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Vitamin D3 enhances mood in healthy subjects durin... [Psychopharmacology (Berl). 1998]... - 0 views

www.ncbi.nlm.nih.gov/...9539254 vitamin D seasons affective disorder depression
shared by Nathan Goodyear on 09 Dec 10 - No Cached
  • Nathan Goodyear on 09 Dec 10
     
    Vitamin D3 enhances mood in healthy subjects during winter.
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European Journal of Clinical Nutrition - Abstract of article: Effect of vitamin C on co... - 0 views

www.nature.com/...1602261a.html Vitamin C common cold flu immune enhancing effect nutrition
shared by Nathan Goodyear on 05 Oct 11 - No Cached
  • Nathan Goodyear on 05 Oct 11
     
    vitamin C shown to reduce the # of colds over a 5 year period.  Showing a long-term immune enhancing effect of vitamin C
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Frontiers | Performance enhancement at the cost of potential brain plasticity: neural r... - 0 views

journal.frontiersin.org/...full psychostimulants stimulants prescription brain neuroscience neuroplasticity methylphenidate amphetamine dopamine norepinephrine serotonin cognition
shared by Nathan Goodyear on 06 Jun 14 - No Cached
  • Nathan Goodyear on 06 Jun 14
     
    Great article on the detriment of prescription stimulants for cognitive enhancement.  The authors describe an inverted "U" efficacy curve.
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Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola fr... - 0 views

www.spandidos-publications.com/...497 Grifola frondosa maitake mushrooms cancer NK cells IL-12
shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    The D-Fraction from maitake mushrooms enhanced the cytotoxicity from NK cells through IL-12 signaling.
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Ankle Support - 0 views

www.wheelchairindia.com/...Tynor-Knee-Cap-Pair Knee Cap and Anklet Comfeel Pair Relieve Knee Pain Tynor Knee Cap Pair Tynor Anklet Comfeel knee cap ankle support kneecaps tynor ankle support anklet comfeel knee cap pair tynor knee cap
shared by wheelchairindia9 on 12 Mar 16 - No Cached
  • wheelchairindia9 on 12 Mar 16
     
    Tynor Knee Cap Pair Knee Caps are tubular supports widely used in orthopaedic practice to provide mild compression warmth & support to the limbs and joints, to allay pain and inflammation, generally associated with old age, arthritis, sports injury etc. Hypoallergenic Four way stretch Uniform compression Simple pull on application Tynor Knee Cap (Pair) Features Bilayered , cotton on the inside Dermophillic interpahse with the skin Better sweat absorption Better comfort Better patient compliance. No allergies or rash Bilayered, nylon on the outside Ensures long life Excellent aesthetics Color fastness. Two layers enclose air space retains body heat effectively Provides therapeutic warmth and assuring support to the knee. Four-way stretchable seamless tubular fabric Effective compression Enhanced comfort. No vaso constriction. Adjusts compression even on uneven diameters
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Tynor Wrist Brace with Thumb - 0 views

www.wheelchairindia.com/...Tynor-Wrist-Brace-with-Thumb Tennis Elbow Support Help Relief From Forearm porous and a comfortable material firm grip with silicon pad Custom compression and fit compressive strength and support free and natural movement
shared by wheelchairindia9 on 25 Mar 16 - No Cached
  • wheelchairindia9 on 25 Mar 16
     
    Tynor Wrist Brace with Thumb is created to reinforce, prevent and partially immobilize the wrist and the palm. This wrist brace allows natural and free activity of the fingers. It keeps the affected area compact and maintains the body heat to lessen the local pain inflammation. Its has high quality striped elastic webbing which provides high modulus of elasticity which gives the comfortable feel. It is made from the strong, durable, porous and a comfortable material which remains for a long time. This Wrist Brace provides excellent compressive strength and support to the wrist. Its Hook loop closures allow easy application and removal. It fits comfortably around the wrist and comes in universal sizing. It also has an anatomical thumb opening which fastens the healing process. It keeps the thumb in relaxed and comfortable position. Its extra porous material allows the proper ventilation to the affected skin. Tynor Wrist Brace with Thumb Wrist brace with thumb is designed to support, protect and partially immobilize the wrist and the palm while allowing free and natural movement of the fingers. It compresses the area and retains the body heat to allay local pain and inflammation. Extra grip. Extra porous Controlled compression. Anatomical thumb placement. Tynor Wrist Brace with Thumb Features High quality , striped elastic webbing Strong and durable Porous and comfortable High modulus of elasticity- Retains shape and size for a long time. Excellent compressive strength, better support Hook loop closures Easy to apply and remove Ensures optimal compression Better fitting and universal sizing. Anatomical thumb opening Better pain relief and healing. Thumb in abduction remains relaxed, no fatigue Improves comfort Allows free and natural movement of the thumb and fingers. Tynor Tennis Elbow Support Tennis Elbow Support is designed to help provide relief from generalized pain and tenderness in the forearm and elbow caused by repetitiv
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Enhanced Human Neutrophil Vitamin C Status, Chemotaxis and Oxidant Generation Following... - 0 views

