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Nathan Goodyear

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects - 0 views

www.ncbi.nlm.nih.gov/...PMC3669033

Tongkat Ali long jack cortisol stress testosterone hormone hormones

shared by Nathan Goodyear on 09 Mar 15 - No Cached
  • At the age of 60, testosterone levels are typically only 40-50% of youthful levels and may be lower
  • Eurycoma contains a group of small peptides referred to as “eurypeptides” that are known to have effects in improving energy status and sex drive in studies of rodents
  • The effects of tongkat ali in restoring normal testosterone levels appears to be less due to actually “stimulating” testosterone synthesis, but rather by increasing the release rate of “free” testosterone from its binding hormone, sex-hormone-binding-globulin (SHBG)
  • ...6 more annotations...
  • The current study found that daily supplementation with tongkat ali root extract (200 mg/day) improves stress hormone profile (lower cortisol; higher testosterone) and certain mood state parameters (lower tension, anger, and confusion)
  • tongkat ali supplementation (100 mg/day) improved lean body mass, 1-RM strength, and arm circumference to a significantly greater degree compared to a placebo group.
  • In a recent 12-week trial [46] of Eurycoma longifolia supplementation (300 mg/day), men (30–55 years of age) showed significant improved compared to placebo in the Physical Functioning domain of the SF-36 quality of life survey
  • sexual libido was increased by 11%
  • In men with low testosterone levels (average age 51 years), one month of daily supplementation with tongkat ali extract (200 mg/day) resulted in a significant improvement in serum testosterone levels and quality-of-life parameters
  • rise in cortisol and drop in testosterone is an early signal of “overtraining”
  • Nathan Goodyear on 09 Mar 15
     
    Tongkat Ali, commonly known as long jack, is found to reduce stress and increase Testosterone.  Stress is one of the common causes of low T in men.  It appears that long Jack functions as an adaptogen.
Nathan Goodyear

An adaptive response to uncertainty can lead to weight gain during dieting attempts - 0 views

emph.oxfordjournals.org/...369.full

weight loss nutrition diet weight obesity overweight dieting

shared by Nathan Goodyear on 03 Jan 17 - No Cached
  • dieting attempts cause weight gain via providing (misleading) information about the environment to the subconscious systems that control body mass
  • Our model predicts that energy reserves should respond to repeated attempts to diet by weight cycling and becoming greater from one cycle to the next
  • the very conditions that cause weight gain initially—a glut of food—causes further weight gain once cyclical dieting begins
  • ...1 more annotation...
  • There is evidence that among weight cycling, people those who switch between dieting and binge-eating more frequently gain more weight
  • Nathan Goodyear on 03 Jan 17
     
    yo-yo dieting leads to weight gain, in part, due to increase food intake in between the calorie restriction phases.  The calorie restriction suppresses metabolic rate and results in muscle loss; both of which contribute to the rebound weight gain seen by so many.
Nathan Goodyear

JAMA Network | JAMA | Trends in Obesity Among Adults in the United States, 2005 to 2014 - 0 views

jama.jamanetwork.com/article.aspx

obesity

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    Obesity trends continue in the wrong direction.  According to most recent stats, 40% of American women are obese and 35% of men are obese.  Severe obesity sits at 10% for American women.
Nathan Goodyear

Muscle Strength and Body Mass Index as Long-Term Predictors of Mortality in Initially Healthy Men - 0 views

biomedgerontology.oxfordjournals.org/...M168.full

strength muscle hand-grip strength hand-grip strength test mortality

shared by Nathan Goodyear on 21 Jun 16 - No Cached
  • Nathan Goodyear on 21 Jun 16
     
    low strength via hand-grip strength test found to be associated with increased mortality risk.
Nathan Goodyear

Measuring Adiposity in Patients: The Utility of Body Mass Index (BMI), Percent Body Fat, and Leptin - 0 views

dl-web.dropbox.com/...Leptin%20Testing.pdf

leptin hormone weight loss overweight obesity

shared by Nathan Goodyear on 26 Apr 12 - No Cached
  • Nathan Goodyear on 26 Apr 12
     
