Dr. Goodyear

Apo B is a key structural component of all the atherogenic lipoprotein particles, including LDL, VLDL, and IDL

Each of these atherogenic particles carries only one apo B molecule; thus, the total apo B level represents the total number of circulating atherogenic lipoprotein particles and provides the clinician a more accurate picture of a patient's risk of cardiovascular events

apo B include the fact that it does not require a fasting specimen

the mean and population-safe protein requirements were estimated to be 0.93 and 1.2 g · kg−1 · d

diet containing 0.90 g · kg−1 · d−1 was at or above physiologic protein requirements for sedentary men

The current EAR recommendation and RDA for protein are 0.66 and 0.80 g · kg−1 · d−1, respectively. We believe that these recommendations are tentative because no long-term studies have suggested that these values would maintain nitrogen balance along with lean body mass, muscle mass, serum protein concentrations, immunity, functional capacity etc

PSA levels in media were increased by 3α-diol

Similarly to 3α-diol, 3β-diol also increased PSA levels in media in a concentration-dependent manner

intracellular DHT is synthesized from inactive androgen 3α- and 3β-diol via different pathways in prostate cancer cells

Sex steroid hormones are primarily responsible for sex difference in adult HPA function; androgens inhibit whereas estrogens enhance HPA axis activation after a stressor

the PVN contains relatively high levels of AR (Bingaman et al., 1994; Zhou et al., 1994) and ERβ (Alves et al., 1998; Hrabovszky et al., 1998; Somponpun and Sladek, 2003) but is essentially devoid of ERα

the nonaromatizable androgen DHT and the nonselective ER ligand E2 influence HPA reactivity by acting on neurons within or surrounding the PVN