Group items tagged progesteron - Dr. Goodyear

Anti-inflammatory effect of proteoglyca - PubMed Mobile - 0 views

www.ncbi.nlm.nih.gov/...22314502

progesterone LPS inflammation anti-inflammatory TLR4 BHRT HRT hormone hormones

shared by Nathan Goodyear on 07 Jun 12 - No Cached

Nathan Goodyear on 07 Jun 12

progesterone inhibits LPS stimulated inflammation. Progesterone actually inhibits TLR4 activation. The statement that progesterone has no place in hormone therapy is both uneducated and uninformed.

<div class="cArrow"> </div><div class="cContentInner">progesterone inhibits LPS stimulated inflammation. Progesterone actually inhibits TLR4 activation. The statement that progesterone has no place in hormone therapy is both uneducated and uninformed.</div>

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Breast Cancer Research | Full text | Progesterone metabolites regulate induction, growt... - 0 views

breast-cancer-research.com/...R38

breast cancer progesterone metabolite metabolites 5-alpha-pregnanediol 4-pregnene

shared by Nathan Goodyear on 23 Jan 14 - No Cached

Nathan Goodyear on 23 Jan 14

5alpha pregnanes and 4 pregnanes stimulate ER and PR negative breast cancer cells. Progesterone metabolites stimulate or inhibit cancer potential independent of receptor status. Though we know that progesterone metabolite balance can increase receptor binding.

<div class="cArrow"> </div><div class="cContentInner">5alpha pregnanes and 4 pregnanes stimulate ER and PR negative breast cancer cells. Progesterone metabolites stimulate or inhibit cancer potential independent of receptor status. Though we know that progesterone metabolite balance can increase receptor binding.</div>

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Plasma membrane receptors for the... [Biochem Biophys Res Commun. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10860824

hormone receptors hormones progesterone metabolite metabolites 3-alpha pregnene 5-alpha pregnene 5-alpha pregnenes

shared by Nathan Goodyear on 28 Jan 14 - No Cached

Nathan Goodyear on 28 Jan 14

The receptors for 5 alpha progesterone and 3 alpha hydroxyprogesterone are distinct from other hormone receptors. These receptors are plasma membrane bound. Through these receptors, these progesterone metabolites initiate autocrine and paracrine activity. E2 increased 5 alpha progesterone receptors. This is very important in ER-/PR- breast cancer, but does still have significance in ER+/PR+ cancer as well.

<div class="cArrow"> </div><div class="cContentInner">The receptors for 5 alpha progesterone and 3 alpha hydroxyprogesterone are distinct from other hormone receptors. These receptors are plasma membrane bound. Through these receptors, these progesterone metabolites initiate autocrine and paracrine activity. E2 increased 5 alpha progesterone receptors. This is very important in ER-/PR- breast cancer, but does still have significance in ER+/PR+ cancer as well.</div>

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Menstrual and hormonal alterations in juvenile systemi... [Lupus. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19074167

progesterone low Lupus SLE juvenile hormone hormones

shared by Nathan Goodyear on 30 Oct 13 - No Cached

Nathan Goodyear on 30 Oct 13

low Progesterone and progesterone "disturbances" found to be common in juvenile Lupus. The authors in this study proposed it was due to low follicular reserves. The point is that low progesterone increases inflammatory cytokines.

<div class="cArrow"> </div><div class="cContentInner">low Progesterone and progesterone "disturbances" found to be common in juvenile Lupus. The authors in this study proposed it was due to low follicular reserves. The point is that low progesterone increases inflammatory cytokines.</div>

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Progesterone Metabolites Regulate Breast Cell Tumors - 0 views

www.medscape.com/...809131

progesterone metabolites progesterone metabolites 5alpha-dihydroprogesterone 3alpha-dihydroprogesterone hormones hormone breast cancer

shared by Nathan Goodyear on 18 Jun 14 - No Cached

Nathan Goodyear on 18 Jun 14

As much fanfare that is given to ER/PR + breast cancer, the large percentage of breast cancers are ER/PR -. Thus, hormonal therapy doesn't work...at least that is how the story goes. This study finds the metabolites of Progesterone to be equally telling. Two Progesterone metabolites play significant roles in growth versus inhibition of growth. The metabolite 5alpha-dihydroprogesterone is procarcingenic in in vitro and in vivo studies and the metabolite 3alpha-dihydroprogesterone inhibits the pro growth effects in the same in vitro and in vivo studies.

