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synthetic progestins promote estrogen alpha Receptor activity: increased growth potential

synthetic progestin (MPA) off sets beneficial estrogen heart benefits

bioidentical progesterone lowers breast cancer risk; synthetic progestins increase breast cancer risk

study finds that HRT given as women transition through menopause has benefiical effect in people with Alzheimer's.  However, when given years later, after menopause, no benefit is found.  In fact, rates increased.  Several flaws with this study.  First, they used synthetic hormones, particularily progestins.  Second, there seems to be no thought that the interpretation of the signal  has changed.  For example, we know that when men have low T, their estrogen receptor status changes from ER beta to ER alpha, which is more proinflammatory.  Third, use bioidentical hormones and compare these to synthetic hormones.

Recurrent early pregnancy losses can be prevented not with provera, not with progestin, but with progesterone. The use of progesterone by the functional medicine movement has long been advocated and supported in the science; now the allopathic medicine will try to claim it as its own.

study of 80,377 postmenopausal women found no increase/decrease in breast cancer in women on estradiol and progesterone (RR 1.0).  However, estradiol and provera (synthetic progestin) found a 69% increased breast cancer risk (RR 1.69).

Is breast cancer a product of the environment?  Not totally, but the environment does play a role and the IOM discuss the current knowledge on the environment and breast cancer

I look forward to the published results of this study as this abstract references the WHI as the "same entry" criteria.  I imagine the HRT would be the same too, but will wait to see.  There is a serious problem with proper reporting of synthetic estrogens as bioidentical estrogens and synthetic progestins as bioidentical progesterone;  Also, what is the dosage. Most individuals are massively overdosed.  This study was said to be a "landmark".  Could just be don't use synthetic hormones: which is what the WHI said.

No surprise that progesterone and the synthetic progestin medroxyprogesterone acetate (MPA) have different effects on the vascular endothelium. MPA inhibits NO production, whereas Progesterone maintains NO production.  MPA promoted platelet adhesion whereas Progesterone did not--significant implication in plaque formation.

This study cannot make the conclusion AT ALL.  They claim to say hormones should not be used to prevent chronic disease. Yet, the study they use to support this statement, the WHI, did not look at hormones.  The WHI looked at premarin and medroxyprogesterone acetate, a progestin.  They are not the hormones the body makes. Second, the WHI looked at women that were 6 years postmenopausal, on average, and then they added in bad drugs, disguised as hormone like, and then were dosed high.   If one desires to truly make a statement of prevention, one needs to pre-empt testing and therapy before disease.  Additionally, the study needs to match the hormones needed at the right physiologic level in the right balance.   One must also ensure proper hormone metabolism and know hormone receptor status.  This study does non of the above and the conclusion of this study is irrelevant.  In fact, I think the authors of this study have undergone scientific malpractice in their conclusions.

Yale study finds estrogen therapy in improves health in women ages 50-59.  The problems with hormone therapy is synthetics and overdosing.  The problem with the WHI was they used medroxy progesterone acetate--a synthetic progestin.   That is not progesterone.  This study estimated that 91,000 + died due to the uneducated view that estrogen HRT is dangerous.  What is dangerous is leaving the HRT and BHRT recommendations to those with conflicts of interest and a lack of knowledge of the science.

Estradiol has been shown to have positive health effects on vascular endothelium.  The synthetic progestin, medroxyprogesterone acetate, negates this.  

Bleeding patterns of the hormone replacement therapies in the postmenopausal estrogen and progestin interventions trial.

watch out!  bioidentical progesterone provides improved symptom control versus synthetic progestin MPA

progesterone shows no increased risk of breast cancer; compared to synthetic progestins significantly increased risk

Progesterone, that is progesterone (not progestin, provera...) found to inhibit ER alpha activity in breast cancer. 

contraceptive patch and progestin injectable contraception associated with highest risk of thromboembolism in women with diabetes.

very nice of how glucocorticoids and progesterone interact with the immune system.   This review article discusses the current understanding of  how hormones can contribute to autoimmune disease states through inflammation.