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Nathan Goodyear

Salivary testosterone in postmenopausal women with... [J Rheumatol. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9632063

salivary testosterone

shared by Nathan Goodyear on 18 Jan 11 - No Cached
  • CONCLUSION: Testosterone in saliva is a useful indicator for monitoring androgenic status in women with RA.
  • Nathan Goodyear on 18 Jan 11
     
    saliva testing validated in women with RA
Nathan Goodyear

Re: Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women... - 0 views

jnci.oxfordjournals.org/...380.full

hormones breast cancer SHBG

shared by Nathan Goodyear on 28 Jan 11 - No Cached
  • Nathan Goodyear on 28 Jan 11
     
    non-SHBG bound serum estradiol, testosterone and DHEA reveal increase breast cancer risk; other studies show saliva testing equal to serum non-bound SHBG hormones
Nathan Goodyear

Estrogen synthesis in human colon cancer epithelial cells | Alternative Medicine Review... - 0 views

findarticles.com/...ai_65068489

colon cancer estrogen aromatase quercetin

shared by Nathan Goodyear on 09 Feb 11 - No Cached
  • These findings demonstrate for the first time that colorectal adenocarcinoma cell lines express aromatase. Interestingly, the enzyme activity was inhibited by quercetin, one major dietary flavonoid, by tamoxifen, a hormonal therapeutic agent for breast cancer, and by raloxifene, used in the prevention of postmenopausal osteoporosis.
  • Nathan Goodyear on 09 Feb 11
     
    colon cancer cells regulated by Estrogen through aromatase activity
Nathan Goodyear

Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Blood Coagulation and... - 0 views

atvb.ahajournals.org/...3071.short

transdermal bioidentical estrogen progesterone estradiol thromboembolism DVT

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    transdermal estrogen/progesterone therapy does not increase thrombotic risk
Nathan Goodyear

Differential Effects of Oral and Transdermal Estrogen/Progesterone Regimens on Sensitiv... - 0 views

atvb.ahajournals.org/...1671.short

oral estradiol estrogen transdermal bioidentical DVT thromboembolism

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    transdermal estradiol does not increase blood clot risk, when compared with oral estradiol
Nathan Goodyear

ScienceDirect - Maturitas : Transdermal estradiol does not impair hemostatic biomarkers... - 0 views

www.sciencedirect.com/...S0378512204001173

DVT thromboembolism transdermal estradiol bioidentical hormones

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    transdermal estradiol does not increase thrombotic risk
Nathan Goodyear

Salivary, but not serum or urinary levels of progesterone are elevated after topical ap... - 0 views

onlinelibrary.wiley.com/...full

saliva progesterone salivary transdermal therapy

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    salivary levels, not serum, reflect topical progesterone therapy
Nathan Goodyear

Oestriol in the treatment of postmenopausal urgenc... [Maturitas. 1993] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8107615

estriol E3 treatment

shared by Nathan Goodyear on 30 Mar 11 - No Cached
  • oestriol produced both subjective and objective improvement in lower urinary tract function
  • Nathan Goodyear on 30 Mar 11
     
    oestriol produced both subjective and objective improvement in lower urinary tract function
Nathan Goodyear

Caution on the use of saliva measurements to monitor absorption of progesterone from tr... - 0 views

www.maturitas.org/...abstract

saliva measurements salivary testing hormone progesterone

shared by Nathan Goodyear on 12 Jul 11 - No Cached
  • Nathan Goodyear on 12 Jul 11
     
    conclusion incorrect.  blood testing is a poor testing method of transdermal progesterone therapy would be the more accurate conclusion.  Other studies have shown that transdermal progesterone therapy raises progesterone in saliva when blood levels show no change.
Nathan Goodyear

Tissue-Specific Increases in 11β-Hydroxysteroid Dehydrogenase Type 1 in Norma... - 0 views

www.ncbi.nlm.nih.gov/...PMC2795198

menopause 11-betaHSD1 11-betaHSD cortisol post-menopause post menopause women hormone hormones metabolism weight

shared by Nathan Goodyear on 29 May 14 - No Cached
  • Nathan Goodyear on 29 May 14
     
    11 beta HSD type 1 increases in menopause in normal weight women.  This may explain some of the metabolism changes seen in women post-menopause.
Nathan Goodyear

Dehydroepiandrosterone for women in the peri- or postmenopausal phase. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25609024

DHEA women female hormone hormones dehydroepiandrosterone

shared by Nathan Goodyear on 06 Feb 15 - No Cached
  • Nathan Goodyear on 06 Feb 15
     
    Supporting evidence for DHEA improvement for women is mixed and minimal.  Full article is not available so the question as whether a need was indicated based on testing is not available.  Side effects were seen with DHEA--primarily acne.  
Nathan Goodyear