www.ncbi.nlm.nih.gov/...PMC4425162 immune system vitamin C neutrophils
shared by Nathan Goodyear on 11 Oct 17 - No Cached
  • Nathan Goodyear on 11 Oct 17
     
    Vitamin C enhances neutrophil function in study of 14 women.  The study found that their plasma vitamin C status was low.  No increase in new neutrophil generation was noted.  During the study, they only reached 70 micromol/L from the pre-study <50 micromol/L.  I wonder if the study had used higher doses and/or followed longer, they would have seen an increase in the neutrophil numbers?
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Intraperitoneal Oxidative Stress in Rabbits with Papillomavirus-Associated Head and Nec... - 0 views

clincancerres.aacrjournals.org/...4289.long Ozone cancer COX-2 immunotherapy NK cells NK
shared by Nathan Goodyear on 02 Nov 18 - No Cached
  • Nathan Goodyear on 02 Nov 18
     
    O2-O3 triggers tumoricidal immune response after application of a repetitive highly oxidative stimulus by insufflation of a medical O3/O2 gas mixture into the peritoneal cavity in animal model. O3/O2-PP treatment, indicates an enhanced activation of the innate and adaptive arms of the immune system, implicating a role of activated TILs In the anti cancer effects of the O3. Interestingly, COX2 expression was decreased.
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Therapeutic hyperthermia: The old, the new, and the upcoming - Critical Reviews in Onco... - 1 views

www.croh-online.com/...fulltext hyperthermia hyperthermic therapy cancer oncology
shared by Nathan Goodyear on 30 Aug 18 - No Cached
  • not well understood, but it is felt to be a combination of both heat-induced necrosis and of protein inactivation (e.g., repair enzymes) as opposed to DNA damage
  • alterations in tumor cytoskeletal and membrane structures, which disrupt cell motility and intracellular signal transduction
  • A common explanation for HT-enhancement of RT and CT involves inhibition of homologous recombination repair of double-strand DNA breaks, preventing cells from repairing sub-lethal damage
  • ...15 more annotations...
  • it does appear to inhibit rejoining of RT-induced DNA breaks more than is commonly observed after RT alone
  • HT damages cells and enhances RT and CT sensitivity as a function of both temperature and duration of treatment
  • as temperature or duration increase, the rate of cell killing also increases
  • At temperatures above 42 °C, tumor vasculature is damaged, resulting in decreased blood flow
  • Cancer cells are particularly vulnerable to heating; in vivo studies have shown that temperatures in the range of 40–44 °C cause more selective damage to tumor cells
  • cancerous blood vessels are chaotic, leaky, and inefficient
  • selective cytotoxic effect on tumor cells include inhibition of key cancer cell-signaling pathways such as AKT, inducing apoptosis, suppression of cancer stem cell proliferation, and others
  • increase in immunological attacks against tumors after HT, which were believed to be achieved through activation of HSPs and subsequent modulation of the innate and adaptive immune responses against tumor cells
  • HT does lead to activation of the immune system and HSP-induced cell death through modification of the tumor cell surface
  • These HSPs and tumor antigens are taken up by dendritic cells and macrophages and go on to induce specific anti-tumor immunity
  • In vivo studies demonstrate HT-enhancement of NK cell activity, and HT has been shown to increase neutrophilic granulocytes with anti-tumor activity
  • it has become increasingly clear that HT results in immune stimulation, through both direct heat-mediated cell killing as well as innate and adaptive immune system modulation
  • The term hyperthermia is used in this review to refer to heating within the clinically accepted range of 40–45 °C
  • temperatures above 42.5–43 °C the exposure time can be halved with each 1 °C increase while maintaining equivalent cell killing
  • gradual heating at 43 °C for 1 h worked through an apoptotic pathway
  • Nathan Goodyear on 30 Aug 18
     
    Comprehensive review of hyperthemic therapy.
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Hypnosis For Women | Enhancing Performance | Life Enrichment Counseling - 0 views

www.trinablum.com hypnosis for women
shared by sofiawalker171 on 29 Dec 17 - No Cached
  • sofiawalker171 on 29 Dec 17
     
