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Bisphenol A at Low Nanomolar Doses Confers Chemoresistance in Estrogen Recept... - 0 views

www.ncbi.nlm.nih.gov/...PMC2649216 ER-alpha estrogen receptor Bisphenol A toxins cancer breast
shared by Nathan Goodyear on 18 Oct 12 - No Cached
  • Nathan Goodyear on 18 Oct 12
     
    How do environmental chemicals interfere?  This study shows how Bisphenol A actually interferes at the site of the estrogen receptor alpha.  Bisphenol A decreased the efficacy of chemotherapy in ER +/- breast cancer.  Again, the focus is on the interaction with ER alpha.
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Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoest... - 0 views

carcin.oxfordjournals.org/...1567.short xenoestrogens cancer environmental toxins estrogen
shared by Nathan Goodyear on 18 Mar 12 - No Cached
  • Nathan Goodyear on 18 Mar 12
     
    article discusses the increased estrogenic effect of the xenoestrogens found in chemical toxins.  This has serious implications in cancer that is estrogenic.
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A glyphosate-based herbicide induces necros... [Toxicol In Vitro. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22200534 glyphosate low T testosterone men
shared by Nathan Goodyear on 10 Jan 12 - No Cached
  • Nathan Goodyear on 10 Jan 12
     
    low exposure to glyphosate-based herbicide (round up) decreases Testosterone production by 35%.   This occurs at very low exposure levels of 1 ppm.  In a rat study, large doses causes ACUTE rat TESTICULAR TOXICITY. I think both men and women should be very careful around this chemical
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Obesity - Abstract of article: Body Weight Loss and Weight Maintenance in Relation to H... - 0 views

www.nature.com/...oby2005142a.html obesity weight-loss overweight oolong green tea fat oxidation
shared by Nathan Goodyear on 25 Nov 11 - No Cached
  • Nathan Goodyear on 25 Nov 11
     
    oolong green tea shown to work synergistically with caffeine to increase thermogenesis and fat oxidation resulting in weight loss.  Nature always seems to provide the right balance of chemicals to give the best results. 
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In vitro neurotoxicity of methylisothiazolinone, ... [J Neurosci. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12196562 methylisothiazolinone MI neurotoxic neurology brain neurotoxicity
shared by Nathan Goodyear on 15 Jul 13 - No Cached
  • Nathan Goodyear on 15 Jul 13
     
    Scary.  Common component of many OTC creams and ointments contain chemical, methylisothiazolinone that is neurotoxic.
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Monsanto Roundup: The Impacts of Glyphosate Herbicide on Human Health. Pathways to Mode... - 0 views

www.globalresearch.ca/...5342520 monsanto roundup glyphosate
shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Glyphosate inhibits CYP 450 enzymes.  The author states it well: "glyphosate enhances the damaging effects fo other food borne chemical residues and environnmental toxins.  Additionally, Glyphosate disrupts gut bacterial function in the human gut. This dysbiosis is well known to cause systemic disease, such as obesity, diabetes...
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Taylor & Francis Online :: The microbiome as a target for endocrine disruptors: Novel c... - 0 views

www.tandfonline.com/...23273739.2014.964539 EDC endocrine disrupting chemicals gut flora gut microbiome gut microbiota Testosterone autoimmune disease
shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • Nathan Goodyear on 30 Apr 15
     
    EDCs are proposed to disrupted gut micro biome and thus effect androgen production and autoimmune risk.
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Chronic Inflammation and Cytokines in the Tumor Microenvironment - 0 views

www.hindawi.com/...149185 inflammation cytokines tumor cancer inflammatory IL-6 IL-10 TNF-alpha
shared by Nathan Goodyear on 26 Jun 15 - No Cached
  • Nathan Goodyear on 26 Jun 15
     
    Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma.
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natural ingredients - 0 views

www.diigo.com/...ub3e natural ingredients
shared by spicesboard on 10 Aug 15 - No Cached
  • spicesboard on 10 Aug 15
     
    Spices are special kind of natural products that offer not only great food/ culinary value in terms of aroma, taste, colour and so on, but also tremendous nutritive and therapeutic value because of their chemical composition. http://www.internationalspiceconference.com/delegate-registration.html
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EWG Report || BodyBurden 2 - The Pollution in Newborns - 0 views

www.ewg.org/...execsumm.php pollution newborns bodyburden toxins toxicity
shared by Nathan Goodyear on 21 Mar 11 - Cached
  • Tests revealed a total of 287 chemicals in the group.
  • Of the 287 chemicals we detected in umbilical cord blood, we know that 180 cause cancer in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause birth defects or abnormal development in animal tests
  • Nathan Goodyear on 21 Mar 11
     