Testosterone for peri- and postmenopausal women. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16235365

Testosterone women female hormone hormones

shared by Nathan Goodyear on 06 Feb 15 - No Cached
  • Nathan Goodyear on 06 Feb 15
     
    Cochrane review for Testosterone therapy for women points to lacking data.  The lengths of study reached a maximum of 2 years with the average at 6 months.  Improvement in sexual function was found in post-menopausal women, but safety and long-term data is lacking.
Nathan Goodyear

The Benefits and Harms of Systemic Testosterone Therapy in Postmenopausal Women With No... - 0 views

press.endocrine.org/...jc.2014-2262

Testosterone women female hormone hormones menopause

shared by Nathan Goodyear on 06 Feb 15 - No Cached
  • Nathan Goodyear on 06 Feb 15
     
    Only abstract available.  Meta-analysis of Testosterone therapy in post-menopausal women finds significant bias, some improvement in sexual function and cholesterol levels, yet safety and long-term data is significantly lacking.  Take this with studies on endogenous Testosterone in women, significant caution needs to be followed with Testosterone in women. Only abstract available here.
Nathan Goodyear

Relationship between Low Free Testosterone Levels and Loss of Muscle Mass : Scientific ... - 0 views

www.nature.com/...srep01818.html

muscle men male hormone Testosterone free Testosterone low T low Testosterone

shared by Nathan Goodyear on 05 Mar 15 - No Cached
  • Our data confirm that a low FT level is a significant predictor of a risk for loss of appendicular muscle
  • Total lean mass is associated with bioavailable T in postmenopausal women
  • Further studies are needed to determine the role of androgens in preserving muscle mass in women
  • ...11 more annotations...
  • Approximately 1% to 2% of T in the blood exists as FT
  • appendicular muscle loss was significantly associated with low levels of FT
  • These results suggest that a threshold level of FT exists for muscle loss, rather than a dose-response relationship
  • In the previous cross-sectional and longitudinal studies of French and American men, no dose-response relationships were reported between T and muscle mass
  • A minimal serum level of FT may be needed to preserve muscle mass in men, regardless of race/ethnicity.
  • Our result is in line with previous studies that reported a relationship between low FT and low muscle mass in men
  • T stimulates protein synthesis and inhibits protein degradation in muscle cells
  • T also increases satellite cell replication and activation in older men
  • In this study, no significant association between TT levels and muscle loss were observed
  • Although a progressive decrease in TT levels with ageing is observed in middle-aged and elderly American men16, 17, the TT levels do not change during ageing in Japanese men
  • FT levels may be a good marker for the loss of muscle mas
  • Nathan Goodyear on 05 Mar 15
     
    study of Japanese men finds that low free Testosterone was a predictor of decrease in muscle mass.
Nathan Goodyear

Correlation between Hormonal Statuses and Metabolic Syndrome in Postmenopausal Women - 0 views

www.ncbi.nlm.nih.gov/...PMC4064771

metabolic syndrome metabolic syndrome Testosterone SHBG hormone hormones women post menopause

shared by Nathan Goodyear on 30 Jun 14 - No Cached
  • Nathan Goodyear on 30 Jun 14
     
    Study of 110 women finds metabolic syndrome prevalence at 39%.  The women with metabolic syndrome had statistically higher Testosterone levels and statistically lower SHBG.  This stands in start contrast to metabolic syndrome in men.
Nathan Goodyear

Low Sex-Hormone Binding Globulin is Associated with the Metabolic Syndrome in Postmenop... - 0 views

www.ncbi.nlm.nih.gov/...PMC1633722

metabolic syndrome MetS SHBG post-menopause post menopause menopause Testosterone free androgen index women female hormone hormones

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    low SHBG in post-menopausal women correlates with increased risk of metabolic syndrome.  More than that, there is an inverse correlation with SHBG in women and metabolic syndrome components.  Also, Increasing components of MetS was correlated with Testosterone and free androgen index.
Nathan Goodyear

Circulating 2-hydroxy and 16-α hydroxy estrone levels and risk of breast canc... - 1 views

www.ncbi.nlm.nih.gov/...PMC2562592

estrogen metabolism menopause post-menopause post menopause estrogen metabolite 2-OH-estrone 16-alpha-OH-estrone 2:16alpha-OH estrone breast cancer risk hormone hormones

