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Nathan Goodyear

Sex Hormone Levels and Risk of Cardiovascular Events in Postmenopausal Women - 0 views

circ.ahajournals.org/...1688.long

menopause Testosterone SHBG CVD women MetS hormone hormones metabolic syndrome

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    Menopause in women is associated with increasing free Testosterone, lower SHBG and increased CVD and MetS.
Nathan Goodyear

Relationship between endogenous testosterone and ... [Metabolism. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18555838

Testosterone women postmenopause hormone hormones CRP CVD menopause

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    Post menopause transition associated with increase in Testosterone levels in women.  This is associated with an increase in CRP and CVD.
Nathan Goodyear

Low Sex-Hormone Binding Globulin is Associated with the Metabolic Syndrome in Postmenop... - 0 views

www.ncbi.nlm.nih.gov/...PMC1633722

metabolic syndrome Menopause SHBG Testosterone MetS women hormone hormones

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    Post menopause associated with lower SHBG, increase in free Testosterone and increase in metabolic syndrome.
Nathan Goodyear

Effect of Medroxyprogesterone Acetate on Endothelium-Dependent Vasodilation in Postmeno... - 0 views

circ.ahajournals.org/...1773.long

estrogen estradiol endothelium hormone HRT BHRT medroxyprogesterone acetate medroxyprogesterone

shared by Nathan Goodyear on 14 Oct 13 - No Cached
  • Nathan Goodyear on 14 Oct 13
     
    Estradiol has been shown to have positive health effects on vascular endothelium.  The synthetic progestin, medroxyprogesterone acetate, negates this.  
Nathan Goodyear

Breast Cancer Research | Full text | The combined influence of multiple sex and growth ... - 0 views

breast-cancer-research.com/...R99

breast cancer estrogen estradiol estrone Testosterone women hormone hormones

shared by Nathan Goodyear on 16 Dec 13 - No Cached
  • Nathan Goodyear on 16 Dec 13
     
    Elevated estradiol, estrone, and Testosterone increases breast cancer risk by 50 to 200% depending on the hormone(s) elevated.
Nathan Goodyear

The Benefits and Harms of Systemic T... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25279572

Testosterone women Postmenopause post-menopause female hormones hormone

shared by Nathan Goodyear on 06 Oct 14 - No Cached
  • Nathan Goodyear on 06 Oct 14
     
    Review of data of Testosterone in post-menopausal women is seriously lacking--especially long-term safety data and this is worrisome as other data points to increased CVD and cancer with increasing Testosterone levels in women.
Nathan Goodyear

The Benefits and Harms of Systemic Dehydroepiandrosterone (DHEA) in Postmenopausal Wome... - 0 views

press.endocrine.org/...jc.2014-2261

DHEA women hormone hormones

shared by Nathan Goodyear on 07 Oct 14 - No Cached
  • Nathan Goodyear on 07 Oct 14
     
    Review of the data points to poor quality of evidence dealing with DHEA in post-menopausal women with normal adrenal function.  Yet if DHEA is low, which is >95% produced by adrenals in women, then how can the adrenal function be "normal".   The meta-analysis found no improvement in libido and/or sexual function, and no improvement in lipids, glucose, weight... was noted.  Essentially not positive or negative effects were noted.  Abstract only available here, so dosage is a question.
Nathan Goodyear

Why women gain weight with adjuvant chemotherapy for breast cancer. - 0 views

jco.ascopubs.org/...1418.short

pre-menopause postmenopause chemotherapy cancer women hormone hormones

shared by Nathan Goodyear on 08 Oct 14 - No Cached
  • Nathan Goodyear on 08 Oct 14
     
    weight gain in cancer treatment seems to be directed at adjuvant therapy (chemo) and premenopausal status.
Nathan Goodyear