<div class="cArrow"> </div><div class="cContentInner">As much fanfare that is given to ER/PR + breast cancer, the large percentage of breast cancers are ER/PR -. Thus, hormonal therapy doesn't work...at least that is how the story goes. This study finds the metabolites of Progesterone to be equally telling. Two Progesterone metabolites play significant roles in growth versus inhibition of growth. The metabolite 5alpha-dihydroprogesterone is procarcingenic in in vitro and in vivo studies and the metabolite 3alpha-dihydroprogesterone inhibits the pro growth effects in the same in vitro and in vivo studies.</div>

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Progesterone metabolites in breast cancer - 0 views

erc.endocrinology-journals.org/...717.long

progesterone metabolism metabolites breast cancer hormones progesterone metabolites

shared by Nathan Goodyear on 12 Jun 14 - No Cached

In breast tumor tissue and tumorigenic cell lines, 5α-reductase activity and mRNA expression are significantly higher, whereas 3α- and 20α-HSO activities and mRNA expression are significantly lower than in normal breast tissue and nontumorigenic cells
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Studies using various breast cell lines have shown that 5αP and 3αHP have opposing actions in terms of cell proliferation and adhesion; 5αP stimulates cell proliferation (through increased mitosis and decreased apoptosis) and cell detachment, whereas 3αHP suppresses cell proliferation (through decreased mitosis and increased apoptosis) and detachment
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the paracrine/ autocrine functions of 5αP are cancer-promoting and those of 3αHP are cancer-inhibiting
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Nathan Goodyear on 12 Jun 14

Awesome article on progesterone metabolism in breast cancer. The author, weibe, describes 2 categories of progesterone metabolites in breast tissue: 5alpha-pregnanes and 4-pregnenes. The author describes 3 primary enzymes that control the balance between these 2 metabolites--5alpha reductase, 3alpha-HSO, and 20alpha-HSO. The resultant balance of 5alpha-dihydroprogesterone and 3alpha-dihydroprogesterone helps to determine the cancer potential of breast tissue.

<div class="cArrow"> </div><div class="cContentInner">Awesome article on progesterone metabolism in breast cancer. The author, weibe, describes 2 categories of progesterone metabolites in breast tissue: 5alpha-pregnanes and 4-pregnenes. The author describes 3 primary enzymes that control the balance between these 2 metabolites--5alpha reductase, 3alpha-HSO, and 20alpha-HSO. The resultant balance of 5alpha-dihydroprogesterone and 3alpha-dihydroprogesterone helps to determine the cancer potential of breast tissue.</div>

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The frequency of salivary progesterone sampling an... [Gynecol Endocrinol. 1992] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...1502930

saliva salivary testing progesterone

shared by Nathan Goodyear on 22 Nov 10 - No Cached

A single mid-luteal salivary progesterone estimation or the mid-luteal Lenton progesterone index (n = 4) satisfactorily reflected the normal luteal phase, but a frequency of one sample every 3 days over the luteal phase (n = 5-6) was necessary to allow recognition of a short luteal phase or poor progesterone surge.
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Nathan Goodyear on 22 Nov 10

The frequency of salivary progesterone sampling and the diagnosis of luteal phase insufficiency.

<div class="cArrow"> </div><div class="cContentInner">The frequency of salivary progesterone sampling and the diagnosis of luteal phase insufficiency. </div>

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A randomized, controlled trial comparing the efficacy and safety of aqueous subcutaneou... - 0 views

humrep.oxfordjournals.org/...humrep.deu194.short

BHRT HRT Progesterone infertility

shared by Nathan Goodyear on 13 Aug 14 - No Cached

Nathan Goodyear on 13 Aug 14

Bioidentical progesterone used in IVF. This is not new, the SQ administration is. So, physicians cry against BHRT, yet bioidentical progesterone has been used for years in the treatment of infertility.

