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Nathan Goodyear

High-dose vitamin C therapy for inclusion body myositis. - PubMed - NCBI - 0 views

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    study finds "high dose" IV vitamin C benefited 3 of 5 patients in short 4 week study.  The "high dose" was not high dose at all, so that fact that a low dose of IV vitamin C will benefit dermatomysotis in over 50% of the patients in this very small study points to the question, what if actually high dose vitamin C is used.
fnfdoc

Pregnancy Calculator Guide For Pregnant Women | Health Blog - 0 views

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    Pregnancy calculator guide or how to use pregnancy calculator? There are some questions which you are curious to find the answer about these. We covered briefly this topic for you. You will get the answer here also, What are pregnancy symptoms and due date calculation procedures?
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    After getting married, every couple certainly wants to have a baby. So, when a wife gets pregnant, both she and the husband want to know as soon as possible when she will give birth. Usually, a married couple will go to a hospital and follow USG test to know the predicted birth date. However, you can actually calculate it by your own. You should know when your last period was started so then you are able to find a due date. Today, there is what is called pregnancy calculator. It can be used by everyone. If you are curious about it, let's pay attention to the following discussion.
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    After getting married, every couple certainly wants to have a baby. So, when a wife gets pregnant, both she and the husband want to know as soon as possible when she will give birth. Usually, a married couple will go to a hospital and follow USG test to know the predicted birth date. However, you can actually calculate it by your own. You should know when your last period was started so then you are able to find a due date. Today, there is what is called pregnancy calculator. It can be used by everyone. If you are curious about it, let's pay attention to the following discussion.
Nathan Goodyear

Cureus | Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet,... - 1 views

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    Asking questions that challenge dogma is difficult.  This individual case study just does that.  Case study finds that ketogenic diet, hyperthermic therapy, and hyperbaric oxygen reduce the side effects of chemo, improved quality of life, and at the time of the publication, remission of disease.
pearlgwenson

Questions to Ask When Choosing the Best Day Spa as a Gift - 1 views

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    Spa gift card is another unique gift you can give to friends or loved ones on special occasions or holidays.
Nathan Goodyear

Diabetes Care - 0 views

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    supplementation of Vitamin K2 in healthy men improved insulin sensitivity.  The question of whether it improves insulin sensitivity in unhealthy men and/or diabetes is not confirmed here.
Nathan Goodyear

Testosterone therapy for reduced libido in women - 0 views

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    Testosterone and libido in women: the data is limited.  The data that links low T in women to low libido is not present.  That questions the whole low T, libido theory in women.
Nathan Goodyear

Availability of evidence of benefits on overall survival and quality of life of cancer ... - 0 views

  • Although the goal of cancer treatment is to improve the quantity and quality of life,123 clinical trials designed to gain regulatory approval for new drugs often evaluate indirect or “surrogate” measures of drug efficacy. These endpoints show that an agent has biological activity, but they are not reliable surrogates for improved survival4567891011 or quality of life46111213
  • two recent systematic reviews suggest that the strength of association between surrogates in cancer clinical trials and life extension is generally low
  • Available data from the US show that only a small proportion of cancer treatments approved by the US Food and Drug Administration (FDA) unequivocally show benefits on survival or quality of life.30
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  • We sought to systematically evaluate the evidence base for all new drugs and new indications for the treatment of solid tumours and haematological malignancies approved by the EMA in the five year period 2009-13
  • Three investigators (AP, EP, and EG) independently extracted data on and descriptively analysed the following trial features: characteristics of the participant population, study design (randomisation, crossover from experimental to control group, and blinding of investigators and participants), experimental and control groups, enrolment, primary and secondary endpoints, magnitude of benefit on survival and quality of life, and narrative interpretation of the findings
  • Only 18 of the 68 (26%) were supported by a pivotal study powered to evaluate overall survival as the primary outcome
  • From 2009 to 2013, the EMA approved use of 48 oncology drugs
  • Seventeen drugs were approved for treatment of haematological malignancies and 51 for treatment of solid tumours
  • Overall, 72 clinical trials supported the approval of 68 novel drug uses
  • Our scoring was limited to drugs for solid tumours
  • Among 68 cancer drug indications approved by the EMA in the period 2009-13, and with a median of 5.4 years’ follow-up, only 35 (51%) were associated with a significant improvement in survival (26/35) or quality of life (9/35) over existing treatment options, placebo, or as add on treatment
  • Only two of the 26 drugs shown to extend life also showed benefits on quality of life
  • 33 (49%) had not shown any improvement on survival or quality of life
  • This systematic evaluation of oncology drug approvals by the EMA in 2009-13 shows that most of the drugs (39/68, 57%) entered the market without evidence of improved survival or quality of life
  • At a minimum 3.3 years after market entry, there was still no conclusive evidence that 33 of these 39 cancer drugs either extended or improved life
  • What are potential reasons for the paucity of drug approvals with demonstrable survival advantages over existing treatments?
  • Firstly, only 18 (26%) indications for use in our cohort were supported by trials in which extension of life was the primary outcome
  • None of the pivotal studies supporting oncology drug approvals from 2009 to 2013 included quality of life as a primary outcome measure
  • Most new oncology drugs authorised by the EMA in 2009-13 came onto the market without clear evidence that they improved the quality or quantity of patients’ lives
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    New study from European Medicines Agency questions alot of the new cancer drugs brought to the market 2009-2013.  57% of the new drugs (39/68) were brought to the market without evidence of improved survival or quality of life.
Nathan Goodyear