BMC Cancer | Full text | Estrogen receptor alpha/beta ratio and estrogen rece... - 0 views

www.biomedcentral.com/...425

breast cancer ER alpha ER-alpha ER beta ER-beta SERM tamoxifen anastrazole women hormone hormones female

shared by Nathan Goodyear on 08 Oct 14 - No Cached
  • 75% of human BCs express estrogen receptors (ERs)
  • Nathan Goodyear on 08 Oct 14
     
    ER beta expression and the ratio of ER alpha/ER beta is important in prognosis and effectiveness of SERM therapy like tamoxifen.  This study looked at the aromatase inhibitor anastrazole as well.
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

press.endocrine.org/...jc.2014-2222

gut flora gut microbiome gut microbiota estrogen metabolites metabolism hormone hormones women gut

shared by Nathan Goodyear on 06 May 15 - No Cached
  • Nathan Goodyear on 06 May 15
     
    women with increased gut microbiome diversity found to have increased estrogen metabolites compared to parent estrogen i.e. gut microbiome diversity in women effects estrogen metabolism. 
Nathan Goodyear

Estrogen Metabolism and Risk of Breast Cancer in Postmenopausal Women - 0 views

jnci.oxfordjournals.org/...326.full

estrogen metabolism cancer breast cancer estrogen metabolites

shared by Nathan Goodyear on 16 Jul 15 - No Cached
  • Nathan Goodyear on 16 Jul 15
     
    Get article on estrogen metabolism/metabolites and their effects on the risk of breast cancer in post menopause women.  This article brings to light new information: 2:16alpha estrone ratio is not a great predicted of risk, 2-OH and 4-OH metabolites can form quinone intermediates...
Nathan Goodyear

Associations of the Fecal Microbiome With Urinary Estrogens and Estrogen Metabolites in... - 0 views

press.endocrine.org/...jc.2014-2222

estrogen metabolites gut flora gut microbiome gut microbiota hormones cancer breast cancer microbiome estrogen

shared by Nathan Goodyear on 16 Jul 15 - No Cached
  • Nathan Goodyear on 16 Jul 15
     
    Post-menopause women with increased gut microbiome diversity found to be associated with increased urinary excretion of estrogen metabolites compared to parent estrogens.  This relationship has been shown to be associated with a reduced breast cancer risk.
Nathan Goodyear

Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of en... - 0 views

www.ncbi.nlm.nih.gov/...PMC3241553

estrogen metabolism 2-hydroxyestrone 4-hydroxyestrone estrogen metabolites cancer uterine cancer endometrial cancer hormones 2:16alpha-OHE1 2:16

shared by Nathan Goodyear on 07 Oct 15 - No Cached
  • our results do not support the hypothesis that greater metabolism of oestrogen via the 2-OH pathway, relative to the 16α-OH pathway, protects against endometrial cancer. Indeed our results are more suggestive of an increase in risk, rather than a decrease, with higher levels of 2-OHE1
  • women with a higher 2-OHE1 : 16α-OHE1 ratio did not have a decreased risk of endometrial cancer as compared with women with a lower ratio
  • The findings from this first prospective epidemiological study of oestrogen metabolites and endometrial cancer are in line with results from prospective studies on breast cancer, another oestrogen-related cancer. None of the seven studies on breast cancer reported significant associations overall
  • ...4 more annotations...
  • On the whole, prospective epidemiological data do not support the hypothesis that the 2-hydroxyestrogen pathway is protective, and the 16α-hydroxyestrogen pathway harmful, in hormone-dependent cancers
  • Both 2- and 4-hydroxyestrogens are catecholestrogens, and it has been suggested that catecholestrogens increase risk of oestrogen-mediated cancers through direct genotoxic effects, rather than through stimulation of cell proliferation via binding to oestrogen receptors
  • the evidence is stronger for 4-hydroxyestrogens than for 2-hydroxyestrogens
  • a significant increase in risk of breast cancer with levels of 2-OHE1 has also been reported previously, although it was limited to hormone receptor-negative tumours
  • Nathan Goodyear on 07 Oct 15
     