<div class="cArrow"> </div><div class="cContentInner">Bioidentical progesterone used in IVF. This is not new, the SQ administration is. So, physicians cry against BHRT, yet bioidentical progesterone has been used for years in the treatment of infertility.</div>

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Plasma Membrane Receptors for the Cancer-Regulating Progesterone Metabolites,... - 0 views

www.sciencedirect.com/...S0006291X0092847X

Hormones progesterone metabolites receptors progesterone cancer breast cancer 5alpha-pregnane estradiol

shared by Nathan Goodyear on 07 Oct 16 - No Cached

Nathan Goodyear on 07 Oct 16

The receptor for the progesterone 5alpha pregnane, 5alpha-P, is unregulated in breast cancer cell line MCF-7. Estradiol increases the receptor expression. Not only is there an enzymatic effect in these progesterone pathways, but the receptor is equally unregulated.

<div class="cArrow"> </div><div class="cContentInner">The receptor for the progesterone 5alpha pregnane, 5alpha-P, is unregulated in breast cancer cell line MCF-7. Estradiol increases the receptor expression. Not only is there an enzymatic effect in these progesterone pathways, but the receptor is equally unregulated.</div>

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Progesterone inhibits mature rat dendritic cells in a receptor-mediated fashion - 0 views

intimm.oxfordjournals.org/...287.long

progesterone inflammation dendritic cells T cell Th1 hormone hormones

shared by Nathan Goodyear on 09 Nov 12 - No Cached

Nathan Goodyear on 09 Nov 12

study shows that progesterone directly inhibits pro-inflammatory cytokine signaling in rat dendritic cells. Progesterone here shows to be directly involved in a anti-inflammatory effect.

<div class="cArrow"> </div><div class="cContentInner">study shows that progesterone directly inhibits pro-inflammatory cytokine signaling in rat dendritic cells. Progesterone here shows to be directly involved in a anti-inflammatory effect.</div>

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Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform ... - 0 views

www.nursa.org/retrieveFile.cfm

progesterone receptor progesterone receptors A B PR-A PR-B progesterone receptor receptors

shared by Nathan Goodyear on 12 Nov 12 - No Cached

Nathan Goodyear on 12 Nov 12

Good discussion of PR receptors. This article focus' on the different receptors, mainly A and B, and the nuclear transcriptional signaling.

<div class="cArrow"> </div><div class="cContentInner">Good discussion of PR receptors. This article focus' on the different receptors, mainly A and B, and the nuclear transcriptional signaling.</div>

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ScienceDirect.com - Frontiers in Neuroendocrinology - Progesterone receptors: Form and ... - 0 views

www.sciencedirect.com/...S0091302208000058

progesterone receptors receptor PR brain CNS inflammation anti-inflammatory

shared by Nathan Goodyear on 12 Nov 12 - No Cached

Nathan Goodyear on 12 Nov 12

progesterone through progesterone receptors, shown to have protective, anti-inflammatory effects in the CNS.

<div class="cArrow"> </div><div class="cContentInner">progesterone through progesterone receptors, shown to have protective, anti-inflammatory effects in the CNS.</div>

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Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform - 0 views

www.ncbi.nlm.nih.gov/...PMC187836

progesterone receptor B PR-B progesterone receptor B progesterone receptor breast

shared by Nathan Goodyear on 24 Nov 12 - No Cached

Nathan Goodyear on 24 Nov 12

progesterone receptor B shown to be required for proper breast development

<div class="cArrow"> </div><div class="cContentInner">progesterone receptor B shown to be required for proper breast development</div>

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RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-med... - 0 views

www.jbc.org/...11945.full.pdf+html

progesterone receptor progesterone receptor A PR-A estrogen receptor estrogen receptor progesterone

shared by Nathan Goodyear on 24 Nov 12 - No Cached

Nathan Goodyear on 24 Nov 12

Progesterone receptor A inhibits estrogen receptors.

