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Nathan Goodyear

Estradiol-induced proliferation of papillary and follicular thyroid cancer ce... - 0 views

www.spandidos-publications.com/...1067

thyroid papillary follicular cancer estrogen estradiol hormone hormones ER alpha ER-alpha ER beta ER-beta PR receptors progesterone

shared by Nathan Goodyear on 25 Nov 13 - No Cached
  • Nathan Goodyear on 25 Nov 13
     
    Estradiol increased thyroid papillary and follicular cancer cells via both ER alpha and ER beta in this study.  What is also interesting is that estradiol did not increase PR expression.
Nathan Goodyear

Systemic lupus erythematosus and hormone repla... [Menopause Int. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17540136

SLE Lupus hormone hormones progesterone HRT BHRT menopause

shared by Nathan Goodyear on 30 Oct 13 - No Cached
  • Nathan Goodyear on 30 Oct 13
     
    Women with SLE enter menopause earlier.  This study comments on the need for hormone testing in women with SLE and appropriate therapy as indicated.  This study recommended against estrogen therapy due to studies revealing increased flares.  The problem with those studies is that they looked at OCPs and synthetic HRT.
Nathan Goodyear

Saliva as a Medium for Investigating Intra- and Interindividual Differences in Sex Horm... - 0 views

cebp.aacrjournals.org/...59.full

hormone testing saliva salivary Estrogen progesterone

shared by Nathan Goodyear on 03 Nov 10 - No Cached
  • These results indicate that daily saliva samples can be combined to clarify the interindividual differences in E2 and PG levels in premenopausal women, and that these interindividual differences may be greater than previously imagined.
  • Nathan Goodyear on 03 Nov 10
     
    Saliva as a Medium for Investigating Intra- and Interindividual Differences in Sex Hormone Levels in Premenopausal Women1
Nathan Goodyear

Does experimental pain response vary across the menstrual cycle? A methodological revie... - 0 views

ajpregu.physiology.org/...R245

saliva menstrual cycle salivary hormone pain progesterone Estrogen

shared by Nathan Goodyear on 03 Nov 10 - No Cached
  • Nathan Goodyear on 03 Nov 10
     
    Does experimental pain response vary across the menstrual cycle? A methodological review
Nathan Goodyear

Assessment of bioavailability of oral micronized p... [Gynecol Endocrinol. 1993] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...8213223

saliva salivary hormone testing hormones progesterone bioidentical

shared by Nathan Goodyear on 16 Nov 10 - No Cached
  • The use of non-invasive salivary sampling and a cost-effective, direct enzymeimmunoassay showed a considerable advantage in the present study, compared with previous ones.
  • Nathan Goodyear on 16 Nov 10
     
    saliva testing verified as cost effective and with considerable advantage
Nathan Goodyear

Salivary progesterone and luteal function in two l... [Hum Biol. 1986] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...3759049

saliva testing salivary hormone

shared by Nathan Goodyear on 16 Nov 10 - No Cached
  • Nathan Goodyear on 16 Nov 10
     
    Saliva testing has many potential uses
Nathan Goodyear

Effects of progestogens on the postmenopausal brea... [Climacteric. 2002] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...12419080

progestins progesteron breast cancer hormones

shared by Nathan Goodyear on 04 Nov 10 - No Cached
  • Nathan Goodyear on 04 Nov 10
     
    Effects of progestogens on the postmenopausal breast.
Nathan Goodyear

Bleeding patterns of the hormone replacement thera... [Obstet Gynecol. 2002] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...12423841

progesterone hormones bioidentical estrogen

shared by Nathan Goodyear on 04 Nov 10 - No Cached
  • Nathan Goodyear on 04 Nov 10
     
    Bleeding patterns of the hormone replacement therapies in the postmenopausal estrogen and progestin interventions trial.
Nathan Goodyear

Synthetic progestins induce proliferation of breas... [Mol Cell Endocrinol. 1994] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...7926273

hormones bioidentical progesterone progestins

shared by Nathan Goodyear on 04 Nov 10 - No Cached
  • Nathan Goodyear on 04 Nov 10
     
    Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation.
Nathan Goodyear

Hormone replacement therapy containing progestins and given continuously increases brea... - 0 views

onlinelibrary.wiley.com/...abstract

hormones progesterone progestins breast cancer hormone bioidentical

shared by Nathan Goodyear on 18 Nov 10 - No Cached
  • Nathan Goodyear on 18 Nov 10
     
    Hormone replacement therapy containing progestins and given continuously increases breast carcinoma risk in Sweden
Nathan Goodyear

Salivary estradiol and progesterone during the normal ovulatory menstrual cycle in Chin... - 0 views

www.journals.elsevierhealth.com/...abstract

salivary estradiol

shared by Nathan Goodyear on 20 Jan 11 - No Cached
  • Measurements of these salivary steroids may be used to assess follicular dynamics. Moreover, salivary sampling is simple, convenient and stress free.
  • Nathan Goodyear on 20 Jan 11
     
    salivary sampling is simple, convenient and stress free.
Nathan Goodyear

ScienceDirect - Journal of Steroid Biochemistry : The measurement of hormones in saliva... - 0 views

www.sciencedirect.com/science

saliva hormones testing

shared by Nathan Goodyear on 18 Jan 11 - No Cached
  • The measurement of the salivary level is a valuable clinical tool for some hormones (e.g. Cortisol, oestriol, progesterone
  • Nathan Goodyear on 18 Jan 11
     
    hormone testing in saliva
Nathan Goodyear

Differential Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Sensitiv... - 0 views

atvb.ahajournals.org/...1671.short

oral estradiol estrogen transdermal bioidentical DVT thromboembolism

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    transdermal estradiol does not increase blood clot risk, when compared with oral estradiol
Nathan Goodyear