    2:16 hydroxyestrone ratio not associated with uterine cancer risk.
Nathan Goodyear

Percutaneous progesterone delivery via cream or gel application in postmenopausal women... - 0 views

www.researchgate.net/...ood_saliva_and_capillary_blood

saliva saliva testing salivary testing blood spot capillary blood progesterone hormones

shared by Nathan Goodyear on 22 Jun 15 - No Cached
  • Nathan Goodyear on 22 Jun 15
     
    Topical hormones best evaluated via saliva and/or blood spot. Urine and particularly serum does not increase with dosing.  That does not mean the topical hormone therapy is ineffective, just that serum and urine are not optimal to follow topical therapy.  When looking at endogenous hormones without any therapies: serum, saliva, urine, and blood spot are equivalent.
Nathan Goodyear

Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16α-hydroxyestrone rati... - 0 views

www.ncbi.nlm.nih.gov/...PMC3039007

breast cancer 2-OH-estrone 2-OH 4-OH 2:16alpha-OHE1 2:16 estrogen metabolism

shared by Nathan Goodyear on 02 Jan 13 - No Cached
  • A recent study of nine patients concluded that the urinary EMR is a good approximation for breast tissue EMR
  • A single study in young women not using oral contraceptives found fair correlation coefficients between urinary and plasma EMR
  • All of nine properly designed epidemiological studies (six prospective case-control studies and three retrospective studies) failed to show a significant relationship between urinary or circulating EMR (2OHE1/16αOHE1) and breast cancer risk
  • ...2 more annotations...
  • premenopausal studies on urinary EMR have suggested a potentially weak inverse relationship, associations were not significantly different compared with postmenopausal or overall combined studies
  • at present, there is no evidence that the EMR can predict breast cancer risk
  • Nathan Goodyear on 02 Jan 13
     
    The 2:16 OH estrone pathway is shown to not be predictive biomarker for breast cancer.
Nathan Goodyear

Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in... - 0 views

joe.endocrinology-journals.org/...217.full.pdf

CRP testosterone inflammation men male hormones cytokines

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    This study finds no difference between the sexes as it relates to testosterone and inflammatory cytokines. They only found a correlation with CRP as it relates to oxidized LDL.
Nathan Goodyear

Investigation of the association between the fecal microbiota and breast cancer in post... - 0 views

www.ncbi.nlm.nih.gov/...26032724

breast cancer women hormones gut flora gut microbiome gut microbiota cancer

shared by Nathan Goodyear on 16 Sep 15 - No Cached
  • Nathan Goodyear on 16 Sep 15
     
    women with post menopause breast cancer have altered gut flora compared to women without.
Nathan Goodyear

Effects of hormone replacement therapy on the mammary gland of surgically postmenopausa... - 0 views

www.ajog.org/...abstract

HRT synthetic hormone replacement Premarin Provera. Prempro breast cancer

shared by Nathan Goodyear on 05 Nov 10 - No Cached
  • Nathan Goodyear on 05 Nov 10
     
    Premarin and provera together increase risk of breast cancer development
Nathan Goodyear

Effect of Medroxyprogesterone Acetate on Endothelium-Dependent Vasodilation in Postmeno... - 0 views

circ.ahajournals.org/...1773

MPA synthetic progestins heart cardiac medroxyprogesterone

shared by Nathan Goodyear on 18 Nov 10 - No Cached
  • Nathan Goodyear on 18 Nov 10
     
    synthetic progestin (MPA) off sets beneficial estrogen heart benefits
Nathan Goodyear

Waist Circumference, Waist: Hip Ratio, and Risk of Breast Cancer in the Nurses' Health ... - 0 views

aje.oxfordjournals.org/...1316.short

waist breast circumference cancer risk

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • These data suggest that greater waist circumference increases risk of breast cancer, especially among postmenopausal women
  • Nathan Goodyear on 10 Feb 11
     
    as waist size increases, so does breast cancer risk
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