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Nathan Goodyear

Stress proteins and glial cell functions durin... [Neurochem Res. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22130689

aluminum AL NF-kappaB inflammation TNF-alpha glial cells glia microglia brain neurology vaccines vaccinations curcumin

shared by Nathan Goodyear on 25 Nov 13 - No Cached
  • Nathan Goodyear on 25 Nov 13
     
    aluminum shown to significantly increase NF-kappaB activity and TNF-alpha release from glial cells.  This study also found a reduction with concomitant dosing of curcumin.  All those claiming aluminum in vaccines has no side effects are without merit.
Nathan Goodyear

Aluminum-induced Defective Mitochondrial Metabolism Perturbs Cytoskeletal Dynamics in Human Astrocytoma Cells | Joe Lemire - Academia.edu - 0 views

www.academia.edu/...ics_in_Human_Astrocytoma_Cells

aluminum astrocytes brain inflammation neurology AL

shared by Nathan Goodyear on 25 Nov 13 - No Cached
  • Nathan Goodyear on 25 Nov 13
     
    Aluminum destructive to astrocytes in the brain.
Nathan Goodyear

L-theanine Administration Results in Neuroprot... [Phytother Res. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23097345

l-theanine CVA stroke neurology

shared by Nathan Goodyear on 15 Oct 13 - No Cached
  • Nathan Goodyear on 15 Oct 13
     
    l-Theanine is neuroprotective in rat mode simulating CVA.
Nathan Goodyear

Macrophagic myofasciitis: characterization and pathophysiology - 0 views

www.ncbi.nlm.nih.gov/...PMC3623725

Aluminum vaccines macrophage myofasciitis CNS brain neurology

shared by Nathan Goodyear on 20 Jun 13 - No Cached
  • Nathan Goodyear on 20 Jun 13
     
    Aluminum in vaccines shown to stimulate a massive autoimmune reaction.  These reactions can be localized or distant from site of injection.  Accumulation occurs in the brain and CNS.  The name give is macrophagic myofasciitis.
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

nnr.sagepub.com/...75.long

curcumin DHA TBI traumatic brain injury brain injury neuroinflammation BDNF brain derived neurotrophic factor brain

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
  • TBI elicits oxidative damage to plasma membrane phospholipids
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
  • ...10 more annotations...
  • curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.
  • curcumin may promote the conversion of n-3 DPA to DHA
  • the combination of both nutrients has been reported to produce anti-inflammatory action
  • the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
  • curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.
  • Nathan Goodyear on 31 Aug 15
     
    Curcumin and DHA shown to protect against TBI through a reduction in inflammation and maintenance of brain phospholipid membranes.  BDNF is increases also.
Nathan Goodyear

[Role of glutamate and excitotoxicity in neurologi... [Rev Neurol (Paris). 1996] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8763652

glutamate excitotoxicity

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • Nathan Goodyear on 07 Feb 11
     
    nice abstract on the basic physiologic role of glutamate excitotoxicity
Nathan Goodyear

Coenzyme Q10 reverses pathological phenotype and r... [Neurology. 2001] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...11502923

CoQ10

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • The authors conclude that muscle CoQ10 deficiency can be corrected by supplementation of CoQ10, which appears to stimulate mitochondrial proliferation and to prevent apoptosis.
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 supplementation shown to resolve familial CoQ10 deficiency
Nathan Goodyear

Mitochondrial dysfunction in distal axons contributes to human immunodeficiency virus sensory neuropathy - Lehmann - 2010 - Annals of Neurology - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

mitochondrial dysfunction neuropathy

shared by Nathan Goodyear on 18 May 11 - No Cached
  • Nathan Goodyear on 18 May 11
     
    mitochondrial damage associated with neuropathy
Nathan Goodyear

Relationship of UV exposure to prevalence of multi... [Neurology. 2011] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...21502600

Vitamin D MS UK

shared by Nathan Goodyear on 17 May 11 - No Cached
  • The effect of UVB on generating vitamin D seems the most likely candidate for explaining its relationship with MS
  • UVB exposure and IM together can explain a substantial proportion of the variance of MS
  • Nathan Goodyear on 17 May 11
     