    Body Burden - The Pollution in Newborns
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Effects of endocrine disruptors on obesity. [Int J Androl. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18315718 obesity endocrine disruptors toxins toxicity
shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Most recently, obesity has been proposed to be yet another adverse health effect of exposure to endocrine disrupting chemicals (EDCs) during critical stages of development. Obesity is quickly becoming a significant human health crisis
  • The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers.
  • Nathan Goodyear on 06 Apr 11
     
    Effects of endocrine disruptors on obesity.
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Toxic environment and obesity pandemia: is there a... [Ital J Pediatr. 2010] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...20205780 environment toxic obesity
shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Recent cumulating evidence suggests that obesity may represent an adverse health consequence of exposure during the critical developmental windows to environmental chemicals disrupting endocrine function. Moreover, exposure to these chemicals seems to play a key role in the development of obesity-related metabolic and cardiovascular diseases.
  • Nathan Goodyear on 06 Apr 11
     
    Toxic environment and obesity
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Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxid... - 0 views

www.ncbi.nlm.nih.gov/...PMC3180189 cancer reverse warburg effect warburg effect NF-kapppB HIF-1alpha Cav-1 H2O2
shared by Nathan Goodyear on 12 Nov 14 - No Cached
  • reducing oxidative stress with powerful antioxidants, is an important strategy for cancer prevention, as it would suppress one of the key early initiating steps where DNA damage and tumor-stroma metabolic-coupling begins. This would prevent cancer cells from acting as metabolic “parasites
  • Oxidative stress in cancer-associated fibroblasts triggers autophagy and mitophagy, resulting in compartmentalized cellular catabolism, loss of mitochondrial function, and the onset of aerobic glycolysis, in the tumor stroma. As such, cancer-associated fibroblasts produce high-energy nutrients (such as lactate and ketones) that fuel mitochondrial biogenesis and oxidative metabolism in cancer cells. We have termed this new energy-transfer mechanism the “reverse Warburg effect.
  • Then, oxidative stress, in cancer-associated fibroblasts, triggers the activation of two main transcription factors, NFκB and HIF-1α, leading to the onset of inflammation, autophagy, mitophagy and aerobic glycolysis in the tumor microenvironment
  • ...38 more annotations...
  • oxidative stress and ROS, produced in cancer-associated fibroblasts, has a “bystander effect” on adjacent cancer cells, leading to DNA damage, genomic instability and aneuploidy, which appears to be driving tumor-stroma co-evolution
  • tumor cells produce and secrete hydrogen peroxide, thereby “fertilizing” the tumor microenvironment and driving the “reverse Warburg effect.”
  • This type of stromal metabolism then produces high-energy nutrients (lactate, ketones and glutamine), as well as recycled chemical building blocks (nucleotides, amino acids, fatty acids), to literally “feed” cancer cells
  • loss of stromal caveolin (Cav-1) is sufficient to drive mitochondrial dysfunction with increased glucose uptake in fibroblasts, mimicking the glycolytic phenotype of cancer-associated fibroblasts.
  • oxidative stress initiated in tumor cells is transferred to cancer-associated fibroblasts.
  • Then, cancer-associated fibroblasts show quantitative reductions in mitochondrial activity and compensatory increases in glucose uptake, as well as high ROS production
  • These findings may explain the prognostic value of a loss of stromal Cav-1 as a marker of a “lethal” tumor microenvironment
  • aerobic glycolysis takes place in cancer-associated fibroblasts, rather than in tumor cells, as previously suspected.
  • our results may also explain the “field effect” in cancer biology,5 as hydrogen peroxide secreted by cancer cells, and the propagation of ROS production, from cancer cells to fibroblasts, would create an increasing “mutagenic field” of ROS production, due to the resulting DNA damage
  • Interruption of this process, by addition of catalase (an enzyme that detoxifies hydrogen peroxide) to the tissue culture media, blocks ROS activity in cancer cells and leads to apoptotic cell death in cancer cells
  • In this new paradigm, cancer cells induce oxidative stress in neighboring cancer-associated fibroblasts
  • cancer-associated fibroblasts have the largest increases in glucose uptake
  • cancer cells secrete hydrogen peroxide, which induces ROS production in cancer-associated fibroblasts
  • Then, oxidative stress in cancer-associated fibroblast leads to decreases in functional mitochondrial activity, and a corresponding increase in glucose uptake, to fuel aerobic glycolysis