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of a... - 0 views

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    Very nice mouse study. They reduced hypoxia signialing, HIF-1alpha, via daily vitamin C administration. Also a very interesting point, that the vitamin C had a much longer half life within the tumor than normal tissue-up to 48 hours compared to 30 minutes in normal. So, that begs the question, what does higher dose do? In this study they also saw a reduction in angiogenesis and tumor growth.
Nathan Goodyear

The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer - 0 views

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    Oxidative stress/inflammation via HIF-1alpha increase D3 which increases rT3 to increase proliferation in cancer; in contrast, there is a decrease in D1 and D2 to decrease T3 and T4. The question is the systemic versus the TME.
ivfconcep

How does surrogacy work - Complete Parents Guide to find a loving surrogate mother - 0 views

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    It is true that Surrogate mothers are real angels for childless couples. But to know how does surrogacy work is important questions to be answered first.
umar111

Computer Science: Computer hardware - 0 views

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    Computer Science Tuesday, April 25, 2023 Computer hardware Computer hardware is the physical components that make up a computer system. It includes everything from the central processing unit (CPU) to the monitor, keyboard, and mouse. Understanding the different types of hardware and how they work together is essential for anyone who works with computers. In this article, we will explore the various components of computer hardware, including internal and external components, and the peripherals that connect to them. We will also discuss the importance of hardware maintenance, the latest advancements in computer technology, and factors to consider when choosing the right hardware for your needs. Whether you are a computer technician, a gamer, or simply someone who uses a computer for everyday tasks, this article will help you better understand the world of computer hardware. Introduction to Computer Hardware Computer hardware refers to the physical components that make up a computer system. It includes everything from the processor and memory to input/output devices such as the keyboard and monitor. In this article, we will explore the different types of computer hardware and their functions. What is Computer Hardware Computer hardware refers to the physical components of a computer system. It includes all the components that can be touched, seen, and used to interact with a computer, such as the monitor, keyboard, and mouse. Hardware is different from computer software, which refers to the programs and applications that run on a computer system. History of Computer Hardware The history of computer hardware dates back to the 1820s when Charles Babbage, an English mathematician, and inventor, designed the first analytical engine, which was considered to be the first mechanical computer. With time, more complex electronic computers were developed, including the first Intel microprocessor in 1971. Since then, computer hardware has continued to evolve, becoming
harshitatyagi

When should IVF be done? - 0 views

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    The most generic question that interrupts every couple's mind is when the IVF process should be done. Is it done when one fails to conceive, or is it done when one suffers from secondary infertility.
Nathan Goodyear

Testosterone treatment and risk of venous thromboembolism: population based case-contro... - 0 views