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • 2-OH estrogens bind to the estrogen receptor (ER) with affinity equivalent to or greater than estradiol
  • previous prospective studies have not observed any significant associations with either 2-OH or 16α-OH estrone or the ratio of the two metabolites and breast cancer risk overall.
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      whether that risk is increased or decreased
  • it has been hypothesized that metabolism favoring the 2-OH over the 16α-OH pathway may be inversely associated with breast cancer risk (28).
  • ...24 more annotations...
  • they may act as only weak mitogens (14, 15), or as inhibitors of proliferation
  • No significant associations have been observed between 2-OH estrone and breast cancer risk
  • While 16α-OH estrone binds to the ER with lower affinity than estradiol, it binds covalently (18-20) and once bound, fails to down-regulate the receptor (21). Thus, 16α-OH estrone stimulates cell proliferation in a manner comparable to estradiol in ER+ breast cancer cell lines
  • In this large prospective study of 2-OH and 16α-OH estrone metabolites and breast cancer risk, we did not observe any significant associations overall with either individual metabolite or with the ratio of the two metabolites
  • we observed positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with lower BMI and women with ER-/PR-tumors,
  • To date, several epidemiologic studies have examined the association between the 2-OH and 16α-OH estrogen metabolites and breast cancer risk with inconclusive results.
  • circulating estrogen levels have been associated more strongly with ER+/PR+ tumors than with ER-/PR- tumors
  • our results do not support the hypothesis that metabolism favoring the 2-OH estrone pathway is more beneficial to breast cancer risk than that favoring the 16α-OH estrone pathway
  • we observed significant positive associations of both 2-OH estrone and the 2:16α-OH estrone ratio with ER-/PR-tumors
  • Three (30, 32, 33) of four (30-33) studies observed RRs above 1 for the association between 16α-OH estrone and breast cancer risk (range of RRs=1.23-2.47); none of the point estimates was statistically significant though one trend was suggestive
  • based on animal studies, 2-OH estrone and the 2:16α-OH estrone ratio have been hypothesized to be inversely associated with breast cancer risk
  • No significant associations have been observed between 2-OH estrone, 16α-OH estrone, or the 2:16α-OH estrone ratio and breast cancer risk and the direction of the estimates is not consistent across studies.
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      better worded is no consistent, significant associations.   There are some studies that point to the 16 catecholestrogen and increased cancer risk; limited studies show negative effects of 2 catecholestrogens on cancer risk and prospective studies available pretty much dispel the idea that the 2:16 ratio has an risk predictability.
  • we observed a suggestive inverse association with 16α-OH estrone and a significant positive association with the 2:16α-OH estrone ratio among lean women, suggesting possible associations in a low estrogen environment.
  • 16α-OH estrone increases unscheduled DNA synthesis in mouse mammary cells (27) and hence also may be genotoxic
  • Although 2-OH estrogens are capable of redox cycling, the semiquinones and quinones (i.e., the oxidized forms) form stable DNA adducts that are reversible without DNA destruction
  • In our population of PMH nonusers, we observed no associations with ER+/PR+ tumors, but significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with ER-/PR- tumors
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      one of the few studies to find this association between 2 catecholestrogens and the 2:16 ratio and ER-/PR-tumors
  • Animal and in vitro studies have shown that hydroxy estrogens can induce DNA damage either directly, through the formation of quinones and DNA adducts, or indirectly, through redox cycling and the generation of reactive oxygen species
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      genotoxic via directe DNA adducts and indirectly via ROS; this is in addition to the proliferative effect
  • we observed a significant positive association between the 2:16α-OH estrone ratio and breast cancer risk among lean women
  • No significant associations have been observed with the 2:16α-OH estrone ratio
  • In the Danish study, no associations were observed with either ER+ or ER- tumors among PMH nonusers
  • significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio were observed among PMH users with ER+, but not ER-, tumors
  • it is possible that the genotoxicity of 2-OH estrone plays a role in hormone receptor negative tumors
  • 4-OH estrogens have a greater estrogenic potential than 2-OH estrogens, given the lower dissociation rate from estrogen receptors compared with estradiol (61), and are potentially more genotoxic since the quinones form unstable adducts, leading to depurination and mutation in vitro and in vivo
  • the balance between the catechol (i.e., 2-OH and 4-OH) and methoxy (i.e., 2-Me and 4-Me) estrogens may impact risk
  • Nathan Goodyear on 21 Aug 14
     
    The risks of estrogen metabolism are not clear cut.  Likely never will be due to the complexity of individual metabolism.  This study found no correlation between 2OH-Estrone and 2OH:16alpha-Estrone and breast cancer risk in ER+/PR+ breast cancer.  Translated: no benefit in breast cancer risk in 2OH-Estrone metabolism or increased 2OH:16alpha estrone metabolism.  There was a positive association between 2OH-Estrone and 2:16alpha-Estrone in women with ER-/PR- tumors and low BMI.
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Nathan Goodyear

Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health ... - 0 views

jamanetwork.com/...1108676

diabetes statin statin therapy

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Study finds increased risk of diabetes in post menopause women on statin therapy.  The authors here propose it as a class effect but also is associated with increased dosing.
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