  • cancer cells show significant increases in mitochondrial activity, and decreases in glucose uptake
  • fibroblasts and cancer cells in co-culture become metabolically coupled, resulting in the development of a “symbiotic” or “parasitic” relationship.
  • cancer-associated fibroblasts undergo aerobic glycolysis (producing lactate), while cancer cells use oxidative mitochondrial metabolism.
  • We have previously shown that oxidative stress in cancer-associated fibroblasts drives a loss of stromal Cav-1, due to its destruction via autophagy/lysosomal degradation
  • a loss of stromal Cav-1 is sufficient to induce further oxidative stress, DNA damage and autophagy, essentially mimicking pseudo-hypoxia and driving mitochondrial dysfunction
  • loss of stromal Cav-1 is a powerful biomarker for identifying breast cancer patients with early tumor recurrence, lymph-node metastasis, drug-resistance and poor clinical outcome
  • this type of metabolism (aerobic glycolysis and autophagy in the tumor stroma) is characteristic of a lethal tumor micro-environment, as it fuels anabolic growth in cancer cells, via the production of high-energy nutrients (such as lactate, ketones and glutamine) and other chemical building blocks
  • the upstream tumor-initiating event appears to be the secretion of hydrogen peroxide
  • one such enzymatically-active protein anti-oxidant that may be of therapeutic use is catalase, as it detoxifies hydrogen peroxide to water
  • numerous studies show that “catalase therapy” in pre-clinical animal models is indeed sufficient to almost completely block tumor recurrence and metastasis
  • by eliminating oxidative stress in cancer cells and the tumor microenvironment,55 we may be able to effectively cut off the tumor's fuel supply, by blocking stromal autophagy and aerobic glycolysis
  • breast cancer patients show systemic evidence of increased oxidative stress and a decreased anti-oxidant defense, which increases with aging and tumor progression.68–70 Chemotherapy and radiation therapy then promote further oxidative stress.69 Unfortunately, “sub-lethal” doses of oxidative stress during cancer therapy may contribute to tumor recurrence and metastasis, via the activation of myofibroblasts.
  • a loss of stromal Cav-1 is associated with the increased expression of gene profiles associated with normal aging, oxidative stress, DNA damage, HIF1/hypoxia, NFκB/inflammation, glycolysis and mitochondrial dysfunction
  • cancer-associated fibroblasts show the largest increases in glucose uptake, while cancer cells show corresponding decreases in glucose uptake, under identical co-culture conditions
  • Thus, increased PET glucose avidity may actually be a surrogate marker for a loss of stromal Cav-1 in human tumors, allowing the rapid detection of a lethal tumor microenvironment.
  • it appears that astrocytes are actually the cell type responsible for the glucose avidity.
  • In the brain, astrocytes are glycolytic and undergo aerobic glycolysis. Thus, astrocytes take up and metabolically process glucose to lactate.7
  • Then, lactate is secreted via a mono-carboxylate transporter, namely MCT4. As a consequence, neurons use lactate as their preferred energy substrate
  • both astrocytes and cancer-associated fibroblasts express MCT4 (which extrudes lactate) and MCT4 is upregulated by oxidative stress in stromal fibroblasts.34
  • In accordance with the idea that cancer-associated fibroblasts take up the bulk of glucose, PET glucose avidity is also now routinely used to measure the extent of fibrosis in a number of human diseases, including interstitial pulmonary fibrosis, postsurgical scars, keloids, arthritis and a variety of collagen-vascular diseases.
  • PET glucose avidity and elevated serum inflammatory markers both correlate with poor prognosis in breast cancers.
  • PET signal over-estimates the actual anatomical size of the tumor, consistent with the idea that PET glucose avidity is really measuring fibrosis and inflammation in the tumor microenvironment.
  • human breast and lung cancer patients can be positively identified by examining their exhaled breath for the presence of hydrogen peroxide.
  • tumor cell production of hydrogen peroxide drives NFκB-activation in adjacent normal cells in culture6 and during metastasis,103 directly implicating the use of antioxidants, NFκB-inhibitors and anti-inflammatory agents, in the treatment of aggressive human cancers.
  • Nathan Goodyear on 12 Nov 14
     
    Good description of the communication between cancer cells and fibroblasts.  This theory is termed the "reverse Warburg effect".
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http://www.trjfas.org/pdf/issue_12_01/0121.pdf - 0 views

www.trjfas.org/...0121.pdf probiotics
shared by Nathan Goodyear on 01 Apr 15 - No Cached
  • Nathan Goodyear on 01 Apr 15
     
