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Nathan Goodyear

The Association between Premature Coronary Art... [Arch Iran Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25065277

low T Testosterone low T low Testosterone free Testosterone Total Testosterone CAD coronary artery disease atherosclerosis heart disease men male hormone hormones health

shared by Nathan Goodyear on 30 Jul 14 - No Cached
  • Nathan Goodyear on 30 Jul 14
     
    Low free and Total Testosterone levels found to be associated with premature CAD in men.  Some confounders were present, which they tried to account for--this should leave some healthy questioning of this study results.  That being said, this is not the first time low T has been found to be associated with CAD in men.  This study found a statistical significant association with Free and Total Testosterone levels in young men.  Another point to consider is the Low T a cause or a biomarker and an effect of poor/declining health?  I would so more to the biomarker point.
Nathan Goodyear

Levels of serum testosterone predict prevalent but not incident non... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25708291

Testosterone NAFLD non-alcoholic fatty liver liver disease men male hormone hormones

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Lower Testosterone associated with increased prevalence of NAFLD in men.   Higher Testosterone levels did not reduce or reverse progression of NAFLD in men. This points to Testosterone as just one piece of the metabolic puzzle in metabolic syndrome, NAFLD... in men.  
Nathan Goodyear

Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study: The Journal of Clinical Endocrinology & Metabolism: Vol 87, No 2 - 0 views

press.endocrine.org/...jcem.87.2.8201

low T Testosterone low T low Testosterone male men hormone hormones DHT aging BMI MMAS Massachusetts Male Aging Study

shared by Nathan Goodyear on 11 Aug 14 - No Cached
  • Nathan Goodyear on 11 Aug 14
     
    MMAS study finds an age associated decline in Total Testosterone and free Testosterone levels. This study focus on the % decline based on other variables i.e. age, BMI...IN contrast, a 3.5% rise in DHT levels were observed. There is debate about the correlation of serum DHT and intra-tissue DHT. In fact, studies suggest there is little correlation.
Nathan Goodyear

Testosterone therapy not associated with myocardial infarction, stroke | Endocrinology - 0 views

www.healio.com/...h-myocardial-infarction-stroke

low T Testosterone therapy treatment cardiovascular disease MI stroke men male hormone hormones

shared by Nathan Goodyear on 19 May 14 - No Cached
  • Nathan Goodyear on 19 May 14
     
    Retrospective study finds no increase in new MI and/or stroke in men with Testosterone therapy.  There are some men that Testosterone therapy is cardioprotective and some that are not.
Nathan Goodyear

The effect of ezetimibe-statin combination on steroid hormone produ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25712655

Testosterone men male hormone hormones statin cholesterol CVD cardiovascular disease

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Statin and combined Ezetimibe-statin therapy reduce Testosterone levels in men--though combination therapy reduced LH and Testosterone levels less than high dose statin therapy, but it still did reduce Testosterone.  This is so counterproductive and reveals much of the thought behind cholesterol.  Low T in men is associated with all CVD.
Nathan Goodyear

Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome? - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25851658

SHBG total Testosterone free Testosterone Testosterone metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 13 Apr 15 - No Cached
  • Nathan Goodyear on 13 Apr 15
     
    Nice study of Chinese men, only abstract available, finds that serum total Testosterone and SHBG were inversely associated with metabolic syndrome in men.  SHBG association was the strongest and TT the weakest.  Free Testosterone had no association in this study.
Nathan Goodyear

[Serum testosterone: a possible marker for colorectal cancer]. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8295527

Testosterone colon cancer colorectal cancer low Testosterone low T CEA men male hormone hormones

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Colorectal cancer associated with decreased Testosterone levels in men.  This paper looked at total serum Testosterone.  The authors proposed that CEA plus Testosterone could be used in follow up.
Nathan Goodyear

Low testosterone levels are associated with metabolic syndrome, in elderly men: the role of body weight, lipids, insulin resistance and inflammation; the Ikaria study - 0 views

eurheartj.oxfordjournals.org/...P4295.short

low T Testosterone metabolic syndrome metabolic syndrome MetS men male hormones hormone hs-CRP insulin HDL waist circumference inflammation

shared by Nathan Goodyear on 13 Mar 14 - No Cached
  • Nathan Goodyear on 13 Mar 14
     