    Dr. Braverman nicely discusses the importance of evaluating leptin in the evaluation of obesity.
Nathan Goodyear

Estradiol in elderly men. [Aging Male. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12198740

estrogen estradiol estrone men aromatase activity hormone

shared by Nathan Goodyear on 30 Apr 12 - No Cached
  • Plasma levels of estradiol do not necessarily reflect tissue-level activity
  • age-associated increased aromatization of testosterone
  • Estradiol levels are highly significantly positively related to body fat mass and more specifically to subcutaneous abdominal fat
  • Nathan Goodyear on 30 Apr 12
     
    Review of the sources of estrogens in men and the impact it has on a man's physiology.
Nathan Goodyear

Relationship between endogenous testosterone and cardiovascular risk in early postmenopausal women - 0 views

www.metabolismjournal.com/...abstract

testosterone women high elevated CRP inflammation BMI obesity overweight post-menopausal CVD

shared by Nathan Goodyear on 10 May 12 - No Cached
  • Body mass index and waist circumference were significantly higher in the group with testosterone levels
  • Median CRP levels were greater in the group with higher testosterone level
  • ET-1 levels were also higher in women with greater testosterone levels
  • ...2 more annotations...
  • An association of testosterone with CRP (r = 0.416, P = .004) and ET-1 (r = 0.323, P = .031) was observed
  • Testosterone was also associated with waist circumference and blood pressure (P = .001)
  • Nathan Goodyear on 10 May 12
     
    testosterone associated with elevated CRP, increase BMI, and increased waist circumference in early, post-menopausal women.
Nathan Goodyear

Associations of Maternal Prepregnancy Body Mass Index and Gestational Weight Gain With Adult Offspring Cardiometabolic Risk FactorsClinical Perspective - 0 views

circ.ahajournals.org/...1381

obesity obese overweight pregnancy health cardiovascular children offspring

shared by Nathan Goodyear on 14 May 12 - No Cached
  • Nathan Goodyear on 14 May 12
     
    Obesity of pregnant mothers effect the future cardiovascular health of their future children. The time to work on the health of your future children, is before couples actually get pregnant.
Nathan Goodyear

Measurement of salivary cortisol with liquid chromatography-tandem mass spectrometry in patients undergoing dynamic endocrine testing - Perogamvros - 2009 - Clinical Endocrinology - Wiley Online Library - 1 views

onlinelibrary.wiley.com/...abstract

saliva salivary test testing evaluation cortisol BHRT LC-MS

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    LC-MS/MS shows excellent sensitivity and specificity for cortisol evaluation
Nathan Goodyear

Diagnostic Characteristics of Late-Night Salivary Cortisol Using Liquid Chromatography-Tandem Mass Spectrometry - 0 views

jcem.endojournals.org/...4555.abstract

cortisol night-time LC-MS saliva salivary hormone hormones testing test evaluation BHRT

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    night-time cortisol via LC shown to reliable in detection of Cushing Syndrome
Nathan Goodyear

Development and validation of stable-isotope dilution liquid chromatography-tandem mass spectrometric method for determination of salivary progesterone - Higashi - 2011 - Biomedical Chromatography - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...full

hormone hormones liquid chromatography saliva salivary testing test evaluation BHRT progesterone

shared by Nathan Goodyear on 26 Nov 11 - No Cached
  • Nathan Goodyear on 26 Nov 11
     
    LC-ESI-MS/MS) for hormone evaluation has been validated for hormone testing.  Progesterone was used in this study.
Nathan Goodyear

Targeting gut microbiota in obesity: effects of prebiotics and probiotics : Article : Nature Reviews Endocrinology - 0 views

www.nature.com/...nrendo.2011.126.html

LPS lipopolysaccharides gut microbiota dysbiosis inflammation obesity metabolic endotoxemia health probiotics

