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Nathan Goodyear

Direct and Indirect Inhibition of Th1 Development by Progesterone and Glucocorticoids - 0 views

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    Progesterone found to modulate the immune system.  Progesterone decreases Th1 activity to increase Th2.  This has significant immune mediated disorders/disease.
Nathan Goodyear

Progesterone treatment inhibits the inflammatory a... [Brain Res. 2005] - PubMed - NCBI - 0 views

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    progesterone shown to decrease NF-KappaB and other inflammatory signaling after TBI in rat model. Part of the role of progesterone is as an anti-inflammatory.
Nathan Goodyear

Effects of progesterone administration on infarct volume and functional deficits follow... - 0 views

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    progesterone shown to provide substantial reduction in volume of infarct in rat stroke model.  This is very promising, and with with other studies revealing the same benefit in the human brain, progesterone should become a part of initial treatment in those with acute brain injuries and should be evaluated for those with aging diseases of the brain.
Nathan Goodyear

Percutaneous administration of progesterone: blood levels an... : Menopause - 1 views

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    serum evaluation of progesterone is not reliable method of testing following transdermal progesterone
Nathan Goodyear

Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain i... - 0 views

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    Abstract on listed here: but bioidentical progesterone and allopregnanolone (product of progesterone metabolism) shown to reduce inflammation after TBI.  This inflammation is what results in much of the post-TBI complications.
Nathan Goodyear

Opposing actions of the progesterone metabolites, 5α-dihydroprogesterone (5αP... - 0 views

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    Progesterone metabolites play key role in breast cancer carcinogenesis or inhibition of carcinogenesis.  The key active progesterone metabolites discussed in this article are 5 alpha pregnene and 3 alpha hydroxyprogesterone.
Nathan Goodyear

Progesterone enhances transthyretin expressio... [J Mol Neurosci. 2011] - PubMed - NCBI - 0 views

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    Postmenopausal cognitive decline is a common complaint.  Declining Estradiol and progesterone have been implicated, in part, to this cognitive decline.  This study finds that progesterone increases expression of Transthyretin, a protein that processes amyloid Beta protein.  This amyloid Beta protein is associated with damage found in Alzheimer's. 
Nathan Goodyear

Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorect... - 0 views

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    ER and PR are suggested to play role in colon cancer.  The question is do they play a role in carcinogenesis or does the expression of the receptors indicate something else i.e. attempt at differentiation through progesterone.  Also, what receptors are involver here: ER alpha or beta.  Likewise for the progesterone receptors
Nathan Goodyear

Efficacy of the Progesterone Receptor Antagonist Mifepristone for Palliative Therapy of... - 0 views

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    Another study points to mifepristone in the benefit of progesterone receptor blockade in late stage cancer.
Nathan Goodyear

Progesterone receptor modulates ER[agr] action in breast cancer : Nature : Nature Publi... - 0 views

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    Abstract only available here.  Progesterone and Progesterone receptor key to regulating ER alpha and slowing breast cancer growth.
Nathan Goodyear

Pregnancy, progesterone and progestins in relation... [J Steroid Biochem Mol Biol. 2005... - 0 views

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    Bioidentical Progesterone does not increase breast cancer risk
Nathan Goodyear

Low saliva progesterone concentrations are associa... [BJOG. 2009] - PubMed result - 0 views

  • Measurement of saliva progesterone may be of value in the prediction of early preterm labour and in determining which women might benefit from progesterone supplementation.
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    saliva progesterone usefull in predicting preterm labor
Nathan Goodyear

Salivary progesterone excellently reflects free and total progesterone in plasma during... - 0 views

  • Evidently salivary progesterone is a very good alternative to plasma as a sample for use in follow-up during pregnancy.
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    salivary progesterone validated during pregnancy
Nathan Goodyear

Salivary estradiol and progesterone during the nor... [Eur J Obstet Gynecol Reprod Biol... - 0 views

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    salivary testing of estradiol and progesterone shown to be statistically similar to blood estradiol and progesterone.  And, "salivary sampling is simple, convenient, and stress free".  End of debate.
Nathan Goodyear

Progesterone induces the growth and infiltrat... [Biomed Res Int. 2014] - PubMed - NCBI - 0 views

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    Progesterone shown to stimulate growth and migration of astrocytes in the brain.  The has both implications in cancer, such as in astrocytomas, but also in TBI.  The study also found that the Progesterone antagonist RU486 inhibited this effect.  A more thorough evaluation would have included the pregnane metabolites.
Nathan Goodyear

Effect of Progesterone on Melanoma Cell Growth : Steroid Hormone Action: Genomic & Non-... - 0 views

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    Progesterone decreased melanoma cell growth in cell line study.  This inhibition occurred through non-progesterone receptor pathways.
Nathan Goodyear

Progesterone receptor modulates ER[agr] action in breast cancer : Nature : Nature Publi... - 1 views

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    Progesterone, that is progesterone (not progestin, provera...) found to inhibit ER alpha activity in breast cancer. 
Nathan Goodyear

Role of progesterone metabolites in mammary cancer | Cambridge Core - 0 views

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    Progesterone metabolites in breast cancer
Nathan Goodyear

Pregnancy-Specific Down-Regulation of NF-κB Expression in T Cells in Humans I... - 0 views

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    this article discusses how progesterone protects the developing pregnancy.  Progesterone down regulates NF-kappaB and thus downregulates Th1 activity.
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