Sex steroids and the thyroid. [Best Pract Res Clin Endocrinol Metab. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19942152

sex hormones Estrogen Progesterone Testosterone Estradiol thyroid function steroids

shared by Nathan Goodyear on 07 Aug 11 - No Cached
  • Nathan Goodyear on 07 Aug 11
     
    sex hormones effect thyroid function
Nathan Goodyear

Serum allopregnanolone levels in pre... [J Clin Endocrinol Metab. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10902789

PMS PMDD allopregnanolone progesterone

shared by Nathan Goodyear on 05 Sep 11 - No Cached
  • Nathan Goodyear on 05 Sep 11
     
    PMS/PMDD improves with allopregnanolone levels similar to late pregnancy
Nathan Goodyear

Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise and exceed expec... - 0 views

www.nature.com/ja201711

Ivermectin cancer

shared by Nathan Goodyear on 19 Mar 18 - No Cached
  • The avermectins are known to possess pronounced antitumor activity
  • Over the past few years, there have been steadily increasing reports that ivermectin may have varying uses as an anti-cancer agent, as it has been shown to exhibit both anti-cancer and anti-cancer stem cell properties
  • In human ovarian cancer and NF2 tumor cell lines, high-dose ivermectin inactivates protein kinase PAK1 and blocks PAK1-dependent growth
  • ...13 more annotations...
  • PAK1 is essential for the growth of more than 70% of all human cancers, including breast, prostate, pancreatic, colon, gastric, lung, cervical and thyroid cancers, as well as hepatoma, glioma, melanoma, multiple myeloma and for neurofibromatosis tumors
  • Ivermectin suppresses breast cancer by activating cytostatic autophagy, disrupting cellular signaling in the process, probably by reducing PAK1 expression
  • Cancer stem cells are a key factor in cancer cells developing resistance to chemotherapies and these results indicate that a combination of chemotherapy agents plus ivermectin could potentially target and kill cancer stem cells, a paramount goal in overcoming cancer
  • Triple-negative breast cancers, which lack estrogen, progesterone and HER2 receptors, account for 10–20% of breast cancers and are associated with poor prognosis
  • Ivermectin addition led to transcriptional modulation of genes associated with epithelial–mesenchymal transition and maintenance of a cancer stem cell phenotype in triple-negative breast cancers cells, resulting in impairment of clonogenic self-renewal in vitro and inhibition of tumor growth and metastasis in vivo
  • Ivermectin-induced cytostatic autophagy also leads to suppression of tumor growth in breast cancer xenografts, causing researchers to believe there is scope for using ivermectin to inhibit breast cancer cell proliferation and that the drug is a potential treatment for breast cancer
  • ivermectin synergizes with the chemotherapy agents cytarabine and daunorubicin to induce cell death in leukemia cells
  • Ivermectin inhibits proliferation and increases apoptosis of various human cancers
  • Activation of WNT-TCF signaling is implicated in multiple diseases, including cancers of the lungs and intestine,
  • A new screening system has found that ivermectin inhibits the expression of WNT-TCF targets
  • It represses the levels of C-terminal β-catenin phosphoforms and of cyclin D1 in an okadaic acid-sensitive manner, indicating its action involves protein phosphatases
  • In vivo, ivermectin selectively inhibits TCF-dependent, but not TCF-independent, xenograft growth without side effects
  • ivermectin has an exemplary safety record, it could swiftly become a useful tool as a WNT-TCF pathway response blocker to treat WNT-TCF-dependent diseases, encompassing multiple cancers.117
  • Nathan Goodyear on 19 Mar 18
     
    Ivermectin shows promise and usefullness in several cancer types.  This is a review article.
Nathan Goodyear

Sex hormone synthesis, regulation, and function | McMaster Pathophysiology Review - 0 views

www.pathophys.org/sexhormones

hormones HPA Testosterone DHEA estradiol LH FSH Progesterone androgens estrogen

shared by Nathan Goodyear on 02 Oct 17 - No Cached
  • Nathan Goodyear on 02 Oct 17
     
    Good review of the HPA-sex hormone pathways, called the Hypothalamic-Pituitary-Gondal axis, including HP feedback.  This is not a study but has nice diagrams. This is based on 14 referenced articles and 1 book chapter.
Nathan Goodyear

Nongenomic actions of steroid hormones | Nature Reviews Molecular Cell Biology - 0 views

www.nature.com/nrm1009

estrogen cancer progesterone hormones non-genomic signaling genomic signaling

shared by Nathan Goodyear on 09 Apr 21 - No Cached
  • Nathan Goodyear on 09 Apr 21
     
    Excellent review of non-genomic signaling. Only abstract available here-see Dropbox Research/ResearchStudies/Hormones
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