    Vitamin D and MS in the UK
Nathan Goodyear

Vitamin D intake and incidence of multiple scleros... [Neurology. 2004] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...14718698

vitamin d MS

shared by Nathan Goodyear on 17 May 11 - No Cached
  • a protective effect of vitamin D intake on risk of developing MS.
  • Nathan Goodyear on 17 May 11
     
    vitamin D intake protects against risk of MS
Nathan Goodyear

Central obesity and increased risk of dementia mor... [Neurology. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18367704

central obesity risk dementia

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • Fifty percent of adults have central obesity
  • Central obesity in midlife increases risk of dementia independent of diabetes and cardiovascular comorbidities
  • Nathan Goodyear on 12 Apr 11
     
    central obesity and dementia
Nathan Goodyear

How environmental and genetic factors combine to c... [Neurotoxicology. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18031821

autism spectrum disorders ASD

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • Genetic polymorphisms adversely affecting sulfur metabolism, methylation, detoxification, dopamine signaling and the formation of neuronal networks occur more frequently in autistic subjects.
  • a "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.
  • Nathan Goodyear on 05 Jul 11
     
    proposed hypothesis of autism
Nathan Goodyear

Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis - 0 views

www.neurology.org/...382

vitamin D MS multiple Sclerosis inflammation IL-17

shared by Nathan Goodyear on 25 Feb 16 - No Cached
  • Nathan Goodyear on 25 Feb 16
     
    High dose vitamin D (10,400 IU) found to reduce IL-17, CD161 and effector memory cells; in contrast low dose vitamin D (800 IU)  did not.  The study also called into question the traditional target range of vitamin D.  The authors here proposed 40-60
Nathan Goodyear

Neurological benefits of omega-3 fatty acids. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18543124

EPA DHA omega 3 omega-3 essential fatty acids brain

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Nathan Goodyear on 20 Feb 16
     
    EPA/DHA are highly concentrated in neuronal synapse.
Nathan Goodyear

Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis - 0 views

www.neurology.org/...WNL.0000000000002316

multiple Sclerosis MS vitamin D inflammation IL-17

shared by Nathan Goodyear on 07 Jan 16 - No Cached
  • Nathan Goodyear on 07 Jan 16
     
    Not only is high dose vitamin D3 therapy more effective in reducing IL-17 compared to low dose, but it is safe to in individuals with MS.  The hot topic these days is immunotherapy: that is exactly what vitamin D therapy is.
Nathan Goodyear

Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy - 1 views

www.ncbi.nlm.nih.gov/...PMC5067498

DCA dichloroacetate dichloracetic acid cancer colon cancer

shared by Nathan Goodyear on 18 Jan 18 - No Cached
  • inhibition of mitochondrial pyruvate dehydrogenase kinase
  • inhibition of aerobic glycolysis (the Warburg effect) and activation of mitochondrial potassium ion channels
  • angiogenesis blockade
  • ...5 more annotations...
  • changes in expression of HIF1-α
  • alteration of pH regulators V-ATPase and MCT1, and other cell survival regulators such as PUMA, GLUT1, Bcl2 and p53
  • DCA as a cancer stabilizing agent
  • A protocol of natural medications was developed to address the dose-limiting neurologic toxicity, in collaboration with a naturopathic physician (Andrews). The oral DCA regimen that was developed included three natural medications acetyl L-carnitine[29-31], R-alpha lipoic acid[32-34] and benfotiamine[35-37], for the primary purpose of neuropathy prevention
  • measurable benefits from DCA therapy in 60%-70% of cases
  • Nathan Goodyear on 18 Jan 18
     
    Good review of dichloracetate or DCA in antitumor activity.  DCA has been shown to have numerous anticancer properties.
rajeshsharma10

Best Neuro Hospital in Hyderabad | Neuro Specialty Hospital in Hyderabad - 0 views

www.prathimahospitals.com/...neurology

best neuro hospital in hyderabad

shared by rajeshsharma10 on 16 Jul 18 - No Cached
  • rajeshsharma10 on 16 Jul 18
     
    Prathima Hospital is the best neuro hospital in hyderabad. Department of neuro sciences located in kachiguda and kukatpally.
spineneuro

French to India Medical Travel: Le meilleur neurochirurgien Gamma Knife à Delhi offre le meilleur de la neurologie - 0 views

frenchtoindiamedicaltravel.blogspot.com/...ers-the-best-in-neurology.html

chirurgie au couteau gamma chirurgien au couteau gamma en Inde

shared by spineneuro on 14 Mar 22 - No Cached
  • spineneuro on 14 Mar 22
     
    La chirurgie au couteau gamma avec le meilleur neurochirurgien au couteau gamma à Delhi est très inférieure d'environ 30 à 70% moins chère par rapport au coût de la chirurgie dans les pays développés.
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