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Nathan Goodyear

Correlation between elevated serum ferritin and HbA1c in type 2 diabetes mellitus - International Journal of Research in Medical Sciences - ScopeMed.org - Online Journal Management System - 0 views

www.scopemed.org/?mno=33486

ferritin diabetes glucose

shared by Nathan Goodyear on 04 Nov 15 - No Cached
  • Nathan Goodyear on 04 Nov 15
     
    positive correlation between ferritin and HgbA1c and fasting blood glucose.
Nathan Goodyear

International Journal of Obesity - Identification of skeletal muscle mass depletion across age and BMI groups in health and disease[mdash]there is need for a unified definition - 0 views

www.nature.com/...ijo2014161a.html

Muscle mass fat free mass lead dry mass fat obesity body composition muscle muscle loss sarcopenic obesity sarcopenia

shared by Nathan Goodyear on 18 Nov 15 - No Cached
  • Nathan Goodyear on 18 Nov 15
     
    good article to review the components of body composition.
Nathan Goodyear

International Journal of Impotence Research - Mechanisms of action of PDE5 inhibition in erectile dysfunction - 0 views

www.nature.com/...3901205a.html

ED PDE5 PDE5 inhibitors erectile dysfunction impotence men male NO

shared by Nathan Goodyear on 08 Sep 14 - No Cached
  • Nitric oxide (NO) is produced from oxygen and L-arginine under the control of nitric oxide synthase (NOS)
  • Cyclic GMP is the intracellular trigger for penile erection
  • PDE5 is the predominant phosphodiesterase in the corpus cavernosum
  • Nathan Goodyear on 08 Sep 14
     
    Nice review of the mechanism of action of PDE5 inhibitors and ED.
Nathan Goodyear

Evaluation of candidal colonization and specific humoral responses against Candida albicans in patients with psoriasis - Taheri Sarvtin - 2014 - International Journal of Dermatology - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...abstract

candida candida albicans candidiasis yeast psoriasis dermatology

shared by Nathan Goodyear on 03 Dec 15 - No Cached
  • Nathan Goodyear on 03 Dec 15
     
    higher colonization of candida albicans found in people with psoriasis vs controls.  Higher in oral cultures vs skin.
Nathan Goodyear

Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes: A 2-Year Randomized, Controlled TrialTwo-Year Moderate Alcohol Intervention in Adults With Type 2 Diabetes | Annals of Internal Medicine - 0 views

annals.org/article.aspx

wine CVD cardiovascular disease heart health diabetes mediterranean diet alcohol

shared by Nathan Goodyear on 10 Dec 15 - No Cached
  • Nathan Goodyear on 10 Dec 15
     
    wine, red and white, with a mediterranean diet reduced cardiometabolic risk  in individuals with diabetes.  The volume of nightly intake of wine was 5 oz.
Nathan Goodyear

International Journal of Obesity - Abstract of article: Antibiotic use and childhood body mass index trajectory - 0 views

www.nature.com/...ijo2015218a.html

antibiotics gut microbiota gut flora gut microbiome gut metabolism

shared by Nathan Goodyear on 26 Oct 15 - No Cached
  • Nathan Goodyear on 26 Oct 15
     
    study finds that increased use of antibiotics throughout childhood leads to increased weight in adulthood. The authors observed "reversible, persistent, and progressive effects. We shouldn't be surprised. This effect has been seen in the cattle industry for years. Also displays the amazing effects of the gut flora on metabolism.
Nathan Goodyear

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC - Stockwin - 2010 - International Journal of Cancer - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...ijc.25499

DCA dichloroacetate dichloracetic acid chemotherapy cancer

shared by Nathan Goodyear on 08 Nov 18 - No Cached
  • Nathan Goodyear on 08 Nov 18
     
    DCA works in synergy, augments, effects of anti-mitochondrial chemo agents cisplatin and topetecan
Nathan Goodyear

