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Diagnosing and managing low serum testosterone - 0 views

www.ncbi.nlm.nih.gov/...PMC4255853 Low Testosterone low T low Testosterone men male hormone hormones
shared by Nathan Goodyear on 15 Dec 14 - No Cached
  • Nathan Goodyear on 15 Dec 14
     
    Review on low T in men: diagnosis and therapy.
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Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cr... - 0 views

mct.aacrjournals.org/...1161.full CBD cannabidiol cancer apoptosis breast breast cancer
shared by Nathan Goodyear on 14 Dec 14 - No Cached
  • Nathan Goodyear on 14 Dec 14
     
    Cannabidiol (CBD) induces cancer cell apoptosis in human cell culture.
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Prenatal letrozole produces a subpopulation of male rats with same-... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25462593 letrozole femara hormone hormones
shared by Nathan Goodyear on 10 Dec 14 - No Cached
  • Nathan Goodyear on 10 Dec 14
     
    Now this is an interesting study.  In utero exposure to letrozole (femara) which is an aromatase inhibitor, is associated with same sex preference.  Only abstract available, but this study points to environment, hormone effects in early development and future sexual preference.  No difference in serum hormone levels were seen.  
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Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian pros... - 0 views

ajcn.nutrition.org/...1160.full nutrition diet glycemic index glycemic load cancer breast cancer carbohydrates sugar menopause women premenopause
shared by Nathan Goodyear on 09 Dec 14 - No Cached
  • GI is a measure of carbohydrate quality in relation to glucose availability and is independent of quantity, whereas GL is a measure of the total glycemic effect and hence is anindicator of the insulin demand of the diet. High-glycemic diets are in fact generally associated with greater insulin secretion
  • the consumption of large quantities of high-GI foods rather than the consumption of high quantities of carbohydrates is linked to the development of breast cancer.
  • Nathan Goodyear on 09 Dec 14
     
    High glycemic load and glycemic index associated with increased breast cancer risk in premenopausal women.
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Nutrition & Metabolism | Full text | Over-stimulation of insulin/IGF-1 signaling by Wes... - 0 views

www.nutritionandmetabolism.com/...41 cancer nutrition diet sugar carbohydrates insulin IGF-1 acne insulin resistance western diet
shared by Nathan Goodyear on 09 Dec 14 - No Cached
  • Nathan Goodyear on 09 Dec 14
     
    Elevated insulin and IGF-1 as a result of the typical western diet results in increased risk of many of the chronic diseases of aging that we see in America--cancer.
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http://annonc.oxfordjournals.org/content/12/11/1533.full.pdf#page=1&view=FitH - 0 views

annonc.oxfordjournals.org/...1533.full.pdf cancer carbohydrates insulin breast cancer diet nutrition glycemic index glycemic load IGF-1 SHBG
shared by Nathan Goodyear on 09 Dec 14 - No Cached
  • Nathan Goodyear on 09 Dec 14
     
    Study finds link between higher glycemic index and glycemic load with increased breast cancer risk.   The proposed mechanisms are: hyperinsulinemia and its affinity for IGF-1 receptor resulting in a + growth signal.  Increased IGF-1 via the same mechanism. Insulin and IGF-1 have negative regulation effects on SHBG. This all makes sense as insulin receptors are highly expressed on cancer cells.
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Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp testosterone low t low Testosterone CVD cardiovascular mortality therapy
shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  • Nathan Goodyear on 01 Dec 14
     
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
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http://www.drperlmutter.com/wp-content/uploads/2014/04/CANCER-carbs.pdf - 0 views

www.drperlmutter.com/...CANCER-carbs.pdf ketogenic diet ketogenic diet cancer nutrition
shared by Nathan Goodyear on 08 Dec 14 - No Cached
  • Nathan Goodyear on 08 Dec 14
     
    2011 article on the benefits of a ketogenic diet in the treatment of cancer.
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Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation - 0 views

www.sciencedirect.com/...S0098299711000501 oxidative Stress health disease
shared by Nathan Goodyear on 05 Dec 14 - No Cached
  • Nathan Goodyear on 05 Dec 14
     
    Oxidative Stress
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Incidence of Prostate Cancer in Hypogonadal Men Receiving Testosterone Therapy: Observa... - 0 views

www.jurology.com/...abstract low T low testosterone low t Testosterone prostate cancer men male hormone hormones therapy
shared by Nathan Goodyear on 03 Dec 14 - No Cached
  • Nathan Goodyear on 03 Dec 14
     
    new study looked at 3 cohorts of Testosterone therapy in men.  The active cohorts found not increased risk of Prostate cancer in men with testosterone therapy at 5 years.
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Effects of testosterone administration on cognitive function in hys... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25430996 Testosterone women female hormone hormones menopause brain cognition memory hysterectomy
shared by Nathan Goodyear on 02 Dec 14 - No Cached
  • Nathan Goodyear on 02 Dec 14
     