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    Testosterone is great when needed, not doped; but Testosterone is not without risks.  Population case-control study finds increased blood clot risk in first 6 months of Testosterone therapy.  To many variables left unanswered by this study.  
Smile Reef

Choosing The Right Dentist for Your Child - 0 views

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    Smile Reef is the premier Pediatric Dentist office in Las Vegas and has been specially designed to be attractive, calming and inviting for your children.
Nathan Goodyear

Hormone Replacement Therapy in the Geriatric Patient: Current State of the Evidence and... - 0 views

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    TSH is not a reliable reproducible reflection of tissue T3 levels. In fact, in many ways TSH is merely just a screening tool. Research has shown that inflammation decreases TSH levels.
Nathan Goodyear

Biological functions and clinical implications of oestrogen receptors alfa and beta in ... - 0 views

  • ERα-positive cells respond to E2 with increased proliferation
  • ERβ was artificially introduced into these cells, E2-induced proliferation was inhibited
  • The proliferative response to E2 seems to be determined by the ratio of ERα/ERβ. The functions of ERβ in the breast are probably related to its antiproliferative as well as its prodifferentiative functions
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  • The risk of developing PC seems to be related to the diet
  • In the human prostate, ERβ is expressed in the basal epithelial cells and AR in the luminal epithelium.
  • For many years, DHT was considered to be the main hormone guiding prostate development and function. However, the idea was challenged when in 2001 Mahendroo et al. showed that mice in which both forms of 5α-reductase had been inactivated, have a normal functional prostate [50]. The question was then raised as to what is the real function of DHT in the prostate. In 1989 we hypothesized that DHT is a precursor of an oestrogen, 5α-androstane-3β,17β-diol (3β-Adiol) and that physiological levels of an oestrogen could be produced in the total absence of aromatase [51]. We later demonstrated that 3β-Adiol is abundant in the prostate and is a good natural ligand for ERβ
  • The overall effect of oestrogens in the immune system is determined by a balance between ERα and ERβ signalling
  • The hypothesis of our group is that ERβ plays an important role in regulating the differentiation of pluripotent haematopoietic progenitor cells whereas ERα induces proliferation
  • In tissues and cell lines of mammary epithelium for example, it has been noticed that E2 in the presence of ERα elicits proliferation, but in the presence of ERβ it inhibits proliferation
  • ERα and ERβ have distinctive tissue distributions and to the great surprise of endocrinologists [7] many tissues previously thought to be ‘oestrogen-insensitive tissues’ were found to be ERβ positive and oestrogen sensitive. The most notable of the ERα-negative ERβ-abundant tissues were the epithelium of the rodent ventral prostate [8], the granulosa cells of the ovaries [9] and the parenchyma of the lungs
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    Awesome article discusses the different balance of ER alpha and ER beta and the effects on tissue as it relates to proliferation versus differentiation.  This has clear implications in disease.  Physicians prescribing hormones without a knowledge and understanding of this are only causing potential harm to their clients.
Nathan Goodyear

The question of declining sperm density revisited: an analysis of 101 studies published... - 0 views

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    Re-analysis of Carlsen's work on sperm count finds consistent decline in sperm count.  Swan and authors found a 1.5% decline in US men from 1934-1996 and 3% annual decline in European/Australian men over same time frame.  This was a meta-analysis of 101 studies from 1934-1996.  Yes, there is geographical variation, but the overall trend is one of decline.
Nathan Goodyear

Nutrition Journal | Full text | Effects of coenzyme Q10 supplementation (300 ... - 0 views

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    CoQ10 reduced inflammatory cytokines IL-6 and TNF-alpha.  CoQ10 also increased SOD, catalase, and glutathione perioxidase.  The duration of therapy was quite short--12 weeks.  The patients included in the study had pre-existing CAD.
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    study finds prolonged exposure to estrogen associated with increased colorectal cancer risk in postmenopausal women. So many unanswered questions. What was the ER status of these patients? What was the weight of these patients? One cannot simply compare estrogen exposure to colorectal cancer risk and say aha! What is the environment of the individual(s)?!Thanks visit; blog.hoop.la
Nathan Goodyear

What's going on? The question of time trends in autism. - 0 views

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    time trends of autism
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