    Low Serum Testosterone inversely associated metabolic syndrome in men.  This study was conducted in the Ikaria islands.  No association was found with women and Testosterone.  In men, Testosterone was inversely associated with waist circumference, hs-CRP, insulin, and HDL.
Nathan Goodyear

Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina - 0 views

eje-online.org/...285.long

Testosterone therapy low T cardiovascular risk men male hormone hormones disease coagulation fibrinogen PAI-1 tPA

shared by Nathan Goodyear on 29 Jul 14 - No Cached
  • Nathan Goodyear on 29 Jul 14
     
    Thrombosis and cardiovascular risk is a hot topic in Testosterone therapy in men.  This study showed that topical "physiologic" Testosterone therapy provided no negative effects on the coagulation system.  No changes were documented in tPA, PAI-1, and fibrinogen levels in men with chronic stable angina.  This stands in contrast to supra-physiologic therapy of Testosterone that leads to hypofibrinogenemia.
Nathan Goodyear

Methadone induces testosterone suppression in patients with opioid addiction : Scientific Reports : Nature Publishing Group - 0 views

www.nature.com/...srep06189.html

Testosterone methadone opiates low T low Testosterone men male hormone hormones women female

shared by Nathan Goodyear on 02 Sep 14 - No Cached
  • Nathan Goodyear on 02 Sep 14
     
    Methadone use in men is associated with significant reduction in serum Total Testosterone levels in men.  In women, just the opposite is true, though this did not reach statistical significance.  The higher the dose of methadone in men, the lower the Testosterone.  The link between opiates and low T in men is very strong.  This is the first that I am aware of that points to the opposite effect in women.
Nathan Goodyear

Access : Prognostic and predictive value of plasma testosterone levels in patients receiving first-line chemotherapy for metastatic castrate-resistant prostate cancer : British Journal of Cancer - 0 views

www.nature.com/...bjc2014189a.html

Testosterone prostate cancer men male hormone hormones

shared by Nathan Goodyear on 14 Apr 14 - No Cached
  • Nathan Goodyear on 14 Apr 14
     
    Higher base-line Testosterone levels associated with longer overall survival in men with prostate cancer.  The comparison was 32.7 months with higher T levels versus 22.4 months with lower T levels.  Anemia was also a poor prognostic variable.  Whether exogenous Testosterone therapy will change this is still unclear, but the authors suggest that this should play a role in whether to use salvage hormone therapy.
Nathan Goodyear

Longitudinal and cross-sectional rel... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24552220

low T Testosterone elderly men E1 Estrone health male hormone hormones men's health

shared by Nathan Goodyear on 24 Feb 14 - No Cached
  • Nathan Goodyear on 24 Feb 14
     
    This study found that lower TT and E1 associated with more "poor health" as defined by questionnaire.  The conclusion might lead one to think that Estrogen therapy is need in men.  Eightly percent of estrogen production in men occurs from Testosterone.  If Testosterone declines, then estrogen production will likewise decline.  A simple fact that the authors did not comment on.  Also, E1 binds with high affinity to ER alpha, which is pro-inflammatory and pro-proliferative: neither of which is a positive health benefit.   This appears to point more to a broad HPA suppression as an association to the "poor health".
Nathan Goodyear

Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and non-fatal cardiovascular events, and mortality in men aged 1... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...27106765

CVD low T low testosterone estradiol Testosterone DHT dihydrotestosterone male health male hormones cardiovascular disease

shared by Nathan Goodyear on 26 Apr 16 - No Cached
  • Nathan Goodyear on 26 Apr 16
     
    study of middle aged men (mean age--50) finds no correlation between Testosterone, DHT, and higher Estradiol levels in CVD outcomes, including mortality.  Men who died during the study had lower total Testosterone, free Testosterone, and DHT levels than those that survived during the study.
Nathan Goodyear