    Non-medical study finds that probiotics can be used to eliminate pathogenic bacteria.  These probiotics release bactericidal and/or bacteriostatic chemicals that can eradicate/control pathogenic and opportunistic bacteria in aquaculture.  This same logic should be applied to the Gut as well.
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PTFE Syringe Filters Sterile and Non Sterile - Axiva - 0 views

www.axivafilters.com/...ptfe-filters PTFE Syringe Filters Sterile PTFE Syringe Filters
shared by Rahul Sharma on 04 Sep 18 - No Cached
  • Rahul Sharma on 04 Sep 18
     
    PTFE syringe filters is used for the filtration of antagonistic chemicals, including acids and non-aqueous solvents. Axiva provides both sterile and non sterile PTFE syringe filters to our clients.
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How to remove dead skin? - 0 views

beautybycagla.com/how-to-remove-dead-skin hormones hormone cancer Testosterone Men inflammation Disease Male low obesity
shared by beautybycagla on 24 Mar 19 - No Cached
  • beautybycagla on 24 Mar 19
     
    This process, which has different methods such as laser peeling, chemical peeling, and natural peeling, removes toxins from our skin, becomes younger and the pores in our skin are cleaned deeply. In order to get rid of the dead skin on your skin, you can benefit from laser or chemical peeling in order to reach the shiny and smooth skin in a short time, as well as prepare your own peeling with some materials at home; you can have more vivid and smooth skin.
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Glass Fiber Syringe Filters Manufacturer | Axiva - 0 views

www.axivafilters.com/...g-f Glass Fiber Syringe Filters
shared by Rahul Sharma on 09 Oct 18 - No Cached
  • Rahul Sharma on 09 Oct 18
     
    Glass fiber syringe filters are biologically and chemically inert, high retentive depth filters with high dirt holding capacity. This syringe filters are made up 100% borosilicate glass fiber that is 100% binder free.
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Cosmetic Cause Health Problems | Your Health Our Priority - 0 views

www.fnfdoc.com/...cosmetic-cause-health-problems Cosmetic Health Makeup
shared by fnfdoc on 02 May 18 - No Cached
  • fnfdoc on 02 May 18
     
    Personel care items like cosmetic including mascara foundations, body lotions and soaps, hair style products very vital value regarding health and science. Everybody used toxic chemicals in the form of cosmetics. How we take good and healthy steps for good and safe beauty.
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Manufacturer of Carvedilol impurity - 0 views

www.olympusimpuritiesstandard.com/...carvedilol-impurity Carvedilol Impurities
shared by pritikulkarni on 31 May 17 - No Cached
  • pritikulkarni on 31 May 17
     
    Carvedilol Impurities and its products are provided by Olympus Chemical & Fertilizers which is professional impurity manufacturer and supplier. We provide you with wide variety of products of Carvedilol impurities.Olympus Chemicals and Fertilizers is here to help you best class and best value for pharmacopoeia impurities including carvedilol impurities, procedure impurities, metabolite and dilapidation impurities, etc., We provide you best occupied standard as per need, description and your need of impurities.
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Nembutal Liquid | pills nembutal |Nembutal Liquid | - 0 views

www.roidsmeds.com/...nembutal-liquid
shared by ashleyobama on 28 May 20 - No Cached
  • ashleyobama on 28 May 20
     
    Nembutal Liquid is best quality and prices at First Trust Chemicals. Visit our website and place your order online. Nembutal Liquid Pentobarbital (trade name: Nembutal) is a drug from the barbiturate class. It was widely used during the 1940s and 1950s as a sleeping pill (i.e. hypnotic) or anti-anxiety drug (i.e. sedative). Unlike modern sleeping pills, Nembutal is highly lethal in overdose. Because it is very reliable and brings about peaceful death, it is one of drugs of choice for assisted suicide. Nembutal is used by euthanasia organizations in the United States (Oregon Death With Dignity Act), Switzerland (Dignitas) and The Netherlands. Nembutal Liquid Since it was so easy to overdose on Nembutal (whether accidentally or intentionally), it was almost universally taken off the market and replaced by safer sleeping pills. Nembutal was removed from the Australian prescribing schedule in 1998. However, Nembutal remains in use by veterinary surgeons in order to euthanase bigger animals. Many people were successful in obtaining veterinary Nembutal for their suicide. The famous American actress Marilyn Monroe supposedly used Nembutal to end her life. The brand name "Nembutal" was coined by Dr. John S. Lundy, who started using it in 1930, from the structural formula of the sodium salt-Na (sodium) + ethyl + methyl + butyl + al (common suffix for barbiturates). Nembutal is trademarked and manufactured by the Danish pharmaceutical company Lundbeck
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