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Nathan Goodyear

Arch Intern Med -- Abstract: Effect of Different Antilipidemic Agents and Diets on Mortality: A Systematic Review, April 11, 2005, Studer et al. 165 (7): 725 - 0 views

archinte.ama-assn.org/...725

Omega-3 fish oil lipids cholesterol

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • Statins and n-3 fatty acids are the most favorable lipid-lowering interventions with reduced risks of overall and cardiac mortality.
  • Nathan Goodyear on 15 Feb 11
     
    Omega-3 most favorable lipid lowering agent
Nathan Goodyear

Cell - GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects - 0 views

www.cell.com/...S0092-8674(10)00888-3

Omega-3 DHA EPA insulin resistance Diabetes

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • ω-3 FA receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo
  • Nathan Goodyear on 15 Feb 11
     
    Omega-3 improves insulin sensitivity
Nathan Goodyear

Mechanism of Human SIRT1 Activation by Resveratrol - 0 views

www.jbc.org/...17187.short

Resveratrol SIRT1

shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell cycle regulation, and life span extension
  • resveratrol was shown to increase life span in three model organisms through a Sir2-dependent pathway.
  • Nathan Goodyear on 18 Mar 11
     
    Resveratrol potentially increases life span through SIRT1 activation
Nathan Goodyear

SpringerLink - Diabetologia, Volume 42, Number 2 - 0 views

www.springerlink.com/...l50vrq37getytvjw

fatty acids saturated fats glucose insulin

shared by Nathan Goodyear on 27 May 11 - No Cached
  • Nathan Goodyear on 27 May 11
     
    The type of fat you eat can increase the insulin response to glucose.  For example, saturated fats + glucose  promote a larger insulin response than does glucose alone.
Nathan Goodyear

Polyunsaturated fatty acids inhibit hepatic stearo... [Lipids. 1996] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8729090

Omega-3 SCD stearoyl-CoA desaturease obesity weight gain

shared by Nathan Goodyear on 27 May 11 - No Cached
  • Nathan Goodyear on 27 May 11
     
    Poly-unsaturated fats, particularily Omega-3, blocks SCD activity
Nathan Goodyear

Hormonal and metabolic effects of polyunsaturated fatty acids in young women with polycystic ovary syndrome: results from a cross-sectional analysis and a randomized, placebo-controlled, crossover trial - 0 views

www.ajcn.org/...652.abstract

metabolic syndrome Omega-3 PCOS

shared by Nathan Goodyear on 09 May 11 - No Cached
  • n−3 PUFAs improves androgenic profiles in PCOS
  • Nathan Goodyear on 09 May 11
     
    omega shown to reduce androgens in women with PCOS
Nathan Goodyear

Anti-obesity effects of green tea: from bedside to... [Mol Nutr Food Res. 2006] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...16470636

obesity weight loss green tea extract

shared by Nathan Goodyear on 05 May 11 - No Cached
  • Green tea, green tea catechins, and epigallocatechin gallate (EGCG) have been demonstrated in cell culture and animal models of obesity to reduce adipocyte differentiation and proliferation, lipogenesis, fat mass, body weight, fat absorption, plasma levels of triglycerides, free fatty acids, cholesterol, glucose, insulin and leptin, as well as to increase beta-oxidation and thermogenesis.
  • Studies conducted with human subjects report reduced body weight and body fat, as well as increased fat oxidation and thermogenesis and thereby confirm findings in cell culture systems and animal models of obesity
  • Nathan Goodyear on 05 May 11
     
    Green tea and Green tea extract aid in many areas of weight loss
Nathan Goodyear

Long chain omega 3 polyunsaturated fatty acids sup... [J Nutr Health Aging. 2011] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...21267525

shared by Nathan Goodyear on 09 Jun 11 - No Cached
  • Nathan Goodyear on 09 Jun 11
     
    Omega-3 improves depression symptoms in elderly
Nathan Goodyear

Dietary Sugars Stimulate Fatty Acid Synthesis in Adults - 0 views

jn.nutrition.org/...1039.abstract

fructose HCFS obesity overweight fat Sugars diet dietary

shared by Nathan Goodyear on 19 Aug 11 - No Cached
  • Nathan Goodyear on 19 Aug 11
     
    fructose intake equals fat storage
Nathan Goodyear

Omega-3 fatty acids in inflammation and autoimmune diseases. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12480795

omega 3 omega-3 fish oil inflammation autoimmune disease

shared by Nathan Goodyear on 07 Feb 16 - No Cached
  • Nathan Goodyear on 07 Feb 16
     
    review article finds omega-3 supplementation reduced inflammation in autoimmune disease.
Nathan Goodyear