    Trina Blum, a professional hypnotherapist providing hypnosis for women so that they can enhance their life and fulfill it with happiness and success. To know more, visit the website: https://www.trinablum.com/
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First case of postmortem study in a patient vaccinated against SARS-CoV-2 - 0 views

www.ncbi.nlm.nih.gov/...PMC8051011 SARS-CoV-2 COVID-19 ADE COVID COVID19 vaccination antibody dependent enhancement
shared by Nathan Goodyear on 30 Jul 21 - No Cached
  • Nathan Goodyear on 30 Jul 21
     
    Antibody dependent viral enhancement from the vaccine.
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The telomerase activator TA-65 elongates short telomeres and increases health span of a... - 0 views

www.ncbi.nlm.nih.gov/...PMC3627294 TA-65 telomere Telomerase telomerase activator aging natural wellness health
shared by Nathan Goodyear on 16 May 16 - No Cached
  • studies have demonstrated that the shortest telomeres are causal of reduced cell viability
  • a stable and enforced expression of telomerase leads to an improved health-span, accompanied by an extension of lifespan
  • TA-65 influences the percentage of cellular short telomeres through the activation of telomerase
  • ...17 more annotations...
  • TA-65 administration during 4 months significantly improved the capacity to uptake glucose after a glucose pulse
  • liver protective action of TA-65
  • A disadvantage of mTERT potentiation could be associated to its capacity to favor proliferation of cancerous cells in murine models
  • TA-65 treated mice presented a similar incidence of malignant cancers at time of death, with a tendency to show decreased sarcomas and slightly increased lymphomas
  • We demonstrate here that TA-65 leads to a significant rescue of short telomeres through telomerase activation
  • TA-65 treatment increases proliferation and mobilization potential of mouse keratinocytes in vitro, a situation mimicking telomerase overexpression
  • TAT2, a similar molecule, have beneficial effects in the activation of CD8+ T lymphocytes from HIV-infected patients where they observe an increase of the proliferative potential and enhancement of cytokine/chemokine production
  • TA-65 resulted in a similar rescue of short telomeres in leukocytes post-treatment as observed with humans, most likely through an activation of telomerase
  • we observe that TA-65 lead to 10 fold increase of telomerase RNA levels in the liver of treated mice comparing to the non-treated same-age cohorts
  • TA-65 regulates telomerase at the transcription level, probably through the regulation of the MAPK pathway
  • TA-65 dependent telomerase activation results in a better organ fitness as demonstrated by the improved scores at the glucose tolerance test and insulin levels at fasting
  • TA-65 supplemented mice also present modest enhancement of the subcutaneous and epidermal thickness, as well as higher bone density, representative of an overall fitness status improvemen
  • TA-65 treated mice present higher levels of RBC and hemoglobin comparing to the control cohorts
  • improved health-span of TA-65 treated mice is not accompanied by increased cancer incidence, which may be related to the fact that TERT levels are very modestly increased in all tissues tested except for the liver
  • systemic telomerase overexpression from the germline leads to protection from aging associated pathologies
  • similar situation could be mimicked expressing telomerase late in life in a telomerase deficient background
  • we observed a higher proliferation rate and a partial protection from cell death in some tissues of TA65 treated mice
  • Nathan Goodyear on 16 May 16
     
    TA-65 shown to increase telomerase activity, and thus telomere length of short telomeres, in mouse study.  
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Bad Credit Surgery Loans- Convenient Way to Obtain Quick Funds for Urgency! - 0 views

is.gd/a7E5gB bad credit surgery loans surgery loans personal loans for cosmetic surgery plastic surgery loans
shared by Alan Rann on 18 Oct 16 - No Cached
  • Alan Rann on 18 Oct 16
     
    Bad credit surgery loans helps you get great looks and enhance your personality by the surgery treatment. With the assistance of this loan deal you can get enough finances with simple repayment tenure. This is unsecured type of monetary aid so no need to place collateral and faxing documents to the lender.
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AquaGold IP Facial Care - 0 views

phitensg.com/aquagold-ip-facial-care AquaGold IP Facial Care
shared by Phiten Singapore on 12 Jan 17 - No Cached
  • Phiten Singapore on 12 Jan 17
     
