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Nathan Goodyear

Intratumoral injections of viscum album mistletoe in malignant left inguinal large sarcoma - 0 views

www.longdom.org/...uinal-large-sarcoma-34385.html

sarcoma cancer mistletoe

shared by Nathan Goodyear on 27 May 20 - No Cached
  • Nathan Goodyear on 27 May 20
     
    intratumoral + IV mistletoe found to be helpful in reduction in cancer cell proliferation.
Nathan Goodyear

Starting the fight in the tumor: expert recommendations for the development of human in... - 0 views

www.ncbi.nlm.nih.gov/...PMC6290929

intra lesional injection cancer intratumoral injection intratumoral intratumoral protocol intra-tumoral injection

shared by Nathan Goodyear on 26 Dec 23 - No Cached
  • Nathan Goodyear on 26 Dec 23
     
    To guide protocol creation, i.e. needle sizes, injections…
Nathan Goodyear

Assessment of Image-Guided Intratumoral Delivery of Immunotherapeutics in Patients With... - 0 views

jamanetwork.com/...2768765

intratumoral protocol intratumoral injection cancer intratumoral

shared by Nathan Goodyear on 26 Dec 23 - No Cached
  • Nathan Goodyear on 26 Dec 23
     
    Shown to be safe across broad spectrum of tumor types.
Nathan Goodyear

More evidence intratumoral DHT synthesis drives castration-resistant prostate cancer Wi... - 0 views

www.ajandrology.com/article.asp

DHEA DHT prostate cancer 3 beta HSD

shared by Nathan Goodyear on 17 Jan 14 - No Cached
  • Nathan Goodyear on 17 Jan 14
     
    Mouse model shows that intratumor conversion of DHEA to DHT stimulates tumor growth in prostate cancer model.
Nathan Goodyear

Intratumoral Application of Standardized Mistletoe Extracts Down Regulates Tumor Weight... - 0 views

www.researchgate.net/...and_Necrosis_in_a_Murine_Model

mistletoe

shared by Nathan Goodyear on 27 May 20 - No Cached
  • Nathan Goodyear on 27 May 20
     
    Intratumoral mistletoe injections reduces proliferation and increases apoptosis in breast cancer mouse model.
Nathan Goodyear

Hypereosinophilia Induced by High-Dose Intratumoral and Peritumoral Mistletoe Applicati... - 0 views

www.liebertpub.com/...10755530050120664

pancreatic cancer mistletoe eosinophils cancer

shared by Nathan Goodyear on 27 May 20 - No Cached
  • Nathan Goodyear on 27 May 20
     
    IV and Intratumoral mistletoe induced hypereosinophilia in pancreatic cancer case study.
Nathan Goodyear

Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy - 0 views

erc.endocrinology-journals.org/...R175.full

prostate cancer DHT 3-beta-diol 3-alpha-diol metabolites metabolite male men hormone hormones androgen deprivation therapy

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Additional studies have similarly found that prostate tissue levels of DHT in PCa patients treated with ADT therapy before prostatectomy declined by only ∼75% versus declines of ∼95% in serum levels
  • In a recent study in healthy men, treatment for 1 month with a GnRH antagonist to suppress testicular androgen synthesis caused a 94% decline in serum testosterone, but only a 70–80% decline in prostate tissue testosterone and DHT
  • progression to CRPC was associated with increased intratumoral accumulation or synthesis of testosterone.
  • ...9 more annotations...
  • the intraprostatic synthesis of testosterone from adrenal-derived precursors likely accounts for the relatively high testosterone levels in prostate after ADT
  • In addition, AR activity in these cells is likely further enhanced by multiple mechanisms that sensitize AR to low levels of androgens
  • higher affinity ligand DHT (approximately eightfold higher affinity
  • type 2 5α-reductase (SRD5A2) being the major enzyme in prostate
  • reduce DHT to 5α-androstane-3α,17β-diol (3α-androstanediol; Ji et al. 2003, Rizner et al. 2003), which is then glucuronidated to form 3α-androstanediol glucuronide by the enzymes UDP glycosyltransferase 2, B15 (UGT2B15) or UGT2B17
  • DHT in prostate is inactivated by the enzyme AKR1C2, which is also termed 3α-hydroxysteroid dehydrogenase type 3 (3α-HSD type 3
    • Nathan Goodyear
      Nathan Goodyear on 03 Feb 14
       
