacet... - 0 views

  • Treatment of cells with resveratrol, a small-molecule agonist of Sirtuin activity, potentiates chromatin-associated SIRT1 protein on the cIAP-2 promoter region, an effect that correlates with a loss of NF-B-regulated gene expression
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    resveratrol decreases NF-kappa Beta expression and thus reduces inflammation
Nathan Goodyear

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer ... - 0 views

  • sulforaphane, a natural compound derived from broccoli/broccoli sprouts
  • Sulforaphane inhibits breast CSCs
  • These findings support the use of sulforaphane for the chemoprevention of breast cancer stem cells
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    Sulforaphane, naturally found in broccoli  inhibits breast CSCs
Nathan Goodyear

Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl ... - 0 views

  • These results demonstrate that, despite the inherent stability of the epigenomic marks established early in life through behavioral programming, they are potentially reversible in the adult brain.
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    We are products of our genetics and our environment
Nathan Goodyear

Glutamate and the glutamate receptor system: a tar... [Int J Geriatr Psychiatry. 2003] ... - 0 views

  • Under certain conditions, glutamate has a toxic action resulting from an activation of specific glutamate receptors, which leads to acute or chronic death of nerve cells.
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    deep, heavy read on glutamate excitotoxicity and neuronal death leading to neurodegenerative disease
Nathan Goodyear

The Relationship between Alzheimer's Disease and Diabetes: Type 3 Diabetes? - ACAM Inte... - 0 views

  • AD has its foundation in neuroendocrinology
  • Referring to AD as type 3 diabetes has its foundation in the fact that the CNS in AD is characterized by a paucity of insulin and resistance of the insulin receptors
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    Insulin/Glucose dysregulation and Alzheimer's disease
Nathan Goodyear

Hyperinsulinemia provokes synchronous increases in... [Arch Neurol. 2005] - PubMed result - 0 views

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    elevated insulin increases brain inflammation and thus increases alzheimer's disease risk
Nathan Goodyear

Exposure to metals. [Prim Care. 2000] - PubMed result - 0 views

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    nice review on heavy metal toxins and their effects
Nathan Goodyear

Minocycline‐induced lupus: clinical features and response to rechallenge - 0 views

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    we need to think twice before prescribing minocycline for dermatologic conditions
Nathan Goodyear

ENVIRONMENTAL LUPUS SYNDROMES - 0 views

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    over 70 drugs implicated in lupus syndromes
Nathan Goodyear

Drug-Related Lupus - NEJM - 0 views

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    Drug induced lupus exceeds 70 known drugs
Nathan Goodyear

ScienceDirect - Molecular Immunology : Mechanisms of heavy metal-induced autoimmunity - 0 views

  • Mechanisms of heavy metal-induced autoimmunity
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    Heavy metals and autoimmune disease
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