Medium Chain Triglycerides (MCTs) | Nutrition Review - 0 views

nutritionreview.org/...edium-chain-triglycerides-mcts

MCT medium chain fatty acids medium chain triglycerides

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • lower caloric content than LCTs
  • MCTs are not stored in fat deposits in the body as much as LCTs
  • MCTs have been shown to enhance thermogenesis
  • Nathan Goodyear on 20 Feb 16
     
    great review of medium chain triglycerides.
Nathan Goodyear

Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling - 0 views

www.ncbi.nlm.nih.gov/...PMC4741919

adenoid cystic carcinoma

shared by Nathan Goodyear on 03 Oct 18 - No Cached
  • Cisplatin and 5-FU or CAP (cisplatin, doxorubicin, and cyclophosphamide) regimens can be used for combination chemotherapy
  • patients with advanced salivary gland malignancy treated with the CAP regimen achieved partial response (PR) or stable disease (SD) rates of 67% (8 out of 12 patients)
  • Agents commonly given as monotherapy for treating ACC are cisplatin, mitoxantrone, epirubicin, vinorelbine, paclitaxel, and gemcitabine. However, few of these agents have shown efficacy
  • ...23 more annotations...
  • single agent mitoxantrone or vinorelbine were recommended as reasonable choices
  • ACC is subdivided into 3 histological groups based on solid components of the tumor including cribriform, tubular, and solid
  • Cribriform and tubular ACCs usually exhibit a more indolent course, whereas the solid subtype is associated with worse prognosis
  • ACC consists of two different cell types: inner luminal epithelial cells and outer myoepithelial cells
  • epithelial cells express c-kit, cox-2 and Bcl-2
  • myoepithelial cells express EGFR and MYB
  • a balanced translocation of the v-myb avian myeloblastosis viral oncogene homolog-nuclear factor I/B (MYB-NFIB) is considered to be a signature molecular event of ACC oncogenesis
  • As a transcription factor, MYB is known to modulate multiple genetic downstream targets involved in oncogenesis, such as cox-2, c-kit, Bcl-2 and BclX
  • Various signaling cascades are essential for cancer cells to survive and grow. The PI3K/Akt/mTOR pathway is one of them
  • This pathway regulates cell survival and growth and is upregulated in many cancers
  • Mutations in genes associated with DNA repair are frequently found in familial cancer syndromes, such as hereditary breast-ovarian cancer syndrome (HBOC), hereditary non-polyposis colorectal cancer (HNPCC, also called Lynch syndrome) and Li-Fraumeni syndrome [30, 31]. These mutations were also reported in non-hereditary cancers
  • 70% of ACC samples (58 of 84) were found to have genetic alterations in the MYB/MYC pathway, indicating that changes in this pathway are crucial in ACC pathogenesis
  • The second most frequently mutated pathway was involved in chromatin remodeling (epigenetic modification), a pathway that includes multiple histone related proteins, and was altered in 44% of samples
  • C-kit
  • VEGF, iNOS and NF-κB were noted to be highly expressed in ACC cells as compared to normal salivary gland cells
  • members of the SOX family, such as SOX 4 and SOX10, are overexpressed in ACC
  • FABP7 (Fatty acid binding protein 7) and AQP1 (Aquaporin 1) tend to be overexpressed in ACC cell lines
  • considerable variability in HER2 overexpression ranging from 0–58% in patients with ACC
  • the study with cetuximab and concurrent chemoradiation or chemotherapy showed the highest ORR (total 43%, 9.5% CR and 33% PR), but this regimen was only given to the EGFR positive patients
  • Cancer immunotherapy can be classified into 3 major groups. Active immunization using anti-tumor vaccines to induce and recruit T cells, passive immunization based on monoclonal antibodies, and adoptive cell transfer to expand tumor-reactive autologous T cells ex vivo and then reintroduce these cells into the same individual
  • LAK cells showed cytotoxicity against ACC cells
  • cytokine-induced cell apoptosis and the cytotoxic effect of the LAK cells contributed to tumor regression
  • molecular finding of the MYB-NFIB fusion gene has the greatest potential to target what appears to be a fundamental event in disease pathogenesis
  • Nathan Goodyear on 03 Oct 18
     
    good review of adenoid cystic carcinoma
Nathan Goodyear

Survey of n-3 and n-6 polyunsaturated fatty acids in fish and fish products - 0 views

www.ncbi.nlm.nih.gov/...PMC3543232

omega 3 omega-6 omega-3 fish EPA DHA ALA diet nutrition

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    Good read on the omega 3 versus omega 6 content of different fish.
Nathan Goodyear

Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation - 0 views

www.ncbi.nlm.nih.gov/...PMC5405524

epigenetics nutrigenomics omega 3 omega-3 diet nutrition methylation fats EPA DHA

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • Nathan Goodyear on 15 Sep 17
     
