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Nathan Goodyear

http://care.diabetesjournals.org/content/33/11/2390.full.pdf - 0 views

care.diabetesjournals.org/...2390.full.pdf

metabolic syndrome metabolic syndrome profession

shared by Nathan Goodyear on 26 Sep 14 - No Cached
  • Nathan Goodyear on 26 Sep 14
     
    Now this is an interesting study--metabolic syndrome rates of US professions.
Nathan Goodyear

Presence of Metabolic Syndrome in Football Linemen - 0 views

www.ncbi.nlm.nih.gov/...PMC2582553

metabolic syndrome football MetS health

shared by Nathan Goodyear on 26 Sep 14 - No Cached
  • Nathan Goodyear on 26 Sep 14
     
    Our findings should generate significant doubt about the presumed health of collegiate football linemen.  That is a startling conclusion.  This conclusion comes from the fact that 49% of Lineman evaluated in this study were found to have Metabolic Syndrome.
Nathan Goodyear

The effects of treatment of subclinical hypothyroi... [Med Arh. 2007] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...17582969

subclinical hypothyroidism insulin resistance treatment hypothyroid thyroid metabolic syndrome hormone hormones

shared by Nathan Goodyear on 02 Feb 11 - No Cached
  • These data support an important role of treatment of SH in support metabolic control and insulin sensitivity.
  • Nathan Goodyear on 02 Feb 11
     
    Treatment of sub-clinical hypothyroidism required to improve insulin resistance
Nathan Goodyear

Effects of Hypo- and Hyperthyroidism on Noradrenergic Activity and Glycerol Concentrati... - 0 views

press.endocrine.org/...jc.2003-030576

thyroid hormone adipose tissue adipose fat obesity metabolism noradrenaline norepinephrine

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Thyroid hormone increased localized norepinephrine production and liposlys resulting in decreases SQ adipose tissue compared to hypothyroid.  This study showed a localized effect of adipose tissue by thyroid hormone. 
Nathan Goodyear

Small Differences in Thyroid Function May Be Important for Body Mass Index and the Occu... - 0 views

press.endocrine.org/...jc.2004-2225

Thyroid hypothyroid hypothyroidism hormone hormones BMI metabolism obesity weight

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Even small movements of thyroid function within the "reference rage of normal" is associated with significant metabolic, BMI, and weight effects.
Nathan Goodyear

Thyroid Hormone and Cardiac Disease: From Basic Concepts to Clinical Application - 0 views

www.ncbi.nlm.nih.gov/...PMC3134399

T3 cardiovascular death disease heart health MI myocardial infarction CHF heart failure thyroid hormone hormones hypothyroid hypothyroidism CVD

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Low T3 post MI is associated with increased CHF, morbidity and mortality.  Article discusses thyroid hormones and cardiac function/remodeling post infarct.  The article also lays the ground work for a new study of T3 in patients post MI to be followed for 6 months.
Nathan Goodyear

Low-T3 Syndrome - 0 views

circ.ahajournals.org/...708.long

T3 low T3 cardiac heart disease CVD cardiovascular thyroid hormone hormones hypothyroid hypothyroidism

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • More than 80% of the biologically active hormone triiodothyronine (T3) derives from peripheral conversion of prohormone thyroxine (T4) secreted by the thyroid gland
  • Low thyroid hormone concentrations, in particular low serum T3 concentrations, are a common finding in patients with nonthyroidal illnesses, including cardiac disorders
  • a direct relationship between low circulating levels of T3 and adverse prognosis of cardiac patients
  • ...4 more annotations...
  • The present study clearly shows the existence of a strong association between the reduction of biologically active T3 and mortality in a large population of cardiac hospitalized patients
  • highly significant increase in the incidence of cardiac and cumulative deaths in patients with low T3 compared with patients with normal T3 levels
  • the relevance of the low T3 state as a strong, independent predictor of mortality in cardiac patients
  • low T3 concentrations are a strong independent predictive marker of poor prognosis in cardiac patients
  • Nathan Goodyear on 03 Jul 12
     
    low T3 associated with poor prognosis in cardiac patients.   Poor prognosis = death.  T3 is important in cardiac remodeling, which is inherently important with cardiac disease.
Nathan Goodyear

Acute myocardial infarction and thyroid function: New pathophysiological and therapeuti... - 0 views

informahealthcare.com/...07853890.2011.573501

thyroid hormone hormones T3 heart attack heart health myocardial infarction MI

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Thyroid hormone plays significant role in cardiac remodeling after acute myocardial infarction.  Thyroid hormone, particularly T3 as the vast majority of T3 is produced in heart tissue via D1 enzymatic activity, improves cardiac contractility, reduces systemic vascular resistance, reduces cardiac work load, decreases blood pressure, improves cardiac metabolism, and thus improves outcomes post MI.
Nathan Goodyear

Thyroid hormone treated astrocytes induce maturation of cerebral cortical neurons throu... - 0 views

www.ncbi.nlm.nih.gov/...PMC3740295

thyroid hormone T3 astrocyte brain health cognition disease

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    T3 plays a significant role in astrocyte maturation.  This has significant cognitive and disease impact.
Nathan Goodyear

Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns: Molecular Endocr... - 0 views

press.endocrine.org/...me.2010-0095

thyroid hormone receptors hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • the majority of TRs is located in the nucleus
  • Nathan Goodyear on 24 Sep 14
     
    thyroid hormone transportation.  The majority of the thyroid hormone receptors are in the nucleus of the cell.
Nathan Goodyear

http://press.endocrine.org/doi/pdf/10.1210/jc.2013-1813 - 0 views

press.endocrine.org/...jc.2013-1813

thyroid hormone hormones T4 T3 cognition

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Higher T4 and T3 results in improved cognitive function.  Higher with the normal reference range that is.  Thyroid levels cannot be taken purely in reference to "normal".
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

press.endocrine.org/...jc.2011-1329

T4 T3 hypothyroid hypothyroidism thyroid lipids weight loss metabolism cholesterol hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • tissue euthyroidism is the net result of multiple steps including conversion of the prohormone T4 into its active metabolite T3, which is ultimately responsible for signaling at the end-organ target level
  • The circulating and intracellular pools of T3 of treated hypothyroid patients (i.e. devoid of endogenous TH production) depend entirely on the conversion of exogenous l-T4 into T3
  • TH is the major regulator of basal metabolic rate
  • ...8 more annotations...
  • The substitution of l-T3 for l-T4 caused a significant weight loss
  • The substitution of l-T3 for l-T4 caused a significant reduction in lipid parameters
  • TH action is increased in the liver, and the SHBG increase supports this hypothesis
  • The changes in serum lipid metabolism parameters are similar to the effects observed with drugs approved for the treatment of dyslipidemia
  • This differential response appears to be limited to the lipid metabolism and SHBG, whereas no differences in indices of insulin resistance were detected. This is remarkable because hyperthyroid states are associated with an increase in hepatic gluconeogenesis (37), and overt thyrotoxicosis is a known cause of secondary diabetes.
  • Despite the increase in serum T3, the l-T3 treatment did not cause major changes in cardiovascular or musculoskeletal function, as indicated by the echocardiographic and maximal exercise tolerance tests and DXA studies.
  • Similarly, no significant differences were observed in blood pressure, heart rate, or endothelial vascular function
  • In conclusion, the results of this pharmacology, proof-of-concept study indicate that replacement therapy of hypothyroidism with l-T3, compared with l-T4 causes weight loss and favorable changes in the lipid profile without appreciable side effects
  • Nathan Goodyear on 24 Sep 14
     
    Crossover study finds T3 versus T4 results in more weight loss, improved lipid management and increased SHBG without any adverse cardiovascular effects.   The T3 was dosed 3 x daily due to its short half life compared to T4.
Nathan Goodyear

Induction of oral tolerance in human autoimmune thyr... [Thyroid. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9545109

T4 T3 autoimmune autoimmune disease immune system thyroid disease

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    combined T4/T3 in desiccated thyroid found to reduce cellular immunity in those with autoimmune thyroid disease.
Nathan Goodyear

Desiccated Thyroid Extract Compared With Levothyroxine in the Treatment of Hypothyroidi... - 0 views

press.endocrine.org/...jc.2012-4107

hypothyroid hypothyroidism thyroid T4 T3 hormones metabolism

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Our study has shown DTE therapy caused modest weight loss, and nearly half (48.6%) of the study patients expressed preference for DTE over l-T4
  • our study showed significantly higher TSH in the DTE-treated group, which suggests that the improvement observed in the DTE-treated group is not mediated through the changes in TSH levels
  • Nathan Goodyear on 24 Sep 14
     
    Study finds desiccated thyroid (armour thyroid) was associated with great weight loss, mood improvement than T4 alone.  Desiccated thyroid was preferred by patients in the study.  Conversion rate was 100 mcg T4 to 88 mg desiccated thyroid.
Nathan Goodyear

Combination Treatment with T4 and T3: Toward Personalized Replacement Therapy in Hypoth... - 0 views

press.endocrine.org/...jc.2011-3399

hypothyroid hypothyroidism T4 T3 thyroid metabolism hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    reference review suggests improved results with combined T4/T3 treatment for hypothyroid patients.  Also, a good review of thyroid metabolism.  Patients prefer the combination therapy versus T4 alone indicating improved symptoms with combined therapy.
Nathan Goodyear

Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with ... - 0 views

www.nejm.org/...NEJM199902113400603

Armour T4 T3 synthroid hypothyroidism hypothyroid thyroid

shared by Nathan Goodyear on 01 Aug 11 - No Cached
  • Nathan Goodyear on 01 Aug 11
     
    Armour Thyroid (T4 and T3 combined) provides better symptom control when compared to synthroid alone (T4)
Nathan Goodyear

Potential uses of T3 in the treatment of human dis... [Clin Cornerstone. 2005] - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...16399246

T3 hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • riiodothyronine (T3), formed by the monodeiodination of T4, is the biologically active form of thyroid hormone
  • Nathan Goodyear on 01 Feb 11
     
    T3 is the active, biologically form of the thyroid hormone
Nathan Goodyear

A rare case of amiodarone-induced hypothyroidis... [Int J Angiol. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22942634

CVD cardiovascular disease cardiovascular disease prescription medications prescriptions hypothyroid hypothyroidism heart

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Very interesting case study of amiodarone induced hypothyroidism that resulted in pericardial effusion and cardiac tamponade.
Nathan Goodyear

Proinflammatory cytokines inhibit the expre... [Eur J Endocrinol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11916626

inflammation cytokines cytokine IL-1beta IL-6 TNF-alpha thyroid hypothyroid hypothyroidism deiodinase

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    inflammatory cytokine IL-1beta reduced deiodinase transcription, thus reducing T4 to T3 conversion.  The inflammatory cytokines TNF-alpha and IL-6 did also but to a lesser degree.
Nathan Goodyear

Relative vitamin D insufficiency in Hashimoto's thyr... [Thyroid. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21751884

vitamin D vitamin D Hashimoto's thyroiditis hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    low vitamin D levels associated with Hashimoto's thyroiditis.
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