Hypercalcemia: A Complication of Advanced Chronic Liver Disease | JAMA Internal Medicine | JAMA Network - 0 views

jamanetwork.com/...607804

liver hypercalcemia liver disease

shared by Nathan Goodyear on 21 Aug 18 - No Cached
  • Nathan Goodyear on 21 Aug 18
     
    Hypercalcemia is a common finding in liver disease, especially cancer of the liver, whether primary or mets.  Also, consider hyperparathyroidism and excessive vitamin D supplementation.
Nathan Goodyear

Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy | Cancer Cell International | Full Text - 0 views

cancerci.biomedcentral.com/...s12935-015-0241-x

curcumin tumeric cancer colorectal cancer colon cancer

shared by Nathan Goodyear on 11 Sep 17 - No Cached
  • Nathan Goodyear on 11 Sep 17
     
    curcumin effective in inhibition of cancer and cancer stem cell activity through increasing apoptotic genes, affecting cellular signaling, altering growth factor receptors, microRNAs, tumor spheroid formation, and epithelial-mesenchymal transition; and found to be helpful in increasing chemo sensitivity to chemo and radiotherapy.
Nathan Goodyear

Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative | Cardiology | JAMA Internal Medicine | The JAMA Network - 0 views

jamanetwork.com/...1108676

diabetes statin statin therapy

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Study finds increased risk of diabetes in post menopause women on statin therapy.  The authors here propose it as a class effect but also is associated with increased dosing.
Nathan Goodyear

Platelet Transfusion: A Clinical Practice Guideline From the AABB | Annals of Internal Medicine | American College of Physicians - 0 views

annals.org/...l-practice-guideline-from-aabb

platelets

shared by Nathan Goodyear on 10 Jan 19 - No Cached
  • Nathan Goodyear on 10 Jan 19
     
    Platelets and "recommended" indications for transfusion.
Nathan Goodyear

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues | PNAS - 0 views

www.pnas.org/...13604

vitamin C cancer

shared by Nathan Goodyear on 06 Oct 18 - No Cached
  • Ascorbate is transported into cells as such by sodium-dependent transporters, whereas dehydroascorbic acid is transported into cells by glucose transporters and then immediately reduced internally to ascorbate
  • Nathan Goodyear on 06 Oct 18
     
    vitamin C inhibits tumor growth via prooxidant effect of vitamin C.
Nathan Goodyear

Anti-helminth compound niclosamide downregulates Wnt Signaling and elicits antitumor responses in tumors with activating APC mutations - 0 views

www.ncbi.nlm.nih.gov/...PMC3117125

Niclosamide Wnt cancer colon cancer

shared by Nathan Goodyear on 21 Mar 18 - No Cached
  • Others have reported that niclosamide inhibits the NF-κB pathway in leukemia cell lines (26) or mTOR signaling in MCF-7 breast cancer cells
  • niclosamide enhances the anti-tumor effect of oxaliplatin
  • In the more rapidly growing tumor (HCT116), a dose of 200 mg/kg of body weight was needed to suppress the tumor growth
  • ...13 more annotations...
  • however, 100 mg/kg of niclosamide could suppress the growth of the relatively slow-growing tumor (CRC039) to the same level
  • niclosamide was confirmed to inhibit the growth of human CRCs in NOD/SCID mice
  • niclosamide can inhibit Wnt pathway activation in CRC
  • The mechanism of action of the niclosamide in our studies is thought to be through internalization of Fzd1 and downregulation of Wnt pathway intermediaries
  • Recently, Jin et al. (26) reported that niclosamide inhibited the NF-κB pathway and increased reactive oxygen species levels to induce apoptosis in AML cells. In contrast, we did not observe any inhibitory effect of niclosamide on NF-κB signaling in our CRC model
  • oral administration of niclosamide does result in sufficient distribution of the drug into tumor tissue, to prove a prolonged inhibitory effect on Wnt/ß-catenin signaling, resulting in tumor growth inhibition
  • we required higher doses (100 ~ 200 mg/kg body weight) of niclosamide in order to demonstrate significant inhibition of tumor growth in NOD/SCID mice
  • niclosamide concentrations in tumor tissue showed good correlation with those in plasma, suggesting the efficient distribution of niclosamide from blood to tumor tissue
  • we observed downregulation of Dvl2 and ß-catenin cytosolic expression in niclosamide-treated tumor cells in vivo
  • One potential concern for the use of niclosamide as an anticancer therapy is the poor absorption of this drug
  • The Wnt signaling pathway, fundamental to embryonic tissue patterning, is also activated in stem-like cells
  • The canonical Wnt pathway is activated in approximately 80% of sporadic CRC primarily due to mutations in the APC gene
  • recent observations reveal that Wnt ligands or inhibitors may affect the growth and survival of colon cancer cells in spite of the presence of APC or CTNNB1 mutations
  • Nathan Goodyear on 21 Mar 18
     
