Intratumoral injections of viscum album mistletoe in malignant left inguinal large sarcoma - 0 views
Intratumoral Application of Standardized Mistletoe Extracts Down Regulates Tumor Weight... - 0 views
Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy - 0 views
-
Additional studies have similarly found that prostate tissue levels of DHT in PCa patients treated with ADT therapy before prostatectomy declined by only ∼75% versus declines of ∼95% in serum levels
-
In a recent study in healthy men, treatment for 1 month with a GnRH antagonist to suppress testicular androgen synthesis caused a 94% decline in serum testosterone, but only a 70–80% decline in prostate tissue testosterone and DHT
-
progression to CRPC was associated with increased intratumoral accumulation or synthesis of testosterone.
- ...9 more annotations...
Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androg... - 0 views
-
PSA levels in media were increased by 3α-diol
-
Similarly to 3α-diol, 3β-diol also increased PSA levels in media in a concentration-dependent manner
-
intracellular DHT is synthesized from inactive androgen 3α- and 3β-diol via different pathways in prostate cancer cells
- ...12 more annotations...
-
DHT metabolites play an important role of intra-prostate DHT synthesis in those following ADT. This is a proposed mechanism for the failure rate and aggressive nature of prostate cancer that fails ADT. 3-alpha androstanediol is converted via 3 alpha HSD back to DHT. In contrast, 3-beta androstanediol cannot.