shared by Nathan Goodyear on 18 Jan 12 - No Cached
  • gut microbes have a role in the host's metabolic homeostasis
  • lipopolysaccharide (LPS)
  • Associations between circulating LPS level, consumption of a high-fat diet and the presence of obesity and type 2 diabetes mellitus have been confirmed in humans
  • ...8 more annotations...
  • high-fat diet induces metabolic endotoxemia in healthy individuals.
  • A link between energy intake (high-fat diet) and metabolic endotoxemia has also been described
  • associations have been proposed between high-fat diet, metabolic endotoxemia and levels of inflammatory markers (TLRs and SOCS3) in mononuclear cells
  • metabolic endotoxemia is associated with systemic and adipose tissue inflammation in pregnant women with obesity
  • A growing amount of evidence indicates that changes in the integrity of the intestinal barrier occur both in the proximal and the distal part of the gut, which can contribute to the entrance of LPS into the systemic circulation
  • intestinal endocannabinoid system
  • The low-grade systemic inflammation that characterizes the obese phenotype is controlled by peptides that are produced in the gut. These peptides are influenced by the presence or absence of the gut microbiota
  • these findings suggest that the gut microbiota modulates the biological systems that regulate the availability of nutrients, energy storage, fat mass development and inflammation in the host, which are all components of the obese phenotype
  • Nathan Goodyear on 18 Jan 12
     
    good look of how the the gut health, or lack there of, can influence energy homeostasis and contribute to obesity.  This article points to the presence of LPS playing a role in metabolic endotoxemia.  It does discuss the importance of the microbiota and their possible role in the low-grade systemic inflammation condition that is obesity.
Nathan Goodyear

Effect of Body Mass Index on Peak Growth Hormone Response to Provocative Testing in Children with Short Stature - 0 views

www.ncbi.nlm.nih.gov/...PMC2795667

HGH human growth hormone provocative testing growth hormone L-Dopa

shared by Nathan Goodyear on 17 Jul 12 - No Cached
  • Nathan Goodyear on 17 Jul 12
     
    HGH evaluation using provocative testing.
Nathan Goodyear

Steroid measurement with LC-MS/MS... [J Steroid Biochem Mol Biol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20036331

LC-MS_MS hormone hormones saliva salivary testing evaluation mass spectroscopy

shared by Nathan Goodyear on 05 Jun 12 - No Cached
  • Nathan Goodyear on 05 Jun 12
     
    LC-MS/MS overcomes the limitations of immunoassays in hormone testing.  LC-MS/MS is the new gold standard with sensitivity, specificity, and ease second to none.  LC-MS/MS is the bench science now coming to the practice of medicine.
Nathan Goodyear

Challenges and benefits of endogenous steroid an... [Bioanalysis. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22122603

saliva salivary testing hormone hormones LC-MS_MS mass spectroscopy GC-MS

shared by Nathan Goodyear on 05 Jun 12 - No Cached
  • Nathan Goodyear on 05 Jun 12
     
    LC-MS/MS shown to be "accurate and highly sensitive" when compared to GC-MS for saliva testing of hormones.  Up to this point, GC-MS has been considered the "gold standard".
Nathan Goodyear

Principles and clinical applications of ... [J Endocrinol Invest. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21738000

LC-MS_MS hormone hormones testing evaluation mass spectroscopy

shared by Nathan Goodyear on 05 Jun 12 - No Cached
  • Nathan Goodyear on 05 Jun 12
     
    LC-MS/MS will be the new gold standard in hormone evaluation.
Nathan Goodyear

Salivary Hormone Measurement Using LC/MS/MS: Specific and Patient- Friendly Tool for Assessment of Endocrine Function - 0 views

www.jstage.jst.go.jp/..._pdf

hormone hormones saliva salivary testing mass spectroscopy LC MS liquid chromatography

shared by Nathan Goodyear on 19 Sep 12 - No Cached
  • Nathan Goodyear on 19 Sep 12
     
    Great review on the literature of LC-MS/MS and now the new ESI-MS/MS method in saliva hormone testing. This technique is highly sensitive and specific. This article goes through the literature support for each hormone. It also discusses how/why saliva testing is valid. Conclusion: "the author believes that the saliva-based hormone test will be integrated into clinical practice in the near future".
Nathan Goodyear