Relationship between low free testosterone levels and loss of muscle mass. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23660939

free Testosterone total Testosterone muscle Testosterone sarcopenia muscle loss men male hormone hormones

shared by Nathan Goodyear on 05 Apr 15 - No Cached
  • Nathan Goodyear on 05 Apr 15
     
    low free Testosterone associated with muscle loss in men compared to no association with total Testosterone in Japanese men.
Nathan Goodyear

Testosterone Substitution Normalizes Elevated Serum Leptin Levels in Hypogonadal Men: The Journal of Clinical Endocrinology & Metabolism: Vol 82, No 8 - 0 views

press.endocrine.org/...jcem.82.8.4174

leptin low T low Testosterone low T testosterone obese obesity men male hormone hormones

shared by Nathan Goodyear on 03 Nov 14 - No Cached
  • Nathan Goodyear on 03 Nov 14
     
    Men with low T and elevated Leptin, have Leptin normalized with Testosterone therapy.  In obese men, Leptin is inversely associated with Testosterone.  This points to more cause/effect relationship with low T, elevated Leptin, and obesity in men.
Nathan Goodyear

Seasonal variation of salivary testosterone in men, normally cycling women, and women using hormonal contraceptives - 0 views

www.ncbi.nlm.nih.gov/...PMC3494403

men male hormone hormones testing seasonal Testosterone saliva salivary hormones salivary hormone

shared by Nathan Goodyear on 18 May 15 - No Cached
  • Nathan Goodyear on 18 May 15
     
    study of 296 men with mean age at 22.7, have peak salivary Testosterone production in December and January. 
Nathan Goodyear

Low Testosterone Concentration and Atherosclerotic Disease Markers in Male Patients With Type 2 Diabetes: The Journal of Clinical Endocrinology & Metabolism: Vol 0, No 0 - 0 views

press.endocrine.org/...jc.2014-2585

low T low Testosterone low T Testosterone carotid intima-media thickness IMT intima-medial thickness atherosclerosis hsCRP free Testosterone endothelial dysfunction men male hormones hormone cardiovascular disease CVD

shared by Nathan Goodyear on 21 Oct 14 - No Cached
  • Nathan Goodyear on 21 Oct 14
     
    Study of men < 70 finds that low Total Testosterone and Free Testosterone is associated with increased Carotid Intima-media thickness (CIMT), increased endothelial dysfunction.  Atherosclerotic plaque and hsCRP were also found to correlate but were adjusted out when age, DM, HgbA1c, lipids, and BMI were excluded.
Nathan Goodyear

Calculated free testosterone and radioimmunoassay free testosterone as a predictor of subnormal levels of total testosterone. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21997201

low T low Testosterone Testosterone male hormones men hormones

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • Nathan Goodyear on 19 Sep 16
     
    In this study, calculated low free Testosterone correlated better with TT than radioimmunoassay free Testosterone.
Nathan Goodyear

Testosterone Levels Increase 50% with Weight Loss, Exercise - 0 views

www.diabetesincontrol.com/...e-50-with-weight-loss-exercise

low T Testosterone weight loss obesity men male hormone hormones

shared by Nathan Goodyear on 14 May 14 - No Cached
  • Nathan Goodyear on 14 May 14
     
    Weight loss increases Testosterone levels.  This author points to low Testosterone as merely a biomarker of poor health.  In some this is correct, but Testosterone can have significant positive effects.
Nathan Goodyear

Testosterone level and mortality in elderly men with systolic chronic heart failure - 0 views

www.ncbi.nlm.nih.gov/...PMC3739581

low T testosterone heart failure mortality congestive CHF men male hormone hormones hypogonadism

shared by Nathan Goodyear on 06 Apr 14 - No Cached
  • Nathan Goodyear on 06 Apr 14
     
    Good article.  Heart failure in men associated with lower Total Testosterone and estimated Free Testosterone. The severity of disease was associated with lower Testosterone levels.   I wish they would have measured free levels not estimated them.   Increased SHBG concentrations was associated increased CHF as well. This study found no association with mortality.
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