<div class="cArrow"> </div><div class="cContentInner">Progesterone receptor A inhibits estrogen receptors.</div>

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Breast Cancer Patients with Progesterone Receptor PR-A-Rich Tumors Have Poorer Disease-... - 0 views

Nathan Goodyear on 26 Nov 12

Balance of progesterone receptor A and B shown to influence survival rates in ER+/PR+ breast cancer on hormonal therapy.

<div class="cArrow"> </div><div class="cContentInner">Balance of progesterone receptor A and B shown to influence survival rates in ER+/PR+ breast cancer on hormonal therapy.</div>

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Progesterone receptor plays a major antiinfla... [Mol Endocrinol. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16772530

progesterone receptor progesterone receptors PR inflammation NF-KappaB progesterone receptor receptors COX-2

shared by Nathan Goodyear on 26 Nov 12 - No Cached

Nathan Goodyear on 26 Nov 12

progesterone receptor inhibits inflammation through NF-kappaB inhibition and through lack of activation of COX-2.

<div class="cArrow"> </div><div class="cContentInner">progesterone receptor inhibits inflammation through NF-kappaB inhibition and through lack of activation of COX-2.</div>

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Relative Expression of Progesterone Receptors A and B in Endometrioid Cancers of the En... - 0 views

cancerres.aacrjournals.org/...4576.long

progesterone receptor progesterone receptors A B PR-A PR-B endometrial cancer uterine progesterone receptor receptors

shared by Nathan Goodyear on 26 Nov 12 - No Cached

Nathan Goodyear on 26 Nov 12

Balance of progesterone receptors A and B in the development of endometrial cancer.

<div class="cArrow"> </div><div class="cContentInner">Balance of progesterone receptors A and B in the development of endometrial cancer.</div>

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ScienceDirect.com - The Journal of Steroid Biochemistry and Molecular Biology - Differe... - 0 views

www.sciencedirect.com/...S0960076097001192

progesterone receptor progesterone receptors PR-A PR-B progesterone receptor receptors hormone hormones

shared by Nathan Goodyear on 11 May 13 - No Cached

Nathan Goodyear on 11 May 13

progesterone receptor status varies through a woman's menstrual cycle. PR-A dominates throughout, but the PR-A to PR-B ratio declines up to ovulation.

<div class="cArrow"> </div><div class="cContentInner">progesterone receptor status varies through a woman's menstrual cycle. PR-A dominates throughout, but the PR-A to PR-B ratio declines up to ovulation.</div>

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High Testosterone and Low Progesterone Circulating Levels in Premenopausal Patients wit... - 0 views

cancerres.aacrjournals.org/...841.long

Testosterone progesterone hormones cancer women female hormones breast pre-menopause

shared by Nathan Goodyear on 15 Sep 16 - No Cached

Nathan Goodyear on 15 Sep 16

higher Testosterone levels, in conjunction with lower progesterone levels, found in premenopausal women with breast hyperplasia and breast cancer. The authors point to elevated androgens in breast cancer induction and development. This same hormone patter, low progesterone/elevated Testosterone, is associated with PCOS in women.

<div class="cArrow"> </div><div class="cContentInner">higher Testosterone levels, in conjunction with lower progesterone levels, found in premenopausal women with breast hyperplasia and breast cancer. The authors point to elevated androgens in breast cancer induction and development. This same hormone patter, low progesterone/elevated Testosterone, is associated with PCOS in women.</div>

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Luteal start vaginal micronized progesterone improves pregnancy success in women with r... - 0 views

www.fertstert.org/...abstract

progesterone infertility miscarriage pregnancy hormones women

shared by Nathan Goodyear on 18 Jan 17 - No Cached

Nathan Goodyear on 18 Jan 17

Recurrent early pregnancy losses can be prevented not with provera, not with progestin, but with progesterone. The use of progesterone by the functional medicine movement has long been advocated and supported in the science; now the allopathic medicine will try to claim it as its own.

<div class="cArrow"> </div><div class="cContentInner">Recurrent early pregnancy losses can be prevented not with provera, not with progestin, but with progesterone. The use of progesterone by the functional medicine movement has long been advocated and supported in the science; now the allopathic medicine will try to claim it as its own.</div>

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