    IP-facial care product line has AQUAGOLD from Phiten's unique AquaMetal Technology known to strengthen the immune system, enhance the absorption of nutrients, regenerate tissues, & improve circulation. Above all, Gold have been regarded as a powerful anti-aging agent.
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10 Things I wish I'd known before Breast Augmentation - 0 views

dubaicosmeticsurgeryclinics.blogspot.com/...sh-id-known-before-breast.html #invisible scar breast augmentation #breast Dubai #scar #scarless
shared by hadiyasafdar on 12 Jan 17 - No Cached
  • hadiyasafdar on 12 Jan 17
     
    Breast augmentation procedure is designed to enhance the size and fullness of the breasts, usually with breast implants. If you are unhappy with the appearance of your breasts because they are smaller in size or they have lost their volume or shape due to pregnancy or rapid weight fluctuations, you might consider a breast augmentation to get the breasts of your desire.
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Cardiorespiratory fitness is associated with white matter integrity in aging - Hayes - ... - 0 views

onlinelibrary.wiley.com/...acn3.204 brain exercise fitness brain health aging
shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • CRF impacts cognition and the brain during childhood, exerts minimal influence during young adulthood when indicators of neural structure and function are typically at their lifetime peak, but may again positively impact brain structure and function in OA as cognitive decline begins in later adulthood.
  • enhanced white matter microstructure in high-fit children relative to low-fit children
  • current results support the notion that CRF contributes to successful brain aging
  • ...1 more annotation...
  • there is regional specificity in the associations between peak VO2 and FA
  • Nathan Goodyear on 07 Jun 16
     
    Physical fitness associated with improved brain aging as the body ages.
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Tynor Knee Immobilizer 14 - 0 views

www.wheelchairindia.com/...Tynor-Knee-Immobilizer-14 Tynor Knee Immobilizer 14 Knee Immobilizer 14 Knee Immobilizer Knee Immobilizer braces Knee Immobilizer brace Tynor Knee Immobilizer 14 Buy Online Buy Tynor Knee Immobilizer 14 Tynor Knee Immobilizer 14 Sale
shared by wheelchairindia9 on 16 Mar 16 - No Cached
  • wheelchairindia9 on 16 Mar 16
     
    Tynor Knee Immobilizer 14 is a superb brace to support, immobilize and protect the operated or injured knee while it recovers. It is made according to the anatomically designed aluminum back splints that offers perfect immobilization. It provides perfect grip to the leg and enhanced the comfort. It is light in weight and ensures complete cushioning. It is made up from thecomfortable and soft body that is highly durable. This knee wrap properly fits around the knee and has non-slip properties. It offers great protection to the knee and it can easily remove it, when not required. Tynor Knee Immobilizer 14 Use & Benefit: Has extremely light weight construction Designed with anatomically shaped back splints Made up from soft and comfortable body Provides perfect immobilization Infused with additional patellar strapping Provides perfect grip to the leg Ensures no hot spots on knee protrusions Has body of PUF fused fabric Offers proper cushioning Has anti slip properties Easy to remove when not required
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Hernia Belt - 0 views

www.wheelchairindia.com/...Tynor-Hernia-Belt Tynor Hernia Belt Hernia Belt hernia support belt Abdominal Hernia Belt belt hernia Hernia abdominal support Hernia abdominal support belt tynor hernia hernia support belts Hernia Belts
shared by wheelchairindia9 on 02 Apr 16 - No Cached
  • wheelchairindia9 on 02 Apr 16
     
    Tynor Hernia Belt Hernia belt offers a gentle and constant relief from reducible inguinal hernia by providing adjustable and comfortable pressure to the hernia. On wearing the belt the occurrence of herniation gets eliminated. Tynor hernia belt is available in skin color, can be worn inconspicuously under clothing. Moulded foam pads. Adjustable leg and abdominal strap. Soft and skin friendly materials. Controlled pressure. Tynor Hernia Belt Features Anatomic pads Presses the inguinal aperture at the appropriate angle, enhances the effectiveness. Molded out of special grade ethafoam Appropriate hardness, light weight, smooth and comfortable. Grey color product Can be worn inconspaciously under cloth, aesthetically pleasing. Soft and dermophilic materials No rash no allergy, very comfortable, improve compliance. Adjustable pelvic and leg straps One size fits a large population, controlled & customized pressure possible. Tynor Hernia Belt Measurements Measure circumference around the waist 2 inches below the navel.
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Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunolog... - 0 views