Sex steroids and cardiovascular disease Yeap BB - Asian J Androl - 0 views

www.ajandrology.com/article.asp

cardiovascular disease CVD sex estradiol carotid intima-media thickness hormones hormone men Testosterone estrogen

shared by Nathan Goodyear on 15 Jan 14 - No Cached
  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases.
  • calculations based on mass action equations may not reflect precisely free T measured using a reference method
  • free T declines more steeply with age than total T in both cross-sectional [35] and longitudinal studies, [36] as does free E2 in comparison to total E2
  • ...22 more annotations...
  • T may slow development of or progression of atherosclerosis by modulating effects on insulin resistance, inflammation, endothelial function, preclinical atherosclerosis or the vasculature.
  • these cross-sectional and longitudinal studies support a relationship between low circulating T with CIMT and higher E2 with its progression
  • lower levels of T are biomarkers for aortic vascular disease
  • circulating free T was negatively associated with the presence of AAA
  • luteinizing hormone (LH) was positively associated.
  • low levels of total or bioavailable T were associated with aortic atherosclerosis manifested as calcified deposits detected by radiography
  • Men with total or free T in the lowest quartile had increased adjusted ORs for PAD defined as ABI <0.90, as did men with free E2 in the highest quartile of values
  • The apparent association of SHBG with intermittent claudication reflects the correlation of total T with SHBG, while the contribution of E2 to risk of PAD remains unclear
  • men with total T in the lowest quartile of values (<11.7 nmol l−1 ) experienced an increased incidence of stroke or transient ischemic attack
  • lower total T with increased incidence of CVD events
  • cohort studies in mostly older men have supported the association of lower androgen levels with higher mortality
  • lower total or free T levels were associated with mortality in older men, but with discordant results for cause-specific mortality and for associations of E2
  • several large studies identifying lower endogenous levels of total or free T as independent predictors of all-cause or CVD-related deaths in middle-aged and older men
  • T exhibits anti-inflammatory effects, enhances flow-mediated brachial artery reactivity, and reduces arterial stiffness
  • Short-term T therapy had a beneficial effect on exercise-induced myocardial ischemia in middle-aged men with coronary artery disease or chronic stable angina, [95],[96],[97] and reduced angina frequency in older men with diabetes and coronary artery disease
  • T therapy resulted in an increase in treadmill test duration and time to ST segment depression
  • there are interventional studies supporting a protective effect of exogenous T against myocardial ischemia in men with coronary artery disease
  • employ conservative doses
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      This dosing is 100 fold higher then peak production of a  young man at 20-22.
  • Observational studies indicate that lower levels of endogenous T in older men are associated with the presence of carotid atherosclerosis, aortic and peripheral vascular disease, and incidence of CVD events and mortality
  • Interventional studies have shown beneficial effects of exogenous T on vascular function and on exercise-induced myocardial ischemia in men with coronary artery disease
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      the therapies employed in these studies were massively overdosed.
  • Nathan Goodyear on 15 Jan 14
     
    Nice review of all the sex hormones and their relationship to CVD in men.  
Nathan Goodyear

Characteristics of Secondary, Primary, and Compensated Hypogonadism in Aging Men: Evidence from the European Male Ageing Study: The Journal of Clinical Endocrinology & Metabolism: Vol 95, No 4 - 0 views

press.endocrine.org/...jc.2009-1796

low T Testosterone obesity overweight men male hormone hormones

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Older men were more likely to have primary [relative risk ratio (RRR) = 3.04; P < 0.001] and compensated (RRR = 2.41; P < 0.001) hypogonadism. Body mass index of 30 kg/m2 or higher was associated with secondary hypogonadism (RRR = 8.74; P < 0.001)
  • Nathan Goodyear on 04 Feb 14
     
    The prevalence of low T varies significantly between lean versus overweight men.  This suggests a significant contribution of obesity and its biologic effects as a cause of low T.  The difference is 30%.
Nathan Goodyear

PLOS ONE: Mode of Delivery and Offspring Body Mass Index, Overweight and Obesity in Adult Life: A Systematic Review and Meta-Analysis - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0087896

caesarean section delivery obesity BMI overweight

shared by Nathan Goodyear on 04 Mar 14 - No Cached
  • Nathan Goodyear on 04 Mar 14
     
    Caesarean Section appears to be associated with increased obesity rates, according to meta-analysis.
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