measurement of salivary steroids, by reflecting their free hormone concentration in plasma, may be useful in evaluating endocrine function in both health and disease
salivary testing of testosterone and androstenedione reflects free hormone concentration in plasma, proving to be very useful in evaluating endocrine function and disease
Sochastic sensors and pattern recognition proposed to improve levels of Estradiol, Testosterone, and DHT in salivary sampling in young children. These levels are very low in pre-pubertal children and makes detection by ELIZA difficult. This proposed mechanism improves hormone detection.
another article discusses the seasonal variation of testosterone. Again, testosterone levels are shown to be highest in the fall months and lowest during the summer months. This has been found to be the case in both sexes.
higher fat diet found to increase cortisol and Testosterone levels post meal in health women. The effect was first seen early after lunch (30 minutes).
Increased aromatase activity in men increases testosterone to estrogen production, which causes increase in SHBG and thus a reduction in the bioavailability of free testosterone.
Study shows good predictive value, with very high correlation with free serum levels, of salivary androstenedione and salivary Testosterone levels in women with PCOS. This study suggests using salivary androstenedione:salivary testosterone be used in the diagnosis of PCOS.
Our data showed that Sal-T is a reliable marker of testosterone bioavailability. The results support the inclusion of this biomarker as a noninvasive approach in the diagnosis of male androgen deficiency.
A cut-off value of Sal-T < or = 0.195 nm showed 100% sensibility and specificity to rule out hypogonadism.
early study looking at saliva testing in infertility treatment. This goes back almost 33 years. But of course, it took medicine 176 years to recommend that Vitamin C help prevent scurvy on long sea journeys.
salivary hormone evaluation reveals cortisol increases during athletic competition due primarily to a increase in salivary cortisol production. The result is a decrease in T:C ratio during competition. In the recovery phase, cortisol decreases to baseline, but the testosterone rises above baseline, thus increasing the T:C ratio in the recovery phase. This lasted up to 5 days in this study.
salivary testosterone and DHEA using LC-MS/MS accuracy exceeds 98.5%. Compare that with historical 50% resolution of pain with a hysterectomy. There is no perfect test, but if accuracy exceeds 98%, you have reliable test.
LC-MS for salivary testosterone and DHEA validated. Also, T and DHEA were shown to have specific diurnal rhythms. Changes in levels were also followed after DHEA therapy.