    Epigenetic and really nutrigenomics: 6 week study of 3 gram omega 3 intake induced methylation changes.  Get that?  Only 6 weeks of omega 3 intake induces a change in genetic expression.
Nathan Goodyear

Original Articles: Comparison of Insulin Action on Glucose versus Potassium Uptake in Humans - 0 views

www.ncbi.nlm.nih.gov/...PMC3133473

diabetes insulin resistance potassium hyperkalemia glucose insulin

shared by Nathan Goodyear on 31 Oct 17 - No Cached
  • When treating hyperkalemia, insulin remains efficacious in diabetics and nondiabetics and one does not need to resort to b-agonists, and diabetics do not require different doses of insulin to shift potassium
  • the commonly encountered “insulin-resistant” patients actually have preserved insulin-induced potassium disposal, one wonders why their high insulin levels are not causing hypokalemia
  • insulin independently regulates glucose and potassium uptake into cells and this independence explains why in noninsulin-dependent diabetic insulin resistance leads to impaired insulin uptake into cells but has no effect on the cell's potassium disposal
  • ...9 more annotations...
  • insulin suppresses glycogenolysis, gluconeogenesis, lipolysis and fatty acid release, and protein catabolism and is the principal hormone that stimulates glucose uptake into mainly skeletal muscle and to a certain extent adipocytes
  • Plasma [K+] is a major determinant of the resting potential of all cells
  • Hyperkalemia and hypokalemia are silent yet fatal disturbances because of their arrhythmogenic potentials
  • Basal insulin maintains fasting plasma [K+] within the normal range
  • When insulin levels are suppressed, plasma [K+] rises and pronounced hyperkalemia develops after a potassium load
  • Potassium is a well proven insulin secretagogue
  • Insulin is a key defender against exogenous potassium load by using intracellular buffering to minimize hyperkalemia before renal excretion
  • Hyperkalemia is often encountered in patients with diabetes
  • The insulin-deficient state in type 1 diabetes predisposes to hyperkalemia because of an impaired ability of potassium to enter cells. During hyperglycemic hypertonic states in type 1 and type 2 diabetics, potassium is carried out of cells by convective flux as the most abundant intracellular cation
  • Nathan Goodyear on 31 Oct 17
     
    good review of the potassium, glucose, insulin relationship mostly in diabetes.  In diabetes, hyperkalemia is present due to the hyperglycemia and the associated exchange.  Inuslin independantly regulates potassium and glucose intake into the cell.  INterestingly, in IR found in diabetes, the hyperkalemia is the norm, which should cause hypokalemia--the authors were perplexed by this finding.
Nathan Goodyear

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury - 0 views

www.ncbi.nlm.nih.gov/...PMC5525354

omega 3 omega-3 microglia TBI traumatic brain injury brain inflammation

shared by Nathan Goodyear on 01 Aug 17 - No Cached
  • Nathan Goodyear on 01 Aug 17
     
    Omega 3 supplementation found to blunt microglial TBI inflammation. 
Nathan Goodyear

Nutrients | Free Full-Text | Effect of Probiotics on Metabolic Outcomes in Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | HTML - 0 views

www.mdpi.com/...htm

probiotics alternative medicine natural medicine natural therapies diabetes gestational diabetes

shared by Nathan Goodyear on 15 May 17 - No Cached
  • The gut microbial composition is altered during pregnancy
  • probiotic supplements may contribute to the maintenance of bacterial diversity and glucose homeostasis in individuals with metabolic disturbances
  • Assessment of four randomized controlled trials in this review involving 288 pregnant women with GDM found that a 6–8 week probiotic intervention did not improve FBG or LDL-cholesterol levels
  • ...5 more annotations...
  • probiotic supplementation in women with GDM was associated with significant reductions in insulin resistance
  • One proposed method is by the production of short chain fatty acids (SCFAs), generated as a by-product of bacterial fermentation of dietary fibers. SCFAs act as an energy source for intestinal cells and have been found to regulate the production of hormones effecting energy intake and expenditure such as leptin and grehlin
  • Another hypothesized mechanism of SCFA action includes reducing gastrointestinal permeability by upregulating transcription of tight junction proteins, enhancing production of Glucagon-like peptide-2 (GLP-2) which promotes crypt cell proliferation, and reducing inflammation in colonic epithelial cells by increasing PPAR-gamma activation
  • Maintenance of the integrity of the gut barrier minimizes the concentration of lipopolysaccharide (LPS) in circulation
  • LPS is a structural component of gram negative bacterial cell walls, which induces an immune-cell response upon absorption into the human bloodstream, stimulating proinflammatory cytokine production and the onset of insulin resistance and hyperglycemia
  • Nathan Goodyear on 15 May 17
     
    Review (4 studies) found that 6-8 weeks of probiotic therapy of pregnant women with gestational diabetes improved insulin resistance.
  • Open TeleShop on 17 May 17
     
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