edrv.endojournals.org/...44.full natural killer cells pregnancy loss recurrent immune system miscarriage NK
shared by Nathan Goodyear on 15 Apr 12 - No Cached
  • NK cells have been the cells most extensively studied, primarily because they constitute the predominant leukocyte population present in the endometrium at the time of implantation and in early pregnancy
  • parental chromosomal abnormalities, uterine anatomic anomalies, endometrial infections, endocrine etiologies (luteal phase defect, thyroid dysfunction, uncontrolled diabetes mellitus), antiphospholipid syndrome, inherited thrombophilias, and alloimmune causes
  • estrogen
  • ...28 more annotations...
  • progesterone
  • prolactin
  • In summary, in vivo animal experiments have shown an inhibitory role of estrogen on peripheral NK cell lytic activity, which is partly due to suppression of NK cell output by the bone marrow and partly due to suppression of individual NK cell cytotoxicity. However, in vitro studies so far have failed to show conclusively a direct effect of estrogen on NK cells.
  • At the progesterone concentrations believed to be present in the uterus [up to 10−5 m at the maternal-fetal interface (35)], studies consistently show inhibition of lymphocyte proliferation (33) and inhibition of NK cytolytic activity in vitro
  • The exact role of prolactin in NK cell regulation is unknown.
  • The overall effects of estrogen on NK cells are likely multifactorial, therefore, and depend on the type of cell affected as well as the kind of ER expressed by that cell.
  • It is known that progesterone can directly affect T cell differentiation in vitro, suppressing development of the Th1 pathway and enhancing differentiation along the Th2 pathway (44)
  • Th1 cells predominantly produce interferon-γ (IFN-γ), IL-2, and TNF-β and are involved in cell-mediated immunity. Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13 and stimulate humoral immunity
  • Furthermore, in response to progesterone, γδ T cells produce progesterone-induced blocking factor (PIBF) (54
  • A defining characteristic of NK cells is their ability to lyse target cells without prior sensitization and without restriction by HLA antigens.
  • NK cell function is mainly regulated by IL-2 and IFN-γ
  • IL-2 causes both NK cell proliferation and enhanced cytotoxicity. IFN-γ augments NK cytolytic activity, but does not cause NK proliferation. The two cytokines act synergistically to augment NK cytotoxicity (6).
  • The largest leukocyte population in the endometrium consists of NK cells named large granulated lymphocytes
  • there is a significant increase in the number of uNK cells throughout the secretory phase, which peaks in early pregnancy when uNK cells comprise about 75% of uterine leukocytes (62)
  • Second, uNK cell phenotype changes during the normal menstrual cycle and early pregnancy (68)
  • general proinflammatory effect of estrogen, causing an influx of macrophages and neutrophils, which is antagonized by progesterone through its receptor (70, 71).
  • The mechanism of such a progesterone-induced local immunosuppression is unclear.
  • progesterone plays an important role in proliferation and differentiation of uNK cells (32).
  • Through promotion of a uterine Th2 environment, progesterone could indirectly affect uNK cell function
  • The mechanism of this increase in uNK cell numbers has been addressed in both human and mouse models, and is likely the result of: 1) recruitment of peripheral NK cells to the uterus, and 2) proliferation of existing uNK cells
  • prolactin system plays an important role in implantation and the maintenance of pregnancy
  • the exact pathways of hormonal regulation of NK cells remain to be delineated.
  • The exact function of uNK cells has not yet been unequivocally determined
  • uNK cells express a different cytokine profile, compared with resting peripheral NK cells. mRNAs for granulocyte CSF, M-CSF, GM-CSF, TNF-α, IFN-γ, TGF-β, and leukemia inhibitory factor (LIF) have been found in decidual CD56+ cells
  • Their increased numbers in early pregnancy, their hormonal dependence, and their close proximity to the infiltrating trophoblast all suggest that they play an important role in the regulation of the maternal immune response to the fetal allograft and the control of trophoblast growth and invasion during human pregnancy
  • role of uNK cell-derived cytokines on trophoblast growth and differentiation (114, 115, 116, 117).
  • Th1 immunity to trophoblast is associated with RPL, whereas Th2 immunity is associated with a successful pregnancy
  • RPL is associated with Th1 immunity, for which NK cells are partly responsible.
  • Nathan Goodyear on 15 Apr 12
     
    dysregulated immune system plays role in recurrent miscarriage.  Specifically, this article discusses natural killer cells (NK).
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Monsanto Roundup: The Impacts of Glyphosate Herbicide on Human Health. Pathways to Mode... - 0 views

www.globalresearch.ca/...5342520 monsanto roundup glyphosate
shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Glyphosate inhibits CYP 450 enzymes.  The author states it well: "glyphosate enhances the damaging effects fo other food borne chemical residues and environnmental toxins.  Additionally, Glyphosate disrupts gut bacterial function in the human gut. This dysbiosis is well known to cause systemic disease, such as obesity, diabetes...
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