    Niclosamide found to inhibit Wnt/B-catenin signaling pathway, and thus promotion of apoptosis, in colorectal cancer cells in Vivo study.  It was also found to augment chemotherapeutic.
Nathan Goodyear

International Journal of Obesity - The pharmacology of cannabinoid receptors and their ligands: an overview - 0 views

www.nature.com/...0803272a.html

CBD receptors cannabinoids

shared by Nathan Goodyear on 22 Aug 17 - No Cached
  • Nathan Goodyear on 22 Aug 17
     
    CBD receptors
herbnclay

Calcium Bentonite Clay Benefits - Internal and External Uses - 0 views

www.herbnclay.com/fits-of-calcium-bentonite-clay

best clay mask for oily skin green powder uses natural healing

shared by herbnclay on 23 Jan 18 - No Cached
  • herbnclay on 23 Jan 18
     
    HERB n' CLAY provides you with 100 percent all natural Calcium Bentonite Clay. Bentonite clay has microscopic layers through which it absorbs the toxins in our bowels. It contains silica with high traces of Calcium. In addition there are more than 50 trace elements in Calcium Bentonite Clay.
Nathan Goodyear

Lipopolysaccharide‐induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion - Harmey - 2002 - International Journal of Cancer - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...ijc.10632

VEGF cancer LPS

shared by Nathan Goodyear on 16 Aug 19 - No Cached
  • Nathan Goodyear on 16 Aug 19
     