    Testosterone therapy in women post-hysterectomy, with low total and low free Testosterone, provides no benefit in cognitive function.
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Testosterone and benign prostatic hyperplasia Jarvis TR, Chughtai B, Kaplan SA, - Asian... - 0 views

www.ajandrology.com/preprintarticle.asp Testosterone BPH low T low Testosterone prostate cancer men male hormone hormones
shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • The prevalence of hypogonadism (often defined as serum testosterone < 300 ng dl−1 ) ranges from 6% [10] to as high as 38%
  • The process of BPH, however, continues as men age and despite the fact their serum testosterone decreases
  • Liu et al. [12] demonstrated that in a group of older males (mean age 59.8 years) that there was not a significant correlation of serum testosterone levels (total, free or bioavailable) with either prostate volume or International Prostate Symptom Score (IPSS)
  • ...11 more annotations...
  • in eugonadal men, studies have demonstrated that the prostate can increase in volume by approximately 12%
  • There seems to be little doubt that the treatment with testosterone of a young hypogonadal male leads to significant growth of the prostate
  • Behre et al. [22] demonstrated increased prostate volume and prostate-specific antigen (PSA) levels in hypogonadal men
  • Most studies, however, have shown no effect of exogenous androgens on PSA or prostate volume for older hypogonadal males
  • saturation model
  • They argue that the prostate is relatively insensitive to changes in androgen concentration at normal levels or in mild hypogonadism because the AR is saturated by androgens and therefore maximal androgen-AR binding is achieved. Conversely, the prostate is very sensitive to changes in androgen levels when testosterone is low
  • visceral obesity (one of the most significant components of metabolic syndrome) is associated with prostate volume and influences prostate growth during TRT.
  • This hypothesis of inflammation induced LUTS is also argued to be a mechanism for improvement of LUTS with PDE5I
  • The concept, therefore, that treatment with TRT of hypogonadal males with metabolic syndrome might lead to improvement/stabilization of their LUTS, appears to be confirmed in recent work by Francomano et al.
  • There was also an improvement in components of the patient's metabolic syndrome (such as BMI, waist circumference, hemoglobin A1c [HbA1c], insulin sensitivity, and lipid profile) as well as inflammatory markers and C-reactive protein.
  • They concluded that TRT was safe in this group of men, and hypothesize that TRT mitigates the pro-inflammatory factors associated with metabolic syndrome.
  • Nathan Goodyear on 01 Dec 14
     
    Authors review the literature behind Testosterone and BPH.  The authors highlight the 4 proposed theories behind BPH: Testosterone, Estrogen, inflammation, and metabolic.   The conclusion is mixed: pointing out that no high level of evidence exists on either side of the debate of Testosterone and BPH.
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Inflammation and Native American medicine: the role of botanicals - 0 views

ajcn.nutrition.org/...339.long inflammation native Americans medicine botanicals herbs medicinal natural
shared by Nathan Goodyear on 30 Nov 14 - No Cached
  • Nathan Goodyear on 30 Nov 14
     
    review of medicinal botanicals used by native Americans.
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Resistance exercise training improves heart rate variability and mu... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25384514 exercise resistance training HRV heart rate variability muscle coronary artery disease CAD
shared by Nathan Goodyear on 25 Nov 14 - No Cached
  • Nathan Goodyear on 25 Nov 14
     
    High repetition, low weight is associated with improved Heart rate variability, muscle strength and endurance in non-healthy-CAD patients.
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Recovery from endurance exercise. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1406207 endurance exercise recovery carbohydrates glycogen
shared by Nathan Goodyear on 25 Nov 14 - No Cached
  • Nathan Goodyear on 25 Nov 14
     
    Carbohydrates required to restore muscle/liver glycogen stores.  This older article, abstract available, points to 8-10 grams of carbohydrates/kg body weight.  Though repletion of glycogen stores can occur, recovery of muscle performance may require longer time.  Studies have point to 4-6 days.
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Reverse T3 as a parameter of myocardial function impairment in heart failure. - 0 views

www.pubfacts.com/...n-impairment-in-heart-failure. Thyroid hormone hormones reverse T3 rT3 free T3) CHF congestive heart failure CVD
shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    reverse T3 and the free T3:rT3 can be used to assess prognosis of those with CHF.
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Thyroid Replacement Therapy and Heart Failure - 0 views

circ.ahajournals.org/...385.full thyroid T3 hormone hormones cardiovascular disease heart health failure CHF MI myocardial infarction heart attack heart disease
shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • A good biomarker of intracardiac TH signaling would be helpful but has not been identified. In the absence of such a marker, a rational, cautious therapeutic approach might be to restore and maintain over time biochemical euthyroidism as documented by normal circulating levels of TSH, FT4, and FT3.
  • a low-T3 state resulting from altered peripheral TH metabolism secondary to caloric restriction is associated with impaired cardiac contractility
  • Low-T3 syndrome is the central finding and defines the illness in a variety of acute and chronic severe nonthyroidal illnesses with cardiac origin, including MI, HF, and surgically treated cardiac disease.1 Low circulating levels of T3 in the absence of primary thyroid hypofunction have been found in 20% to 30% of patients with dilated cardiomyopathy.
  • ...1 more annotation...
  • FT3 levels were inversely correlated to coronary artery disease
  • Nathan Goodyear on 24 Sep 14
     
    Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.
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Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling: Endocri... - 0 views

press.endocrine.org/...er.2008-0019 thyroid deiodinase T3 T4 hormone hormones
shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • From a broad perspective, this paradigm can be seen as an example of how hormones are activated or inactivated in a controlled fashion in specific extraglandular tissues, in an analogous role to 5α-reductase and P450 aromatase in sex steroid metabolism and to 11β-hydroxysteroid dehydrogenase in glucocorticoid metabolism.
  • Nathan Goodyear on 24 Nov 14
     
    better source for previous post on thyroid metabolism and deiodinase.
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http://www.neuroanatomy.wisc.edu/coursebook/neuro2(2).pdf - 0 views

www.neuroanatomy.wisc.edu/...neuro2(2).pdf hypothalamus
shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    everything one wants to know on hypothalamus
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Testosterone Supplementation Therapy in the Treatment of Patients With Metabolic Syndro... - 0 views

postgradmed.org/...pgm.2014.11.2843 metabolic syndrome Testosterone low T low Testosterone men male hormone hormones
shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    Only abstract available.  Review of literature of Testosterone in men with Metabolic Syndrome.
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