      The metabolite 3-alpha androstanediol is NOT inactive as this author states.  This DHT metabolite actually can stimulate  ER alpha receptors in the prostate.
  • AKR1C1, is also expressed in prostate. However, in contrast to AKR1C2, it converts DHT primarily to 5α-androstane-3β,17β-diol (3β-androstanediol; Steckelbroeck et al. 2004), which is a potential endogenous ligand for the estrogen receptor β
  • Significantly, intraprostatic testosterone levels were not substantially reduced relative to controls with normal serum androgen levels, although DHT levels were reduced to 18% of controls
  • testosterone levels in many of the CRPC samples were actually increased relative to control tissues (Montgomery et al. 2008). While DHT levels were less markedly increased, this may have reflected DHT catabolism
  • Nathan Goodyear on 03 Feb 14
     
    This article discusses the failure of androgen deprivation therapy and prostate cancer.  This failure is quite common.  The authors point to alpha-DHT as the primary mechanism through AR stimulation.  However, we know that DHT metabolites also stimulate estrogen receptors.
Nathan Goodyear

Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androg... - 0 views

www.nature.com/...srep01528.html

prostate cancer 3-alpha androstanediol 3-beta androstanediol DHT metabolite metabolites

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • PSA levels in media were increased by 3α-diol
  • Similarly to 3α-diol, 3β-diol also increased PSA levels in media in a concentration-dependent manner
  • intracellular DHT is synthesized from inactive androgen 3α- and 3β-diol via different pathways in prostate cancer cells
  • ...12 more annotations...
    • Nathan Goodyear
      Nathan Goodyear on 15 Jul 15
       
      error in statement: DHT metabolites are not inactive, they just don't activate AR.
  • 3β-diol can be a precursor of DHT in prostate cancer cells.
  • serum 3α-diol G levels reflect the androgen milieu in localized prostate cancer patients receiving ADT
  • A few studies reported that 3β-diol is a potential ligand of estrogen receptor β (ERβ) and has an antiproliferative effect
  • our results revealed that 3β-diol is potentially a precursor of DHT in prostate cancer cells
  • Bauman et al. showed that 3α-diol is inactive at AR, but induces prostate growth
  • Prostate cancer cells promoted synthesis from the DHT metabolite 3α-diol during the long duration of ADT
    • Nathan Goodyear
      Nathan Goodyear on 15 Jul 15
       
      the authors highlight the suggestion is that 3alpha-diol's activity is via 3alpha-HSD, but fail to mention that it is known that 3alpha-diol interacts with the ER-alpha in the prostate.
  • verified the synthesis of DHT from 3α- or 3β-diol via different pathways in prostate cancer cells in this study
  • HSD17B6 expression levels in prostate cancer can be useful for the diagnosis of high-risk prostate cancer
  • serum 3α-diol G levels reflect the adrenal androgen milieu in localized prostate cancer patients
  • 3α- and 3β-diol has a much more significant role in intratumoral androgen metabolism during ADT
  • Nathan Goodyear on 27 Jan 14
     
    DHT metabolites play an important role of intra-prostate DHT synthesis in those following ADT.  This is a proposed mechanism for the failure rate and aggressive nature of prostate cancer that fails ADT.   3-alpha androstanediol is converted via 3 alpha HSD back to DHT.  In contrast, 3-beta androstanediol cannot.
Nathan Goodyear

Low-dose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograf... - 0 views

www.ncbi.nlm.nih.gov/...PMC2359693

cancer mistletoe dendritic cells lectins

shared by Nathan Goodyear on 16 Oct 20 - No Cached
  • Nathan Goodyear on 16 Oct 20
     
    Mistletoe Lectin 1 induced tumor regression in mouse xenograft study. Of note in this study, there was an increase in intratumoral dendrites found. In this xenograft study, it is suggested that mistletoe via Lectins 1 induced increased innate immunity in the local tumor microenvironment.
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