    LPS increases angiogenesis and metastasis in cancer tumor model.
Nathan Goodyear

Hyperthermia as an immunotherapy strategy for cancer - 1 views

www.ncbi.nlm.nih.gov/...PMC2828267

cancer hyperthermia

shared by Nathan Goodyear on 29 Nov 18 - No Cached
  • the notion of treating human cancers with heat dates back to the writings of Hippocrates
  • enhance the efficiency of standard cancer therapies, such as chemotherapy and radiation treatment
  • After antigen uptake at tumor sites, APCs have the ability to create a robust response by entering lymphoid compartments and programming lymphocytes
  • ...36 more annotations...
  • Hyperthermia differs fundamentally from fever in that it elevates the core body temperature without changing the physiological set point
  • hyperthermia is induced by increasing the heat load and/or inactivating heat dissipation
  • mor cells [2]. Although significant cell killing could be achieved by heating cells or tissues to temperatures > 42°C for 1 or more hours, the application, measurement and consistency of this temperature range within the setting of cancer clinical trials
  • mild temperature hyperthermia (ie, within the fever-range, 39–41°C)
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      101.2 to 105.8
  • moderate hyperthermia (41°C)
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      105.8 F
  • Hsps are a family of stress-induced proteins
  • they are key regulators of cellular protein activity, turnover and trafficking
  • Hsps ensure appropriate post-translational protein folding, and are able to refold denatured proteins, or mark irreversibly damaged proteins for destruction
  • the ability of fever-range hyperthermia to induce reactive immunity against tumor antigens through DCs and NK-cells is likely mediated by Hsps
  • thermotolerance
  • Hsps support the malignant phenotype of cancer cells by not only affecting the cells’ survival, but also participating in angiogenesis, invasion, metastasis and immortalization mechanisms
  • Hsps released from stressed or dying cells activate dendritic cells (DCs), transforming them into mature APCs
  • In theory, fever-range hyperthermia may take advantage of tumor cell Hsps by inducing their release from tumor cells and augmenting DC priming against tumor antigens
  • In several models of hyperthermia, heat-treated tumors exhibited improved DC priming and generation of systemic immunity to tumor cell
  • hyperthermia alone can enhance antigen display by tumor cells, thus rendering them even more susceptible to programmed immune clearance
  • Fever-range hyperthermia may also induce Hsps
  • Hsps may exert an adjuvant effect by bolstering MHC class II and co-stimulatory molecule expression by DCs
  • thermal ablation of liver tumors in particular has demonstrated an ability to potentiate immune responses [57, 58] and elicit robust T-cell infiltrates at ablation sites
  • specific Hsp, Hsp70, directly inhibits apoptosis pathways in cancer cells, as demonstrated in human pancreatic, prostate and gastric cancer cells
  • Cross-priming is the ability of extracellular Hsps complexed to tumor peptides to be internalized and presented in the context of MHC class I molecules on APCs, thus allowing potent priming of CTLs against tumor antigens
  • It has been reported that Hsps are generated from necrotic tumor cell lysates, but not from tumor cells undergoing apoptosis
  • tumor cells exposed to hyperthermia in the heat shock range (42°C for 4h) prior to lysing, DC activation and cross-priming were significantly enhanced with the application of heat
  • Due to the ability of Hsps to activate DCs directly by chaperoning tumor antigens upon their release [28], it is possible that both local and regional immune stimulation can be achieved with hyperthermia.
  • support the use of hyperthermia as an inducer of Hsps to serve as ‘danger signals’, activating antitumor immune responses
  • whole-body hyperthermia not only augments immune responses, but also stimulates the migration of skin-derived DCs to draining lymph nodes
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      This allows for the activation of lymphocytes by the activated dendritic cells.
  • suggest a valuable role of hyperthermia in DC cancer vaccine strategies
  • In mice treated with fever-range whole-body hyperthermia, tumor growth was significantly inhibited and NK-cell infiltration increased
    • Nathan Goodyear
      Nathan Goodyear on 04 Aug 19
       
      Hyperthermia increased NK cell activation, proliferation, and infiltration, which equals increased cytotoxicity.
  • exposure to fever-range hyperthermia resulted in improved endogenous NK-cell cytotoxicity to several cancer types
  • improved activation and function of DCs and NK cells following hyperthermia
  • Hyperthermia increases the expression ICAM-1 a key adhesion molecule,
  • The combined effects of hyperthermia on lymphoid tissue endothelium and lymphocytes can promote immune surveillance and increase the probability of naive lymphocytes leaving the circulation and encountering their cognate antigen displayed by DCs in lymphoid organs.
  • In independent clinical studies, whole-body hyperthermia resulted in a transient decrease in circulating lymphocytes in patients with advanced cancer [12, 94, 99, 100], a finding which mirrored observations in animal models in which lymphocyte entry into lymph noeds was increased following hyperthermia treatment [93]. Enhanced recruitment of lymphocytes to lymphoid tissues may be exploited in the treatment of malignancies.
  • The initial tumor antigen presentation and initiation of clonal expansion of CTLs transpires in the lymph nodes and cannot take place outside this specialized compartment
  • the ability of DCs present in the lymph nodes to stimulate an anti-tumor immune response is critical
  • hyperthermia has been shown to improve immune surveillance by T-cell
  • and to increase DC trafficking to lymph nodes
  • Nathan Goodyear on 29 Nov 18
     
    Great review of hyperthermia.
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